Details for: PTPN22
Associated with
Other Information
Genular Protein ID: 1620660814
Symbol: PTN22_HUMAN
Name: Tyrosine-protein phosphatase non-receptor type 22
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 10068674
Title: Cloning and characterization of a lymphoid-specific, inducible human protein tyrosine phosphatase, Lyp.
PubMed ID: 10068674
PubMed ID: 21044313
Title: Identification of a variant form of tyrosine phosphatase LYP.
PubMed ID: 21044313
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16710414
Title: The DNA sequence and biological annotation of human chromosome 1.
PubMed ID: 16710414
DOI: 10.1038/nature04727
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 16461343
Title: Identification of substrates of human protein-tyrosine phosphatase PTPN22.
PubMed ID: 16461343
PubMed ID: 17729039
Title: Protein tyrosine phosphatase PTPN22 in human autoimmunity.
PubMed ID: 17729039
PubMed ID: 22427951
Title: PTPN22.6, a dominant negative isoform of PTPN22 and potential biomarker of rheumatoid arthritis.
PubMed ID: 22427951
PubMed ID: 23871208
Title: The autoimmunity-associated gene PTPN22 potentiates toll-like receptor-driven, type 1 interferon-dependent immunity.
PubMed ID: 23871208
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 23991106
Title: Protein tyrosine phosphatase non-receptor type 22 modulates NOD2-induced cytokine release and autophagy.
PubMed ID: 23991106
PubMed ID: 27043286
Title: NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22.
PubMed ID: 27043286
DOI: 10.1172/jci83669
PubMed ID: 18056643
Title: Structure, inhibitor, and regulatory mechanism of Lyp, a lymphoid-specific tyrosine phosphatase implicated in autoimmune diseases.
PubMed ID: 18056643
PubMed ID: 19371084
Title: Crystal structure of the human lymphoid tyrosine phosphatase catalytic domain: insights into redox regulation.
PubMed ID: 19371084
DOI: 10.1021/bi900166y
PubMed ID: 19167335
Title: Large-scale structural analysis of the classical human protein tyrosine phosphatome.
PubMed ID: 19167335
PubMed ID: 18981062
Title: A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus.
PubMed ID: 18981062
DOI: 10.1093/hmg/ddn363
PubMed ID: 21719704
Title: Substrate specificity of lymphoid-specific tyrosine phosphatase (Lyp) and identification of Src kinase-associated protein of 55 kDa homolog (SKAP-HOM) as a Lyp substrate.
PubMed ID: 21719704
PubMed ID: 15208781
Title: A missense single-nucleotide polymorphism in a gene encoding a protein tyrosine phosphatase (PTPN22) is associated with rheumatoid arthritis.
PubMed ID: 15208781
DOI: 10.1086/422827
PubMed ID: 15273934
Title: Genetic association of the R620W polymorphism of protein tyrosine phosphatase PTPN22 with human SLE.
PubMed ID: 15273934
DOI: 10.1086/423790
PubMed ID: 15004560
Title: A functional variant of lymphoid tyrosine phosphatase is associated with type I diabetes.
PubMed ID: 15004560
DOI: 10.1038/ng1323
PubMed ID: 15531553
Title: The codon 620 tryptophan allele of the lymphoid tyrosine phosphatase (LYP) gene is a major determinant of Graves' disease.
PubMed ID: 15531553
DOI: 10.1210/jc.2004-1108
PubMed ID: 15719322
Title: Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: the PTPN22 620W allele associates with multiple autoimmune phenotypes.
PubMed ID: 15719322
DOI: 10.1086/429096
PubMed ID: 16015369
Title: A single-nucleotide polymorphism in the gene encoding lymphoid protein tyrosine phosphatase (PTPN22) confers susceptibility to generalised vitiligo.
PubMed ID: 16015369
PubMed ID: 19265110
Title: Cutting edge: the PTPN22 allelic variant associated with autoimmunity impairs B cell signaling.
PubMed ID: 19265110
PubMed ID: 21287672
Title: Differential association of two PTPN22 coding variants with Crohn's disease and ulcerative colitis.
PubMed ID: 21287672
DOI: 10.1002/ibd.21630
PubMed ID: 22952725
Title: Biochemical and functional studies of lymphoid-specific tyrosine phosphatase (Lyp) variants S201F and R266W.
PubMed ID: 22952725
Sequence Information:
- Length: 807
- Mass: 91705
- Checksum: 1ABE8AE89C9D9FBF
- Sequence:
MDQREILQKF LDEAQSKKIT KEEFANEFLK LKRQSTKYKA DKTYPTTVAE KPKNIKKNRY KDILPYDYSR VELSLITSDE DSSYINANFI KGVYGPKAYI ATQGPLSTTL LDFWRMIWEY SVLIIVMACM EYEMGKKKCE RYWAEPGEMQ LEFGPFSVSC EAEKRKSDYI IRTLKVKFNS ETRTIYQFHY KNWPDHDVPS SIDPILELIW DVRCYQEDDS VPICIHCSAG CGRTGVICAI DYTWMLLKDG IIPENFSVFS LIREMRTQRP SLVQTQEQYE LVYNAVLELF KRQMDVIRDK HSGTESQAKH CIPEKNHTLQ ADSYSPNLPK STTKAAKMMN QQRTKMEIKE SSSFDFRTSE ISAKEELVLH PAKSSTSFDF LELNYSFDKN ADTTMKWQTK AFPIVGEPLQ KHQSLDLGSL LFEGCSNSKP VNAAGRYFNS KVPITRTKST PFELIQQRET KEVDSKENFS YLESQPHDSC FVEMQAQKVM HVSSAELNYS LPYDSKHQIR NASNVKHHDS SALGVYSYIP LVENPYFSSW PPSGTSSKMS LDLPEKQDGT VFPSSLLPTS STSLFSYYNS HDSLSLNSPT NISSLLNQES AVLATAPRID DEIPPPLPVR TPESFIVVEE AGEFSPNVPK SLSSAVKVKI GTSLEWGGTS EPKKFDDSVI LRPSKSVKLR SPKSELHQDR SSPPPPLPER TLESFFLADE DCMQAQSIET YSTSYPDTME NSTSSKQTLK TPGKSFTRSK SLKILRNMKK SICNSCPPNK PAESVQSNNS SSFLNFGFAN RFSKPKGPRN PPPTWNI
Genular Protein ID: 223999078
Symbol: G3K0T4_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 783
- Mass: 88901
- Checksum: 98FBD248CFE5C995
- Sequence:
MDQREILQKF LDEAQSKKIT KEEFANEFLK LKRQSTKYKA DKTYPTTVAE KPKNIKKNRY KDILPYDYSR VELSLITSDE DSSYINANFI KGVYGPKAYI ATQGPLSTTL LDFWRMIWEY SVLIIVMACM EYEMGKEAEK RKSDYIIRTL KVKFNSETRT IYQFHYKNWP DHDVPSSIDP ILELIWDVRC YQEDDSVPIC IHCSAGCGRT GVICAIDYTW MLLKDGIIPE NFSVFSLIRE MRTQRPSLVQ TQEQYELVYN AVLELFKRQM DVIRDKHSGT ESQAKHCIPE KNHTLQADSY SPNLPKSTTK AAKMMNQQRT KMEIKESSSF DFRTSEISAK EELVLHPAKS STSFDFLELN YSFDKNADTT MKWQTKAFPI VGEPLQKHQS LDLGSLLFEG CSNSKPVNAA GRYFNSKVPI TRTKSTPFEL IQQRETKEVD SKENFSYLES QPHDSCFVEM QAQKVMHVSS AELNYSLPYD SKHQIRNASN VKHHDSSALG VYSYIPLVEN PYFSSWPPSG TSSKMSLDLP EKQDGTVFPS SLLPTSSTSL FSYYNSHDSL SLNSPTNISS LLNQESAVLA TAPRIDDEIP PPLPVRTPES FIVVEEAGEF SPNVPKSLSS AVKVKIGTSL EWGGTSEPKK FDDSVILRPS KSVKLRSPKS ELHQDRSSPP PPLPERTLES FFLADEDCMQ AQSIETYSTS YPDTMENSTS SKQTLKTPGK SFTRSKSLKI LRNMKKSICN SCPPNKPAES VQSNNSSSFL NFGFANRFSK PKGPRNPPPT WNI
Genular Protein ID: 3202291649
Symbol: B4DZW8_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Sequence Information:
- Length: 563
- Mass: 63034
- Checksum: 38BA765D6D290B9B
- Sequence:
MLLKDGIIPE NFSVFSLIRE MRTQRPSLVQ TQEQYELVYN AVLELFKRQM DVIRDKHSGT ESQAKHCIPE KNHTLQADSY SPNLPKSTTK AAKMMNQQRT KMEIKESSSF DFRTSEISAK EELVLHPAKS STSFDFLELN YSFDKNADTT MKWQTKAFPI VGEPLQKHQS LGLGSLLFEG CSNSKPVNAA GRYFNSKVPI TRTKSTPFEL IQQRETKEVD SKENFSYLES QPHDSCFVEM QAQKVMHVSS AELNYSLPYD SKHQIRNASN VKHHDSSALG VYSYIPLVEN PYFSSWPPSG TSSKMSLDLP EKQDGTVFPS SLLPTSSTSL FSYYNSHDSL SLNSPTNISS LLNQESAVLA TAPRIDDEIP PPLPVRTPES FIVVEEAGEF SPNVPKSLSS AVKVKIGTSL EWGGTSEPKK FDDSVILRPS KSVKLRSPKS ELHQDRSSPP PPLPERTLES FFLADEDCMQ AQSIETYSTS YPDTMENSTS SKQTLKTPGK SFTRSKSLKI LRNMKKSICN SCPPNKPAES VQSNNSSSFL NFGFANRFSK PKGPRNPPPT WNI
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.