Details for: AMD1

Gene ID: 262

Symbol: AMD1

Ensembl ID: ENSG00000123505

Description: adenosylmethionine decarboxylase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.16
    Marker Score: 3372
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.68
    Marker Score: 2096
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.56
    Marker Score: 6245
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 2.51
    Marker Score: 5294
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.47
    Marker Score: 83938
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.38
    Marker Score: 1384
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 2.18
    Marker Score: 1860
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.14
    Marker Score: 2970
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.12
    Marker Score: 5076
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.02
    Marker Score: 842
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.02
    Marker Score: 684.5
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.02
    Marker Score: 5655
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.99
    Marker Score: 992
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.9
    Marker Score: 12396
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 1.87
    Marker Score: 581
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.84
    Marker Score: 440
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.83
    Marker Score: 1820
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.8
    Marker Score: 4098
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.79
    Marker Score: 1880
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.77
    Marker Score: 1285
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 1.77
    Marker Score: 1343
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.77
    Marker Score: 568
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.74
    Marker Score: 4675
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.73
    Marker Score: 1080
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 1.73
    Marker Score: 2773
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 1.72
    Marker Score: 429
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.72
    Marker Score: 17382
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.71
    Marker Score: 1574
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.71
    Marker Score: 59324
  • Cell Name: NKp44-positive group 3 innate lymphoid cell, human (CL0001079)
    Fold Change: 1.71
    Marker Score: 387
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 1.71
    Marker Score: 429
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.71
    Marker Score: 3872
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.71
    Marker Score: 4301
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 1.7
    Marker Score: 490
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.7
    Marker Score: 6547
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.69
    Marker Score: 2863.5
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.69
    Marker Score: 3434
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.68
    Marker Score: 1781
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.67
    Marker Score: 2162
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.66
    Marker Score: 364.5
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.66
    Marker Score: 2950
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.66
    Marker Score: 2450
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.66
    Marker Score: 3472.5
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.66
    Marker Score: 605
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.65
    Marker Score: 14218
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 1.65
    Marker Score: 1719
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 1.65
    Marker Score: 362
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.64
    Marker Score: 2322
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.63
    Marker Score: 1724
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.63
    Marker Score: 328
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.61
    Marker Score: 1892
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 1.61
    Marker Score: 375
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 1.61
    Marker Score: 692
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.6
    Marker Score: 2552
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.6
    Marker Score: 649
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.6
    Marker Score: 4740
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 1.6
    Marker Score: 1048
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 1.6
    Marker Score: 393
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 1.59
    Marker Score: 1731
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.59
    Marker Score: 385
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 1.58
    Marker Score: 354
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.58
    Marker Score: 2677
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 1.57
    Marker Score: 1231.5
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.57
    Marker Score: 773
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 1.57
    Marker Score: 341
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.57
    Marker Score: 543
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.56
    Marker Score: 40070
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.56
    Marker Score: 360
  • Cell Name: starburst amacrine cell (CL0004232)
    Fold Change: 1.56
    Marker Score: 444
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.56
    Marker Score: 1226
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.56
    Marker Score: 895
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 1.56
    Marker Score: 412
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.55
    Marker Score: 651
  • Cell Name: type I enteroendocrine cell (CL0002277)
    Fold Change: 1.55
    Marker Score: 385
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.54
    Marker Score: 9856
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.54
    Marker Score: 6309
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 1.54
    Marker Score: 383
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 1.54
    Marker Score: 422
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.54
    Marker Score: 538
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.53
    Marker Score: 530
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 1.53
    Marker Score: 659
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 1.53
    Marker Score: 429
  • Cell Name: pre-B-I cell (CL0000956)
    Fold Change: 1.52
    Marker Score: 389
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 1.52
    Marker Score: 698
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 1.52
    Marker Score: 782
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.52
    Marker Score: 1539
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.52
    Marker Score: 452
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 1.51
    Marker Score: 321
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.51
    Marker Score: 391
  • Cell Name: S cone cell (CL0003050)
    Fold Change: 1.51
    Marker Score: 453
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 1.5
    Marker Score: 684
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.5
    Marker Score: 1813
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 1.5
    Marker Score: 740
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.5
    Marker Score: 1262
  • Cell Name: mesothelial fibroblast (CL4023054)
    Fold Change: 1.5
    Marker Score: 443
  • Cell Name: T-helper 1 cell (CL0000545)
    Fold Change: 1.49
    Marker Score: 582.5
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.49
    Marker Score: 5511
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 1.49
    Marker Score: 666
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 1.48
    Marker Score: 418.5
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 1.48
    Marker Score: 449

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Other Information

**Key characteristics:** * AMD1 is a protein that is involved in the metabolism of adenosylmethionine. * It is a member of the SAM family of enzymes, which are involved in the metabolism of methyl groups in organic molecules. * AMD1 is expressed in a variety of cell types, including skeletal muscle satellite stem cells, thyroid follicular cells, basal cells of the prostate epithelium, pancreatic acinar cells, fibroblasts of the mammary gland, luminal cells of the prostate epithelium, fibroblasts of connective tissue of the nonglandular part of the prostate, Mueller cells, oligodendrocytes, and fibroblasts of connective tissue of the glandular part of the prostate. **Pathways and functions:** * AMD1 is involved in the metabolism of adenosylmethionine through a variety of pathways, including the purine metabolic pathway and the polyamine metabolic pathway. * In the purine metabolic pathway, AMD1 is involved in the formation of purines from adenosylmethionine. * In the polyamine metabolic pathway, AMD1 is involved in the formation of spermine and spermidine from adenosylmethionine. * AMD1 also plays a role in the regulation of cell growth and differentiation. **Clinical significance:** * Mutations in the AMD1 gene have been linked to a number of human diseases, including prostate cancer and benign prostatic hyperplasia. * Studies of AMD1 mutations have led to the development of new diagnostic tests for prostate cancer and other diseases that are caused by mutations in the AMD1 gene. * AMD1 is a promising target for cancer therapy, as it is expressed in many cancer cells and is involved in the metabolism of adenosylmethionine.

Genular Protein ID: 3831507987

Symbol: DCAM_HUMAN

Name: S-adenosylmethionine decarboxylase proenzyme

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2460457

Title: Structure and regulation of mammalian S-adenosylmethionine decarboxylase.

PubMed ID: 2460457

DOI: 10.1016/s0021-9258(18)37495-7

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2687270

Title: Site of pyruvate formation and processing of mammalian S-adenosylmethionine decarboxylase proenzyme.

PubMed ID: 2687270

DOI: 10.1016/s0021-9258(19)30047-x

PubMed ID: 1917972

Title: Amino acid residues necessary for putrescine stimulation of human S-adenosylmethionine decarboxylase proenzyme processing and catalytic activity.

PubMed ID: 1917972

DOI: 10.1016/s0021-9258(18)55089-4

PubMed ID: 10574985

Title: Mechanistic studies of the processing of human S-adenosylmethionine decarboxylase proenzyme. Isolation of an ester intermediate.

PubMed ID: 10574985

DOI: 10.1074/jbc.274.49.35059

PubMed ID: 10029540

Title: Role of cysteine-82 in the catalytic mechanism of human S-adenosylmethionine decarboxylase.

PubMed ID: 10029540

DOI: 10.1021/bi9825201

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 10378277

Title: The crystal structure of human S-adenosylmethionine decarboxylase at 2.25-A resolution reveals a novel fold.

PubMed ID: 10378277

DOI: 10.1016/s0969-2126(99)80074-4

PubMed ID: 11583147

Title: The structural basis for substrate specificity and inhibition of human S-adenosylmethionine decarboxylase.

PubMed ID: 11583147

DOI: 10.1021/bi010735w

Sequence Information:

  • Length: 334
  • Mass: 38340
  • Checksum: 1BB433AF412C9179
  • Sequence:
  • MEAAHFFEGT EKLLEVWFSR QQPDANQGSG DLRTIPRSEW DILLKDVQCS IISVTKTDKQ 
    EAYVLSESSM FVSKRRFILK TCGTTLLLKA LVPLLKLARD YSGFDSIQSF FYSRKNFMKP 
    SHQGYPHRNF QEEIEFLNAI FPNGAAYCMG RMNSDCWYLY TLDFPESRVI SQPDQTLEIL 
    MSELDPAVMD QFYMKDGVTA KDVTRESGIR DLIPGSVIDA TMFNPCGYSM NGMKSDGTYW 
    TIHITPEPEF SYVSFETNLS QTSYDDLIRK VVEVFKPGKF VTTLFVNQSS KCRTVLASPQ 
    KIEGFKRLDC QSAMFNDYNF VFTSFAKKQQ QQQS

Genular Protein ID: 446231405

Symbol: A0A088AWN0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 305
  • Mass: 34976
  • Checksum: D3FC9C01EC59ADD8
  • Sequence:
  • MEAAHFFEGT EKLLEVWFSR QQPDANQGSG DLRTIPSESS MFVSKRRFIL KTCGTTLLLK 
    ALVPLLKLAR DYSGFDSIQS FFYSRKNFMK PSHQGYPHRN FQEEIEFLNA IFPNGAAYCM 
    GRMNSDCWYL YTLDFPESRV ISQPDQTLEI LMSELDPAVM DQFYMKDGVT AKDVTRESGI 
    RDLIPGSVID ATMFNPCGYS MNGMKSDGTY WTIHITPEPE FSYVSFETNL SQTSYDDLIR 
    KVVEVFKPGK FVTTLFVNQS SKCRTVLASP QKIEGFKRLD CQSAMFNDYN FVFTSFAKKQ 
    QQQQS

Genular Protein ID: 1808163191

Symbol: Q6N0B2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 334
  • Mass: 38287
  • Checksum: 1BB43573312C9EDC
  • Sequence:
  • MEAAHFFEGT EKLLEVWFSR QQPDANQGSG DLRTIPRSEW DILLKDVQCS IISVTKTDKQ 
    EAYVLSESSM FVSKRCFILK TCGTTLLLKA LVPLLKLARD YSGFDSIQSF FYSRKNFMKP 
    SHQGYPHRNF QEEIEFLNAI FPNGAAYCMG RMNSDCWYLY TLDFPESRVI SQPDQTLEIL 
    MSELDPAVMD QFYMKDGVTA KDVTRESGIR DLIPGSVIDA TMFNPCGYSM NGMKSDGTYW 
    TIHITPEPEF SYVSFETNLS QTSYDDLIRK VVEVFKPGKF VTTLFVNQSS KCRTVLASPQ 
    KIEGFKRLDC QSAMFNDYNF VFTSFAKKQQ QQQS

Genular Protein ID: 334989290

Symbol: Q5VXN5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

Sequence Information:

  • Length: 265
  • Mass: 30497
  • Checksum: 6B1151E4A567E5D7
  • Sequence:
  • MFVSKRRFIL KTCGTTLLLK ALVPLLKLAR DYSGFDSIQS FFYSRKNFMK PSHQGYPHRN 
    FQEEIEFLNA IFPNGAAYCM GRMNSDCWYL YTLDFPESRV ISQPDQTLEI LMSELDPAVM 
    DQFYMKDGVT AKDVTRESGI RDLIPGSVID ATMFNPCGYS MNGMKSDGTY WTIHITPEPE 
    FSYVSFETNL SQTSYDDLIR KVVEVFKPGK FVTTLFVNQS SKCRTVLASP QKIEGFKRLD 
    CQSAMFNDYN FVFTSFAKKQ QQQQS

Genular Protein ID: 714824002

Symbol: B4DZ60_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

Sequence Information:

  • Length: 214
  • Mass: 24465
  • Checksum: CF441EB294491E7A
  • Sequence:
  • MEAAHFFEGT EKLLEVWFSR QQPDANQGSG DLRTIPRYLY TLDFPESRVI SQPDQTLEIL 
    MSELDPAVMD QFYMKDGVTA KDVTRESGIR DLIPGSVIDA TMFNPCGYSM NGMKSDGTYW 
    TIHITPEPEF SYVSFETNLS QTSYDDLIRK VVEVFKPGKF VTTLFVNQSS KCRTVLASPQ 
    KIEGFKRLDC QSAMFNDYNF VFTSFAKKQQ QQQS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.