FBXL3 | ENSG00000005812 | NCBI 26224

Details for: FBXL3

Gene ID: 26224

Symbol: FBXL3

Ensembl ID: ENSG00000005812

Description: F-box and leucine rich repeat protein 3

Associated with

Adaptive immune system
(R-HSA-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-HSA-983168)
Association of tric/cct with target proteins during biosynthesis
(R-HSA-390471)
Chaperonin-mediated protein folding
(R-HSA-390466)
Circadian clock
(R-HSA-400253)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Immune system
(R-HSA-168256)
Metabolism of proteins
(R-HSA-392499)
Neddylation
(R-HSA-8951664)
Post-translational protein modification
(R-HSA-597592)
Protein folding
(R-HSA-391251)
Cytosol
(GO:0005829)
Entrainment of circadian clock by photoperiod
(GO:0043153)
Nuclear body
(GO:0016604)
Nucleus
(GO:0005634)
Protein binding
(GO:0005515)
Protein destabilization
(GO:0031648)
Protein ubiquitination
(GO:0016567)
Regulation of circadian rhythm
(GO:0042752)
Rhythmic process
(GO:0048511)
Scf-dependent proteasomal ubiquitin-dependent protein catabolic process
(GO:0031146)
Scf ubiquitin ligase complex
(GO:0019005)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin ligase complex
(GO:0000151)

Other Information

Proteins

F-box/LRR-repeat protein 3

Genular Protein ID: 2167828531

Symbol: FBXL3_HUMAN

Name: F-box/LRR-repeat protein 3

UniProtKB Accession Codes:

Q9UKT7 B2RB04 Q9P122

Database IDs:

Citations:

PubMed ID: 10531035

Title: Identification of a family of human F-box proteins.

PubMed ID: 10531035

DOI: 10.1016/s0960-9822(00)80020-2

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17463251

Title: SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins.

PubMed ID: 17463251

DOI: 10.1126/science.1141194

PubMed ID: 23452855

Title: Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm.

PubMed ID: 23452855

DOI: 10.1016/j.cell.2013.01.055

PubMed ID: 27565346

Title: Two distinct types of E3 ligases work in unison to regulate substrate ubiquitylation.

PubMed ID: 27565346

DOI: 10.1016/j.cell.2016.07.027

PubMed ID: 30481285

Title: Biallelic variants in FBXL3 cause intellectual disability, delayed motor development and short stature.

PubMed ID: 30481285

DOI: 10.1093/hmg/ddy406

Sequence Information:

Length: 428
Mass: 48707
Checksum: AAEAB31BAF0EA5A5
Sequence:

MKRGGRDSDR NSSEEGTAEK SKKLRTTNEH SQTCDWGNLL QDIILQVFKY LPLLDRAHAS 
QVCRNWNQVF HMPDLWRCFE FELNQPATSY LKATHPELIK QIIKRHSNHL QYVSFKVDSS 
KESAEAACDI LSQLVNCSLK TLGLISTARP SFMDLPKSHF ISALTVVFVN SKSLSSLKID 
DTPVDDPSLK VLVANNSDTL KLLKMSSCPH VSPAGILCVA DQCHGLRELA LNYHLLSDEL 
LLALSSEKHV RLEHLRIDVV SENPGQTHFH TIQKSSWDAF IRHSPKVNLV MYFFLYEEEF 
DPFFRYEIPA THLYFGRSVS KDVLGRVGMT CPRLVELVVC ANGLRPLDEE LIRIAERCKN 
LSAIGLGECE VSCSAFVEFV KMCGGRLSQL SIMEEVLIPD QKYSLEQIHW EVSKHLGRVW 
FPDMMPTW

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: FBXL3

Associated with

Other Information

Identification of a family of human F-box proteins. PubMed ID: 10531035

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins. PubMed ID: 17463251

Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm. PubMed ID: 23452855

Two distinct types of E3 ligases work in unison to regulate substrate ubiquitylation. PubMed ID: 27565346

Biallelic variants in FBXL3 cause intellectual disability, delayed motor development and short stature. PubMed ID: 30481285