FBXL5 | ENSG00000118564 | NCBI 26234

Details for: FBXL5

Gene ID: 26234

Symbol: FBXL5

Ensembl ID: ENSG00000118564

Description: F-box and leucine rich repeat protein 5

Associated with

Adaptive immune system
(R-HSA-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-HSA-983168)
Association of tric/cct with target proteins during biosynthesis
(R-HSA-390471)
Chaperonin-mediated protein folding
(R-HSA-390466)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Immune system
(R-HSA-168256)
Iron uptake and transport
(R-HSA-917937)
Metabolism of proteins
(R-HSA-392499)
Neddylation
(R-HSA-8951664)
Post-translational protein modification
(R-HSA-597592)
Protein folding
(R-HSA-391251)
Transport of small molecules
(R-HSA-382551)
2 iron, 2 sulfur cluster binding
(GO:0051537)
Cytosol
(GO:0005829)
Intracellular iron ion homeostasis
(GO:0006879)
Iron ion binding
(GO:0005506)
Multicellular organismal-level iron ion homeostasis
(GO:0060586)
Nucleus
(GO:0005634)
Perinuclear region of cytoplasm
(GO:0048471)
Positive regulation of protein catabolic process
(GO:0045732)
Protein binding
(GO:0005515)
Protein ubiquitination
(GO:0016567)
Scf-dependent proteasomal ubiquitin-dependent protein catabolic process
(GO:0031146)
Scf ubiquitin ligase complex
(GO:0019005)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin ligase complex
(GO:0000151)

Other Information

Proteins

F-box/LRR-repeat protein 5

Genular Protein ID: 2555734094

Symbol: FBXL5_HUMAN

Name: F-box/LRR-repeat protein 5

UniProtKB Accession Codes:

Q9UKA1 A8MSK4 B4DIB5 Q4W5A8 Q8NHP3 Q9NXN2 Q9P0I0 Q9P0X5 Q9UJT7 Q9UKC8

Database IDs:

Citations:

PubMed ID: 10531037

Title: A family of mammalian F-box proteins.

PubMed ID: 10531037

DOI: 10.1016/s0960-9822(00)80021-4

PubMed ID: 10945468

Title: cDNA cloning and expression analysis of new members of the mammalian F-box protein family.

PubMed ID: 10945468

DOI: 10.1006/geno.2000.6211

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10531035

Title: Identification of a family of human F-box proteins.

PubMed ID: 10531035

DOI: 10.1016/s0960-9822(00)80020-2

PubMed ID: 17532294

Title: FBXL5 interacts with p150Glued and regulates its ubiquitination.

PubMed ID: 17532294

DOI: 10.1016/j.bbrc.2007.05.068

PubMed ID: 19762596

Title: Control of iron homeostasis by an iron-regulated ubiquitin ligase.

PubMed ID: 19762596

DOI: 10.1126/science.1176333

PubMed ID: 19762597

Title: An E3 ligase possessing an iron responsive hemerythrin domain is a regulator of iron homeostasis.

PubMed ID: 19762597

DOI: 10.1126/science.1176326

PubMed ID: 24157836

Title: Nuclear ubiquitination by FBXL5 modulates Snail1 DNA binding and stability.

PubMed ID: 24157836

DOI: 10.1093/nar/gkt935

PubMed ID: 24778179

Title: HERC2 targets the iron regulator FBXL5 for degradation and modulates iron metabolism.

PubMed ID: 24778179

DOI: 10.1074/jbc.m113.541490

PubMed ID: 25249620

Title: FBXL5-mediated degradation of single-stranded DNA-binding protein hSSB1 controls DNA damage response.

PubMed ID: 25249620

DOI: 10.1093/nar/gku876

PubMed ID: 22492618

Title: The structural basis of iron sensing by the human F-box protein FBXL5.

PubMed ID: 22492618

DOI: 10.1002/cbic.201200043

PubMed ID: 22253436

Title: Structural and molecular characterization of iron-sensing hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5).

PubMed ID: 22253436

DOI: 10.1074/jbc.m111.308684

PubMed ID: 32126207

Title: FBXL5 Regulates IRP2 Stability in Iron Homeostasis via an Oxygen-Responsive [2Fe2S] Cluster.

PubMed ID: 32126207

DOI: 10.1016/j.molcel.2020.02.011

Sequence Information:

Length: 691
Mass: 78555
Checksum: 923A1B31590E5145
Sequence:

MAPFPEEVDV FTAPHWRMKQ LVGLYCDKLS KTNFSNNNDF RALLQSLYAT FKEFKMHEQI 
ENEYIIGLLQ QRSQTIYNVH SDNKLSEMLS LFEKGLKNVK NEYEQLNYAK QLKERLEAFT 
RDFLPHMKEE EEVFQPMLME YFTYEELKDI KKKVIAQHCS QKDTAELLRG LSLWNHAEER 
QKFFKYSVDE KSDKEAEVSE HSTGITHLPP EVMLSIFSYL NPQELCRCSQ VSMKWSQLTK 
TGSLWKHLYP VHWARGDWYS GPATELDTEP DDEWVKNRKD ESRAFHEWDE DADIDESEES 
AEESIAISIA QMEKRLLHGL IHNVLPYVGT SVKTLVLAYS SAVSSKMVRQ ILELCPNLEH 
LDLTQTDISD SAFDSWSWLG CCQSLRHLDL SGCEKITDVA LEKISRALGI LTSHQSGFLK 
TSTSKITSTA WKNKDITMQS TKQYACLHDL TNKGIGEEID NEHPWTKPVS SENFTSPYVW 
MLDAEDLADI EDTVEWRHRN VESLCVMETA SNFSCSTSGC FSKDIVGLRT SVCWQQHCAS 
PAFAYCGHSF CCTGTALRTM SSLPESSAMC RKAARTRLPR GKDLIYFGSE KSDQETGRVL 
LFLSLSGCYQ ITDHGLRVLT LGGGLPYLEH LNLSGCLTIT GAGLQDLVSA CPSLNDEYFY 
YCDNINGPHA DTASGCQNLQ CGFRACCRSG E

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: FBXL5

Associated with

Other Information

A family of mammalian F-box proteins. PubMed ID: 10531037

cDNA cloning and expression analysis of new members of the mammalian F-box protein family. PubMed ID: 10945468

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of a family of human F-box proteins. PubMed ID: 10531035

FBXL5 interacts with p150Glued and regulates its ubiquitination. PubMed ID: 17532294

Control of iron homeostasis by an iron-regulated ubiquitin ligase. PubMed ID: 19762596

An E3 ligase possessing an iron responsive hemerythrin domain is a regulator of iron homeostasis. PubMed ID: 19762597

Nuclear ubiquitination by FBXL5 modulates Snail1 DNA binding and stability. PubMed ID: 24157836

HERC2 targets the iron regulator FBXL5 for degradation and modulates iron metabolism. PubMed ID: 24778179

FBXL5-mediated degradation of single-stranded DNA-binding protein hSSB1 controls DNA damage response. PubMed ID: 25249620

The structural basis of iron sensing by the human F-box protein FBXL5. PubMed ID: 22492618

Structural and molecular characterization of iron-sensing hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5). PubMed ID: 22253436

FBXL5 Regulates IRP2 Stability in Iron Homeostasis via an Oxygen-Responsive [2Fe2S] Cluster. PubMed ID: 32126207