FBXW8 | ENSG00000174989 | NCBI 26259

Details for: FBXW8

Gene ID: 26259

Symbol: FBXW8

Ensembl ID: ENSG00000174989

Description: F-box and WD repeat domain containing 8

Associated with

Adaptive immune system
(R-HSA-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-HSA-983168)
Class i mhc mediated antigen processing & presentation
(R-HSA-983169)
Immune system
(R-HSA-168256)
Metabolism of proteins
(R-HSA-392499)
Neddylation
(R-HSA-8951664)
Post-translational protein modification
(R-HSA-597592)
3m complex
(GO:1990393)
Cell population proliferation
(GO:0008283)
Centriole
(GO:0005814)
Ciliary basal body
(GO:0036064)
Cilium assembly
(GO:0060271)
Cul7-ring ubiquitin ligase complex
(GO:0031467)
Cytosol
(GO:0005829)
Golgi apparatus
(GO:0005794)
Golgi organization
(GO:0007030)
Labyrinthine layer blood vessel development
(GO:0060716)
Perinuclear region of cytoplasm
(GO:0048471)
Positive regulation of dendrite morphogenesis
(GO:0050775)
Positive regulation of proteasomal ubiquitin-dependent protein catabolic process
(GO:0032436)
Protein binding
(GO:0005515)
Protein ubiquitination
(GO:0016567)
Scf ubiquitin ligase complex
(GO:0019005)
Ubiquitin-protein transferase activity
(GO:0004842)

Other Information

Proteins

F-box/WD repeat-containing protein 8

Genular Protein ID: 3022225323

Symbol: FBXW8_HUMAN

Name: F-box/WD repeat-containing protein 8

UniProtKB Accession Codes:

Q8N3Y1 Q9UK95

Database IDs:

Citations:

PubMed ID: 10531037

Title: A family of mammalian F-box proteins.

PubMed ID: 10531037

DOI: 10.1016/s0960-9822(00)80021-4

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12481031

Title: CUL7: a DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex.

PubMed ID: 12481031

DOI: 10.1073/pnas.252646399

PubMed ID: 12904573

Title: Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis.

PubMed ID: 12904573

DOI: 10.1073/pnas.1733908100

PubMed ID: 17332328

Title: PARC and CUL7 form atypical cullin RING ligase complexes.

PubMed ID: 17332328

DOI: 10.1158/0008-5472.can-06-3241

PubMed ID: 18498745

Title: The CUL7 E3 ubiquitin ligase targets insulin receptor substrate 1 for ubiquitin-dependent degradation.

PubMed ID: 18498745

DOI: 10.1016/j.molcel.2008.03.009

PubMed ID: 21572988

Title: An OBSL1-Cul7Fbxw8 ubiquitin ligase signaling mechanism regulates Golgi morphology and dendrite patterning.

PubMed ID: 21572988

DOI: 10.1371/journal.pbio.1001060

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24362026

Title: The CUL7/F-box and WD repeat domain containing 8 (CUL7/Fbxw8) ubiquitin ligase promotes degradation of hematopoietic progenitor kinase 1.

PubMed ID: 24362026

DOI: 10.1074/jbc.m113.520106

PubMed ID: 24793695

Title: The 3M complex maintains microtubule and genome integrity.

PubMed ID: 24793695

DOI: 10.1016/j.molcel.2014.03.047

Sequence Information:

Length: 598
Mass: 67394
Checksum: 03B3C283BA46DB6B
Sequence:

MDDYSLDEFR RRWQEELAQA QAPKKRRRPE AAERRARRPE VGSGRGEQAS GDPALAQRLL 
EGAGRPPAAR ATRAEGQDVA SRSRSPLARE GAGGGEQLVD QLIRDLNEMN DVPFFDIQLP 
YELAINIFQY LDRKELGRCA QVSKTWKVIA EDEVLWYRLC QQEGHLPDSS ISDYSCWKLI 
FQECRAKEHM LRTNWKNRKG AVSELEHVPD TVLCDVHSHD GVVIAGYTSG DVRVWDTRTW 
DYVAPFLESE DEEDEPGMQP NVSFVRINSS LAVAAYEDGF LNIWDLRTGK YPVHRFEHDA 
RIQALALSQD DATVATASAF DVVMLSPNEE GYWQIAAEFE VPKLVQYLEI VPETRRYPVA 
VAAAGDLMYL LKAEDSARTL LYAHGPPVTC LDVSANQVAF GVQGLGWVYE GSKILVYSLE 
AGRRLLKLGN VLRDFTCVNL SDSPPNLMVS GNMDGRVRIH DLRSGNIALS LSAHQLRVSA 
VQMDDWKIVS GGEEGLVSVW DYRMNQKLWE VYSGHPVQHI SFSSHSLITA NVPYQTVMRN 
ADLDSFTTHR RHRGLIRAYE FAVDQLAFQS PLPVCRSSCD AMATHYYDLA LAFPYNHV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: FBXW8

Associated with

Other Information

A family of mammalian F-box proteins. PubMed ID: 10531037

The finished DNA sequence of human chromosome 12. PubMed ID: 16541075

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

CUL7: a DOC domain-containing cullin selectively binds Skp1.Fbx29 to form an SCF-like complex. PubMed ID: 12481031

Targeted disruption of p185/Cul7 gene results in abnormal vascular morphogenesis. PubMed ID: 12904573

PARC and CUL7 form atypical cullin RING ligase complexes. PubMed ID: 17332328

The CUL7 E3 ubiquitin ligase targets insulin receptor substrate 1 for ubiquitin-dependent degradation. PubMed ID: 18498745

An OBSL1-Cul7Fbxw8 ubiquitin ligase signaling mechanism regulates Golgi morphology and dendrite patterning. PubMed ID: 21572988

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

The CUL7/F-box and WD repeat domain containing 8 (CUL7/Fbxw8) ubiquitin ligase promotes degradation of hematopoietic progenitor kinase 1. PubMed ID: 24362026

The 3M complex maintains microtubule and genome integrity. PubMed ID: 24793695