FBXO5 | ENSG00000112029 | NCBI 26271

Details for: FBXO5

Gene ID: 26271

Symbol: FBXO5

Ensembl ID: ENSG00000112029

Description: F-box protein 5

Associated with

Apc/c-mediated degradation of cell cycle proteins
(R-HSA-174143)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
G1/s-specific transcription
(R-HSA-69205)
G1/s transition
(R-HSA-69206)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Mitotic metaphase/anaphase transition
(R-HSA-68881)
Mitotic metaphase and anaphase
(R-HSA-2555396)
M phase
(R-HSA-68886)
Phosphorylation of emi1
(R-HSA-176417)
Regulation of apc/c activators between g1/s and early anaphase
(R-HSA-176408)
Scf-beta-trcp mediated degradation of emi1
(R-HSA-174113)
Anaphase-promoting complex binding
(GO:0010997)
Cell division
(GO:0051301)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna damage response
(GO:0006974)
Meiotic spindle
(GO:0072687)
Metal ion binding
(GO:0046872)
Microtubule polymerization
(GO:0046785)
Molecular function inhibitor activity
(GO:0140678)
Negative regulation of cellular senescence
(GO:2000773)
Negative regulation of dna endoreduplication
(GO:0032876)
Negative regulation of meiotic nuclear division
(GO:0045835)
Negative regulation of mitotic metaphase/anaphase transition
(GO:0045841)
Negative regulation of ubiquitin-protein transferase activity
(GO:0051444)
Negative regulation of ubiquitin protein ligase activity
(GO:1904667)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Oocyte maturation
(GO:0001556)
Positive regulation of biomineral tissue development
(GO:0070169)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of g2/m transition of mitotic cell cycle
(GO:0010971)
Positive regulation of mesenchymal stem cell migration
(GO:1905322)
Positive regulation of osteoblast differentiation
(GO:0045669)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Protein ubiquitination
(GO:0016567)
Regulation of dna replication
(GO:0006275)
Regulation of mitotic cell cycle
(GO:0007346)
Regulation of mitotic nuclear division
(GO:0007088)
Spindle
(GO:0005819)
Spindle assembly involved in female meiosis i
(GO:0007057)
Ubiquitin ligase inhibitor activity
(GO:1990948)
Vesicle organization
(GO:0016050)

Other Information

Proteins

FBX5_HUMAN

Genular Protein ID: 1469598569

Symbol: FBX5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q9UKT4 B3KNX5 Q5TF47 Q8WV29 Q9UGC8

Database IDs:

Citations:

PubMed ID: 10531035

Title: Identification of a family of human F-box proteins.

PubMed ID: 10531035

DOI: 10.1016/s0960-9822(00)80020-2

PubMed ID: 11988738

Title: E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1).

PubMed ID: 11988738

DOI: 10.1038/ncb785

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12791267

Title: Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase.

PubMed ID: 12791267

DOI: 10.1016/s1534-5807(03)00153-9

PubMed ID: 15469984

Title: Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC inhibitor Emi1.

PubMed ID: 15469984

DOI: 10.1091/mbc.e04-07-0598

PubMed ID: 15148369

Title: Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome.

PubMed ID: 15148369

DOI: 10.1073/pnas.0402442101

PubMed ID: 16439210

Title: The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1.

PubMed ID: 16439210

DOI: 10.1016/j.cell.2005.10.038

PubMed ID: 16921029

Title: Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor.

PubMed ID: 16921029

DOI: 10.1101/gad.1454006

PubMed ID: 17234884

Title: The APC/C inhibitor, Emi1, is essential for prevention of rereplication.

PubMed ID: 17234884

DOI: 10.1101/gad.1495007

PubMed ID: 17485488

Title: Emi1 is needed to couple DNA replication with mitosis but does not regulate activation of the mitotic APC/C.

PubMed ID: 17485488

DOI: 10.1083/jcb.200611166

PubMed ID: 17875940

Title: Loss of Emi1-dependent anaphase-promoting complex/cyclosome inhibition deregulates E2F target expression and elicits DNA damage-induced senescence.

PubMed ID: 17875940

DOI: 10.1128/mcb.00908-07

PubMed ID: 19211842

Title: DNA damage triggers p21WAF1-dependent Emi1 down-regulation that maintains G2 arrest.

PubMed ID: 19211842

DOI: 10.1091/mbc.e08-08-0818

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23708001

Title: Emi1 preferentially inhibits ubiquitin chain elongation by the anaphase-promoting complex.

PubMed ID: 23708001

DOI: 10.1038/ncb2755

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 29850565

Title: Two Transcripts of FBXO5 Promote Migration and Osteogenic Differentiation of Human Periodontal Ligament Mesenchymal Stem Cells.

PubMed ID: 29850565

DOI: 10.1155/2018/7849294

PubMed ID: 29875408

Title: EMI1 switches from being a substrate to an inhibitor of APC/CCDH1 to start the cell cycle.

PubMed ID: 29875408

DOI: 10.1038/s41586-018-0199-7

PubMed ID: 23708605

Title: Electron microscopy structure of human APC/C(CDH1)-EMI1 reveals multimodal mechanism of E3 ligase shutdown.

PubMed ID: 23708605

DOI: 10.1038/nsmb.2593

PubMed ID: 26083744

Title: Atomic structure of the APC/C and its mechanism of protein ubiquitination.

PubMed ID: 26083744

DOI: 10.1038/nature14471

Sequence Information:

Length: 447
Mass: 50146
Checksum: 196FBC2578F92120
Sequence:

MSRRPCSCAL RPPRCSCSAS PSAVTAAGRP RPSDSCKEES STLSVKMKCD FNCNHVHSGL 
KLVKPDDIGR LVSYTPAYLE GSCKDCIKDY ERLSCIGSPI VSPRIVQLET ESKRLHNKEN 
QHVQQTLNST NEIEALETSR LYEDSGYSSF SLQSGLSEHE EGSLLEENFG DSLQSCLLQI 
QSPDQYPNKN LLPVLHFEKV VCSTLKKNAK RNPKVDREML KEIIARGNFR LQNIIGRKMG 
LECVDILSEL FRRGLRHVLA TILAQLSDMD LINVSKVSTT WKKILEDDKG AFQLYSKAIQ 
RVTENNNKFS PHASTREYVM FRTPLASVQK SAAQTSLKKD AQTKLSNQGD QKGSTYSRHN 
EFSEVAKTLK KNESLKACIR CNSPAKYDCY LQRATCKREG CGFDYCTKCL CNYHTTKDCS 
DGKLLKASCK IGPLPGTKKS KKNLRRL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: FBXO5

Associated with

Other Information

Identification of a family of human F-box proteins. PubMed ID: 10531035

E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APC(Cdh1). PubMed ID: 11988738

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and analysis of human chromosome 6. PubMed ID: 14574404

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Prophase destruction of Emi1 by the SCF(betaTrCP/Slimb) ubiquitin ligase activates the anaphase promoting complex to allow progression beyond prometaphase. PubMed ID: 12791267

Plk1 regulates activation of the anaphase promoting complex by phosphorylating and triggering SCFbetaTrCP-dependent destruction of the APC inhibitor Emi1. PubMed ID: 15469984

Role of Polo-like kinase in the degradation of early mitotic inhibitor 1, a regulator of the anaphase promoting complex/cyclosome. PubMed ID: 15148369

The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1. PubMed ID: 16439210

Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor. PubMed ID: 16921029

The APC/C inhibitor, Emi1, is essential for prevention of rereplication. PubMed ID: 17234884

Emi1 is needed to couple DNA replication with mitosis but does not regulate activation of the mitotic APC/C. PubMed ID: 17485488

Loss of Emi1-dependent anaphase-promoting complex/cyclosome inhibition deregulates E2F target expression and elicits DNA damage-induced senescence. PubMed ID: 17875940

DNA damage triggers p21WAF1-dependent Emi1 down-regulation that maintains G2 arrest. PubMed ID: 19211842

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Emi1 preferentially inhibits ubiquitin chain elongation by the anaphase-promoting complex. PubMed ID: 23708001

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Two Transcripts of FBXO5 Promote Migration and Osteogenic Differentiation of Human Periodontal Ligament Mesenchymal Stem Cells. PubMed ID: 29850565

EMI1 switches from being a substrate to an inhibitor of APC/CCDH1 to start the cell cycle. PubMed ID: 29875408

Electron microscopy structure of human APC/C(CDH1)-EMI1 reveals multimodal mechanism of E3 ligase shutdown. PubMed ID: 23708605

Atomic structure of the APC/C and its mechanism of protein ubiquitination. PubMed ID: 26083744