TINF2 | ENSG00000092330 | NCBI 26277

Details for: TINF2

Gene ID: 26277

Symbol: TINF2

Ensembl ID: ENSG00000092330

Description: TERF1 interacting nuclear factor 2

Associated with

Base-excision repair, ap site formation
(R-HSA-73929)
Base excision repair
(R-HSA-73884)
Cell cycle
(R-HSA-1640170)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular senescence
(R-HSA-2559583)
Chromosome maintenance
(R-HSA-73886)
Cleavage of the damaged purine
(R-HSA-110331)
Cleavage of the damaged pyrimidine
(R-HSA-110329)
Depurination
(R-HSA-73927)
Depyrimidination
(R-HSA-73928)
Dna damage/telomere stress induced senescence
(R-HSA-2559586)
Dna repair
(R-HSA-73894)
Extension of telomeres
(R-HSA-180786)
Inhibition of dna recombination at telomere
(R-HSA-9670095)
Meiosis
(R-HSA-1500620)
Meiotic synapsis
(R-HSA-1221632)
Packaging of telomere ends
(R-HSA-171306)
Polymerase switching on the c-strand of the telomere
(R-HSA-174411)
Processive synthesis on the c-strand of the telomere
(R-HSA-174414)
Recognition and association of dna glycosylase with site containing an affected purine
(R-HSA-110330)
Recognition and association of dna glycosylase with site containing an affected pyrimidine
(R-HSA-110328)
Removal of the flap intermediate from the c-strand
(R-HSA-174437)
Reproduction
(R-HSA-1474165)
Telomere c-strand (lagging strand) synthesis
(R-HSA-174417)
Telomere c-strand synthesis initiation
(R-HSA-174430)
Telomere extension by telomerase
(R-HSA-171319)
Telomere maintenance
(R-HSA-157579)
Chromosome, telomeric region
(GO:0000781)
Dna binding
(GO:0003677)
Negative regulation of epithelial cell proliferation
(GO:0050680)
Negative regulation of protein adp-ribosylation
(GO:0010836)
Negative regulation of telomere maintenance via telomerase
(GO:0032211)
Nuclear body
(GO:0016604)
Nuclear matrix
(GO:0016363)
Nuclear telomere cap complex
(GO:0000783)
Nucleoplasm
(GO:0005654)
Perinucleolar chromocenter
(GO:0010370)
Positive regulation of telomere maintenance
(GO:0032206)
Protein binding
(GO:0005515)
Protein localization to chromosome, telomeric region
(GO:0070198)
Regulation of telomere maintenance via telomere lengthening
(GO:1904356)
Shelterin complex
(GO:0070187)
Telomere assembly
(GO:0032202)
Telomere capping
(GO:0016233)
Telomeric dna binding
(GO:0042162)

Other Information

Proteins

TERF1-interacting nuclear factor 2

Genular Protein ID: 1292154244

Symbol: TINF2_HUMAN

Name: TERF1-interacting nuclear factor 2

UniProtKB Accession Codes:

Q9BSI4 B3W5Q7 Q9H904 Q9UHC2

Database IDs:

Citations:

PubMed ID: 10581025

Title: TIN2, a new regulator of telomere length in human cells.

PubMed ID: 10581025

DOI: 10.1038/70508

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12768206

Title: POT1 as a terminal transducer of TRF1 telomere length control.

PubMed ID: 12768206

DOI: 10.1038/nature01688

PubMed ID: 15231715

Title: POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex.

PubMed ID: 15231715

DOI: 10.1101/gad.1215404

PubMed ID: 15316005

Title: TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres.

PubMed ID: 15316005

DOI: 10.1074/jbc.m409047200

PubMed ID: 15383534

Title: Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins.

PubMed ID: 15383534

DOI: 10.1074/jbc.m409293200

PubMed ID: 16166375

Title: Shelterin: the protein complex that shapes and safeguards human telomeres.

PubMed ID: 16166375

DOI: 10.1101/gad.1346005

PubMed ID: 16880378

Title: A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly.

PubMed ID: 16880378

DOI: 10.1073/pnas.0605303103

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19279399

Title: The long and short of it: a new isoform of TIN2 in the nuclear matrix.

PubMed ID: 19279399

DOI: 10.4161/cc.8.6.8337

PubMed ID: 19229133

Title: A novel form of the telomere-associated protein TIN2 localizes to the nuclear matrix.

PubMed ID: 19229133

DOI: 10.4161/cc.8.6.7941

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 18202258

Title: A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins.

PubMed ID: 18202258

DOI: 10.1126/science.1151804

PubMed ID: 18252230

Title: TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita.

PubMed ID: 18252230

DOI: 10.1016/j.ajhg.2007.10.004

Sequence Information:

Length: 451
Mass: 50023
Checksum: E5A7FD11CE523979
Sequence:

MATPLVAGPA ALRFAAAASW QVVRGRCVEH FPRVLEFLRS LRAVAPGLVR YRHHERLCMG 
LKAKVVVELI LQGRPWAQVL KALNHHFPES GPIVRDPKAT KQDLRKILEA QETFYQQVKQ 
LSEAPVDLAS KLQELEQEYG EPFLAAMEKL LFEYLCQLEK ALPTPQAQQL QDVLSWMQPG 
VSITSSLAWR QYGVDMGWLL PECSVTDSVN LAEPMEQNPP QQQRLALHNP LPKAKPGTHL 
PQGPSSRTHP EPLAGRHFNL APLGRRRVQS QWASTRGGHK ERPTVMLFPF RNLGSPTQVI 
SKPESKEEHA IYTADLAMGT RAASTGKSKS PCQTLGGRAL KENPVDLPAT EQKENCLDCY 
MDPLRLSLLP PRARKPVCPP SLCSSVITIG DLVLDSDEEE NGQGEGKESL ENYQKTKFDT 
LIPTLCEYLP PSGHGAIPVS SCDCRDSSRP L

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: TINF2

Associated with

Other Information

TIN2, a new regulator of telomere length in human cells. PubMed ID: 10581025

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

POT1 as a terminal transducer of TRF1 telomere length control. PubMed ID: 12768206

POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex. PubMed ID: 15231715

TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres. PubMed ID: 15316005

Telosome, a mammalian telomere-associated complex formed by multiple telomeric proteins. PubMed ID: 15383534

Shelterin: the protein complex that shapes and safeguards human telomeres. PubMed ID: 16166375

A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly. PubMed ID: 16880378

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

The long and short of it: a new isoform of TIN2 in the nuclear matrix. PubMed ID: 19279399

A novel form of the telomere-associated protein TIN2 localizes to the nuclear matrix. PubMed ID: 19229133

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. PubMed ID: 28112733

A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins. PubMed ID: 18202258

TINF2, a component of the shelterin telomere protection complex, is mutated in dyskeratosis congenita. PubMed ID: 18252230