FGF20 | ENSG00000078579 | NCBI 26281

Details for: FGF20

Gene ID: 26281

Symbol: FGF20

Ensembl ID: ENSG00000078579

Description: fibroblast growth factor 20

Associated with

Activated point mutants of fgfr2
(R-HSA-2033519)
Constitutive signaling by aberrant pi3k in cancer
(R-HSA-2219530)
Disease
(R-HSA-1643685)
Diseases of signal transduction by growth factor receptors and second messengers
(R-HSA-5663202)
Downstream signaling of activated fgfr1
(R-HSA-5654687)
Downstream signaling of activated fgfr2
(R-HSA-5654696)
Downstream signaling of activated fgfr3
(R-HSA-5654708)
Downstream signaling of activated fgfr4
(R-HSA-5654716)
Fgfr1 ligand binding and activation
(R-HSA-190242)
Fgfr1 mutant receptor activation
(R-HSA-1839124)
Fgfr1c ligand binding and activation
(R-HSA-190373)
Fgfr2 ligand binding and activation
(R-HSA-190241)
Fgfr2 mutant receptor activation
(R-HSA-1839126)
Fgfr2c ligand binding and activation
(R-HSA-190375)
Fgfr3 ligand binding and activation
(R-HSA-190239)
Fgfr3 mutant receptor activation
(R-HSA-2033514)
Fgfr3b ligand binding and activation
(R-HSA-190371)
Fgfr3c ligand binding and activation
(R-HSA-190372)
Fgfr4 ligand binding and activation
(R-HSA-190322)
Frs-mediated fgfr1 signaling
(R-HSA-5654693)
Frs-mediated fgfr2 signaling
(R-HSA-5654700)
Frs-mediated fgfr3 signaling
(R-HSA-5654706)
Frs-mediated fgfr4 signaling
(R-HSA-5654712)
Igf1r signaling cascade
(R-HSA-2428924)
Insulin receptor signalling cascade
(R-HSA-74751)
Intracellular signaling by second messengers
(R-HSA-9006925)
Irs-mediated signalling
(R-HSA-112399)
Irs-related events triggered by igf1r
(R-HSA-2428928)
Mapk1/mapk3 signaling
(R-HSA-5684996)
Mapk family signaling cascades
(R-HSA-5683057)
Negative regulation of fgfr1 signaling
(R-HSA-5654726)
Negative regulation of fgfr2 signaling
(R-HSA-5654727)
Negative regulation of fgfr3 signaling
(R-HSA-5654732)
Negative regulation of fgfr4 signaling
(R-HSA-5654733)
Negative regulation of the pi3k/akt network
(R-HSA-199418)
Phospholipase c-mediated cascade: fgfr1
(R-HSA-5654219)
Phospholipase c-mediated cascade; fgfr2
(R-HSA-5654221)
Phospholipase c-mediated cascade; fgfr3
(R-HSA-5654227)
Phospholipase c-mediated cascade; fgfr4
(R-HSA-5654228)
Pi-3k cascade:fgfr1
(R-HSA-5654689)
Pi-3k cascade:fgfr2
(R-HSA-5654695)
Pi-3k cascade:fgfr3
(R-HSA-5654710)
Pi-3k cascade:fgfr4
(R-HSA-5654720)
Pi3k/akt signaling in cancer
(R-HSA-2219528)
Pi3k cascade
(R-HSA-109704)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-HSA-6811558)
Pip3 activates akt signaling
(R-HSA-1257604)
Raf/map kinase cascade
(R-HSA-5673001)
Shc-mediated cascade:fgfr1
(R-HSA-5654688)
Shc-mediated cascade:fgfr2
(R-HSA-5654699)
Shc-mediated cascade:fgfr3
(R-HSA-5654704)
Shc-mediated cascade:fgfr4
(R-HSA-5654719)
Signaling by activated point mutants of fgfr1
(R-HSA-1839122)
Signaling by activated point mutants of fgfr3
(R-HSA-1839130)
Signaling by fgfr
(R-HSA-190236)
Signaling by fgfr1
(R-HSA-5654736)
Signaling by fgfr1 in disease
(R-HSA-5655302)
Signaling by fgfr2
(R-HSA-5654738)
Signaling by fgfr2 in disease
(R-HSA-5655253)
Signaling by fgfr3
(R-HSA-5654741)
Signaling by fgfr3 in disease
(R-HSA-5655332)
Signaling by fgfr4
(R-HSA-5654743)
Signaling by fgfr in disease
(R-HSA-1226099)
Signaling by insulin receptor
(R-HSA-74752)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signaling by type 1 insulin-like growth factor 1 receptor (igf1r)
(R-HSA-2404192)
Animal organ morphogenesis
(GO:0009887)
Cell-cell signaling
(GO:0007267)
Cell differentiation
(GO:0030154)
Cytoplasm
(GO:0005737)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Fibroblast growth factor receptor binding
(GO:0005104)
Fibroblast growth factor receptor signaling pathway
(GO:0008543)
Growth factor activity
(GO:0008083)
Heparan sulfate proteoglycan binding
(GO:0043395)
Inner ear auditory receptor cell differentiation
(GO:0042491)
Negative regulation of neuron apoptotic process
(GO:0043524)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of dopaminergic neuron differentiation
(GO:1904340)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of protein phosphorylation
(GO:0001934)
Receptor-receptor interaction
(GO:0090722)
Regulation of cardiac muscle cell proliferation
(GO:0060043)
Regulation of cell migration
(GO:0030334)
Regulation of dopamine secretion
(GO:0014059)
Signaling receptor binding
(GO:0005102)
Signal transduction
(GO:0007165)

Other Information

Proteins

Fibroblast growth factor 20

Genular Protein ID: 76584741

Symbol: FGF20_HUMAN

Name: Fibroblast growth factor 20

UniProtKB Accession Codes:

Q9NP95 B2RPH5

Database IDs:

Citations:

PubMed ID: 10913340

Title: Molecular cloning and characterization of human FGF-20 on chromosome 8p21.3-p22.

PubMed ID: 10913340

DOI: 10.1006/bbrc.2000.3142

PubMed ID: 11032730

Title: FGF-20, a novel neurotrophic factor, preferentially expressed in the substantia nigra pars compacta of rat brain.

PubMed ID: 11032730

DOI: 10.1006/bbrc.2000.3675

PubMed ID: 11306498

Title: Identification of a novel human fibroblast growth factor and characterization of its role in oncogenesis.

PubMed ID: 11306498

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16597617

Title: Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family.

PubMed ID: 16597617

DOI: 10.1074/jbc.m601252200

PubMed ID: 18252210

Title: Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synuclein.

PubMed ID: 18252210

DOI: 10.1016/j.ajhg.2007.09.021

PubMed ID: 19133659

Title: FGF20 and Parkinson's disease: no evidence of association or pathogenicity via alpha-synuclein expression.

PubMed ID: 19133659

DOI: 10.1002/mds.22442

PubMed ID: 20094046

Title: Fibroblast growth factor signalling: from development to cancer.

PubMed ID: 20094046

DOI: 10.1038/nrc2780

PubMed ID: 22698282

Title: FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man.

PubMed ID: 22698282

DOI: 10.1016/j.devcel.2012.04.018

PubMed ID: 19564416

Title: Homodimerization controls the fibroblast growth factor 9 subfamily's receptor binding and heparan sulfate-dependent diffusion in the extracellular matrix.

PubMed ID: 19564416

DOI: 10.1128/mcb.01780-08

Sequence Information:

Length: 211
Mass: 23499
Checksum: AB04608C16060CC1
Sequence:

MAPLAEVGGF LGGLEGLGQQ VGSHFLLPPA GERPPLLGER RSAAERSARG GPGAAQLAHL 
HGILRRRQLY CRTGFHLQIL PDGSVQGTRQ DHSLFGILEF ISVAVGLVSI RGVDSGLYLG 
MNDKGELYGS EKLTSECIFR EQFEENWYNT YSSNIYKHGD TGRRYFVALN KDGTPRDGAR 
SKRHQKFTHF LPRPVDPERV PELYKDLLMY T

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: FGF20

Associated with

Other Information

Molecular cloning and characterization of human FGF-20 on chromosome 8p21.3-p22. PubMed ID: 10913340

FGF-20, a novel neurotrophic factor, preferentially expressed in the substantia nigra pars compacta of rat brain. PubMed ID: 11032730

Identification of a novel human fibroblast growth factor and characterization of its role in oncogenesis. PubMed ID: 11306498

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family. PubMed ID: 16597617

Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synuclein. PubMed ID: 18252210

FGF20 and Parkinson's disease: no evidence of association or pathogenicity via alpha-synuclein expression. PubMed ID: 19133659

Fibroblast growth factor signalling: from development to cancer. PubMed ID: 20094046

FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man. PubMed ID: 22698282

Homodimerization controls the fibroblast growth factor 9 subfamily's receptor binding and heparan sulfate-dependent diffusion in the extracellular matrix. PubMed ID: 19564416