ERAL1 | ENSG00000132591 | NCBI 26284

Details for: ERAL1

Gene ID: 26284

Symbol: ERAL1

Ensembl ID: ENSG00000132591

Description: Era like 12S mitochondrial rRNA chaperone 1

Associated with

Metabolism of proteins
(R-HSA-392499)
Mitochondrial translation
(R-HSA-5368287)
Mitochondrial translation elongation
(R-HSA-5389840)
Mitochondrial translation initiation
(R-HSA-5368286)
Mitochondrial translation termination
(R-HSA-5419276)
Translation
(R-HSA-72766)
Cytosol
(GO:0005829)
Gtp binding
(GO:0005525)
Mitochondrial inner membrane
(GO:0005743)
Mitochondrial matrix
(GO:0005759)
Mitochondrion
(GO:0005739)
Protein binding
(GO:0005515)
Ribosomal small subunit assembly
(GO:0000028)
Ribosomal small subunit binding
(GO:0043024)
Rna binding
(GO:0003723)
Rrna binding
(GO:0019843)

Other Information

Proteins

GTPase Era, mitochondrial

Genular Protein ID: 1183420419

Symbol: ERAL1_HUMAN

Name: GTPase Era, mitochondrial

UniProtKB Accession Codes:

O75616 B3KN21 C9JEC6 O75617 Q8WUY4 Q96LE2 Q96TC0

Database IDs:

Citations:

PubMed ID: 10945472

Title: Isolation and preliminary characterization of the human and mouse homologues of the bacterial cell cycle gene era.

PubMed ID: 10945472

DOI: 10.1006/geno.2000.6243

PubMed ID: 11733036

Title: Mammalian homologue of E. coli Ras-like GTPase (ERA) is a possible apoptosis regulator with RNA binding activity.

PubMed ID: 11733036

DOI: 10.1046/j.1365-2443.2001.00480.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

PubMed ID: 20604745

Title: Human ERAL1 is a mitochondrial RNA chaperone involved in the assembly of the 28S small mitochondrial ribosomal subunit.

PubMed ID: 20604745

DOI: 10.1042/bj20100757

PubMed ID: 20430825

Title: ERAL1 is associated with mitochondrial ribosome and elimination of ERAL1 leads to mitochondrial dysfunction and growth retardation.

PubMed ID: 20430825

DOI: 10.1093/nar/gkq305

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28449065

Title: A homozygous missense mutation in ERAL1, encoding a mitochondrial rRNA chaperone, causes Perrault syndrome.

PubMed ID: 28449065

DOI: 10.1093/hmg/ddx152

Sequence Information:

Length: 437
Mass: 48350
Checksum: 5C2454A1D9AFF5AA
Sequence:

MAAPSWRGAR LVQSVLRVWQ VGPHVARERV IPFSSLLGFQ RRCVSCVAGS AFSGPRLASA 
SRSNGQGSAL DHFLGFSQPD SSVTPCVPAV SMNRDEQDVL LVHHPDMPEN SRVLRVVLLG 
APNAGKSTLS NQLLGRKVFP VSRKVHTTRC QALGVITEKE TQVILLDTPG IISPGKQKRH 
HLELSLLEDP WKSMESADLV VVLVDVSDKW TRNQLSPQLL RCLTKYSQIP SVLVMNKVDC 
LKQKSVLLEL TAALTEGVVN GKKLKMRQAF HSHPGTHCPS PAVKDPNTQS VGNPQRIGWP 
HFKEIFMLSA LSQEDVKTLK QYLLTQAQPG PWEYHSAVLT SQTPEEICAN IIREKLLEHL 
PQEVPYNVQQ KTAVWEEGPG GELVIQQKLL VPKESYVKLL IGPKGHVISQ IAQEAGHDLM 
DIFLCDVDIR LSVKLLK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ERAL1

Associated with

Other Information

Isolation and preliminary characterization of the human and mouse homologues of the bacterial cell cycle gene era. PubMed ID: 10945472

Mammalian homologue of E. coli Ras-like GTPase (ERA) is a possible apoptosis regulator with RNA binding activity. PubMed ID: 11733036

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. PubMed ID: 16625196

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

An unappreciated role for RNA surveillance. PubMed ID: 14759258

Human ERAL1 is a mitochondrial RNA chaperone involved in the assembly of the 28S small mitochondrial ribosomal subunit. PubMed ID: 20604745

ERAL1 is associated with mitochondrial ribosome and elimination of ERAL1 leads to mitochondrial dysfunction and growth retardation. PubMed ID: 20430825

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

A homozygous missense mutation in ERAL1, encoding a mitochondrial rRNA chaperone, causes Perrault syndrome. PubMed ID: 28449065