Details for: FGF21

Gene ID: 26291

Symbol: FGF21

Ensembl ID: ENSG00000105550

Description: fibroblast growth factor 21

Associated with

  • Assembly of active lpl and lipc lipase complexes
    (R-HSA-8963889)
  • Cellular hexose transport
    (R-HSA-189200)
  • Plasma lipoprotein assembly, remodeling, and clearance
    (R-HSA-174824)
  • Plasma lipoprotein remodeling
    (R-HSA-8963899)
  • Slc-mediated transmembrane transport
    (R-HSA-425407)
  • Transport of small molecules
    (R-HSA-382551)
  • Animal organ morphogenesis
    (GO:0009887)
  • Cell-cell signaling
    (GO:0007267)
  • Cell differentiation
    (GO:0030154)
  • Cellular response to glucagon stimulus
    (GO:0071377)
  • Cellular response to glucose stimulus
    (GO:0071333)
  • Cellular response to low-density lipoprotein particle stimulus
    (GO:0071404)
  • Cellular response to xenobiotic stimulus
    (GO:0071466)
  • Cytoplasm
    (GO:0005737)
  • Endoplasmic reticulum unfolded protein response
    (GO:0030968)
  • Endothelial cell apoptotic process
    (GO:0072577)
  • Extracellular region
    (GO:0005576)
  • Extracellular space
    (GO:0005615)
  • Fibroblast growth factor receptor binding
    (GO:0005104)
  • Fibroblast growth factor receptor signaling pathway
    (GO:0008543)
  • Growth factor activity
    (GO:0008083)
  • Negative regulation of endothelial cell apoptotic process
    (GO:2000352)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of cold-induced thermogenesis
    (GO:0120162)
  • Positive regulation of erk1 and erk2 cascade
    (GO:0070374)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of glucose import
    (GO:0046326)
  • Positive regulation of low-density lipoprotein receptor activity
    (GO:1905599)
  • Positive regulation of mapkkk cascade by fibroblast growth factor receptor signaling pathway
    (GO:0090080)
  • Positive regulation of protein phosphorylation
    (GO:0001934)
  • Positive regulation of triglyceride catabolic process
    (GO:0010898)
  • Protein binding
    (GO:0005515)
  • Regulation of cell migration
    (GO:0030334)
  • Regulation of low-density lipoprotein particle clearance
    (GO:0010988)
  • Response to activity
    (GO:0014823)
  • Response to methionine
    (GO:1904640)
  • Response to nutrient levels
    (GO:0031667)
  • Signal transduction
    (GO:0007165)

Other Information

Genular Protein ID: 55002547

Symbol: FGF21_HUMAN

Name: Fibroblast growth factor 21

UniProtKB Accession Codes:

Q9NSA1 Q8N683

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 GO 31 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 3 PIRSF 1 PRINTS 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 10858549

Title: Identification of a novel FGF, FGF-21, preferentially expressed in the liver.

PubMed ID: 10858549

DOI: 10.1016/s0167-4781(00)00067-1

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 15902306

Title: FGF-21 as a novel metabolic regulator.

PubMed ID: 15902306

DOI: 10.1172/jci23606

PubMed ID: 17623664

Title: Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21.

PubMed ID: 17623664

DOI: 10.1074/jbc.m704165200

PubMed ID: 18829467

Title: C-terminal tail of FGF19 determines its specificity toward Klotho co-receptors.

PubMed ID: 18829467

DOI: 10.1074/jbc.m803319200

PubMed ID: 19117008

Title: Different roles of N- and C- termini in the functional activity of FGF21.

PubMed ID: 19117008

DOI: 10.1002/jcp.21675

PubMed ID: 20094046

Title: Fibroblast growth factor signalling: from development to cancer.

PubMed ID: 20094046

DOI: 10.1038/nrc2780

Sequence Information:

  • Length: 209
  • Mass: 22300
  • Checksum: 27925C52A0023823
  • Sequence:
    • MDSDETGFEH SGLWVSVLAG LLLGACQAHP IPDSSPLLQF GGQVRQRYLY TDDAQQTEAH 
LEIREDGTVG GAADQSPESL LQLKALKPGV IQILGVKTSR FLCQRPDGAL YGSLHFDPEA 
CSFRELLLED GYNVYQSEAH GLPLHLPGNK SPHRDPAPRG PARFLPLPGL PPALPEPPGI 
LAPQPPDVGS SDPLSMVGPS QGRSPSYAS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.