Map2k1 | ENSMUSG00000004936 | NCBI 26395

Details for: Map2k1

Gene ID: 26395

Symbol: Map2k1

Ensembl ID: ENSMUSG00000004936

Description: mitogen-activated protein kinase kinase 1

Associated with

Axon guidance
(R-MMU-422475)
Developmental biology
(R-MMU-1266738)
Frs2-mediated activation
(R-MMU-170968)
L1cam interactions
(R-MMU-373760)
Map2k and mapk activation
(R-MMU-5674135)
Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk3 (erk1) activation
(R-MMU-110056)
Mapk family signaling cascades
(R-MMU-5683057)
Negative feedback regulation of mapk pathway
(R-MMU-5674499)
Negative regulation of mapk pathway
(R-MMU-5675221)
Nervous system development
(R-MMU-9675108)
Prolonged erk activation events
(R-MMU-169893)
Raf-independent mapk1/3 activation
(R-MMU-112409)
Raf/map kinase cascade
(R-MMU-5673001)
Raf activation
(R-MMU-5673000)
Signaling by ntrk1 (trka)
(R-MMU-187037)
Signaling by ntrks
(R-MMU-166520)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signalling to erks
(R-MMU-187687)
Signal transduction
(R-MMU-162582)
Signal transduction by l1
(R-MMU-445144)
Atp binding
(GO:0005524)
Bergmann glial cell differentiation
(GO:0060020)
Cell motility
(GO:0048870)
Cellular senescence
(GO:0090398)
Cerebellar cortex formation
(GO:0021697)
Endodermal cell differentiation
(GO:0035987)
Epithelial cell proliferation involved in lung morphogenesis
(GO:0060502)
Erbb2-erbb3 signaling pathway
(GO:0038133)
Erk1 and erk2 cascade
(GO:0070371)
Face development
(GO:0060324)
Golgi inheritance
(GO:0048313)
Heart development
(GO:0007507)
Insulin-like growth factor receptor signaling pathway
(GO:0048009)
Insulin receptor signaling pathway
(GO:0008286)
Keratinocyte differentiation
(GO:0030216)
Labyrinthine layer development
(GO:0060711)
Lung morphogenesis
(GO:0060425)
Map-kinase scaffold activity
(GO:0005078)
Mapk cascade
(GO:0000165)
Map kinase kinase activity
(GO:0004708)
Melanosome transport
(GO:0032402)
Mitogen-activated protein kinase kinase kinase binding
(GO:0031435)
Myelination
(GO:0042552)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of gene expression
(GO:0010629)
Negative regulation of homotypic cell-cell adhesion
(GO:0034111)
Negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
(GO:1903298)
Neuron differentiation
(GO:0030182)
Neuron projection morphogenesis
(GO:0048812)
Placenta blood vessel development
(GO:0060674)
Positive regulation of autophagy
(GO:0010508)
Positive regulation of axonogenesis
(GO:0050772)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of endodermal cell differentiation
(GO:1903226)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of muscle contraction
(GO:0045933)
Positive regulation of protein serine/threonine kinase activity
(GO:0071902)
Positive regulation of ras protein signal transduction
(GO:0046579)
Positive regulation of transcription elongation by rna polymerase ii
(GO:0032968)
Protein-containing complex binding
(GO:0044877)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine/tyrosine kinase activity
(GO:0004712)
Protein serine/threonine kinase activator activity
(GO:0043539)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Protein tyrosine kinase activity
(GO:0004713)
Regulation of axon regeneration
(GO:0048679)
Regulation of erk1 and erk2 cascade
(GO:0070372)
Regulation of golgi inheritance
(GO:0090170)
Regulation of neurotransmitter receptor localization to postsynaptic specialization membrane
(GO:0098696)
Regulation of stress-activated mapk cascade
(GO:0032872)
Regulation of vascular associated smooth muscle contraction
(GO:0003056)
Response to axon injury
(GO:0048678)
Response to glucocorticoid
(GO:0051384)
Response to oxidative stress
(GO:0006979)
Scaffold protein binding
(GO:0097110)
Schwann cell development
(GO:0014044)
Small gtpase binding
(GO:0031267)
Thymus development
(GO:0048538)
Thyroid gland development
(GO:0030878)
Trachea formation
(GO:0060440)
Triglyceride homeostasis
(GO:0070328)
Type b pancreatic cell proliferation
(GO:0044342)
Vesicle transport along microtubule
(GO:0047496)

Other Information

Proteins

Dual specificity mitogen-activated protein kinase kinase 1

Genular Protein ID: 3687378162

Symbol: MP2K1_MOUSE

Name: Dual specificity mitogen-activated protein kinase kinase 1

UniProtKB Accession Codes:

P31938

Database IDs:

Citations:

PubMed ID: 1411546

Title: The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product.

PubMed ID: 1411546

DOI: 10.1126/science.1411546

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1381507

Title: Purification of a murine protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene product: relationship to the fission yeast byr1 gene product.

PubMed ID: 1381507

DOI: 10.1073/pnas.89.17.8205

PubMed ID: 8385802

Title: A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf.

PubMed ID: 8385802

DOI: 10.1126/science.8385802

PubMed ID: 9563949

Title: Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor.

PubMed ID: 9563949

DOI: 10.1126/science.280.5364.734

PubMed ID: 10409742

Title: Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization.

PubMed ID: 10409742

DOI: 10.1128/mcb.19.8.5523

PubMed ID: 15118098

Title: Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists.

PubMed ID: 15118098

DOI: 10.1073/pnas.0305894101

PubMed ID: 19219045

Title: A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal.

PubMed ID: 19219045

DOI: 10.1038/nsmb.1564

PubMed ID: 9779990

Title: Signaling by dual specificity kinases.

PubMed ID: 9779990

DOI: 10.1038/sj.onc.1202251

PubMed ID: 15520807

Title: The RAF proteins take centre stage.

PubMed ID: 15520807

DOI: 10.1038/nrm1498

PubMed ID: 19565474

Title: The ERK signaling cascade--views from different subcellular compartments.

PubMed ID: 19565474

DOI: 10.1002/biof.52

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21779493

Title: The ERK cascade: distinct functions within various subcellular organelles.

PubMed ID: 21779493

DOI: 10.1177/1947601911407328

PubMed ID: 23319590

Title: SCF(Fbxw15) mediates histone acetyltransferase binding to origin recognition complex (HBO1) ubiquitin-proteasomal degradation to regulate cell proliferation.

PubMed ID: 23319590

DOI: 10.1074/jbc.m112.426882

Sequence Information:

Length: 393
Mass: 43474
Checksum: 01D1D18572AE40E7
Sequence:

MPKKKPTPIQ LNPAPDGSAV NGTSSAETNL EALQKKLEEL ELDEQQRKRL EAFLTQKQKV 
GELKDDDFEK ISELGAGNGG VVFKVSHKPS GLVMARKLIH LEIKPAIRNQ IIRELQVLHE 
CNSPYIVGFY GAFYSDGEIS ICMEHMDGGS LDQVLKKAGR IPEQILGKVS IAVIKGLTYL 
REKHKIMHRD VKPSNILVNS RGEIKLCDFG VSGQLIDSMA NSFVGTRSYM SPERLQGTHY 
SVQSDIWSMG LSLVEMAVGR YPIPPPDAKE LELLFGCHVE GDAAETPPRP RTPGRPLSSY 
GMDSRPPMAI FELLDYIVNE PPPKLPSGVF SLEFQDFVNK CLIKNPAERA DLKQLMVHAF 
IKRSDAEEVD FAGWLCSTIG LNQPSTPTHA ASI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Map2k1

Associated with

Other Information

The primary structure of MEK, a protein kinase that phosphorylates the ERK gene product. PubMed ID: 1411546

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Purification of a murine protein-tyrosine/threonine kinase that phosphorylates and activates the Erk-1 gene product: relationship to the fission yeast byr1 gene product. PubMed ID: 1381507

A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf. PubMed ID: 8385802

Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor. PubMed ID: 9563949

Kinase suppressor of Ras forms a multiprotein signaling complex and modulates MEK localization. PubMed ID: 10409742

Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists. PubMed ID: 15118098

A Mek1-Mek2 heterodimer determines the strength and duration of the Erk signal. PubMed ID: 19219045

Signaling by dual specificity kinases. PubMed ID: 9779990

The RAF proteins take centre stage. PubMed ID: 15520807

The ERK signaling cascade--views from different subcellular compartments. PubMed ID: 19565474

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

The ERK cascade: distinct functions within various subcellular organelles. PubMed ID: 21779493

SCF(Fbxw15) mediates histone acetyltransferase binding to origin recognition complex (HBO1) ubiquitin-proteasomal degradation to regulate cell proliferation. PubMed ID: 23319590