Map2k3 | ENSMUSG00000018932 | NCBI 26397

Details for: Map2k3

Gene ID: 26397

Symbol: Map2k3

Ensembl ID: ENSMUSG00000018932

Description: mitogen-activated protein kinase kinase 3

Associated with

Activated tak1 mediates p38 mapk activation
(R-MMU-450302)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular senescence
(R-MMU-2559583)
Cytokine signaling in immune system
(R-MMU-1280215)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Interleukin-17 signaling
(R-MMU-448424)
Map kinase activation
(R-MMU-450294)
Myd88 cascade initiated on plasma membrane
(R-MMU-975871)
Myd88 dependent cascade initiated on endosome
(R-MMU-975155)
Myd88-independent tlr4 cascade
(R-MMU-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-MMU-166058)
Oxidative stress induced senescence
(R-MMU-2559580)
Signaling by interleukins
(R-MMU-449147)
Toll-like receptor cascades
(R-MMU-168898)
Toll like receptor 2 (tlr2) cascade
(R-MMU-181438)
Toll like receptor 3 (tlr3) cascade
(R-MMU-168164)
Toll like receptor 4 (tlr4) cascade
(R-MMU-166016)
Toll like receptor 5 (tlr5) cascade
(R-MMU-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-MMU-168181)
Toll like receptor 9 (tlr9) cascade
(R-MMU-168138)
Toll like receptor 10 (tlr10) cascade
(R-MMU-168142)
Toll like receptor tlr1:tlr2 cascade
(R-MMU-168179)
Toll like receptor tlr6:tlr2 cascade
(R-MMU-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-MMU-975138)
Trif (ticam1)-mediated tlr4 signaling
(R-MMU-937061)
Atp binding
(GO:0005524)
Cardiac muscle contraction
(GO:0060048)
Cellular response to lipopolysaccharide
(GO:0071222)
Cellular response to sorbitol
(GO:0072709)
Cellular response to vascular endothelial growth factor stimulus
(GO:0035924)
Heart development
(GO:0007507)
Inflammatory response
(GO:0006954)
Mapk cascade
(GO:0000165)
Map kinase kinase activity
(GO:0004708)
Negative regulation of hippo signaling
(GO:0035331)
P38mapk cascade
(GO:0038066)
Positive regulation of blood vessel endothelial cell migration
(GO:0043536)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of nitric-oxide synthase biosynthetic process
(GO:0051770)
Positive regulation of protein kinase activity
(GO:0045860)
Positive regulation of protein phosphorylation
(GO:0001934)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Protein tyrosine kinase activity
(GO:0004713)
Regulation of cytokine production
(GO:0001817)
Response to ischemia
(GO:0002931)
Stress-activated protein kinase signaling cascade
(GO:0031098)

Other Information

Proteins

Dual specificity mitogen-activated protein kinase kinase 3

Genular Protein ID: 3471733670

Symbol: MP2K3_MOUSE

Name: Dual specificity mitogen-activated protein kinase kinase 3

UniProtKB Accession Codes:

O09110 P97293 Q91VX1

Database IDs:

Citations:

PubMed ID: 8900184

Title: Purification and identification of a major activator for p38 from osmotically shocked cells: activation of mitogen-activated protein kinase kinase 6 by osmotic shock, tumor necrosis factor-alpha, and H2O2.

PubMed ID: 8900184

DOI: 10.1074/jbc.271.43.26981

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14634666

Title: Rac-MEKK3-MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock.

PubMed ID: 14634666

DOI: 10.1038/ncb1071

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

Length: 347
Mass: 39296
Checksum: 4A2A420EDCA8A2BC
Sequence:

MESPAASPPA SLPQTKGKSK RKKDLRISCV SKPPVSNPTP PRNLDSRTFI TIGDRNFEVE 
ADDLVTISEL GRGAYGVVEK VRHAQSGTIM AVKRIRATVN TQEQKRLLMD LDINMRTVDC 
FYTVTFYGAL FREGDVWICM ELMDTSLDKF YRKVLEKNMK IPEDILGEIA VSIVRALEHL 
HSKLSVIHRD VKPSNVLINK EGHVKMCDFG ISGYLVDSVA KTMDAGCKPY MAPERINPEL 
NQKGYNVKSD VWSLGITMIE MAILRFPYES WGTPFQQLKQ VVEEPSPQLP ADQFSPEFVD 
FTSQCLRKNP AERMSYLELM EHPFFTLHKT KKTDIAAFVK EILGEDS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Map2k3

Associated with

Other Information

Purification and identification of a major activator for p38 from osmotically shocked cells: activation of mitogen-activated protein kinase kinase 6 by osmotic shock, tumor necrosis factor-alpha, and H2O2. PubMed ID: 8900184

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334