Map2k6 | ENSMUSG00000020623 | NCBI 26399

Details for: Map2k6

Gene ID: 26399

Symbol: Map2k6

Ensembl ID: ENSMUSG00000020623

Description: mitogen-activated protein kinase kinase 6

Associated with

Activated tak1 mediates p38 mapk activation
(R-MMU-450302)
Antiviral mechanism by ifn-stimulated genes
(R-MMU-1169410)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular senescence
(R-MMU-2559583)
Cytokine signaling in immune system
(R-MMU-1280215)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Interferon signaling
(R-MMU-913531)
Interleukin-1 family signaling
(R-MMU-446652)
Interleukin-1 signaling
(R-MMU-9020702)
Interleukin-17 signaling
(R-MMU-448424)
Map kinase activation
(R-MMU-450294)
Myd88 cascade initiated on plasma membrane
(R-MMU-975871)
Myd88 dependent cascade initiated on endosome
(R-MMU-975155)
Myd88-independent tlr4 cascade
(R-MMU-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-MMU-166058)
Nod1/2 signaling pathway
(R-MMU-168638)
Nucleotide-binding domain, leucine rich repeat containing receptor (nlr) signaling pathways
(R-MMU-168643)
Oxidative stress induced senescence
(R-MMU-2559580)
Pi5p regulates tp53 acetylation
(R-MMU-6811555)
Pkr-mediated signaling
(R-MMU-9833482)
Regulation of tp53 activity
(R-MMU-5633007)
Regulation of tp53 activity through acetylation
(R-MMU-6804758)
Rna polymerase ii transcription
(R-MMU-73857)
Signaling by interleukins
(R-MMU-449147)
Toll-like receptor cascades
(R-MMU-168898)
Toll like receptor 2 (tlr2) cascade
(R-MMU-181438)
Toll like receptor 3 (tlr3) cascade
(R-MMU-168164)
Toll like receptor 4 (tlr4) cascade
(R-MMU-166016)
Toll like receptor 5 (tlr5) cascade
(R-MMU-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-MMU-168181)
Toll like receptor 9 (tlr9) cascade
(R-MMU-168138)
Toll like receptor 10 (tlr10) cascade
(R-MMU-168142)
Toll like receptor tlr1:tlr2 cascade
(R-MMU-168179)
Toll like receptor tlr6:tlr2 cascade
(R-MMU-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-MMU-975138)
Transcriptional regulation by tp53
(R-MMU-3700989)
Trif (ticam1)-mediated tlr4 signaling
(R-MMU-937061)
Apoptotic process
(GO:0006915)
Atp binding
(GO:0005524)
Bone development
(GO:0060348)
Cardiac muscle contraction
(GO:0060048)
Cellular response to sorbitol
(GO:0072709)
Cytoskeleton
(GO:0005856)
Cytosol
(GO:0005829)
Identical protein binding
(GO:0042802)
Mapk cascade
(GO:0000165)
Map kinase kinase activity
(GO:0004708)
Negative regulation of cold-induced thermogenesis
(GO:0120163)
Nucleoplasm
(GO:0005654)
Osteoblast differentiation
(GO:0001649)
Ovulation cycle process
(GO:0022602)
P38mapk cascade
(GO:0038066)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of map kinase activity
(GO:0043406)
Positive regulation of nitric-oxide synthase biosynthetic process
(GO:0051770)
Positive regulation of prostaglandin secretion
(GO:0032308)
Positive regulation of protein phosphorylation
(GO:0001934)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Protein tyrosine kinase activity
(GO:0004713)
Response to ischemia
(GO:0002931)
Response to xenobiotic stimulus
(GO:0009410)
Stress-activated mapk cascade
(GO:0051403)
Stress-activated protein kinase signaling cascade
(GO:0031098)

Other Information

Proteins

Dual specificity mitogen-activated protein kinase kinase 6

Genular Protein ID: 4147575908

Symbol: MP2K6_MOUSE

Name: Dual specificity mitogen-activated protein kinase kinase 6

UniProtKB Accession Codes:

P70236

Database IDs:

Citations:

PubMed ID: 8861944

Title: Purification and cDNA cloning of SAPKK3, the major activator of RK/p38 in stress- and cytokine-stimulated monocytes and epithelial cells.

PubMed ID: 8861944

DOI: 10.1002/j.1460-2075.1996.tb00790.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12151339

Title: Differential involvement of p38 mitogen-activated protein kinase kinases MKK3 and MKK6 in T-cell apoptosis.

PubMed ID: 12151339

DOI: 10.1093/embo-reports/kvf153

PubMed ID: 12824301

Title: Involvement of MKK6 in TCRalphabeta(int)CD69lo: a target population for apoptotic cell death in thymocytes.

PubMed ID: 12824301

DOI: 10.1096/fj.02-0869fje

PubMed ID: 12893778

Title: Mechanism of p38 MAP kinase activation in vivo.

PubMed ID: 12893778

DOI: 10.1101/gad.1107303

PubMed ID: 12482988

Title: Negative feedback regulation of MKK6 mRNA stability by p38alpha mitogen-activated protein kinase.

PubMed ID: 12482988

DOI: 10.1128/mcb.23.1.370-381.2003

PubMed ID: 15644321

Title: Activation of mitogen-activated protein kinase kinase (MKK) 3 and MKK6 by type I interferons.

PubMed ID: 15644321

DOI: 10.1074/jbc.m410972200

PubMed ID: 16498455

Title: Osteoclast differentiation requires TAK1 and MKK6 for NFATc1 induction and NF-kappaB transactivation by RANKL.

PubMed ID: 16498455

DOI: 10.1038/sj.cdd.4401882

PubMed ID: 16387856

Title: Constitutive activation of MKK6 in chondrocytes of transgenic mice inhibits proliferation and delays endochondral bone formation.

PubMed ID: 16387856

DOI: 10.1073/pnas.0507979103

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20004242

Title: Differential activation of p38MAPK isoforms by MKK6 and MKK3.

PubMed ID: 20004242

DOI: 10.1016/j.cellsig.2009.11.020

PubMed ID: 9779990

Title: Signaling by dual specificity kinases.

PubMed ID: 9779990

DOI: 10.1038/sj.onc.1202251

Sequence Information:

Length: 334
Mass: 37432
Checksum: 62CEF6C28AF50BAC
Sequence:

MSQSKGKKRN PGLKIPKEAF EQPQTSSTPP RDLDSKACIS IGNQNFEVKA DDLEPIVELG 
RGAYGVVEKM RHVPSGQIMA VKRIRATVNS QEQKRLLMDL DVSMRTVDCP FTVTFYGALF 
REGDVWICME LMDTSLDKFY KQVIDKGQTI PEDILGKIAV SIVKALEHLH SKLSVIHRDV 
KPSNVLINTL GQVKMCDFGI SGYLVDSVAK TIDAGCKPYM APERINPELN QKGYSVKSDI 
WSLGITMIEL AILRFPYDSW GTPFQQLKQV VEEPSPQLPA DKFSADFVDF TSQCLKKNSK 
ERPTYPELMQ HPFFTVHESK AADVASFVKL ILGD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Map2k6

Associated with

Other Information

Purification and cDNA cloning of SAPKK3, the major activator of RK/p38 in stress- and cytokine-stimulated monocytes and epithelial cells. PubMed ID: 8861944

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Differential involvement of p38 mitogen-activated protein kinase kinases MKK3 and MKK6 in T-cell apoptosis. PubMed ID: 12151339

Involvement of MKK6 in TCRalphabeta(int)CD69lo: a target population for apoptotic cell death in thymocytes. PubMed ID: 12824301

Mechanism of p38 MAP kinase activation in vivo. PubMed ID: 12893778

Negative feedback regulation of MKK6 mRNA stability by p38alpha mitogen-activated protein kinase. PubMed ID: 12482988

Activation of mitogen-activated protein kinase kinase (MKK) 3 and MKK6 by type I interferons. PubMed ID: 15644321

Osteoclast differentiation requires TAK1 and MKK6 for NFATc1 induction and NF-kappaB transactivation by RANKL. PubMed ID: 16498455

Constitutive activation of MKK6 in chondrocytes of transgenic mice inhibits proliferation and delays endochondral bone formation. PubMed ID: 16387856

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Differential activation of p38MAPK isoforms by MKK6 and MKK3. PubMed ID: 20004242

Signaling by dual specificity kinases. PubMed ID: 9779990