Map2k7 | ENSMUSG00000002948 | NCBI 26400

Details for: Map2k7

Gene ID: 26400

Symbol: Map2k7

Ensembl ID: ENSMUSG00000002948

Description: mitogen-activated protein kinase kinase 7

Associated with

Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular senescence
(R-MMU-2559583)
Cytokine signaling in immune system
(R-MMU-1280215)
Fc epsilon receptor (fceri) signaling
(R-MMU-2454202)
Fceri mediated mapk activation
(R-MMU-2871796)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Interleukin-17 signaling
(R-MMU-448424)
Jnk (c-jun kinases) phosphorylation and activation mediated by activated human tak1
(R-MMU-450321)
Map kinase activation
(R-MMU-450294)
Myd88 cascade initiated on plasma membrane
(R-MMU-975871)
Myd88 dependent cascade initiated on endosome
(R-MMU-975155)
Myd88-independent tlr4 cascade
(R-MMU-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-MMU-166058)
Oxidative stress induced senescence
(R-MMU-2559580)
Signaling by interleukins
(R-MMU-449147)
Toll-like receptor cascades
(R-MMU-168898)
Toll like receptor 2 (tlr2) cascade
(R-MMU-181438)
Toll like receptor 3 (tlr3) cascade
(R-MMU-168164)
Toll like receptor 4 (tlr4) cascade
(R-MMU-166016)
Toll like receptor 5 (tlr5) cascade
(R-MMU-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-MMU-168181)
Toll like receptor 9 (tlr9) cascade
(R-MMU-168138)
Toll like receptor 10 (tlr10) cascade
(R-MMU-168142)
Toll like receptor tlr1:tlr2 cascade
(R-MMU-168179)
Toll like receptor tlr6:tlr2 cascade
(R-MMU-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-MMU-975138)
Trif (ticam1)-mediated tlr4 signaling
(R-MMU-937061)
Apoptotic process
(GO:0006915)
Atp binding
(GO:0005524)
Cellular response to interleukin-1
(GO:0071347)
Cellular response to lipopolysaccharide
(GO:0071222)
Cellular response to osmotic stress
(GO:0071470)
Cytoplasm
(GO:0005737)
Enzyme binding
(GO:0019899)
Jnk cascade
(GO:0007254)
Jun kinase kinase activity
(GO:0008545)
Magnesium ion binding
(GO:0000287)
Map kinase activity
(GO:0004707)
Map kinase kinase activity
(GO:0004708)
Mitogen-activated protein kinase kinase kinase binding
(GO:0031435)
Molecular function activator activity
(GO:0140677)
Nucleus
(GO:0005634)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of jnk cascade
(GO:0046330)
Positive regulation of jun kinase activity
(GO:0043507)
Positive regulation of neuron apoptotic process
(GO:0043525)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of telomere capping
(GO:1904355)
Positive regulation of telomere maintenance
(GO:0032206)
Positive regulation of telomere maintenance via telomerase
(GO:0032212)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Protein phosphatase binding
(GO:0019903)
Protein phosphorylation
(GO:0006468)
Protein serine kinase activity
(GO:0106310)
Protein tyrosine kinase activity
(GO:0004713)
Regulation of motor neuron apoptotic process
(GO:2000671)
Response to heat
(GO:0009408)
Response to osmotic stress
(GO:0006970)
Response to tumor necrosis factor
(GO:0034612)
Response to uv
(GO:0009411)
Response to wounding
(GO:0009611)
Stress-activated mapk cascade
(GO:0051403)

Other Information

Proteins

Dual specificity mitogen-activated protein kinase kinase 7

Genular Protein ID: 3951387252

Symbol: MP2K7_MOUSE

Name: Dual specificity mitogen-activated protein kinase kinase 7

UniProtKB Accession Codes:

Q8CE90 O35406 O35720 O35871 O35872 O54780 O70242 O70243 Q8BSP1 Q9QWG6 Q9R1Z3 Q9R1Z4 Q9R1Z5 Q9R1Z6

Database IDs:

Citations:

PubMed ID: 9405446

Title: Activation of stress-activated protein kinases/c-Jun N-terminal protein kinases (SAPKs/JNKs) by a novel mitogen-activated protein kinase kinase (MKK7).

PubMed ID: 9405446

DOI: 10.1074/jbc.272.51.32378

PubMed ID: 9312105

Title: MKK7 is a stress-activated mitogen-activated protein kinase kinase functionally related to hemipterous.

PubMed ID: 9312105

DOI: 10.1074/jbc.272.40.24994

PubMed ID: 9384583

Title: A novel SAPK/JNK kinase, MKK7, stimulated by TNFalpha and cellular stresses.

PubMed ID: 9384583

DOI: 10.1093/emboj/16.23.7045

PubMed ID: 9535930

Title: Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activated by environmental stresses and physiological stimuli.

PubMed ID: 9535930

DOI: 10.1074/jbc.273.15.9344

PubMed ID: 9891090

Title: The MKK7 gene encodes a group of c-Jun NH2-terminal kinase kinases.

PubMed ID: 9891090

DOI: 10.1128/mcb.19.2.1569

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9733513

Title: A mammalian scaffold complex that selectively mediates MAP kinase activation.

PubMed ID: 9733513

DOI: 10.1126/science.281.5383.1671

PubMed ID: 10629060

Title: Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3.

PubMed ID: 10629060

DOI: 10.1128/mcb.20.3.1030-1043.2000

PubMed ID: 11390361

Title: MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines.

PubMed ID: 11390361

DOI: 10.1101/gad.888501

PubMed ID: 12624093

Title: Different properties of SEK1 and MKK7 in dual phosphorylation of stress-induced activated protein kinase SAPK/JNK in embryonic stem cells.

PubMed ID: 12624093

DOI: 10.1074/jbc.m213182200

PubMed ID: 17496909

Title: Differential regulation and properties of MAPKs.

PubMed ID: 17496909

DOI: 10.1038/sj.onc.1210392

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 20801953

Title: Diverse physiological functions of MKK4 and MKK7 during early embryogenesis.

PubMed ID: 20801953

DOI: 10.1093/jb/mvq098

PubMed ID: 21333379

Title: The bottleneck of JNK signaling: molecular and functional characteristics of MKK4 and MKK7.

PubMed ID: 21333379

DOI: 10.1016/j.ejcb.2010.11.008

PubMed ID: 23963642

Title: The POSH/JIP-1 scaffold network regulates TCR-mediated JNK1 signals and effector function in CD8(+) T cells.

PubMed ID: 23963642

DOI: 10.1002/eji.201343635

PubMed ID: 27084103

Title: POSH regulates CD4+ T cell differentiation and survival.

PubMed ID: 27084103

DOI: 10.4049/jimmunol.1501728

PubMed ID: 28111074

Title: ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Abeta Secretion.

PubMed ID: 28111074

DOI: 10.1016/j.cell.2016.12.044

Sequence Information:

Length: 535
Mass: 59312
Checksum: A96DA75565E3CD0F
Sequence:

MAASSLEQKL SRLEAKLKQE NREARRRIDL NLDISPQRPR PIIVITLSPA PAPSQRAALQ 
LPLANDGGSR SPSSESSPQH PTPPTRPRHM LGLPSTLFTP RSMESIEIDQ KLQEIMKQTG 
YLTIGGQRYQ AEINDLENLG EMGSGTCGQV WKMRFRKTGH IIAVKQMRRS GNKEENKRIL 
MDLDVVLKSH DCPYIVQCFG TFITNTDVFI AMELMGTCAE KLKKRMQGPI PERILGKMTV 
AIVKALYYLK EKHGVIHRDV KPSNILLDER GQIKLCDFGI SGRLVDSKAK TRSAGCAAYM 
APERIDPPDP TKPDYDIRAD VWSLGISLVE LATGQFPYKN CKTDFEVLTK VLQEEPPLLP 
GHMGFSGDFQ SFVKDCLTKD HRKRPKYNKL LEHSFIKHYE ILEVDVASWF KDVMAKTESP 
RTSGVLSQHH LPFFSTSVTW GAWPLAAQTP FQSGVIRCRG RVPSPRRATG GSGGQPCVCA 
GGPGPSFTEM GPSPSPMLSN TFFTPDPGAC PGASTWGLPR RRLCQLLTTS TPGCC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Map2k7

Associated with

Other Information

Activation of stress-activated protein kinases/c-Jun N-terminal protein kinases (SAPKs/JNKs) by a novel mitogen-activated protein kinase kinase (MKK7). PubMed ID: 9405446

MKK7 is a stress-activated mitogen-activated protein kinase kinase functionally related to hemipterous. PubMed ID: 9312105

A novel SAPK/JNK kinase, MKK7, stimulated by TNFalpha and cellular stresses. PubMed ID: 9384583

Human mitogen-activated protein kinase kinase 7 (MKK7) is a highly conserved c-Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) activated by environmental stresses and physiological stimuli. PubMed ID: 9535930

The MKK7 gene encodes a group of c-Jun NH2-terminal kinase kinases. PubMed ID: 9891090

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A mammalian scaffold complex that selectively mediates MAP kinase activation. PubMed ID: 9733513

Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3. PubMed ID: 10629060

MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines. PubMed ID: 11390361

Different properties of SEK1 and MKK7 in dual phosphorylation of stress-induced activated protein kinase SAPK/JNK in embryonic stem cells. PubMed ID: 12624093

Differential regulation and properties of MAPKs. PubMed ID: 17496909

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

Diverse physiological functions of MKK4 and MKK7 during early embryogenesis. PubMed ID: 20801953

The bottleneck of JNK signaling: molecular and functional characteristics of MKK4 and MKK7. PubMed ID: 21333379

The POSH/JIP-1 scaffold network regulates TCR-mediated JNK1 signals and effector function in CD8(+) T cells. PubMed ID: 23963642

POSH regulates CD4+ T cell differentiation and survival. PubMed ID: 27084103

ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Abeta Secretion. PubMed ID: 28111074