Map3k12 | ENSMUSG00000023050 | NCBI 26404

Details for: Map3k12

Gene ID: 26404

Symbol: Map3k12

Ensembl ID: ENSMUSG00000023050

Description: mitogen-activated protein kinase kinase kinase 12

Associated with

Atp binding
(GO:0005524)
Axon
(GO:0030424)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Growth cone
(GO:0030426)
Jnk cascade
(GO:0007254)
Jun kinase kinase kinase activity
(GO:0004706)
Map kinase kinase kinase activity
(GO:0004709)
Negative regulation of motor neuron apoptotic process
(GO:2000672)
Peptidyl-serine phosphorylation
(GO:0018105)
Peptidyl-threonine phosphorylation
(GO:0018107)
Plasma membrane
(GO:0005886)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of erk1 and erk2 cascade
(GO:0070374)
Positive regulation of jun kinase activity
(GO:0043507)
Positive regulation of protein kinase activity
(GO:0045860)
Post-translational protein modification
(GO:0043687)
Protein autophosphorylation
(GO:0046777)
Protein homodimerization activity
(GO:0042803)
Protein kinase binding
(GO:0019901)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activator activity
(GO:0043539)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)

Other Information

Proteins

Mitogen-activated protein kinase kinase kinase 12

Genular Protein ID: 2976609169

Symbol: M3K12_MOUSE

Name: Mitogen-activated protein kinase kinase kinase 12

UniProtKB Accession Codes:

Q60700 P70286 Q3TLL7 Q8C4N7 Q8CBX3 Q8CDL6

Database IDs:

Citations:

PubMed ID: 7983011

Title: Identification, molecular cloning, and characterization of dual leucine zipper bearing kinase. A novel serine/threonine protein kinase that defines a second subfamily of mixed lineage kinases.

PubMed ID: 7983011

DOI: 10.1016/s0021-9258(18)47353-x

PubMed ID: 8769565

Title: Cell-specific expression of the ZPK gene in adult mouse tissues.

PubMed ID: 8769565

DOI: 10.1089/dna.1996.15.631

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8663324

Title: Characterization of dual leucine zipper-bearing kinase, a mixed lineage kinase present in synaptic terminals whose phosphorylation state is regulated by membrane depolarization via calcineurin.

PubMed ID: 8663324

DOI: 10.1074/jbc.271.28.16888

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 28111074

Title: ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Abeta Secretion.

PubMed ID: 28111074

DOI: 10.1016/j.cell.2016.12.044

Sequence Information:

Length: 888
Mass: 96084
Checksum: CFECF1D34F889ABB
Sequence:

MACLHETRTP SPSFGGFVST LSEASMRKLD PDTSDCTPEK DLTPTQCVLR DVVPLGGQGG 
GGPSPSPGGE PPPEPFANSV LQLHEQDTGG PGGATGSPES RASRVRADEV RLQCQSGSGF 
LEGLFGCLRP VWTMIGKAYS TEHKQQQEDL WEVPFEEILD LQWVGSGAQG AVFLGRFHGE 
EVAVKKVRDL KETDIKHLRK LKHPNIITFK GVCTQAPCYC ILMEFCAQGQ LYEVLRAGRP 
VTPSLLVDWS MGIAGGMNYL HLHKIIHRDL KSPNMLITYD DVVKISDFGT SKELSDKSTK 
MSFAGTVAWM APEVIRNEPV SEKVDIWSFG VVLWELLTGE IPYKDVDSSA IIWGVGSNSL 
HLPVPSSCPD GFKILLRQCW NSKPRNRPSF RQILLHLDIA SADVLSTPQE TYFKSQAEWR 
EEVKLHFEKI KSEGTCLHRL EEELVMRRRE ELRHALDIRE HYERKLERAN NLYMELNALM 
LQLELKEREL LRREQALERR CPGLLKSHPS RGLLHGNTME KLIKKRNVPQ KLSPHSKRPD 
ILKTESLLPK LDAALSGVGL PGCPKGPPSP GRSRRGKTRH RKASAKGSCG DLPGLRAALP 
PHEPGGLGSP GGLGVGPSAW DACPPALRGL HHDLLLRKMS SSSPDLLSAA LGARGRGATG 
GARDPGSPPP PQGDTPPSEG SAPGSTSPDS PGGAKGEPPP PVGPGEGVGL LGTGREGTAG 
RGGNRAGSQH LTPAALLYRA AVTRSQKRGI SSEEEEGEVD SEVELPPSQR WPQGPNMRQS 
LSTFSSENPS DVEEGTASEP SPSGTPEVGS TNTDERPDER SDDMCSQGSE IPLDLPTSEV 
VPEREASSLP MQHQDGQGPN PEDSDCDSTE LDNSNSIDAL RPPASLPP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Map3k12

Associated with

Other Information

Identification, molecular cloning, and characterization of dual leucine zipper bearing kinase. A novel serine/threonine protein kinase that defines a second subfamily of mixed lineage kinases. PubMed ID: 7983011

Cell-specific expression of the ZPK gene in adult mouse tissues. PubMed ID: 8769565

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterization of dual leucine zipper-bearing kinase, a mixed lineage kinase present in synaptic terminals whose phosphorylation state is regulated by membrane depolarization via calcineurin. PubMed ID: 8663324

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

ApoE2, ApoE3, and ApoE4 Differentially Stimulate APP Transcription and Abeta Secretion. PubMed ID: 28111074