Map3k5 | ENSMUSG00000071369 | NCBI 26408

Details for: Map3k5

Gene ID: 26408

Symbol: Map3k5

Ensembl ID: ENSMUSG00000071369

Description: mitogen-activated protein kinase kinase kinase 5

Associated with

Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular senescence
(R-MMU-2559583)
Oxidative stress induced senescence
(R-MMU-2559580)
Atp binding
(GO:0005524)
Cellular response to amino acid starvation
(GO:0034198)
Cellular response to hydrogen peroxide
(GO:0070301)
Cellular response to reactive nitrogen species
(GO:1902170)
Cellular response to tumor necrosis factor
(GO:0071356)
Cytoplasm
(GO:0005737)
Endothelial cell apoptotic process
(GO:0072577)
External side of plasma membrane
(GO:0009897)
Identical protein binding
(GO:0042802)
Innate immune response
(GO:0045087)
Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
(GO:0070059)
Intrinsic apoptotic signaling pathway in response to oxidative stress
(GO:0008631)
Ire1-traf2-ask1 complex
(GO:1990604)
Jnk cascade
(GO:0007254)
Jun kinase kinase kinase activity
(GO:0004706)
Magnesium ion binding
(GO:0000287)
Mapk cascade
(GO:0000165)
Map kinase kinase kinase activity
(GO:0004709)
Neuron apoptotic process
(GO:0051402)
Neuron intrinsic apoptotic signaling pathway in response to oxidative stress
(GO:0036480)
P38mapk cascade
(GO:0038066)
Positive regulation of apoptotic process
(GO:0043065)
Positive regulation of cardiac muscle cell apoptotic process
(GO:0010666)
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
(GO:0043280)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of jnk cascade
(GO:0046330)
Positive regulation of jun kinase activity
(GO:0043507)
Positive regulation of mapk cascade
(GO:0043410)
Positive regulation of myoblast differentiation
(GO:0045663)
Positive regulation of p38mapk cascade
(GO:1900745)
Positive regulation of protein kinase activity
(GO:0045860)
Positive regulation of protein phosphorylation
(GO:0001934)
Positive regulation of vascular associated smooth muscle cell proliferation
(GO:1904707)
Programmed necrotic cell death
(GO:0097300)
Protein-containing complex
(GO:0032991)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein homodimerization activity
(GO:0042803)
Protein kinase activity
(GO:0004672)
Protein kinase binding
(GO:0019901)
Protein kinase complex
(GO:1902911)
Protein phosphatase binding
(GO:0019903)
Protein phosphorylation
(GO:0006468)
Protein serine kinase activity
(GO:0106310)
Regulation of programmed cell death
(GO:0043067)
Response to endoplasmic reticulum stress
(GO:0034976)
Response to ischemia
(GO:0002931)
Stress-activated mapk cascade
(GO:0051403)

Other Information

Proteins

Mitogen-activated protein kinase kinase kinase 5

Genular Protein ID: 913995872

Symbol: M3K5_MOUSE

Name: Mitogen-activated protein kinase kinase kinase 5

UniProtKB Accession Codes:

O35099 Q14AY5

Database IDs:

Citations:

PubMed ID: 9367868

Title: Molecular cloning and characterization of the mouse apoptosis signal-regulating kinase 1.

PubMed ID: 9367868

DOI: 10.1006/bbrc.1997.7580

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11266364

Title: ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis.

PubMed ID: 11266364

DOI: 10.1093/embo-reports/kve046

PubMed ID: 11920685

Title: Activation of apoptosis signal-regulating kinase 1 by the stress-induced activating phosphorylation of pre-formed oligomer.

PubMed ID: 11920685

DOI: 10.1002/jcp.10080

PubMed ID: 14749717

Title: Involvement of ASK1 in Ca2+-induced p38 MAP kinase activation.

PubMed ID: 14749717

DOI: 10.1038/sj.embor.7400072

PubMed ID: 15864310

Title: ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity.

PubMed ID: 15864310

DOI: 10.1038/ni1200

PubMed ID: 16527894

Title: A balance between Raf-1 and Fas expression sets the pace of erythroid differentiation.

PubMed ID: 16527894

DOI: 10.1182/blood-2005-09-3866

PubMed ID: 16648474

Title: Direct interaction and reciprocal regulation between ASK1 and calcineurin-NFAT control cardiomyocyte death and growth.

PubMed ID: 16648474

DOI: 10.1128/mcb.26.10.3785-3797.2006

PubMed ID: 17456047

Title: Regulation of apoptosis signal-regulating kinase 1 by protein phosphatase 2Cepsilon.

PubMed ID: 17456047

DOI: 10.1042/bj20070231

PubMed ID: 18948261

Title: Murine protein serine/threonine kinase 38 activates apoptosis signal-regulating kinase 1 via Thr 838 phosphorylation.

PubMed ID: 18948261

DOI: 10.1074/jbc.m807219200

PubMed ID: 17883330

Title: Apoptosis signal-regulating kinase 1 in stress and immune response.

PubMed ID: 17883330

DOI: 10.1146/annurev.pharmtox.48.113006.094606

PubMed ID: 19389260

Title: The roles of ASK family proteins in stress responses and diseases.

PubMed ID: 19389260

DOI: 10.1186/1478-811x-7-9

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22399290

Title: S100 proteins modulate protein phosphatase 5 function: a link between CA2+ signal transduction and protein dephosphorylation.

PubMed ID: 22399290

DOI: 10.1074/jbc.m111.329771

Sequence Information:

Length: 1380
Mass: 154512
Checksum: BE68D225EBBCDF38
Sequence:

MGTEAGEGIT FSVPPFASVG FCTIPEGGSC RRGGGAATAA EGEPSLQPLL VPPPPPPPGS 
FWNVESAAAP GTSCPTTAPG SSATRGRGNS GSGGGRRTTV AYVINEASQG QLVVAESEAL 
QSLREACEAV GATLETLHFG KLDFGETAVL DRFYNADIAV VEMSDAFRQP SLFYHLGVRE 
SFSMANNIIL YCDTNSDSLQ SLKEIICQKN TVCTGNYTFI PYMVTPHNKV YCCDSSFMKG 
LTELMQPNFE LLLGPICLPL VDRFVQLLKV AQASSSQYFR ESILSDIRKA RNLYTGKELA 
AELARIRQRV DNIEVLTADI VINLLLSYRD IQDYDSIVKL VETLEKLPTF DLASHHHVKF 
HYAFALNRRN LPGDRAKALD IMIPMVQSEE QVASDMYCLV GRIYKDMFLD SNFTDTESRD 
HGASWFKKAF ESEPTLQSGI NYAVLLLAAG HQFESSFELR KVGVKLSSLL GKKGNLEKLQ 
SYWEVGFFLG ASVLANDHLR VIQASEKLFR LKTPAWYLKS IVETILIYKH FVKLTTEQPS 
AKQELVDFWM DFLVEATKTD VTVVRFPVLI LEPTKIYQPS YLSINNEVEE KTISIWHVLP 
DDKKGIHEWN FGASSVRGVS ISKFEERCCF LYVLHNSDDF QIYFCTELHC KRFFEMVNTI 
TEEKGRGAED GDCEGDSLEY DYEYDENGDR VVLGKGTYGI VYAGRDLSNQ VRIAIKEIPE 
RDSRYSQPLH EEIALHKHLK HKNIVQYLGS FSENGFIKIF MEQVPGGSLS ALLRSKWGPL 
KDNEQTIGFY TKQILEGLKY LHDNQIVHRD IKGDNVLINT YSGVLKISDF GTSKRLAGIN 
PCTETFTGTL QYMAPEIIDK GPRGYGKAAD IWSLGCTIIE MATGKPPFYE LGEPQAAMFK 
VGMFKVHPEI PESMSAEAKA FILKCFEPDP DKRACANDLL IDEFLKVSSK KKKTQPKLSA 
LSTGSNEYLR SISLPVPVLV EDTSSSSEYG SVSPDTELKA DPFSFKARAK SCGEKDGKGI 
RTLFLGIPDE NFEDHSAPPS PEEKDSGFFM LRKDSERRAT LHRILTEDQD KVVRNLMESL 
AQGAEEPKLK WEHITTLISS LREFVRSTDR KIIATTLSKL KLELDFDSHG ISQVQVVLFG 
FQDAVNKVLR NHNIKPHWMF ALDSIIRKAV QTAITILVPE LRPHFSLASE SDTADPEDLD 
VEDEHEELSS NQTVRRPQAI TEDAVATSGV STLSSTVSHD SQNAHRSLNV QLGRMKIETN 
RLLEELVRKE RELQALLHQA IEEKDQEIRH LKLKSQPIDI PGFPVCHLNS PGTTTEDSEL 
PGWLRENGAD EDTISRFLAE DYTLVDVLYY VTRDDLKCLR LRGGMLCTLW KAIIDFRNKC

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Map3k5

Associated with

Other Information

Molecular cloning and characterization of the mouse apoptosis signal-regulating kinase 1. PubMed ID: 9367868

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis. PubMed ID: 11266364

Activation of apoptosis signal-regulating kinase 1 by the stress-induced activating phosphorylation of pre-formed oligomer. PubMed ID: 11920685

Involvement of ASK1 in Ca2+-induced p38 MAP kinase activation. PubMed ID: 14749717

ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity. PubMed ID: 15864310

A balance between Raf-1 and Fas expression sets the pace of erythroid differentiation. PubMed ID: 16527894

Direct interaction and reciprocal regulation between ASK1 and calcineurin-NFAT control cardiomyocyte death and growth. PubMed ID: 16648474

Regulation of apoptosis signal-regulating kinase 1 by protein phosphatase 2Cepsilon. PubMed ID: 17456047

Murine protein serine/threonine kinase 38 activates apoptosis signal-regulating kinase 1 via Thr 838 phosphorylation. PubMed ID: 18948261

Apoptosis signal-regulating kinase 1 in stress and immune response. PubMed ID: 17883330

The roles of ASK family proteins in stress responses and diseases. PubMed ID: 19389260

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

S100 proteins modulate protein phosphatase 5 function: a link between CA2+ signal transduction and protein dephosphorylation. PubMed ID: 22399290