Mapk1 | ENSMUSG00000063358 | NCBI 26413

Details for: Mapk1

Gene ID: 26413

Symbol: Mapk1

Ensembl ID: ENSMUSG00000063358

Description: mitogen-activated protein kinase 1

Associated with

Apoptosis
(R-MMU-109581)
Apoptotic factor-mediated response
(R-MMU-111471)
Axon guidance
(R-MMU-422475)
Cell cycle
(R-MMU-1640170)
Cell cycle, mitotic
(R-MMU-69278)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular response to heat stress
(R-MMU-3371556)
Cellular senescence
(R-MMU-2559583)
Cytochrome c-mediated apoptotic response
(R-MMU-111461)
Cytokine signaling in immune system
(R-MMU-1280215)
Developmental biology
(R-MMU-1266738)
Downregulation of smad2/3:smad4 transcriptional activity
(R-MMU-2173795)
Esr-mediated signaling
(R-MMU-8939211)
Extra-nuclear estrogen signaling
(R-MMU-9009391)
Fc epsilon receptor (fceri) signaling
(R-MMU-2454202)
Fceri mediated mapk activation
(R-MMU-2871796)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-MMU-2029480)
G alpha (i) signalling events
(R-MMU-418594)
G alpha (q) signalling events
(R-MMU-416476)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Golgi cisternae pericentriolar stack reorganization
(R-MMU-162658)
Gpcr downstream signalling
(R-MMU-388396)
Growth hormone receptor signaling
(R-MMU-982772)
Hemostasis
(R-MMU-109582)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Insulin receptor signalling cascade
(R-MMU-74751)
Interferon gamma signaling
(R-MMU-877300)
Interferon signaling
(R-MMU-913531)
Interleukin-17 signaling
(R-MMU-448424)
Intracellular signaling by second messengers
(R-MMU-9006925)
Intrinsic pathway for apoptosis
(R-MMU-109606)
L1cam interactions
(R-MMU-373760)
Mapk1 (erk2) activation
(R-MMU-112411)
Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk family signaling cascades
(R-MMU-5683057)
Mitf-m-regulated melanocyte development
(R-MMU-9730414)
Mitotic prophase
(R-MMU-68875)
M phase
(R-MMU-68886)
Myd88-independent tlr4 cascade
(R-MMU-166166)
Ncam signaling for neurite out-growth
(R-MMU-375165)
Negative regulation of fgfr1 signaling
(R-MMU-5654726)
Negative regulation of fgfr2 signaling
(R-MMU-5654727)
Negative regulation of fgfr3 signaling
(R-MMU-5654732)
Negative regulation of fgfr4 signaling
(R-MMU-5654733)
Negative regulation of the pi3k/akt network
(R-MMU-199418)
Nervous system development
(R-MMU-9675108)
Neutrophil degranulation
(R-MMU-6798695)
Nuclear events (kinase and transcription factor activation)
(R-MMU-198725)
Oncogene induced senescence
(R-MMU-2559585)
Opioid signalling
(R-MMU-111885)
Oxidative stress induced senescence
(R-MMU-2559580)
Pip3 activates akt signaling
(R-MMU-1257604)
Platelet activation, signaling and aggregation
(R-MMU-76002)
Programmed cell death
(R-MMU-5357801)
Raf-independent mapk1/3 activation
(R-MMU-112409)
Raf/map kinase cascade
(R-MMU-5673001)
Recycling pathway of l1
(R-MMU-437239)
Regulation of actin dynamics for phagocytic cup formation
(R-MMU-2029482)
Regulation of hsf1-mediated heat shock response
(R-MMU-3371453)
Rho gtpase effectors
(R-MMU-195258)
Rna polymerase ii transcription
(R-MMU-73857)
Senescence-associated secretory phenotype (sasp)
(R-MMU-2559582)
Signaling by activin
(R-MMU-1502540)
Signaling by fgfr
(R-MMU-190236)
Signaling by fgfr1
(R-MMU-5654736)
Signaling by fgfr2
(R-MMU-5654738)
Signaling by fgfr3
(R-MMU-5654741)
Signaling by fgfr4
(R-MMU-5654743)
Signaling by gpcr
(R-MMU-372790)
Signaling by insulin receptor
(R-MMU-74752)
Signaling by interleukins
(R-MMU-449147)
Signaling by nodal
(R-MMU-1181150)
Signaling by ntrk1 (trka)
(R-MMU-187037)
Signaling by ntrks
(R-MMU-166520)
Signaling by nuclear receptors
(R-MMU-9006931)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signaling by tgf-beta receptor complex
(R-MMU-170834)
Signaling by tgfb family members
(R-MMU-9006936)
Signalling to erks
(R-MMU-187687)
Signal transduction
(R-MMU-162582)
Signal transduction by l1
(R-MMU-445144)
Smad2/smad3:smad4 heterotrimer regulates transcription
(R-MMU-2173796)
Thrombin signalling through proteinase activated receptors (pars)
(R-MMU-456926)
Toll-like receptor cascades
(R-MMU-168898)
Toll like receptor 2 (tlr2) cascade
(R-MMU-181438)
Toll like receptor 3 (tlr3) cascade
(R-MMU-168164)
Toll like receptor 4 (tlr4) cascade
(R-MMU-166016)
Toll like receptor 5 (tlr5) cascade
(R-MMU-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-MMU-168181)
Toll like receptor 9 (tlr9) cascade
(R-MMU-168138)
Toll like receptor 10 (tlr10) cascade
(R-MMU-168142)
Toll like receptor tlr1:tlr2 cascade
(R-MMU-168179)
Toll like receptor tlr6:tlr2 cascade
(R-MMU-168188)
Transcriptional activity of smad2/smad3:smad4 heterotrimer
(R-MMU-2173793)
Transcriptional and post-translational regulation of mitf-m expression and activity
(R-MMU-9856649)

Other Information

Proteins

ERT1

Genular Protein ID: 1494599539

Symbol: MK01_MOUSE

Name: ERT1

UniProtKB Accession Codes:

P63085 P27703 Q3V1U6

Database IDs:

Citations:

PubMed ID: 1649458

Title: Sequence of pp42/MAP kinase, a serine/threonine kinase regulated by tyrosine phosphorylation.

PubMed ID: 1649458

DOI: 10.1093/nar/19.13.3743

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8444355

Title: Novel CDC2-related protein kinases produced in murine hematopoietic stem cells.

PubMed ID: 8444355

DOI: 10.1016/0378-1119(93)90411-u

PubMed ID: 1849075

Title: Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase).

PubMed ID: 1849075

DOI: 10.1002/j.1460-2075.1991.tb08021.x

PubMed ID: 8221888

Title: MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo.

PubMed ID: 8221888

DOI: 10.1016/0092-8674(93)90383-2

PubMed ID: 10080542

Title: Flt3 signaling involves tyrosyl-phosphorylation of SHP-2 and SHIP and their association with Grb2 and Shc in Baf3/Flt3 cells.

PubMed ID: 10080542

DOI: 10.1002/jlb.65.3.372

PubMed ID: 11090077

Title: Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways.

PubMed ID: 11090077

PubMed ID: 10753946

Title: Phosphorylation of paxillin via the ERK mitogen-activated protein kinase cascade in EL4 thymoma cells.

PubMed ID: 10753946

DOI: 10.1074/jbc.275.15.11333

PubMed ID: 11702783

Title: PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase.

PubMed ID: 11702783

DOI: 10.1016/s1534-5807(01)00035-1

PubMed ID: 12134156

Title: Molecular interpretation of ERK signal duration by immediate early gene products.

PubMed ID: 12134156

DOI: 10.1038/ncb822

PubMed ID: 15118098

Title: Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists.

PubMed ID: 15118098

DOI: 10.1073/pnas.0305894101

PubMed ID: 15899793

Title: bHLH-zip transcription factor Spz1 mediates mitogen-activated protein kinase cell proliferation, transformation, and tumorigenesis.

PubMed ID: 15899793

DOI: 10.1158/0008-5472.can-04-3658

PubMed ID: 15923189

Title: GIT1 is a scaffold for ERK1/2 activation in focal adhesions.

PubMed ID: 15923189

DOI: 10.1074/jbc.m502271200

PubMed ID: 16162500

Title: Features of the catalytic domains and C termini of the MAPK signal-integrating kinases Mnk1 and Mnk2 determine their differing activities and regulatory properties.

PubMed ID: 16162500

DOI: 10.1074/jbc.m508356200

PubMed ID: 17947660

Title: Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.

PubMed ID: 17947660

DOI: 10.4049/jimmunol.179.9.5864

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 18034455

Title: Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.

PubMed ID: 18034455

DOI: 10.1021/pr0701254

PubMed ID: 19131326

Title: Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.

PubMed ID: 19131326

DOI: 10.1074/mcp.m800451-mcp200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21262971

Title: Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling.

PubMed ID: 21262971

DOI: 10.1074/jbc.m110.205021

PubMed ID: 16393692

Title: The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions.

PubMed ID: 16393692

DOI: 10.1080/02699050500284218

PubMed ID: 19565474

Title: The ERK signaling cascade--views from different subcellular compartments.

PubMed ID: 19565474

DOI: 10.1002/biof.52

PubMed ID: 21779493

Title: The ERK cascade: distinct functions within various subcellular organelles.

PubMed ID: 21779493

DOI: 10.1177/1947601911407328

PubMed ID: 22022510

Title: ISG15 modulates development of the erythroid lineage.

PubMed ID: 22022510

DOI: 10.1371/journal.pone.0026068

PubMed ID: 26240334

Title: FXR1P is a GSK3beta substrate regulating mood and emotion processing.

PubMed ID: 26240334

DOI: 10.1073/pnas.1506491112

PubMed ID: 27783954

Title: The phosphatase Dusp7 drives meiotic resumption and chromosome alignment in mouse oocytes.

PubMed ID: 27783954

DOI: 10.1016/j.celrep.2016.10.007

Sequence Information:

Length: 358
Mass: 41276
Checksum: 3BBCF22471EDBA0B
Sequence:

MAAAAAAGPE MVRGQVFDVG PRYTNLSYIG EGAYGMVCSA YDNLNKVRVA IKKISPFEHQ 
TYCQRTLREI KILLRFRHEN IIGINDIIRA PTIEQMKDVY IVQDLMETDL YKLLKTQHLS 
NDHICYFLYQ ILRGLKYIHS ANVLHRDLKP SNLLLNTTCD LKICDFGLAR VADPDHDHTG 
FLTEYVATRW YRAPEIMLNS KGYTKSIDIW SVGCILAEML SNRPIFPGKH YLDQLNHILG 
ILGSPSQEDL NCIINLKARN YLLSLPHKNK VPWNRLFPNA DSKALDLLDK MLTFNPHKRI 
EVEQALAHPY LEQYYDPSDE PIAEAPFKFD MELDDLPKEK LKELIFEETA RFQPGYRS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Mapk1

Associated with

Other Information

Sequence of pp42/MAP kinase, a serine/threonine kinase regulated by tyrosine phosphorylation. PubMed ID: 1649458

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Novel CDC2-related protein kinases produced in murine hematopoietic stem cells. PubMed ID: 8444355

Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase). PubMed ID: 1849075

MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo. PubMed ID: 8221888

Flt3 signaling involves tyrosyl-phosphorylation of SHP-2 and SHIP and their association with Grb2 and Shc in Baf3/Flt3 cells. PubMed ID: 10080542

Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways. PubMed ID: 11090077

Phosphorylation of paxillin via the ERK mitogen-activated protein kinase cascade in EL4 thymoma cells. PubMed ID: 10753946

PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase. PubMed ID: 11702783

Molecular interpretation of ERK signal duration by immediate early gene products. PubMed ID: 12134156

Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists. PubMed ID: 15118098

bHLH-zip transcription factor Spz1 mediates mitogen-activated protein kinase cell proliferation, transformation, and tumorigenesis. PubMed ID: 15899793

GIT1 is a scaffold for ERK1/2 activation in focal adhesions. PubMed ID: 15923189

Features of the catalytic domains and C termini of the MAPK signal-integrating kinases Mnk1 and Mnk2 determine their differing activities and regulatory properties. PubMed ID: 16162500

Quantitative time-resolved phosphoproteomic analysis of mast cell signaling. PubMed ID: 17947660

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain. PubMed ID: 18034455

Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry. PubMed ID: 19131326

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling. PubMed ID: 21262971

The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions. PubMed ID: 16393692

The ERK signaling cascade--views from different subcellular compartments. PubMed ID: 19565474

The ERK cascade: distinct functions within various subcellular organelles. PubMed ID: 21779493

ISG15 modulates development of the erythroid lineage. PubMed ID: 22022510

FXR1P is a GSK3beta substrate regulating mood and emotion processing. PubMed ID: 26240334

The phosphatase Dusp7 drives meiotic resumption and chromosome alignment in mouse oocytes. PubMed ID: 27783954