Mapk3 | ENSMUSG00000063065 | NCBI 26417

Details for: Mapk3

Gene ID: 26417

Symbol: Mapk3

Ensembl ID: ENSMUSG00000063065

Description: mitogen-activated protein kinase 3

Associated with

Antiviral mechanism by ifn-stimulated genes
(R-MMU-1169410)
Apoptosis
(R-MMU-109581)
Apoptotic factor-mediated response
(R-MMU-111471)
Axon guidance
(R-MMU-422475)
Cell cycle
(R-MMU-1640170)
Cell cycle, mitotic
(R-MMU-69278)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular response to heat stress
(R-MMU-3371556)
Cellular senescence
(R-MMU-2559583)
Cytochrome c-mediated apoptotic response
(R-MMU-111461)
Cytokine signaling in immune system
(R-MMU-1280215)
Developmental biology
(R-MMU-1266738)
Downregulation of smad2/3:smad4 transcriptional activity
(R-MMU-2173795)
Fc epsilon receptor (fceri) signaling
(R-MMU-2454202)
Fceri mediated mapk activation
(R-MMU-2871796)
Fcgamma receptor (fcgr) dependent phagocytosis
(R-MMU-2029480)
G alpha (q) signalling events
(R-MMU-416476)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Golgi cisternae pericentriolar stack reorganization
(R-MMU-162658)
Gpcr downstream signalling
(R-MMU-388396)
Growth hormone receptor signaling
(R-MMU-982772)
Hemostasis
(R-MMU-109582)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Insulin receptor signalling cascade
(R-MMU-74751)
Interferon gamma signaling
(R-MMU-877300)
Interferon signaling
(R-MMU-913531)
Interleukin-17 signaling
(R-MMU-448424)
Intracellular signaling by second messengers
(R-MMU-9006925)
Intrinsic pathway for apoptosis
(R-MMU-109606)
Isg15 antiviral mechanism
(R-MMU-1169408)
L1cam interactions
(R-MMU-373760)
Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk3 (erk1) activation
(R-MMU-110056)
Mapk family signaling cascades
(R-MMU-5683057)
Mitf-m-regulated melanocyte development
(R-MMU-9730414)
Mitotic prophase
(R-MMU-68875)
M phase
(R-MMU-68886)
Myd88-independent tlr4 cascade
(R-MMU-166166)
Ncam signaling for neurite out-growth
(R-MMU-375165)
Negative regulation of fgfr1 signaling
(R-MMU-5654726)
Negative regulation of fgfr2 signaling
(R-MMU-5654727)
Negative regulation of fgfr3 signaling
(R-MMU-5654732)
Negative regulation of fgfr4 signaling
(R-MMU-5654733)
Negative regulation of the pi3k/akt network
(R-MMU-199418)
Nervous system development
(R-MMU-9675108)
Nuclear events (kinase and transcription factor activation)
(R-MMU-198725)
Oncogene induced senescence
(R-MMU-2559585)
Oxidative stress induced senescence
(R-MMU-2559580)
Pip3 activates akt signaling
(R-MMU-1257604)
Platelet activation, signaling and aggregation
(R-MMU-76002)
Programmed cell death
(R-MMU-5357801)
Raf-independent mapk1/3 activation
(R-MMU-112409)
Raf/map kinase cascade
(R-MMU-5673001)
Regulation of actin dynamics for phagocytic cup formation
(R-MMU-2029482)
Regulation of hsf1-mediated heat shock response
(R-MMU-3371453)
Rho gtpase effectors
(R-MMU-195258)
Rho gtpases activate nadph oxidases
(R-MMU-5668599)
Rho gtpases activate wasps and waves
(R-MMU-5663213)
Rna polymerase ii transcription
(R-MMU-73857)
Rna polymerase i promoter clearance
(R-MMU-73854)
Rna polymerase i promoter opening
(R-MMU-73728)
Rna polymerase i transcription
(R-MMU-73864)
Senescence-associated secretory phenotype (sasp)
(R-MMU-2559582)
Signaling by activin
(R-MMU-1502540)
Signaling by fgfr
(R-MMU-190236)
Signaling by fgfr1
(R-MMU-5654736)
Signaling by fgfr2
(R-MMU-5654738)
Signaling by fgfr3
(R-MMU-5654741)
Signaling by fgfr4
(R-MMU-5654743)
Signaling by gpcr
(R-MMU-372790)
Signaling by insulin receptor
(R-MMU-74752)
Signaling by interleukins
(R-MMU-449147)
Signaling by nodal
(R-MMU-1181150)
Signaling by ntrk1 (trka)
(R-MMU-187037)
Signaling by ntrks
(R-MMU-166520)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signaling by tgf-beta receptor complex
(R-MMU-170834)
Signaling by tgfb family members
(R-MMU-9006936)
Signalling to erks
(R-MMU-187687)
Signal transduction
(R-MMU-162582)
Signal transduction by l1
(R-MMU-445144)
Smad2/smad3:smad4 heterotrimer regulates transcription
(R-MMU-2173796)
Thrombin signalling through proteinase activated receptors (pars)
(R-MMU-456926)
Toll-like receptor cascades
(R-MMU-168898)
Toll like receptor 2 (tlr2) cascade
(R-MMU-181438)
Toll like receptor 3 (tlr3) cascade
(R-MMU-168164)
Toll like receptor 4 (tlr4) cascade
(R-MMU-166016)
Toll like receptor 5 (tlr5) cascade
(R-MMU-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-MMU-168181)
Toll like receptor 9 (tlr9) cascade
(R-MMU-168138)
Toll like receptor 10 (tlr10) cascade
(R-MMU-168142)
Toll like receptor tlr1:tlr2 cascade
(R-MMU-168179)
Toll like receptor tlr6:tlr2 cascade
(R-MMU-168188)
Transcriptional activity of smad2/smad3:smad4 heterotrimer
(R-MMU-2173793)
Transcriptional and post-translational regulation of mitf-m expression and activity
(R-MMU-9856649)

Other Information

Proteins

Mitogen-activated protein kinase 3

Genular Protein ID: 2504217350

Symbol: MK03_MOUSE

Name: Mitogen-activated protein kinase 3

UniProtKB Accession Codes:

Q63844 Q61531 Q8K0X5 Q91YW5

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8424957

Title: Molecular cloning of a mouse extracellular signal regulated kinase (erk-1).

PubMed ID: 8424957

DOI: 10.1016/0167-4781(93)90074-n

PubMed ID: 1717989

Title: Mouse Erk-1 gene product is a serine/threonine protein kinase that has the potential to phosphorylate tyrosine.

PubMed ID: 1717989

DOI: 10.1073/pnas.88.19.8845

PubMed ID: 1716439

Title: Molecular analysis of microtubule-associated protein-2 kinase cDNA from mouse and rat brain.

PubMed ID: 1716439

DOI: 10.1089/dna.1991.10.505

PubMed ID: 8444355

Title: Novel CDC2-related protein kinases produced in murine hematopoietic stem cells.

PubMed ID: 8444355

DOI: 10.1016/0378-1119(93)90411-u

PubMed ID: 1459009

Title: Identification of new protein kinase genes, similar to kinases of the cdc2 family and expressed in murine hematopoietic stem cells.

PubMed ID: 1459009

PubMed ID: 10080542

Title: Flt3 signaling involves tyrosyl-phosphorylation of SHP-2 and SHIP and their association with Grb2 and Shc in Baf3/Flt3 cells.

PubMed ID: 10080542

DOI: 10.1002/jlb.65.3.372

PubMed ID: 11090077

Title: Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways.

PubMed ID: 11090077

PubMed ID: 11702783

Title: PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase.

PubMed ID: 11702783

DOI: 10.1016/s1534-5807(01)00035-1

PubMed ID: 12134156

Title: Molecular interpretation of ERK signal duration by immediate early gene products.

PubMed ID: 12134156

DOI: 10.1038/ncb822

PubMed ID: 15118098

Title: Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists.

PubMed ID: 15118098

DOI: 10.1073/pnas.0305894101

PubMed ID: 15899793

Title: bHLH-zip transcription factor Spz1 mediates mitogen-activated protein kinase cell proliferation, transformation, and tumorigenesis.

PubMed ID: 15899793

DOI: 10.1158/0008-5472.can-04-3658

PubMed ID: 15923189

Title: GIT1 is a scaffold for ERK1/2 activation in focal adhesions.

PubMed ID: 15923189

DOI: 10.1074/jbc.m502271200

PubMed ID: 16162500

Title: Features of the catalytic domains and C termini of the MAPK signal-integrating kinases Mnk1 and Mnk2 determine their differing activities and regulatory properties.

PubMed ID: 16162500

DOI: 10.1074/jbc.m508356200

PubMed ID: 17947660

Title: Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.

PubMed ID: 17947660

DOI: 10.4049/jimmunol.179.9.5864

PubMed ID: 18034455

Title: Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain.

PubMed ID: 18034455

DOI: 10.1021/pr0701254

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 19131326

Title: Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.

PubMed ID: 19131326

DOI: 10.1074/mcp.m800451-mcp200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21262971

Title: Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling.

PubMed ID: 21262971

DOI: 10.1074/jbc.m110.205021

PubMed ID: 16393692

Title: The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions.

PubMed ID: 16393692

DOI: 10.1080/02699050500284218

PubMed ID: 19565474

Title: The ERK signaling cascade--views from different subcellular compartments.

PubMed ID: 19565474

DOI: 10.1002/biof.52

PubMed ID: 21779493

Title: The ERK cascade: distinct functions within various subcellular organelles.

PubMed ID: 21779493

DOI: 10.1177/1947601911407328

Sequence Information:

Length: 380
Mass: 43066
Checksum: 49C14A95B627237F
Sequence:

MAAAAAAPGG GGGEPRGTAG VVPVVPGEVE VVKGQPFDVG PRYTQLQYIG EGAYGMVSSA 
YDHVRKTRVA IKKISPFEHQ TYCQRTLREI QILLRFRHEN VIGIRDILRA PTLEAMRDVY 
IVQDLMETDL YKLLKSQQLS NDHICYFLYQ ILRGLKYIHS ANVLHRDLKP SNLLINTTCD 
LKICDFGLAR IADPEHDHTG FLTEYVATRW YRAPEIMLNS KGYTKSIDIW SVGCILAEML 
SNRPIFPGKH YLDQLNHILG ILGSPSQEDL NCIINMKARN YLQSLPSKTK VAWAKLFPKS 
DSKALDLLDR MLTFNPNKRI TVEEALAHPY LEQYYDPTDE PVAEEPFTFD MELDDLPKER 
LKELIFQETA RFQPGAPEGP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Mapk3

Associated with

Other Information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Molecular cloning of a mouse extracellular signal regulated kinase (erk-1). PubMed ID: 8424957

Mouse Erk-1 gene product is a serine/threonine protein kinase that has the potential to phosphorylate tyrosine. PubMed ID: 1717989

Molecular analysis of microtubule-associated protein-2 kinase cDNA from mouse and rat brain. PubMed ID: 1716439

Novel CDC2-related protein kinases produced in murine hematopoietic stem cells. PubMed ID: 8444355

Identification of new protein kinase genes, similar to kinases of the cdc2 family and expressed in murine hematopoietic stem cells. PubMed ID: 1459009

Flt3 signaling involves tyrosyl-phosphorylation of SHP-2 and SHIP and their association with Grb2 and Shc in Baf3/Flt3 cells. PubMed ID: 10080542

Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways. PubMed ID: 11090077

PEA-15 mediates cytoplasmic sequestration of ERK MAP kinase. PubMed ID: 11702783

Molecular interpretation of ERK signal duration by immediate early gene products. PubMed ID: 12134156

Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists. PubMed ID: 15118098

bHLH-zip transcription factor Spz1 mediates mitogen-activated protein kinase cell proliferation, transformation, and tumorigenesis. PubMed ID: 15899793

GIT1 is a scaffold for ERK1/2 activation in focal adhesions. PubMed ID: 15923189

Features of the catalytic domains and C termini of the MAPK signal-integrating kinases Mnk1 and Mnk2 determine their differing activities and regulatory properties. PubMed ID: 16162500

Quantitative time-resolved phosphoproteomic analysis of mast cell signaling. PubMed ID: 17947660

Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain. PubMed ID: 18034455

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry. PubMed ID: 19131326

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling. PubMed ID: 21262971

The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions. PubMed ID: 16393692

The ERK signaling cascade--views from different subcellular compartments. PubMed ID: 19565474

The ERK cascade: distinct functions within various subcellular organelles. PubMed ID: 21779493