Details for: Mapk8

Gene ID: 26419

Symbol: Mapk8

Ensembl ID: ENSMUSG00000021936

Description: mitogen-activated protein kinase 8

Associated with

Other Information

Genular Protein ID: 534352893

Symbol: MK08_MOUSE

Name: Mitogen-activated protein kinase 8

UniProtKB Accession Codes:

Q91Y86

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 EC 2 ELM 1 EMBL 1 Ensembl 1 ExpressionAtlas 1 GO 69 Gene3D 1 GeneTree 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MGI 1 MINT 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 3 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 9 RefSeq 1 Rhea 6 SMART 1 SMR 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 10523642

Title: JSAP1, a novel jun N-terminal protein kinase (JNK)-binding protein that functions as a scaffold factor in the JNK signaling pathway.

PubMed ID: 10523642

DOI: 10.1128/mcb.19.11.7539

PubMed ID: 9393873

Title: JNK1, JNK2 and JNK3 are p53 N-terminal serine 34 kinases.

PubMed ID: 9393873

DOI: 10.1038/sj.onc.1201401

PubMed ID: 9096336

Title: Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH2-terminal kinase activation, and defects in AP-1 transcriptional activity.

PubMed ID: 9096336

DOI: 10.1073/pnas.94.7.3004

PubMed ID: 9207092

Title: Mitogen-activated protein kinase kinase 7 is an activator of the c-Jun NH2-terminal kinase.

PubMed ID: 9207092

DOI: 10.1073/pnas.94.14.7337

PubMed ID: 10811224

Title: JNK is required for effector T-cell function but not for T-cell activation.

PubMed ID: 10811224

DOI: 10.1038/35011091

PubMed ID: 11602244

Title: The AP-1 repressor, JDP2, is a bona fide substrate for the c-Jun N-terminal kinase.

PubMed ID: 11602244

DOI: 10.1016/s0014-5793(01)02907-6

PubMed ID: 11562351

Title: Requirement of the JIP1 scaffold protein for stress-induced JNK activation.

PubMed ID: 11562351

DOI: 10.1101/gad.922801

PubMed ID: 12391307

Title: JLP: a scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors.

PubMed ID: 12391307

DOI: 10.1073/pnas.232310199

PubMed ID: 14499478

Title: Cytoplasmic retention sites in p190RhoGEF confer anti-apoptotic activity to an EGFP-tagged protein.

PubMed ID: 14499478

DOI: 10.1016/s0169-328x(03)00263-8

PubMed ID: 15345747

Title: Phosphoproteomic analysis of the developing mouse brain.

PubMed ID: 15345747

DOI: 10.1074/mcp.m400085-mcp200

PubMed ID: 16166642

Title: JAMP, a Jun N-terminal kinase 1 (JNK1)-associated membrane protein, regulates duration of JNK activity.

PubMed ID: 16166642

DOI: 10.1128/mcb.25.19.8619-8630.2005

PubMed ID: 16618812

Title: JNK1 phosphorylation of SCG10 determines microtubule dynamics and axodendritic length.

PubMed ID: 16618812

DOI: 10.1083/jcb.200511055

PubMed ID: 17761173

Title: GRASP-1 is a neuronal scaffold protein for the JNK signaling pathway.

PubMed ID: 17761173

DOI: 10.1016/j.febslet.2007.08.008

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 19966288

Title: JNK-mediated turnover and stabilization of the transcription factor p45/NF-E2 during differentiation of murine erythroleukemia cells.

PubMed ID: 19966288

DOI: 10.1073/pnas.0909153107

PubMed ID: 21297631

Title: Phosphorylation of SCG10/stathmin-2 determines multipolar stage exit and neuronal migration rate.

PubMed ID: 21297631

DOI: 10.1038/nn.2755

PubMed ID: 22441692

Title: JNK regulates the photic response of the mammalian circadian clock.

PubMed ID: 22441692

DOI: 10.1038/embor.2012.37

PubMed ID: 23963642

Title: The POSH/JIP-1 scaffold network regulates TCR-mediated JNK1 signals and effector function in CD8(+) T cells.

PubMed ID: 23963642

DOI: 10.1002/eji.201343635

PubMed ID: 27084103

Title: POSH regulates CD4+ T cell differentiation and survival.

PubMed ID: 27084103

DOI: 10.4049/jimmunol.1501728

PubMed ID: 28943315

Title: NLRP3 phosphorylation is an essential priming event for inflammasome activation.

PubMed ID: 28943315

DOI: 10.1016/j.molcel.2017.08.017

PubMed ID: 29153991

Title: Serine 347 Phosphorylation by JNKs Negatively Regulates OCT4 Protein Stability in Mouse Embryonic Stem Cells.

PubMed ID: 29153991

DOI: 10.1016/j.stemcr.2017.10.017

PubMed ID: 36812915

Title: Exercise-activated hepatic autophagy via the FN1-alpha5beta1 integrin pathway drives metabolic benefits of exercise.

PubMed ID: 36812915

DOI: 10.1016/j.cmet.2023.01.011

Sequence Information:

  • Length: 384
  • Mass: 44229
  • Checksum: A7320EF933E9CF85
  • Sequence:
    • MSRSKRDNNF YSVEIGDSTF TVLKRYQNLK PIGSGAQGIV CAAYDAILER NVAIKKLSRP 
FQNQTHAKRA YRELVLMKCV NHKNIIGLLN VFTPQKSLEE FQDVYIVMEL MDANLCQVIQ 
MELDHERMSY LLYQMLCGIK HLHSAGIIHR DLKPSNIVVK SDCTLKILDF GLARTAGTSF 
MMTPYVVTRY YRAPEVILGM GYKENVDLWS VGCIMGEMVC HKILFPGRDY IDQWNKVIEQ 
LGTPCPEFMK KLQPTVRTYV ENRPKYAGYS FEKLFPDVLF PADSEHNKLK ASQARDLLSK 
MLVIDASKRI SVDEALQHPY INVWYDPSEA EAPPPKIPDK QLDEREHTIE EWKELIYKEV 
MDLEERTKNG VIRGQPSPLA QVQQ

Genular Protein ID: 2471540824

Symbol: G3X8U9_MOUSE

Name: N/A

UniProtKB Accession Codes:

G3X8U9

Database IDs:

AGR 1 ARBA 5 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 11 ChiTaRS 1 DNASU 1 EC 2 Ensembl 2 ExpressionAtlas 1 GO 23 Gene3D 1 GeneTree 1 InterPro 6 MGI 2 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PeptideAtlas 1 Pfam 1 PhylomeDB 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 Rhea 6 RuleBase 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21750661

Title: Modernizing reference genome assemblies.

PubMed ID: 21750661

Sequence Information:

  • Length: 427
  • Mass: 48178
  • Checksum: 29843ED9722FF2EA
  • Sequence:
    • MSRSKRDNNF YSVEIGDSTF TVLKRYQNLK PIGSGAQGIV CAAYDAILER NVAIKKLSRP 
FQNQTHAKRA YRELVLMKCV NHKNIIGLLN VFTPQKSLEE FQDVYIVMEL MDANLCQVIQ 
MELDHERMSY LLYQMLCGIK HLHSAGIIHR DLKPSNIVVK SDCTLKILDF GLARTAGTSF 
MMTPYVVTRY YRAPEVILGM GYKENVDIWS VGCIMGEMIK GGVLFPGTDH IDQWNKVIEQ 
LGTPCPEFMK KLQPTVRTYV ENRPKYAGYS FEKLFPDVLF PADSEHNKLK ASQARDLLSK 
MLVIDASKRI SVDEALQHPY INVWYDPSEA EAPPPKIPDK QLDEREHTIE EWKELIYKEV 
MDLEERTKNG VIRGQPSPLG AAMINGSQHP SSSPSVNDMS SMSTDPTLAS DTDSSLEASA 
GPLGCCR

Genular Protein ID: 4023563603

Symbol: A6P3E4_MOUSE

Name: N/A

UniProtKB Accession Codes:

A6P3E4

Database IDs:

AGR 1 ARBA 5 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 11 ChiTaRS 1 DNASU 1 EC 2 EMBL 2 Ensembl 2 GO 6 Gene3D 1 GeneTree 1 InterPro 6 MGI 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 2 Rhea 6 RuleBase 1 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15345747

Title: Phosphoproteomic analysis of the developing mouse brain.

PubMed ID: 15345747

DOI: 10.1074/mcp.M400085-MCP200

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21750661

Title: Modernizing reference genome assemblies.

PubMed ID: 21750661

Sequence Information:

  • Length: 384
  • Mass: 44022
  • Checksum: 76E49A950E64C1A1
  • Sequence:
    • MSRSKRDNNF YSVEIGDSTF TVLKRYQNLK PIGSGAQGIV CAAYDAILER NVAIKKLSRP 
FQNQTHAKRA YRELVLMKCV NHKNIIGLLN VFTPQKSLEE FQDVYIVMEL MDANLCQVIQ 
MELDHERMSY LLYQMLCGIK HLHSAGIIHR DLKPSNIVVK SDCTLKILDF GLARTAGTSF 
MMTPYVVTRY YRAPEVILGM GYKENVDIWS VGCIMGEMIK GGVLFPGTDH IDQWNKVIEQ 
LGTPCPEFMK KLQPTVRTYV ENRPKYAGYS FEKLFPDVLF PADSEHNKLK ASQARDLLSK 
MLVIDASKRI SVDEALQHPY INVWYDPSEA EAPPPKIPDK QLDEREHTIE EWKELIYKEV 
MDLEERTKNG VIRGQPSPLA QVQQ

Genular Protein ID: 1410390569

Symbol: Q7TSJ7_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q7TSJ7

Database IDs:

AGR 1 ARBA 5 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 11 ChiTaRS 1 DNASU 1 EC 2 EMBL 2 Ensembl 2 GO 6 Gene3D 1 GeneTree 1 InterPro 6 MGI 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 3 Rhea 6 RuleBase 1 SAM 1 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21750661

Title: Modernizing reference genome assemblies.

PubMed ID: 21750661

Sequence Information:

  • Length: 427
  • Mass: 48386
  • Checksum: 822396CFE35786A7
  • Sequence:
    • MSRSKRDNNF YSVEIGDSTF TVLKRYQNLK PIGSGAQGIV CAAYDAILER NVAIKKLSRP 
FQNQTHAKRA YRELVLMKCV NHKNIIGLLN VFTPQKSLEE FQDVYIVMEL MDANLCQVIQ 
MELDHERMSY LLYQMLCGIK HLHSAGIIHR DLKPSNIVVK SDCTLKILDF GLARTAGTSF 
MMTPYVVTRY YRAPEVILGM GYKENVDLWS VGCIMGEMVC HKILFPGRDY IDQWNKVIEQ 
LGTPCPEFMK KLQPTVRTYV ENRPKYAGYS FEKLFPDVLF PADSEHNKLK ASQARDLLSK 
MLVIDASKRI SVDEALQHPY INVWYDPSEA EAPPPKIPDK QLDEREHTIE EWKELIYKEV 
MDLEERTKNG VIRGQPSPLG AAMINGSQHP SSSPSVNDMS SMSTDPTLAS DTDSSLEASA 
GPLGCCR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.