Nr5a1 | ENSMUSG00000026751 | NCBI 26423

Details for: Nr5a1

Gene ID: 26423

Symbol: Nr5a1

Ensembl ID: ENSMUSG00000026751

Description: nuclear receptor subfamily 5, group A, member 1

Associated with

Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Metabolism of proteins
(R-MMU-392499)
Nuclear receptor transcription pathway
(R-MMU-383280)
Post-translational protein modification
(R-MMU-597592)
Rna polymerase ii transcription
(R-MMU-73857)
Sumo e3 ligases sumoylate target proteins
(R-MMU-3108232)
Sumoylation
(R-MMU-2990846)
Sumoylation of intracellular receptors
(R-MMU-4090294)
Adrenal gland development
(GO:0030325)
Calcineurin-mediated signaling
(GO:0097720)
Chromatin binding
(GO:0003682)
Cytosol
(GO:0005829)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Double-stranded dna binding
(GO:0003690)
Enzyme binding
(GO:0019899)
Female gonad development
(GO:0008585)
Hormone-mediated signaling pathway
(GO:0009755)
Hormone metabolic process
(GO:0042445)
Intracellular receptor signaling pathway
(GO:0030522)
Leydig cell differentiation
(GO:0033327)
Luteinization
(GO:0001553)
Maintenance of protein location in nucleus
(GO:0051457)
Male gonad development
(GO:0008584)
Male sex determination
(GO:0030238)
Negative regulation of female gonad development
(GO:2000195)
Nuclear receptor activity
(GO:0004879)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Phospholipid binding
(GO:0005543)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of male gonad development
(GO:2000020)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Reproductive process
(GO:0022414)
Response to gonadotropin-releasing hormone
(GO:0097210)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulator complex
(GO:0090575)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Sertoli cell differentiation
(GO:0060008)
Sex determination
(GO:0007530)
Tissue development
(GO:0009888)
Transcription by rna polymerase ii
(GO:0006366)
Transcription coregulator binding
(GO:0001221)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

Steroidogenic factor 1

Genular Protein ID: 1012763860

Symbol: STF1_MOUSE

Name: Steroidogenic factor 1

UniProtKB Accession Codes:

P33242 Q812G5

Database IDs:

Citations:

PubMed ID: 1545809

Title: Embryonal long terminal repeat-binding protein is a murine homolog of FTZ-F1, a member of the steroid receptor superfamily.

PubMed ID: 1545809

DOI: 10.1128/mcb.12.3.1286-1291.1992

PubMed ID: 8413309

Title: Characterization of the mouse FTZ-F1 gene, which encodes a key regulator of steroid hydroxylase gene expression.

PubMed ID: 8413309

DOI: 10.1210/mend.7.7.8413309

PubMed ID: 12239114

Title: A polymorphic form of steroidogenic factor-1 is associated with adrenocorticotropin resistance in y1 mouse adrenocortical tumor cell mutants.

PubMed ID: 12239114

DOI: 10.1210/en.2002-220349

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8395013

Title: The orphan receptors NGFI-B and steroidogenic factor 1 establish monomer binding as a third paradigm of nuclear receptor-DNA interaction.

PubMed ID: 8395013

DOI: 10.1128/mcb.13.9.5794-5804.1993

PubMed ID: 17210646

Title: Cyclic AMP stimulates SF-1-dependent CYP11A1 expression through homeodomain-interacting protein kinase 3-mediated Jun N-terminal kinase and c-Jun phosphorylation.

PubMed ID: 17210646

DOI: 10.1128/mcb.02253-06

PubMed ID: 15707893

Title: Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1.

PubMed ID: 15707893

DOI: 10.1016/j.cell.2005.01.024

PubMed ID: 15721253

Title: Crystallographic identification and functional characterization of phospholipids as ligands for the orphan nuclear receptor steroidogenic factor-1.

PubMed ID: 15721253

DOI: 10.1016/j.molcel.2005.02.002

PubMed ID: 18988706

Title: Structure of SF-1 bound by different phospholipids: evidence for regulatory ligands.

PubMed ID: 18988706

DOI: 10.1210/me.2007-0508

Sequence Information:

Length: 462
Mass: 52077
Checksum: 67045B563403CF5A
Sequence:

MDYSYDEDLD ELCPVCGDKV SGYHYGLLTC ESCKGFFKRT VQNNKHYTCT ESQSCKIDKT 
QRKRCPFCRF QKCLTVGMRL EAVRADRMRG GRNKFGPMYK RDRALKQQKK AQIRANGFKL 
ETGPPMGVPP PPPPPPDYML PPSLHAPEPK ALVSGPPSGP LGDFGAPSLP MAVPGPHGPL 
AGYLYPAFSN RTIKSEYPEP YASPPQQPGP PYSYPEPFSG GPNVPELILQ LLQLEPEEDQ 
VRARIVGCLQ EPAKSRSDQP APFSLLCRMA DQTFISIVDW ARRCMVFKEL EVADQMTLLQ 
NCWSELLVLD HIYRQVQYGK EDSILLVTGQ EVELSTVAVQ AGSLLHSLVL RAQELVLQLH 
ALQLDRQEFV CLKFLILFSL DVKFLNNHSL VKDAQEKANA ALLDYTLCHY PHCGDKFQQL 
LLCLVEVRAL SMQAKEYLYH KHLGNEMPRN NLLIEMLQAK QT

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Nr5a1

Associated with

Other Information

Embryonal long terminal repeat-binding protein is a murine homolog of FTZ-F1, a member of the steroid receptor superfamily. PubMed ID: 1545809

Characterization of the mouse FTZ-F1 gene, which encodes a key regulator of steroid hydroxylase gene expression. PubMed ID: 8413309

A polymorphic form of steroidogenic factor-1 is associated with adrenocorticotropin resistance in y1 mouse adrenocortical tumor cell mutants. PubMed ID: 12239114

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The orphan receptors NGFI-B and steroidogenic factor 1 establish monomer binding as a third paradigm of nuclear receptor-DNA interaction. PubMed ID: 8395013

Cyclic AMP stimulates SF-1-dependent CYP11A1 expression through homeodomain-interacting protein kinase 3-mediated Jun N-terminal kinase and c-Jun phosphorylation. PubMed ID: 17210646

Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1. PubMed ID: 15707893

Crystallographic identification and functional characterization of phospholipids as ligands for the orphan nuclear receptor steroidogenic factor-1. PubMed ID: 15721253

Structure of SF-1 bound by different phospholipids: evidence for regulatory ligands. PubMed ID: 18988706