Cul3 | ENSMUSG00000004364 | NCBI 26554

Details for: Cul3

Gene ID: 26554

Symbol: Cul3

Ensembl ID: ENSMUSG00000004364

Description: cullin 3

Associated with

Adaptive immune system
(R-MMU-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-MMU-983168)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular response to chemical stress
(R-MMU-9711123)
Class i mhc mediated antigen processing & presentation
(R-MMU-983169)
Degradation of dvl
(R-MMU-4641258)
Hedgehog 'on' state
(R-MMU-5632684)
Immune system
(R-MMU-168256)
Keap1-nfe2l2 pathway
(R-MMU-9755511)
Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk family signaling cascades
(R-MMU-5683057)
Metabolism of proteins
(R-MMU-392499)
Neddylation
(R-MMU-8951664)
Post-translational protein modification
(R-MMU-597592)
Raf/map kinase cascade
(R-MMU-5673001)
Regulation of ras by gaps
(R-MMU-5658442)
Rhobtb1 gtpase cycle
(R-MMU-9013422)
Rhobtb2 gtpase cycle
(R-MMU-9013418)
Rhobtb3 atpase cycle
(R-MMU-9706019)
Rhobtb gtpase cycle
(R-MMU-9706574)
Rho gtpase cycle
(R-MMU-9012999)
Signaling by hedgehog
(R-MMU-5358351)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signaling by wnt
(R-MMU-195721)
Signal transduction
(R-MMU-162582)
Tcf dependent signaling in response to wnt
(R-MMU-201681)
Anaphase-promoting complex-dependent catabolic process
(GO:0031145)
Cell migration
(GO:0016477)
Cell morphogenesis
(GO:0000902)
Cell projection organization
(GO:0030030)
Cellular response to amino acid stimulus
(GO:0071230)
Centrosome
(GO:0005813)
Copii vesicle coating
(GO:0048208)
Cul3-ring ubiquitin ligase complex
(GO:0031463)
Cyclin binding
(GO:0030332)
Cytoplasm
(GO:0005737)
Embryonic cleavage
(GO:0040016)
Endoplasmic reticulum to golgi vesicle-mediated transport
(GO:0006888)
Fibroblast apoptotic process
(GO:0044346)
Gastrulation
(GO:0007369)
Gene expression
(GO:0010467)
Glutamatergic synapse
(GO:0098978)
Golgi apparatus
(GO:0005794)
Identical protein binding
(GO:0042802)
Inflammatory response
(GO:0006954)
Integrin-mediated signaling pathway
(GO:0007229)
In utero embryonic development
(GO:0001701)
Liver morphogenesis
(GO:0072576)
Mitotic cell cycle
(GO:0000278)
Mitotic metaphase chromosome alignment
(GO:0007080)
Mitotic spindle
(GO:0072686)
Negative regulation of rho protein signal transduction
(GO:0035024)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of type i interferon production
(GO:0032480)
Notch binding
(GO:0005112)
Nuclear protein quality control by the ubiquitin-proteasome system
(GO:0071630)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Polar microtubule
(GO:0005827)
Positive regulation of cytokinesis
(GO:0032467)
Positive regulation of mitotic cell cycle phase transition
(GO:1901992)
Positive regulation of mitotic metaphase/anaphase transition
(GO:0045842)
Positive regulation of protein ubiquitination
(GO:0031398)
Positive regulation of torc1 signaling
(GO:1904263)
Postsynapse
(GO:0098794)
Poz domain binding
(GO:0031208)
Proteasome-mediated ubiquitin-dependent protein catabolic process
(GO:0043161)
Protein autoubiquitination
(GO:0051865)
Protein binding
(GO:0005515)
Protein catabolic process
(GO:0030163)
Protein destabilization
(GO:0031648)
Protein k48-linked ubiquitination
(GO:0070936)
Protein monoubiquitination
(GO:0006513)
Protein polyubiquitination
(GO:0000209)
Protein ubiquitination
(GO:0016567)
Regulation of cellular response to insulin stimulus
(GO:1900076)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Regulation protein catabolic process at postsynapse
(GO:0140252)
Sperm flagellum
(GO:0036126)
Spindle pole
(GO:0000922)
Stem cell division
(GO:0017145)
Stress fiber assembly
(GO:0043149)
Trophectodermal cellular morphogenesis
(GO:0001831)
Ubiquitin-dependent protein catabolic process
(GO:0006511)
Ubiquitin-protein transferase activity
(GO:0004842)
Ubiquitin ligase complex scaffold activity
(GO:0160072)
Ubiquitin protein ligase activity
(GO:0061630)
Ubiquitin protein ligase binding
(GO:0031625)
Wnt signaling pathway
(GO:0016055)

Other Information

Proteins

Cullin-3
Q9CTE0_MOUSE

Genular Protein ID: 1610727110

Symbol: CUL3_MOUSE

Name: Cullin-3

UniProtKB Accession Codes:

Q9JLV5

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10500095

Title: Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells.

PubMed ID: 10500095

DOI: 10.1101/gad.13.18.2375

PubMed ID: 12193649

Title: Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants.

PubMed ID: 12193649

DOI: 10.1073/pnas.172398899

PubMed ID: 14764894

Title: Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers.

PubMed ID: 14764894

DOI: 10.1073/pnas.0307301101

PubMed ID: 15282312

Title: Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2.

PubMed ID: 15282312

DOI: 10.1128/mcb.24.16.7130-7139.2004

PubMed ID: 16162871

Title: Cullin3 is a KLHL10-interacting protein preferentially expressed during late spermiogenesis.

PubMed ID: 16162871

DOI: 10.1095/biolreprod.105.045484

PubMed ID: 16790436

Title: Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a 'tethering' mechanism: a two-site interaction model for the Nrf2-Keap1 complex.

PubMed ID: 16790436

DOI: 10.1074/jbc.m601119200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22358839

Title: Ubiquitin-dependent regulation of COPII coat size and function.

PubMed ID: 22358839

DOI: 10.1038/nature10822

PubMed ID: 27697860

Title: Absolute Amounts and Status of the Nrf2-Keap1-Cul3 Complex within Cells.

PubMed ID: 27697860

DOI: 10.1128/mcb.00389-16

PubMed ID: 27708159

Title: Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice.

PubMed ID: 27708159

DOI: 10.1073/pnas.1614467113

PubMed ID: 34491895

Title: ACLY ubiquitination by CUL3-KLHL25 induces the reprogramming of fatty acid metabolism to facilitate iTreg differentiation.

PubMed ID: 34491895

DOI: 10.7554/elife.62394

Sequence Information:

Length: 768
Mass: 88948
Checksum: 841E20407BD076A3
Sequence:

MSNLSKGTGS RKDTKMRIRA FPMTMDEKYV NSIWDLLKNA IQEIQRKNNS GLSFEELYRN 
AYTMVLHKHG EKLYTGLREV VTEHLINKVR EDVLNSLNNN FLQTLNQAWN DHQTAMVMIR 
DILMYMDRVY VQQNNVENVY NLGLIIFRDQ VVRYGCIRDH LRQTLLDMIA RERKGEVVDR 
GAIRNACQML MILGLEGRSV YEEDFEAPFL EMSAEFFQME SQKFLAENSA SVYIKKVEAR 
INEEIERVMH CLDKSTEEPI VKVVERELIS KHMKTIVEME NSGLVHMLKN GKTEDLACMY 
KLFSRVPNGL KTMCECMSCY LREQGKALVS EEGEGKNPVD YIQGLLDLKS RFDRFLQESF 
NNDRLFKQTI AGDFEYFLNL NSRSPEYLSL FIDDKLKKGV KGLTEQEVET ILDKAMVLFR 
FMQEKDVFER YYKQHLARRL LTNKSVSDDS EKNMISKLKT ECGCQFTSKL EGMFRDMSIS 
NTTMDEFRQH LQATGVSLGG VDLTVRVLTT GYWPTQSATP KCNIPPAPRH AFEIFRRFYL 
AKHSGRQLTL QHHMGSADLN ATFYGPVKKE DGSEVGVGGA QVTGSNTRKH ILQVSTFQMT 
ILMLFNNREK YTFEEIQQET DIPERELVRA LQSLACGKPT QRVLTKEPKS KEIESGHIFT 
VNDQFTSKLH RVKIQTVAAK QGESDPERKE TRQKVDDDRK HEIEAAIVRI MKSRKKMQHN 
VLVAEVTQQL KARFLPSPVV IKKRIEGLIE REYLARTPED RKVYTYVA

Genular Protein ID: 2835699658

Symbol: Q9CTE0_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q9CTE0

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 91
Mass: 10658
Checksum: EB70C7FDD1F9166B
Sequence:

AAKQGESDPE RKETRQKVDD DRKHEIEAAI VRIMKSRKKM QHNVLVAEVT QQLKARFLPS 
PVVIKKRIEG LIEREYLART PEDRKVYTYV A

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cul3

Associated with

Other Information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells. PubMed ID: 10500095

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants. PubMed ID: 12193649

Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers. PubMed ID: 14764894

Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2. PubMed ID: 15282312

Cullin3 is a KLHL10-interacting protein preferentially expressed during late spermiogenesis. PubMed ID: 16162871

Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a 'tethering' mechanism: a two-site interaction model for the Nrf2-Keap1 complex. PubMed ID: 16790436

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Ubiquitin-dependent regulation of COPII coat size and function. PubMed ID: 22358839

Absolute Amounts and Status of the Nrf2-Keap1-Cul3 Complex within Cells. PubMed ID: 27697860

Insulin resistance and diabetes caused by genetic or diet-induced KBTBD2 deficiency in mice. PubMed ID: 27708159

ACLY ubiquitination by CUL3-KLHL25 induces the reprogramming of fatty acid metabolism to facilitate iTreg differentiation. PubMed ID: 34491895

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073