Slc7a11 | ENSMUSG00000027737 | NCBI 26570

Details for: Slc7a11

Gene ID: 26570

Symbol: Slc7a11

Ensembl ID: ENSMUSG00000027737

Description: solute carrier family 7 (cationic amino acid transporter, y+ system), member 11

Associated with

Amino acid transport across the plasma membrane
(R-MMU-352230)
Basigin interactions
(R-MMU-210991)
Cell surface interactions at the vascular wall
(R-MMU-202733)
Hemostasis
(R-MMU-109582)
Slc-mediated transmembrane transport
(R-MMU-425407)
Transport of inorganic cations/anions and amino acids/oligopeptides
(R-MMU-425393)
Transport of small molecules
(R-MMU-382551)
Adult behavior
(GO:0030534)
Amino acid transmembrane transport
(GO:0003333)
Apical part of cell
(GO:0045177)
Astrocyte projection
(GO:0097449)
Brain development
(GO:0007420)
Brush border membrane
(GO:0031526)
Cell surface
(GO:0009986)
Cellular response to oxidative stress
(GO:0034599)
Cellular response to stress
(GO:0033554)
Cystine:glutamate antiporter activity
(GO:0015327)
Dipeptide import across plasma membrane
(GO:0140206)
Glutathione metabolic process
(GO:0006749)
Glutathione transmembrane transport
(GO:0034775)
Intracellular glutamate homeostasis
(GO:0090461)
L-amino acid transmembrane transporter activity
(GO:0015179)
L-cystine transport
(GO:0015811)
L-glutamate import across plasma membrane
(GO:0098712)
L-glutamate transmembrane transport
(GO:0015813)
L-kynurenine transmembrane transport
(GO:0140924)
L-kynurenine transmembrane transporter activity
(GO:0140926)
Lens fiber cell differentiation
(GO:0070306)
Limb development
(GO:0060173)
Lung alveolus development
(GO:0048286)
Membrane
(GO:0016020)
Microvillus membrane
(GO:0031528)
Modulation of chemical synaptic transmission
(GO:0050804)
Negative regulation of ferroptosis
(GO:0110076)
Plasma membrane
(GO:0005886)
Platelet aggregation
(GO:0070527)
Regulation of ampa glutamate receptor clustering
(GO:1904717)
Regulation of cell population proliferation
(GO:0042127)
Regulation of cellular response to oxidative stress
(GO:1900407)
Regulation of cysteine metabolic process
(GO:1901494)
Regulation of glutamate metabolic process
(GO:2000211)
Regulation of glutathione biosynthetic process
(GO:1903786)
Regulation of melanin biosynthetic process
(GO:0048021)
Regulation of neutrophil apoptotic process
(GO:0033029)
Regulation of protein transport
(GO:0051223)
Regulation of synapse organization
(GO:0050807)
Response to nicotine
(GO:0035094)
Response to organic cyclic compound
(GO:0014070)
Response to redox state
(GO:0051775)
Response to toxic substance
(GO:0009636)
Striatum development
(GO:0021756)
Ventricular system development
(GO:0021591)
Visual learning
(GO:0008542)

Other Information

Proteins

Amino acid transport system xc-

Genular Protein ID: 1930051327

Symbol: XCT_MOUSE

Name: Amino acid transport system xc-

UniProtKB Accession Codes:

Q9WTR6

Database IDs:

Citations:

PubMed ID: 10206947

Title: Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins.

PubMed ID: 10206947

DOI: 10.1074/jbc.274.17.11455

PubMed ID: 11136724

Title: Effect of oxygen on induction of the cystine transporter by bacterial lipopolysaccharide in mouse peritoneal macrophages.

PubMed ID: 11136724

DOI: 10.1074/jbc.m007216200

PubMed ID: 12235164

Title: Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expression.

PubMed ID: 12235164

DOI: 10.1074/jbc.m208704200

PubMed ID: 16144837

Title: Redox imbalance in cystine/glutamate transporter-deficient mice.

PubMed ID: 16144837

DOI: 10.1074/jbc.m506439200

PubMed ID: 16037214

Title: Slc7a11 gene controls production of pheomelanin pigment and proliferation of cultured cells.

PubMed ID: 16037214

DOI: 10.1073/pnas.0502856102

PubMed ID: 17035536

Title: Cystine/glutamate exchange modulates glutathione supply for neuroprotection from oxidative stress and cell proliferation.

PubMed ID: 17035536

DOI: 10.1523/jneurosci.3178-06.2006

PubMed ID: 17200146

Title: Expression and function of cystine/glutamate transporter in neutrophils.

PubMed ID: 17200146

DOI: 10.1189/jlb.0606385

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 31396687

Title: Mapping of the cystine-glutamate exchanger in the mouse eye: a role for xCT in controlling extracellular redox balance.

PubMed ID: 31396687

DOI: 10.1007/s00418-019-01805-4

PubMed ID: 33869196

Title: TRIM26 Induces Ferroptosis to Inhibit Hepatic Stellate Cell Activation and Mitigate Liver Fibrosis Through Mediating SLC7A11 Ubiquitination.

PubMed ID: 33869196

DOI: 10.3389/fcell.2021.644901

Sequence Information:

Length: 502
Mass: 55456
Checksum: A4A185102D83992A
Sequence:

MVRKPVVATI SKGGYLQGNM SGRLPSMGDQ EPPGQEKVVL KKKITLLRGV SIIIGTVIGS 
GIFISPKGIL QNTGSVGMSL VFWSACGVLS LFGALSYAEL GTSIKKSGGH YTYILEVFGP 
LLAFVRVWVE LLVIRPGATA VISLAFGRYI LEPFFIQCEI PELAIKLVTA VGITVVMVLN 
STSVSWSARI QIFLTFCKLT AILIIIVPGV IQLIKGQTHH FKDAFSGRDT SLMGLPLAFY 
YGMYAYAGWF YLNFITEEVD NPEKTIPLAI CISMAIITVG YVLTNVAYFT TISAEELLQS 
SAVAVTFSER LLGKFSLAVP IFVALSCFGS MNGGVFAVSR LFYVASREGH LPEILSMIHV 
HKHTPLPAVI VLHPLTMVML FSGDLYSLLN FLSFARWLFM GLAVAGLIYL RYKRPDMHRP 
FKVPLFIPAL FSFTCLFMVV LSLYSDPFST GVGFLITLTG VPAYYLFIVW DKKPKWFRRL 
SDRITRTLQI ILEVVPEDSK EL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Slc7a11

Associated with

Other Information

Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins. PubMed ID: 10206947

Effect of oxygen on induction of the cystine transporter by bacterial lipopolysaccharide in mouse peritoneal macrophages. PubMed ID: 11136724

Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expression. PubMed ID: 12235164

Redox imbalance in cystine/glutamate transporter-deficient mice. PubMed ID: 16144837

Slc7a11 gene controls production of pheomelanin pigment and proliferation of cultured cells. PubMed ID: 16037214

Cystine/glutamate exchange modulates glutathione supply for neuroprotection from oxidative stress and cell proliferation. PubMed ID: 17035536

Expression and function of cystine/glutamate transporter in neutrophils. PubMed ID: 17200146

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

Mapping of the cystine-glutamate exchanger in the mouse eye: a role for xCT in controlling extracellular redox balance. PubMed ID: 31396687

TRIM26 Induces Ferroptosis to Inhibit Hepatic Stellate Cell Activation and Mitigate Liver Fibrosis Through Mediating SLC7A11 Ubiquitination. PubMed ID: 33869196