Details for: AMELY

Gene ID: 266

Symbol: AMELY

Ensembl ID: ENSG00000099721

Description: amelogenin Y-linked

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.6902
    Cell Significance Index: 10.0600
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.6302
    Cell Significance Index: 8.2700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 0.4537
    Cell Significance Index: 10.9900
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.3512
    Cell Significance Index: 4.5900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.2398
    Cell Significance Index: 5.9900
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.0919
    Cell Significance Index: 1.1800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0258
    Cell Significance Index: 0.6900
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.0217
    Cell Significance Index: 0.1300
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0170
    Cell Significance Index: 0.2100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.0112
    Cell Significance Index: 0.2800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0095
    Cell Significance Index: 0.1300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0092
    Cell Significance Index: 0.2900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0075
    Cell Significance Index: 1.3600
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.0036
    Cell Significance Index: 0.0500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0028
    Cell Significance Index: 0.4000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0021
    Cell Significance Index: 0.4300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0018
    Cell Significance Index: 2.7500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0011
    Cell Significance Index: 1.9900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0007
    Cell Significance Index: 1.3400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0005
    Cell Significance Index: 0.0600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0003
    Cell Significance Index: 0.4500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0002
    Cell Significance Index: 0.1300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.0001
    Cell Significance Index: 0.0000
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0003
    Cell Significance Index: -0.1100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0005
    Cell Significance Index: -0.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0006
    Cell Significance Index: -0.4700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0007
    Cell Significance Index: -0.0100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0009
    Cell Significance Index: -0.4200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0009
    Cell Significance Index: -0.4900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0009
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0013
    Cell Significance Index: -0.2300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0015
    Cell Significance Index: -0.0400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0019
    Cell Significance Index: -0.4100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0034
    Cell Significance Index: -0.2300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0038
    Cell Significance Index: -0.4400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0038
    Cell Significance Index: -0.7600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0040
    Cell Significance Index: -0.4200
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: -0.0043
    Cell Significance Index: -0.0500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0059
    Cell Significance Index: -0.3600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0070
    Cell Significance Index: -0.3900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0072
    Cell Significance Index: -0.3200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0082
    Cell Significance Index: -0.2600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0086
    Cell Significance Index: -0.2800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0088
    Cell Significance Index: -0.3100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0091
    Cell Significance Index: -0.7000
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0092
    Cell Significance Index: -0.1300
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.0111
    Cell Significance Index: -0.1400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0119
    Cell Significance Index: -0.4500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0130
    Cell Significance Index: -0.2800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0137
    Cell Significance Index: -0.2900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0137
    Cell Significance Index: -0.3900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0140
    Cell Significance Index: -0.3500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0141
    Cell Significance Index: -0.1300
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0152
    Cell Significance Index: -0.3000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0168
    Cell Significance Index: -0.3500
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0170
    Cell Significance Index: -0.1500
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: -0.0172
    Cell Significance Index: -0.2000
  • Cell Name: basal-myoepithelial cell of mammary gland (CL0002324)
    Fold Change: -0.0172
    Cell Significance Index: -0.1300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0174
    Cell Significance Index: -0.3500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0176
    Cell Significance Index: -0.6100
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.0179
    Cell Significance Index: -0.2000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0182
    Cell Significance Index: -0.4900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0198
    Cell Significance Index: -0.3900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.0201
    Cell Significance Index: -0.4000
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.0202
    Cell Significance Index: -0.3500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0221
    Cell Significance Index: -0.6500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0238
    Cell Significance Index: -0.5700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0245
    Cell Significance Index: -0.8600
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.0246
    Cell Significance Index: -0.5000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0247
    Cell Significance Index: -0.5400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0255
    Cell Significance Index: -0.6600
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.0261
    Cell Significance Index: -0.5100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0272
    Cell Significance Index: -0.7900
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.0286
    Cell Significance Index: -0.4000
  • Cell Name: CD4-positive, alpha-beta T cell (CL0000624)
    Fold Change: -0.0289
    Cell Significance Index: -0.2700
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.0297
    Cell Significance Index: -0.4900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0300
    Cell Significance Index: -0.7500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0309
    Cell Significance Index: -0.3200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0315
    Cell Significance Index: -0.6200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0316
    Cell Significance Index: -0.4500
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.0323
    Cell Significance Index: -0.4300
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.0324
    Cell Significance Index: -0.4300
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.0328
    Cell Significance Index: -0.4900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.0328
    Cell Significance Index: -0.8000
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0330
    Cell Significance Index: -0.5600
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0337
    Cell Significance Index: -0.4100
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.0339
    Cell Significance Index: -0.4400
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0340
    Cell Significance Index: -0.3700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0345
    Cell Significance Index: -0.7200
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.0351
    Cell Significance Index: -0.4100
  • Cell Name: mast cell (CL0000097)
    Fold Change: -0.0365
    Cell Significance Index: -0.4800
  • Cell Name: acinar cell (CL0000622)
    Fold Change: -0.0366
    Cell Significance Index: -0.4600
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0371
    Cell Significance Index: -0.7700
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.0376
    Cell Significance Index: -0.5000
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: -0.0378
    Cell Significance Index: -0.4500
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0378
    Cell Significance Index: -0.5700
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0379
    Cell Significance Index: -0.4300
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: -0.0381
    Cell Significance Index: -0.4300
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: -0.0388
    Cell Significance Index: -0.4300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The AMELY gene is characterized by its Y-linked location, which suggests a specific role in male development and function. The gene is also highly expressed in various cell types, indicating a wide range of biological functions. The AMELY protein is a structural constituent of tooth enamel, and its expression is significantly reduced in individuals with dental anomalies or enamel defects. The gene's involvement in collagen-containing extracellular matrices and enamel mineralization highlights its importance in tissue development and maintenance. **Pathways and Functions** The AMELY gene is involved in several key pathways, including: 1. **Collagen-containing extracellular matrix**: The AMELY protein is a structural component of collagen-containing extracellular matrices, which provide structural support and maintain tissue integrity. 2. **Enamel mineralization**: The AMELY gene is essential for the formation of tooth enamel, a hard, calcified structure that covers the teeth. 3. **Extracellular region**: The AMELY gene is involved in the development and maintenance of the extracellular region, which includes the extracellular matrix, basement membrane, and cell surface. 4. **Structural constituent of tooth enamel**: The AMELY protein is a key component of tooth enamel, providing structural support and maintaining its integrity. **Clinical Significance** The AMELY gene has significant clinical implications, particularly in the context of dental anomalies and enamel defects. Mutations in the AMELY gene have been associated with several dental conditions, including: 1. **Amelogenesis imperfecta**: A genetic disorder characterized by defective enamel formation, leading to tooth discoloration, sensitivity, and increased risk of tooth decay. 2. **Tooth enamel defects**: Mutations in the AMELY gene can result in defects in tooth enamel, leading to increased risk of tooth decay and sensitivity. 3. **Dental anomalies**: The AMELY gene is also involved in the development of dental anomalies, such as tooth shape and size abnormalities. In conclusion, the AMELY gene plays a critical role in the development and maintenance of tooth enamel, and its dysregulation can lead to dental anomalies and enamel defects. Further research is needed to fully understand the mechanisms underlying AMELY gene function and its clinical significance.

Genular Protein ID: 1082520267

Symbol: AMELY_HUMAN

Name: Amelogenin, Y isoform

UniProtKB Accession Codes:

Q99218 Q6RWT1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 GO 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PathwayCommons 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 2 SMART 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 neXtProt 1

Citations:

PubMed ID: 1734713

Title: The human enamel protein gene amelogenin is expressed from both the X and the Y chromosomes.

PubMed ID: 1734713

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2004775

Title: A human X-Y homologous region encodes 'amelogenin'.

PubMed ID: 2004775

DOI: 10.1016/0888-7543(91)90251-9

Sequence Information:

  • Length: 206
  • Mass: 23250
  • Checksum: 9324AB50546DB4D5
  • Sequence:
    • MGTWILFACL VGAAFAMPLP PHPGHPGYIN FSYENSHSQA INVDRIALVL TPLKWYQSMI 
RPPYSSYGYE PMGGWLHHQI IPVVSQQHPL THTLQSHHHI PVVPAQQPRV RQQALMPVPG 
QQSMTPTQHH QPNLPLPAQQ PFQPQPVQPQ PHQPMQPQPP VQPMQPLLPQ PPLPPMFPLR 
PLPPILPDLH LEAWPATDKT KQEEVD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.