Details for: AMELY

Gene ID: 266

Symbol: AMELY

Ensembl ID: ENSG00000099721

Description: amelogenin Y-linked

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: progenitor cell (CL0011026)
    Fold Change: 8.24
    Marker Score: 53068
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 3.16
    Marker Score: 3184
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 2
    Marker Score: 2229
  • Cell Name: T cell (CL0000084)
    Fold Change: 1.26
    Marker Score: 2172
  • Cell Name: B cell (CL0000236)
    Fold Change: 1.19
    Marker Score: 1129
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.16
    Marker Score: 7693
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71834
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48059
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5351
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2743
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.91
    Marker Score: 1475
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5295
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.86
    Marker Score: 501
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 714
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.78
    Marker Score: 405
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.75
    Marker Score: 1202.5
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.72
    Marker Score: 692
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.68
    Marker Score: 546
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.48
    Marker Score: 285
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.46
    Marker Score: 834
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.43
    Marker Score: 387
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.09
    Marker Score: 31
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.09
    Marker Score: 29
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.07
    Marker Score: 79
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 0.07
    Marker Score: 81
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.05
    Marker Score: 17
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.05
    Marker Score: 14
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.05
    Marker Score: 15
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.04
    Marker Score: 18
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 0.04
    Marker Score: 16
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.04
    Marker Score: 33
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.04
    Marker Score: 13
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.03
    Marker Score: 17
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.03
    Marker Score: 39
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.03
    Marker Score: 10
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.03
    Marker Score: 64
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.03
    Marker Score: 120
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.03
    Marker Score: 16
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.02
    Marker Score: 32
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.02
    Marker Score: 13
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.02
    Marker Score: 90
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.02
    Marker Score: 16.5
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.02
    Marker Score: 10
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.02
    Marker Score: 16
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.02
    Marker Score: 11
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.02
    Marker Score: 17
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.02
    Marker Score: 18
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.01
    Marker Score: 60
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.01
    Marker Score: 14
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.01
    Marker Score: 28
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.01
    Marker Score: 24
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.01
    Marker Score: 24
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.01
    Marker Score: 15
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.01
    Marker Score: 19
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.01
    Marker Score: 12.5
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.01
    Marker Score: 11
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.01
    Marker Score: 10
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.01
    Marker Score: 13
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.01
    Marker Score: 16
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.01
    Marker Score: 17
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0
    Marker Score: 17
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0
    Marker Score: 13
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0
    Marker Score: 37
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0
    Marker Score: 10
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0
    Marker Score: 41
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0
    Marker Score: 59
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0
    Marker Score: 37
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0
    Marker Score: 15
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0
    Marker Score: 231
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0
    Marker Score: 13
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0
    Marker Score: 9
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0
    Marker Score: 13
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0
    Marker Score: 15
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0
    Marker Score: 11
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0
    Marker Score: 94
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0
    Marker Score: 13
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0
    Marker Score: 81
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0
    Marker Score: 15
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0
    Marker Score: 43
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 0
    Marker Score: 17
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0
    Marker Score: 12
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0
    Marker Score: 38
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0
    Marker Score: 16
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0
    Marker Score: 12
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0
    Marker Score: 24

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Other Information

**Key characteristics:** * AMELY is a protein of approximately 150 amino acids. * It is encoded by a single gene on the Y chromosome. * It is expressed in a variety of cell types, including progenitor cells, blood vessel endothelial cells, plasma cells, T cells, B cells, goblet cells, cerebral cortex GABAergic interneurons, forebrain radial glial cells, absorptive cells, and intestinal crypt stem cells of the colon. **Pathways and functions:** * AMELY is involved in the formation of the extracellular matrix, which is a complex network of proteins and polysaccharides that provides structural support and elasticity to tissues. * The extracellular matrix is composed of collagen, proteoglycans, and glycoproteins. * AMELY is a key player in the assembly and maintenance of the extracellular matrix. * It is involved in the regulation of cell migration, differentiation, and signaling. **Clinical significance:** Mutations in the AMELY gene have been linked to a number of human diseases, including osteoporosis, enamel defects, and developmental disorders of the central nervous system. These diseases are caused by mutations in genes that are involved in the formation and maintenance of the extracellular matrix. **Additional notes:** * AMELY is a highly conserved protein, with a similar protein found in other species. * It is a key regulator of tooth development and mineralization. * Mutations in the AMELY gene can lead to the formation of abnormal teeth and bones.

Genular Protein ID: 1082520267

Symbol: AMELY_HUMAN

Name: Amelogenin, Y isoform

UniProtKB Accession Codes:

Q99218 Q6RWT1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 Ensembl 2 GO 4 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PathwayCommons 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 2 SAM 1 SMART 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 neXtProt 1

Citations:

PubMed ID: 1734713

Title: The human enamel protein gene amelogenin is expressed from both the X and the Y chromosomes.

PubMed ID: 1734713

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2004775

Title: A human X-Y homologous region encodes 'amelogenin'.

PubMed ID: 2004775

DOI: 10.1016/0888-7543(91)90251-9

Sequence Information:

  • Length: 206
  • Mass: 23250
  • Checksum: 9324AB50546DB4D5
  • Sequence:
    • MGTWILFACL VGAAFAMPLP PHPGHPGYIN FSYENSHSQA INVDRIALVL TPLKWYQSMI 
RPPYSSYGYE PMGGWLHHQI IPVVSQQHPL THTLQSHHHI PVVPAQQPRV RQQALMPVPG 
QQSMTPTQHH QPNLPLPAQQ PFQPQPVQPQ PHQPMQPQPP VQPMQPLLPQ PPLPPMFPLR 
PLPPILPDLH LEAWPATDKT KQEEVD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.