Details for: AMFR

Gene ID: 267

Symbol: AMFR

Ensembl ID: ENSG00000159461

Description: autocrine motility factor receptor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 225.9793
    Cell Significance Index: -35.1500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 142.7989
    Cell Significance Index: -36.2200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 79.1125
    Cell Significance Index: -32.1400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 69.8018
    Cell Significance Index: -35.9100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 33.9254
    Cell Significance Index: -32.3900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 29.9200
    Cell Significance Index: -36.8900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.5505
    Cell Significance Index: -36.3000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 9.4943
    Cell Significance Index: -37.4700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 8.0971
    Cell Significance Index: -24.8700
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.5300
    Cell Significance Index: -16.4800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.8550
    Cell Significance Index: 76.5000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.3857
    Cell Significance Index: 164.9800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.5480
    Cell Significance Index: 21.1200
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.5302
    Cell Significance Index: 24.5500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.3777
    Cell Significance Index: 160.5500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.1683
    Cell Significance Index: 30.0300
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.0709
    Cell Significance Index: 64.2900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0406
    Cell Significance Index: 113.1900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.9804
    Cell Significance Index: 18.1200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9703
    Cell Significance Index: 194.6500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9526
    Cell Significance Index: 154.9400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.8205
    Cell Significance Index: 162.8300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.8074
    Cell Significance Index: 21.5600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.5642
    Cell Significance Index: 29.3900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5561
    Cell Significance Index: 199.4700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5185
    Cell Significance Index: 468.1600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5172
    Cell Significance Index: 357.6900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.4957
    Cell Significance Index: 10.7400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4850
    Cell Significance Index: 57.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4847
    Cell Significance Index: 66.5600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4041
    Cell Significance Index: 30.1200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3955
    Cell Significance Index: 39.1300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.3866
    Cell Significance Index: 69.7000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.3683
    Cell Significance Index: 162.8200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3395
    Cell Significance Index: 9.2400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3379
    Cell Significance Index: 9.7400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3338
    Cell Significance Index: 41.0400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.2700
    Cell Significance Index: 6.7500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2510
    Cell Significance Index: 42.8600
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.2275
    Cell Significance Index: 1.4000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2207
    Cell Significance Index: 10.2900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2149
    Cell Significance Index: 117.3400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.1735
    Cell Significance Index: 19.8800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.1670
    Cell Significance Index: 9.3700
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.1619
    Cell Significance Index: 3.9500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1521
    Cell Significance Index: 4.3600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1516
    Cell Significance Index: 19.4400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1396
    Cell Significance Index: 3.9000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.1379
    Cell Significance Index: 10.5800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0895
    Cell Significance Index: 17.0300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0880
    Cell Significance Index: 55.8800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0785
    Cell Significance Index: 4.9500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0743
    Cell Significance Index: 3.3700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0735
    Cell Significance Index: 138.3600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0455
    Cell Significance Index: 20.6400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0333
    Cell Significance Index: 1.7300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0250
    Cell Significance Index: 1.1100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0224
    Cell Significance Index: 34.5300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0089
    Cell Significance Index: 16.4100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0074
    Cell Significance Index: 10.0100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0051
    Cell Significance Index: 3.7300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0070
    Cell Significance Index: -5.1700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0142
    Cell Significance Index: -1.8400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0158
    Cell Significance Index: -9.8700
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0158
    Cell Significance Index: -1.1200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0327
    Cell Significance Index: -1.1500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0396
    Cell Significance Index: -22.3300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0404
    Cell Significance Index: -30.5600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0809
    Cell Significance Index: -3.8000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0918
    Cell Significance Index: -9.3800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0931
    Cell Significance Index: -19.6100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1075
    Cell Significance Index: -30.9400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1119
    Cell Significance Index: -6.8800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1199
    Cell Significance Index: -7.7400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1302
    Cell Significance Index: -18.9200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1545
    Cell Significance Index: -5.8500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1643
    Cell Significance Index: -18.7600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1788
    Cell Significance Index: -12.0200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2283
    Cell Significance Index: -3.8200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.2730
    Cell Significance Index: -5.8400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2823
    Cell Significance Index: -29.3900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2833
    Cell Significance Index: -7.4500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3288
    Cell Significance Index: -10.5300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3827
    Cell Significance Index: -8.1500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3859
    Cell Significance Index: -6.5000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3910
    Cell Significance Index: -6.7000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4083
    Cell Significance Index: -32.3400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4343
    Cell Significance Index: -22.8000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4432
    Cell Significance Index: -8.6500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4455
    Cell Significance Index: -15.4800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.4572
    Cell Significance Index: -5.4500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5218
    Cell Significance Index: -31.9900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.5891
    Cell Significance Index: -12.9000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.6034
    Cell Significance Index: -8.5900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.6598
    Cell Significance Index: -18.8300
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.6931
    Cell Significance Index: -10.2300
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.8047
    Cell Significance Index: -25.6300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.8047
    Cell Significance Index: -21.5300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.8076
    Cell Significance Index: -17.1400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.8234
    Cell Significance Index: -26.9600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Ubiquitin ligase activity:** AMFR possesses E3 ubiquitin-protein ligase activity, which enables it to recognize and target specific proteins for ubiquitination and degradation. 2. **Cellular localization:** AMFR is primarily localized to the endoplasmic reticulum (ER) and Golgi apparatus, where it regulates protein quality control and trafficking. 3. **Signaling pathway modulation:** AMFR interacts with various signaling molecules, including Wnt, NF-κB, and SREBP, to modulate their activity and downstream effects. 4. **Tissue-specific expression:** AMFR is expressed in a range of cell types, including immune cells, epithelial cells, and neurons, indicating its involvement in multiple physiological and pathological processes. **Pathways and Functions:** 1. **Protein degradation:** AMFR regulates the ubiquitination and degradation of target proteins, which is essential for maintaining protein homeostasis and preventing protein misfolding. 2. **Cell signaling:** AMFR interacts with signaling molecules to modulate their activity and downstream effects, including Wnt, NF-κB, and SREBP pathways. 3. **Immune response:** AMFR is expressed in immune cells, where it regulates the ubiquitination and degradation of proteins involved in immune responses, such as cytokine signaling. 4. **Neurological function:** AMFR is expressed in neurons, where it regulates protein quality control and trafficking, which is essential for neuronal function and survival. **Clinical Significance:** Dysregulation of AMFR has been implicated in various diseases, including: 1. **Cancer:** AMFR overexpression has been observed in several types of cancer, including breast, lung, and colon cancer, suggesting its role in tumorigenesis. 2. **Autoimmune diseases:** AMFR dysregulation has been linked to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where it contributes to protein misfolding and immune response dysregulation. 3. **Neurodegenerative diseases:** AMFR has been implicated in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, where it regulates protein quality control and trafficking. In conclusion, AMFR is a critical regulator of protein degradation, cell signaling, and immune response, and its dysregulation has been implicated in various diseases. Further research is needed to fully elucidate the mechanisms by which AMFR regulates cellular processes and to explore its therapeutic potential in disease treatment.

Genular Protein ID: 2440094864

Symbol: AMFR_HUMAN

Name: E3 ubiquitin-protein ligase AMFR

UniProtKB Accession Codes:

Q9UKV5 P26442 Q8IZ70

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 EMBL 4 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 38 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 13 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10456327

Title: The autocrine motility factor receptor gene encodes a novel type of seven transmembrane protein.

PubMed ID: 10456327

DOI: 10.1016/s0014-5793(99)00966-7

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7626106

Title: Identification of an upstream region that controls the transcription of the human autocrine motility factor receptor.

PubMed ID: 7626106

DOI: 10.1006/bbrc.1995.2031

PubMed ID: 1649192

Title: Purification of human tumor cell autocrine motility factor and molecular cloning of its receptor.

PubMed ID: 1649192

DOI: 10.1016/s0021-9258(18)98859-9

PubMed ID: 11724934

Title: The tumor autocrine motility factor receptor, gp78, is a ubiquitin protein ligase implicated in degradation from the endoplasmic reticulum.

PubMed ID: 11724934

DOI: 10.1073/pnas.251401598

PubMed ID: 12670940

Title: Overexpression of the tumor autocrine motility factor receptor, gp78, a ubiquitin protein ligase (E3), results in increased ubiquitinylation and decreased secretion of apolipoprotein B100 in Hep G2 cells.

PubMed ID: 12670940

DOI: 10.1074/jbc.m302683200

PubMed ID: 16168377

Title: Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase.

PubMed ID: 16168377

DOI: 10.1016/j.molcel.2005.08.009

PubMed ID: 16186510

Title: Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane.

PubMed ID: 16186510

DOI: 10.1073/pnas.0505006102

PubMed ID: 17043353

Title: Sterol-regulated degradation of Insig-1 mediated by the membrane-bound ubiquitin ligase gp78.

PubMed ID: 17043353

DOI: 10.1074/jbc.m608999200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19103148

Title: CYP3A4 ubiquitination by gp78 (the tumor autocrine motility factor receptor, AMFR) and CHIP E3 ligases.

PubMed ID: 19103148

DOI: 10.1016/j.abb.2008.12.001

PubMed ID: 21636303

Title: A ubiquitin ligase-associated chaperone holdase maintains polypeptides in soluble states for proteasome degradation.

PubMed ID: 21636303

DOI: 10.1016/j.molcel.2011.05.010

PubMed ID: 22143767

Title: Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8.

PubMed ID: 22143767

DOI: 10.1073/pnas.1112831108

PubMed ID: 22728137

Title: RING finger palmitoylation of the endoplasmic reticulum Gp78 E3 ubiquitin ligase.

PubMed ID: 22728137

DOI: 10.1016/j.febslet.2012.06.011

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23223569

Title: Ancient ubiquitous protein-1 mediates sterol-induced ubiquitination of 3-hydroxy-3-methylglutaryl CoA reductase in lipid droplet-associated endoplasmic reticulum membranes.

PubMed ID: 23223569

DOI: 10.1091/mbc.e12-07-0564

PubMed ID: 24424410

Title: USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation.

PubMed ID: 24424410

DOI: 10.7554/elife.01369

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 29275994

Title: A Proximity Labeling Strategy Provides Insights into the Composition and Dynamics of Lipid Droplet Proteomes.

PubMed ID: 29275994

DOI: 10.1016/j.devcel.2017.11.020

PubMed ID: 28604676

Title: Cholesterol and fatty acids regulate cysteine ubiquitylation of ACAT2 through competitive oxidation.

PubMed ID: 28604676

DOI: 10.1038/ncb3551

PubMed ID: 29184177

Title: Corrigendum: Cholesterol and fatty acids regulate cysteine ubiquitylation of ACAT2 through competitive oxidation.

PubMed ID: 29184177

DOI: 10.1038/ncb3651

PubMed ID: 31073040

Title: LMBR1L regulates lymphopoiesis through Wnt/beta-catenin signaling.

PubMed ID: 31073040

DOI: 10.1126/science.aau0812

PubMed ID: 31953408

Title: Competitive oxidation and ubiquitylation on the evolutionarily conserved cysteine confer tissue-specific stabilization of Insig-2.

PubMed ID: 31953408

DOI: 10.1038/s41467-019-14231-w

PubMed ID: 37119330

Title: AMFR dysfunction causes autosomal recessive spastic paraplegia in human that is amenable to statin treatment in a preclinical model.

PubMed ID: 37119330

DOI: 10.1007/s00401-023-02579-9

PubMed ID: 36593296

Title: Staphylococcal virulence factor HlgB targets the endoplasmic-reticulum-resident E3 ubiquitin ligase AMFR to promote pneumonia.

PubMed ID: 36593296

DOI: 10.1038/s41564-022-01278-7

PubMed ID: 21914798

Title: The structural and functional basis of the p97/valosin-containing protein (VCP)-interacting motif (VIM): mutually exclusive binding of cofactors to the N-terminal domain of p97.

PubMed ID: 21914798

DOI: 10.1074/jbc.m111.274506

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 643
  • Mass: 72996
  • Checksum: 8782324609C0E62A
  • Sequence:
    • MPLLFLERFP WPSLRTYTGL SGLALLGTII SAYRALSQPE AGPGEPDQLT ASLQPEPPAP 
ARPSAGGPRA RDVAQYLLSD SLFVWVLVNT ACCVLMLVAK LIQCIVFGPL RVSERQHLKD 
KFWNFIFYKF IFIFGVLNVQ TVEEVVMWCL WFAGLVFLHL MVQLCKDRFE YLSFSPTTPM 
SSHGRVLSLL VAMLLSCCGL AAVCSITGYT HGMHTLAFMA AESLLVTVRT AHVILRYVIH 
LWDLNHEGTW EGKGTYVYYT DFVMELTLLS LDLMHHIHML LFGNIWLSMA SLVIFMQLRY 
LFHEVQRRIR RHKNYLRVVG NMEARFAVAT PEELAVNNDD CAICWDSMQA ARKLPCGHLF 
HNSCLRSWLE QDTSCPTCRM SLNIADNNRV REEHQGENLD ENLVPVAAAE GRPRLNQHNH 
FFHFDGSRIA SWLPSFSVEV MHTTNILGIT QASNSQLNAM AHQIQEMFPQ VPYHLVLQDL 
QLTRSVEITT DNILEGRIQV PFPTQRSDSI RPALNSPVER PSSDQEEGET SAQTERVPLD 
LSPRLEETLD FGEVEVEPSE VEDFEARGSR FSKSADERQR MLVQRKDELL QQARKRFLNK 
SSEDDAASES FLPSEGASSD PVTLRRRMLA AAAERRLQKQ QTS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.