AMH | ENSG00000104899 | NCBI 268

Details for: AMH

Gene ID: 268

Symbol: AMH

Ensembl ID: ENSG00000104899

Description: anti-Mullerian hormone

Associated with

Developmental biology
(R-HSA-1266738)
Signaling by bmp
(R-HSA-201451)
Signaling by tgfb family members
(R-HSA-9006936)
Signal transduction
(R-HSA-162582)
Transcriptional regulation of testis differentiation
(R-HSA-9690406)
Anti-mullerian hormone signaling pathway
(GO:1990262)
Cell-cell signaling
(GO:0007267)
Extracellular region
(GO:0005576)
Extracellular space
(GO:0005615)
Gonadal mesoderm development
(GO:0007506)
Growth factor activity
(GO:0008083)
Hormone activity
(GO:0005179)
Leydig cell differentiation
(GO:0033327)
Mullerian duct regression
(GO:0001880)
Negative regulation of ovarian follicle development
(GO:2000355)
Ovarian follicle development
(GO:0001541)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of smad protein signal transduction
(GO:0060391)
Preantral ovarian follicle growth
(GO:0001546)
Protein binding
(GO:0005515)
Response to organic cyclic compound
(GO:0014070)
Response to xenobiotic stimulus
(GO:0009410)
Sex determination
(GO:0007530)
Sex differentiation
(GO:0007548)
Signaling receptor binding
(GO:0005102)
Type ii transforming growth factor beta receptor binding
(GO:0005114)
Urogenital system development
(GO:0001655)

Other Information

Proteins

Muellerian-inhibiting factor

Genular Protein ID: 76971339

Symbol: MIS_HUMAN

Name: Muellerian-inhibiting factor

UniProtKB Accession Codes:

P03971 O75246 Q6GTN3

Database IDs:

Citations:

PubMed ID: 3754790

Title: Isolation of the bovine and human genes for Mullerian inhibiting substance and expression of the human gene in animal cells.

PubMed ID: 3754790

DOI: 10.1016/0092-8674(86)90783-x

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2974034

Title: Proteolytic processing of mullerian inhibiting substance produces a transforming growth factor-beta-like fragment.

PubMed ID: 2974034

DOI: 10.1016/s0021-9258(18)37375-7

PubMed ID: 8469238

Title: Mullerian inhibiting substance requires its N-terminal domain for maintenance of biological activity, a novel finding within the transforming growth factor-beta superfamily.

PubMed ID: 8469238

DOI: 10.1210/mend.7.2.8469238

PubMed ID: 11779604

Title: Relationship between serum muellerian-inhibiting substance and other reproductive hormones in untreated women with polycystic ovary syndrome and normal women.

PubMed ID: 11779604

DOI: 10.1016/s0015-0282(01)02944-2

PubMed ID: 14742691

Title: Anti-Muellerian hormone expression pattern in the human ovary: potential implications for initial and cyclic follicle recruitment.

PubMed ID: 14742691

DOI: 10.1093/molehr/gah015

PubMed ID: 20861221

Title: Processing of anti-mullerian hormone regulates receptor activation by a mechanism distinct from TGF-beta.

PubMed ID: 20861221

DOI: 10.1210/me.2010-0273

PubMed ID: 1483695

Title: Variants of the anti-Mullerian hormone gene in a compound heterozygote with the persistent Mullerian duct syndrome and his family.

PubMed ID: 1483695

DOI: 10.1007/bf00220465

PubMed ID: 8162013

Title: Molecular genetics of the persistent Mullerian duct syndrome: a study of 19 families.

PubMed ID: 8162013

DOI: 10.1093/hmg/3.1.125

PubMed ID: 8872466

Title: A 27 base-pair deletion of the anti-Muellerian type II receptor gene is the most common cause of the persistent Muellerian duct syndrome.

PubMed ID: 8872466

DOI: 10.1093/hmg/5.9.1269

PubMed ID: 34155118

Title: Structure of AMH bound to AMHR2 provides insight into a unique signaling pair in the TGF-beta family.

PubMed ID: 34155118

DOI: 10.1073/pnas.2104809118

Sequence Information:

Length: 560
Mass: 59195
Checksum: D05DCEE4FEDF94C2
Sequence:

MRDLPLTSLA LVLSALGALL GTEALRAEEP AVGTSGLIFR EDLDWPPGSP QEPLCLVALG 
GDSNGSSSPL RVVGALSAYE QAFLGAVQRA RWGPRDLATF GVCNTGDRQA ALPSLRRLGA 
WLRDPGGQRL VVLHLEEVTW EPTPSLRFQE PPPGGAGPPE LALLVLYPGP GPEVTVTRAG 
LPGAQSLCPS RDTRYLVLAV DRPAGAWRGS GLALTLQPRG EDSRLSTARL QALLFGDDHR 
CFTRMTPALL LLPRSEPAPL PAHGQLDTVP FPPPRPSAEL EESPPSADPF LETLTRLVRA 
LRVPPARASA PRLALDPDAL AGFPQGLVNL SDPAALERLL DGEEPLLLLL RPTAATTGDP 
APLHDPTSAP WATALARRVA AELQAAAAEL RSLPGLPPAT APLLARLLAL CPGGPGGLGD 
PLRALLLLKA LQGLRVEWRG RDPRGPGRAQ RSAGATAADG PCALRELSVD LRAERSVLIP 
ETYQANNCQG VCGWPQSDRN PRYGNHVVLL LKMQVRGAAL ARPPCCVPTA YAGKLLISLS 
EERISAHHVP NMVATECGCR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: AMH

Associated with

Other Information

Isolation of the bovine and human genes for Mullerian inhibiting substance and expression of the human gene in animal cells. PubMed ID: 3754790

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Proteolytic processing of mullerian inhibiting substance produces a transforming growth factor-beta-like fragment. PubMed ID: 2974034

Mullerian inhibiting substance requires its N-terminal domain for maintenance of biological activity, a novel finding within the transforming growth factor-beta superfamily. PubMed ID: 8469238

Relationship between serum muellerian-inhibiting substance and other reproductive hormones in untreated women with polycystic ovary syndrome and normal women. PubMed ID: 11779604

Anti-Muellerian hormone expression pattern in the human ovary: potential implications for initial and cyclic follicle recruitment. PubMed ID: 14742691

Processing of anti-mullerian hormone regulates receptor activation by a mechanism distinct from TGF-beta. PubMed ID: 20861221

Variants of the anti-Mullerian hormone gene in a compound heterozygote with the persistent Mullerian duct syndrome and his family. PubMed ID: 1483695

Molecular genetics of the persistent Mullerian duct syndrome: a study of 19 families. PubMed ID: 8162013

A 27 base-pair deletion of the anti-Muellerian type II receptor gene is the most common cause of the persistent Muellerian duct syndrome. PubMed ID: 8872466

Structure of AMH bound to AMHR2 provides insight into a unique signaling pair in the TGF-beta family. PubMed ID: 34155118