Details for: Foxl2

Gene ID: 26927

Symbol: Foxl2

Ensembl ID: ENSMUSG00000050397

Description: forkhead box L2

Associated with

  • Metabolism of proteins
    (R-MMU-392499)
  • Post-translational protein modification
    (R-MMU-597592)
  • Sumo e3 ligases sumoylate target proteins
    (R-MMU-3108232)
  • Sumoylation
    (R-MMU-2990846)
  • Sumoylation of transcription factors
    (R-MMU-3232118)
  • Anatomical structure morphogenesis
    (GO:0009653)
  • Apoptotic dna fragmentation
    (GO:0006309)
  • Cell differentiation
    (GO:0030154)
  • Cysteine-type endopeptidase regulator activity involved in apoptotic process
    (GO:0043028)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Embryonic eye morphogenesis
    (GO:0048048)
  • Extraocular skeletal muscle development
    (GO:0002074)
  • Female gonad development
    (GO:0008585)
  • Female somatic sex determination
    (GO:0019101)
  • Flemming body
    (GO:0090543)
  • Granulosa cell differentiation
    (GO:0060014)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nuclear estrogen receptor binding
    (GO:0030331)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Ovarian follicle development
    (GO:0001541)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0043280)
  • Positive regulation of follicle-stimulating hormone secretion
    (GO:0046881)
  • Positive regulation of luteinizing hormone secretion
    (GO:0033686)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Response to human chorionic gonadotropin
    (GO:0044752)
  • Response to organic cyclic compound
    (GO:0014070)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Single fertilization
    (GO:0007338)
  • Ubiquitin conjugating enzyme binding
    (GO:0031624)
  • Uterus development
    (GO:0060065)

Other Information

Genular Protein ID: 2970740191

Symbol: FOXL2_MOUSE

Name: Forkhead box protein L2

UniProtKB Accession Codes:

O88470 Q8K3X9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 Ensembl 1 ExpressionAtlas 1 GO 33 Gene3D 1 GeneTree 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MGI 1 MoonDB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 3 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 12471206

Title: Evolution and expression of FOXL2.

PubMed ID: 12471206

DOI: 10.1136/jmg.39.12.916

PubMed ID: 9620855

Title: Multistep signaling requirements for pituitary organogenesis in vivo.

PubMed ID: 9620855

DOI: 10.1101/gad.12.11.1691

PubMed ID: 15059956

Title: Forkhead l2 is expressed in the ovary and represses the promoter activity of the steroidogenic acute regulatory gene.

PubMed ID: 15059956

DOI: 10.1210/en.2003-1141

PubMed ID: 16153597

Title: Transcriptional factor FOXL2 interacts with DP103 and induces apoptosis.

PubMed ID: 16153597

DOI: 10.1016/j.bbrc.2005.08.184

PubMed ID: 15944199

Title: Foxl2 is required for commitment to ovary differentiation.

PubMed ID: 15944199

DOI: 10.1093/hmg/ddi210

PubMed ID: 20005806

Title: Somatic sex reprogramming of adult ovaries to testes by FOXL2 ablation.

PubMed ID: 20005806

DOI: 10.1016/j.cell.2009.11.021

PubMed ID: 19797124

Title: Foxl2, a forkhead transcription factor, modulates nonclassical activity of the estrogen receptor-alpha.

PubMed ID: 19797124

DOI: 10.1210/en.2009-0313

PubMed ID: 19106105

Title: FoxL2 and Smad3 coordinately regulate follistatin gene transcription.

PubMed ID: 19106105

DOI: 10.1074/jbc.m806676200

Sequence Information:

  • Length: 375
  • Mass: 38887
  • Checksum: F920C8407686C4B6
  • Sequence:
    • MMASYPEPED TAGTLLAPES GRAVKEAEAS PPSPGKGGGT TPEKPDPAQK PPYSYVALIA 
MAIRESAEKR LTLSGIYQYI IAKFPFYEKN KKGWQNSIRH NLSLNECFIK VPREGGGERK 
GNYWTLDPAC EDMFEKGNYR RRRRMKRPFR PPPAHFQPGK GLFGSGGAAG GCGVPGAGAD 
GYGYLAPPKY LQSGFLNNSW PLPQPPSPMP YASCQMAAAA AAAAAAAAAA GPGSPGAAAV 
VKGLAGPAAS YGPYSRVQSM ALPPGVVNSY NGLGGPPAAP PPPPPPPHPH PHPHAHHLHA 
AAAPPPAPPH HGAAAPPPGQ LSPASPATAA PPAPAPTSAP GLQFACARQP ELAMMHCSYW 
DHDSKTGALH SRLDL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.