Nherf1 | ENSMUSG00000020733 | NCBI 26941

Details for: Nherf1

Gene ID: 26941

Symbol: Nherf1

Ensembl ID: ENSMUSG00000020733

Description: NHERF family PDZ scaffold protein 1

Associated with

Actin cytoskeleton organization
(GO:0030036)
Adenylate cyclase-activating dopamine receptor signaling pathway
(GO:0007191)
Apical part of cell
(GO:0045177)
Apical plasma membrane
(GO:0016324)
Auditory receptor cell stereocilium organization
(GO:0060088)
Beta-2 adrenergic receptor binding
(GO:0031698)
Beta-catenin binding
(GO:0008013)
Bile acid secretion
(GO:0032782)
Brush border membrane
(GO:0031526)
Cell periphery
(GO:0071944)
Cerebrospinal fluid circulation
(GO:0090660)
Channel activator activity
(GO:0099103)
Chloride channel regulator activity
(GO:0017081)
Cilium organization
(GO:0044782)
Cytoplasm
(GO:0005737)
Dopamine receptor binding
(GO:0050780)
Endomembrane system
(GO:0012505)
Establishment of epithelial cell apical/basal polarity
(GO:0045198)
Establishment of golgi localization
(GO:0051683)
Establishment of localization in cell
(GO:0051649)
Extracellular region
(GO:0005576)
Fibroblast migration
(GO:0010761)
Filopodium
(GO:0030175)
Gamma-aminobutyric acid import
(GO:0051939)
Gamma-aminobutyric acid transmembrane transporter activity
(GO:0015185)
Gland morphogenesis
(GO:0022612)
Glutathione transport
(GO:0034635)
Growth factor receptor binding
(GO:0070851)
Identical protein binding
(GO:0042802)
Import across plasma membrane
(GO:0098739)
Intracellular phosphate ion homeostasis
(GO:0030643)
Maintenance of epithelial cell apical/basal polarity
(GO:0045199)
Membrane
(GO:0016020)
Microvillus
(GO:0005902)
Microvillus assembly
(GO:0030033)
Microvillus membrane
(GO:0031528)
Molecular adaptor activity
(GO:0060090)
Myosin ii binding
(GO:0045159)
Negative regulation of canonical wnt signaling pathway
(GO:0090090)
Negative regulation of cell motility
(GO:2000146)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of erk1 and erk2 cascade
(GO:0070373)
Negative regulation of fibroblast migration
(GO:0010764)
Negative regulation of mitotic cell cycle
(GO:0045930)
Negative regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051898)
Negative regulation of platelet-derived growth factor receptor signaling pathway
(GO:0010642)
Negative regulation of sodium:proton antiporter activity
(GO:0032416)
Negative regulation of sodium ion transport
(GO:0010766)
Nuclear migration
(GO:0007097)
Pdz domain binding
(GO:0030165)
Perinuclear region of cytoplasm
(GO:0048471)
Phosphatase binding
(GO:0019902)
Phospholipase c-activating dopamine receptor signaling pathway
(GO:0060158)
Plasma membrane organization
(GO:0007009)
Plasma membrane protein complex
(GO:0098797)
Positive regulation of intrinsic apoptotic signaling pathway
(GO:2001244)
Positive regulation of monoatomic ion transmembrane transport
(GO:0034767)
Protein-containing complex binding
(GO:0044877)
Protein-membrane adaptor activity
(GO:0043495)
Protein binding
(GO:0005515)
Protein domain specific binding
(GO:0019904)
Protein localization
(GO:0008104)
Protein localization to plasma membrane
(GO:0072659)
Regulation of cell shape
(GO:0008360)
Regulation of cell size
(GO:0008361)
Regulation of protein kinase activity
(GO:0045859)
Regulation of renal phosphate excretion
(GO:1903402)
Renal absorption
(GO:0070293)
Renal phosphate ion absorption
(GO:0097291)
Renal sodium ion transport
(GO:0003096)
Ruffle
(GO:0001726)
Sensory perception of sound
(GO:0007605)
Signaling receptor binding
(GO:0005102)
Sodium ion transport
(GO:0006814)
Sperm midpiece
(GO:0097225)
Stereocilium
(GO:0032420)
Stereocilium tip
(GO:0032426)
Transmembrane transporter binding
(GO:0044325)
Type 2 metabotropic glutamate receptor binding
(GO:0031799)
Type 3 metabotropic glutamate receptor binding
(GO:0031800)
Wnt signaling pathway
(GO:0016055)

Other Information

Proteins

Na(+)/H(+) exchange regulatory cofactor NHE-RF1

Genular Protein ID: 3246486062

Symbol: NHRF1_MOUSE

Name: Na(+)/H(+) exchange regulatory cofactor NHE-RF1

UniProtKB Accession Codes:

P70441 Q8BYD8

Database IDs:

Citations:

PubMed ID: 10500246

Title: Molecular cloning of the cDNA and promoter sequences for the mouse sodium-hydrogen exchanger regulatory factor.

PubMed ID: 10500246

DOI: 10.1016/s0167-4781(99)00100-1

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9560162

Title: The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange.

PubMed ID: 9560162

DOI: 10.1038/33458

PubMed ID: 11777944

Title: Negative regulation of immune synapse formation by anchoring lipid raft to cytoskeleton through Cbp-EBP50-ERM assembly.

PubMed ID: 11777944

DOI: 10.4049/jimmunol.168.2.541

PubMed ID: 14531806

Title: PDZK1: I. a major scaffolder in brush borders of proximal tubular cells.

PubMed ID: 14531806

DOI: 10.1046/j.1523-1755.2003.00266.x

PubMed ID: 15466885

Title: New sorting nexin (SNX27) and NHERF specifically interact with the 5-HT4a receptor splice variant: roles in receptor targeting.

PubMed ID: 15466885

DOI: 10.1242/jcs.01379

PubMed ID: 15378723

Title: Phosphoproteome analysis of mouse liver using immobilized metal affinity purification and linear ion trap mass spectrometry.

PubMed ID: 15378723

DOI: 10.1002/rcm.1604

PubMed ID: 17311105

Title: The CD34-related molecule podocalyxin is a potent inducer of microvillus formation.

PubMed ID: 17311105

DOI: 10.1371/journal.pone.0000237

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 18630941

Title: Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis.

PubMed ID: 18630941

DOI: 10.1021/pr800223m

PubMed ID: 19131326

Title: Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.

PubMed ID: 19131326

DOI: 10.1074/mcp.m800451-mcp200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21976599

Title: Participation of the Cl-/HCO(3)- exchangers SLC26A3 and SLC26A6, the Cl- channel CFTR, and the regulatory factor SLC9A3R1 in mouse sperm capacitation.

PubMed ID: 21976599

DOI: 10.1095/biolreprod.111.094037

Sequence Information:

Length: 355
Mass: 38600
Checksum: 331F6BEE31DA0A11
Sequence:

MSADAAAGEP LPRLCCLEKG PNGYGFHLHG EKGKVGQFIR LVEPGSPAEK SGLLAGDRLV 
EVNGENVEKE THQQVVSRIR AALNAVRLLV VDPETDERLK KLGVSIREEL LRPQEKSEQA 
EPPAAADTHE AGDQNEAEKS HLRELRPRLC TMKKGPNGYG FNLHSDKSKP GQFIRAVDPD 
SPAEASGLRA QDRIVEVNGV CMEGKQHGDV VSAIKGGGDE AKLLVVDKET DEFFKKCKVI 
PSQEHLDGPL PEPFSNGEIQ KESSREALVE PASESPRPAL ARSASSDTSE ELNSQDSPKR 
QVSTEPSSTS SSSSDPILDL NISLAVAKER AHQKRSSKRA PQMDWSKKNE LFSNL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Nherf1

Associated with

Other Information

Molecular cloning of the cDNA and promoter sequences for the mouse sodium-hydrogen exchanger regulatory factor. PubMed ID: 10500246

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange. PubMed ID: 9560162

Negative regulation of immune synapse formation by anchoring lipid raft to cytoskeleton through Cbp-EBP50-ERM assembly. PubMed ID: 11777944

PDZK1: I. a major scaffolder in brush borders of proximal tubular cells. PubMed ID: 14531806

New sorting nexin (SNX27) and NHERF specifically interact with the 5-HT4a receptor splice variant: roles in receptor targeting. PubMed ID: 15466885

Phosphoproteome analysis of mouse liver using immobilized metal affinity purification and linear ion trap mass spectrometry. PubMed ID: 15378723

The CD34-related molecule podocalyxin is a potent inducer of microvillus formation. PubMed ID: 17311105

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis. PubMed ID: 18630941

Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry. PubMed ID: 19131326

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Participation of the Cl-/HCO(3)- exchangers SLC26A3 and SLC26A6, the Cl- channel CFTR, and the regulatory factor SLC9A3R1 in mouse sperm capacitation. PubMed ID: 21976599