Afdn | ENSRNOG00000023753 | NCBI 26955

Details for: Afdn

Gene ID: 26955

Symbol: Afdn

Ensembl ID: ENSRNOG00000023753

Description: afadin, adherens junction formation factor

Associated with

Adherens junctions interactions
(R-RNO-418990)
Cell-cell communication
(R-RNO-1500931)
Cell-cell junction organization
(R-RNO-421270)
Cell junction organization
(R-RNO-446728)
Actin filament binding
(GO:0051015)
Adherens junction
(GO:0005912)
Adherens junction maintenance
(GO:0034334)
Apical junction complex
(GO:0043296)
Apical part of cell
(GO:0045177)
Axon
(GO:0030424)
Bicellular tight junction assembly
(GO:0070830)
Brain morphogenesis
(GO:0048854)
Cell-cell adhesion mediated by cadherin
(GO:0044331)
Cell-cell contact zone
(GO:0044291)
Cell-cell junction
(GO:0005911)
Cell adhesion
(GO:0007155)
Cell adhesion molecule binding
(GO:0050839)
Cell junction
(GO:0030054)
Cerebral cortex development
(GO:0021987)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dendrite arborization
(GO:0140059)
Establishment of endothelial intestinal barrier
(GO:0090557)
Establishment of protein localization to plasma membrane
(GO:0061951)
Excitatory synapse
(GO:0060076)
Glutamatergic synapse
(GO:0098978)
Hippocampal mossy fiber to ca3 synapse
(GO:0098686)
Homeostasis of number of cells
(GO:0048872)
Lim domain binding
(GO:0030274)
Negative regulation of cell migration
(GO:0030336)
Neuroepithelial cell differentiation
(GO:0060563)
Nuclear speck
(GO:0016607)
Nucleoplasm
(GO:0005654)
Plasma membrane
(GO:0005886)
Pore complex
(GO:0046930)
Pore complex assembly
(GO:0046931)
Positive regulation of cell-cell adhesion
(GO:0022409)
Positive regulation of cell-cell adhesion mediated by cadherin
(GO:2000049)
Positive regulation of dendrite extension
(GO:1903861)
Positive regulation of dendrite morphogenesis
(GO:0050775)
Positive regulation of dendritic spine morphogenesis
(GO:0061003)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of mini excitatory postsynaptic potential
(GO:0061885)
Postsynaptic density membrane
(GO:0098839)
Postsynaptic specialization organization
(GO:0099084)
Presynaptic active zone membrane
(GO:0048787)
Protein binding
(GO:0005515)
Protein localization to cell junction
(GO:1902414)
Radial glial cell differentiation
(GO:0060019)
Regulation of oligodendrocyte progenitor proliferation
(GO:0070445)
Regulation of postsynapse assembly
(GO:0150052)
Regulation of protein localization
(GO:0032880)
Signal transduction
(GO:0007165)
Small gtpase binding
(GO:0031267)
Somatodendritic compartment
(GO:0036477)
Telencephalon development
(GO:0021537)
Tight junction
(GO:0070160)

Other Information

Proteins

Afadin

Genular Protein ID: 3257408222

Symbol: AFAD_RAT

Name: Afadin

UniProtKB Accession Codes:

O35889 O35890

Database IDs:

Citations:

PubMed ID: 9334353

Title: Afadin: a novel actin filament-binding protein with one PDZ domain localized at cadherin-based cell-to-cell adherens junction.

PubMed ID: 9334353

DOI: 10.1083/jcb.139.2.517

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

PubMed ID: 30463011

Title: A Dock-and-Lock Mechanism Clusters ADAM10 at Cell-Cell Junctions to Promote alpha-Toxin Cytotoxicity.

PubMed ID: 30463011

DOI: 10.1016/j.celrep.2018.10.088

Sequence Information:

Length: 1829
Mass: 207678
Checksum: 45C597A82F109D6F
Sequence:

MSAGGRDEER RKLADIIHHW NANRLDLFEI SQPTEDLEFH GVMRFYFQDK AAGNFATKCI 
RVSSTATTQD VIETLAEKFR PDMRMLSSPK YSLYEVHVSG ERRLDIDEKP LVVQLNWNKD 
DREGRFVLKN ENDAIPAKKA QSNGPEKQEK EGVIQNFKRT LSKKEKKEKK KREKEALRQA 
SDKEERPSQG DDSENSRLAA EVYKDMPETS FTRTISNPEV VMKRRRQQKL EKRMQEFRSS 
DGRPDSGGTL RIYADSLKPN IPYKTILLST TDPADFAVAE SLEKYGLEKE NPKDYCIARV 
MLPPGAQHSD ERGAKEIILD DDECPLQIFR EWPSDKGILV FQLKRRPPDY IPKKMKKHVE 
GKPLKGKDRA DGSGYGSALP PEKLPYLVEL SPGRRNHFAY YSYHTYEDGS DSRDKPKLYR 
LQLSVTEVGT EKFDDNSIQL FGPGIQPHHC DLTNMDGVVT VTPRSMDAET YVDGQRISET 
TMLQSGMRLQ FGTSHVFKFV DPIQDHVLSK RSVDGGLMVK GPRHKPGAVQ ETTFELGGDI 
HSGTALPASR STTRLDSDRV SSASSTAERG MVKPMIRLDQ EQDYRRRESR TQDAAGPELM 
LPASIEFRES SEDSFLSAII NYTNSSTVHF KLSPTYVLYM ACRYVLSSQH RPDISPTERT 
HKAIAVVNKM VSMMEGVIQE VDQVDQKQKN IAGALAFWMA NASELLNFIK QDRDLSRITL 
DAQDVLAHLV QMAFKYLVHC LQSELNNYMP AFLDDPEENS LQRPKIDDVL HTLTGAMSLL 
RRCRVNAALT IQLFSQLFHF INMWLFNRLV TDPDSGLCSH YWGAIIRQQL GHIEAWAEKQ 
GLELAADCHL SRIVQATTLL TMDKYVPDDI PNINSTCFKL NSLQLQALLQ NYHCAPDEPF 
IPTDLIENVV AVAENTADEL ARSDGRDVQL EEDPDLQLPF LLPEDGYSCD VVRNIPNGLQ 
EFLDPLCQRG FCRLVPHTRS PGTWTIYFEG ADYESHLMRE NTELTQPLRK EPEVITVTLK 
KQNGMGLSIV AAKGAGQDKL GIYVKSVVKG GAADVDGRLA AGDQLLSVDG RSLVGLSQER 
AAELMTRTSS VVTLEVAKQG AIYHGLATLL NQPSPMMQRI SDRRGSGKPR PKSEGFELYN 
NSAQNGSPES PQMPWTEYSE PKKLPGDDRL MKNRADHRSS PNVANQPPSP GGKSPYTSGT 
AAKITSVSTG NLCTEEQTPP PRPEAYPIPT QTYTREYFTF PASKSQDRMA PVQNQWPNYE 
EKPHMHTESD HASIAIQRVT RSQEELREEK VYQLERHRVE SGMDRKCDSD MWINQSSSVE 
SSTSSQEHLN HSSKSVTPAS TLTKSGPGRW KTPAAVLPTP VAVSQPIRTD LPPPPPPPPA 
HYTSDFDGIS MDLPLPPPPA NQAAPQSAQV AAAERKKREE HQRWYEKEKA RLEEERERKR 
REQERKLGQM RTQSLNPASF SPLATQAKPE KPSTLQRPQE TVIRELQPQQ QPRTIERRDL 
QYITISKEEL SSGDSLSPDP WKRDAREKLE KQQQMHIVDM LSKEIHELQN KGDRTAEESD 
RLRKLMLEWQ FQKRLQESKQ KDEDDDEEED DDVDTMLIMQ RLEAERRARL QDEERRRQQQ 
LEEMRKREVE DRVRQEEDGR HQEEERVKRD AEEKRRQEEG YYSRLEAERR RQHEEAARRL 
LEPEEPGLSR PPLPQDYEPP SQSSAPSAPP PPPQRNASYL KTQVLSPDSL FTAKFVAYDD 
DDEEENYVPA GPNSYSGSAG TTAGTYDAPR DTREKLSRSQ DADLPGSSGA PENLTFRERQ 
RLFSQGQDVS DKVKASRKLT ELENELNTK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.