Cul1 | ENSMUSG00000029686 | NCBI 26965

Details for: Cul1

Gene ID: 26965

Symbol: Cul1

Ensembl ID: ENSMUSG00000029686

Description: cullin 1

Associated with

Activation of nf-kappab in b cells
(R-MMU-1169091)
Adaptive immune system
(R-MMU-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-MMU-983168)
Apc/c-mediated degradation of cell cycle proteins
(R-MMU-174143)
C-type lectin receptors (clrs)
(R-MMU-5621481)
Cell cycle
(R-MMU-1640170)
Cell cycle, mitotic
(R-MMU-69278)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular response to chemical stress
(R-MMU-9711123)
Class i mhc mediated antigen processing & presentation
(R-MMU-983169)
Clec7a (dectin-1) signaling
(R-MMU-5607764)
Cyclin a:cdk2-associated events at s phase entry
(R-MMU-69656)
Cyclin d associated events in g1
(R-MMU-69231)
Cyclin e associated events during g1/s transition
(R-MMU-69202)
Cytokine signaling in immune system
(R-MMU-1280215)
Dectin-1 mediated noncanonical nf-kb signaling
(R-MMU-5607761)
Degradation of beta-catenin by the destruction complex
(R-MMU-195253)
Degradation of gli1 by the proteasome
(R-MMU-5610780)
Dna replication
(R-MMU-69306)
Downstream signaling events of b cell receptor (bcr)
(R-MMU-1168372)
Downstream tcr signaling
(R-MMU-202424)
Fbxl7 down-regulates aurka during mitotic entry and in early mitosis
(R-MMU-8854050)
Fc epsilon receptor (fceri) signaling
(R-MMU-2454202)
Fceri mediated nf-kb activation
(R-MMU-2871837)
G1 phase
(R-MMU-69236)
G1/s transition
(R-MMU-69206)
G2/m transition
(R-MMU-69275)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Gli3 is processed to gli3r by the proteasome
(R-MMU-5610785)
Gsk3b and btrc:cul1-mediated-degradation of nfe2l2
(R-MMU-9762114)
Hedgehog 'off' state
(R-MMU-5610787)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Interleukin-1 family signaling
(R-MMU-446652)
Interleukin-1 signaling
(R-MMU-9020702)
Interleukin-17 signaling
(R-MMU-448424)
Iron uptake and transport
(R-MMU-917937)
Keap1-nfe2l2 pathway
(R-MMU-9755511)
Map3k8 (tpl2)-dependent mapk1/3 activation
(R-MMU-5684264)
Map kinase activation
(R-MMU-450294)
Metabolism of proteins
(R-MMU-392499)
Mitotic g1 phase and g1/s transition
(R-MMU-453279)
Mitotic g2-g2/m phases
(R-MMU-453274)
Myd88 cascade initiated on plasma membrane
(R-MMU-975871)
Myd88 dependent cascade initiated on endosome
(R-MMU-975155)
Myd88-independent tlr4 cascade
(R-MMU-166166)
Myd88:mal(tirap) cascade initiated on plasma membrane
(R-MMU-166058)
Neddylation
(R-MMU-8951664)
Nik-->noncanonical nf-kb signaling
(R-MMU-5676590)
Nuclear events mediated by nfe2l2
(R-MMU-9759194)
Orc1 removal from chromatin
(R-MMU-68949)
Post-translational protein modification
(R-MMU-597592)
Prolactin receptor signaling
(R-MMU-1170546)
Regulation of apc/c activators between g1/s and early anaphase
(R-MMU-176408)
Regulation of bach1 activity
(R-MMU-9708530)
Regulation of mitotic cell cycle
(R-MMU-453276)
Regulation of plk1 activity at g2/m transition
(R-MMU-2565942)
Regulation of runx2 expression and activity
(R-MMU-8939902)
Rna polymerase ii transcription
(R-MMU-73857)
Scf(skp2)-mediated degradation of p27/p21
(R-MMU-187577)
Scf-beta-trcp mediated degradation of emi1
(R-MMU-174113)
Signaling by hedgehog
(R-MMU-5358351)
Signaling by interleukins
(R-MMU-449147)
Signaling by the b cell receptor (bcr)
(R-MMU-983705)
Signaling by wnt
(R-MMU-195721)
Signal transduction
(R-MMU-162582)
S phase
(R-MMU-69242)
Switching of origins to a post-replicative state
(R-MMU-69052)
Synthesis of dna
(R-MMU-69239)
Tcr signaling
(R-MMU-202403)
Tnfr2 non-canonical nf-kb pathway
(R-MMU-5668541)
Toll-like receptor cascades
(R-MMU-168898)
Toll like receptor 2 (tlr2) cascade
(R-MMU-181438)
Toll like receptor 3 (tlr3) cascade
(R-MMU-168164)
Toll like receptor 4 (tlr4) cascade
(R-MMU-166016)
Toll like receptor 5 (tlr5) cascade
(R-MMU-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-MMU-168181)
Toll like receptor 9 (tlr9) cascade
(R-MMU-168138)
Toll like receptor 10 (tlr10) cascade
(R-MMU-168142)
Toll like receptor tlr1:tlr2 cascade
(R-MMU-168179)
Toll like receptor tlr6:tlr2 cascade
(R-MMU-168188)
Traf6 mediated induction of nfkb and map kinases upon tlr7/8 or 9 activation
(R-MMU-975138)
Transcriptional regulation by runx2
(R-MMU-8878166)
Transport of small molecules
(R-MMU-382551)
Trif (ticam1)-mediated tlr4 signaling
(R-MMU-937061)
Animal organ morphogenesis
(GO:0009887)
Apoptotic process
(GO:0006915)
Cell population proliferation
(GO:0008283)
Protein-macromolecule adaptor activity
(GO:0030674)
Protein binding
(GO:0005515)
Protein monoubiquitination
(GO:0006513)
Protein ubiquitination
(GO:0016567)
Scf-dependent proteasomal ubiquitin-dependent protein catabolic process
(GO:0031146)
Ubiquitin-dependent protein catabolic process
(GO:0006511)
Ubiquitin ligase complex scaffold activity
(GO:0160072)
Ubiquitin protein ligase activity
(GO:0061630)
Ubiquitin protein ligase binding
(GO:0031625)

Other Information

Proteins

Cullin-1

Genular Protein ID: 3573859063

Symbol: CUL1_MOUSE

Name: Cullin-1

UniProtKB Accession Codes:

Q9WTX6 Q9WUI7

Database IDs:

Citations:

PubMed ID: 10097128

Title: Ubiquitin-dependent degradation of IkappaBalpha is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1.

PubMed ID: 10097128

DOI: 10.1073/pnas.96.7.3859

PubMed ID: 10508527

Title: Loss of Cul1 results in early embryonic lethality and dysregulation of cyclin E.

PubMed ID: 10508527

DOI: 10.1038/13886

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9663463

Title: Human CUL-1, but not other cullin family members, selectively interacts with SKP1 to form a complex with SKP2 and cyclin A.

PubMed ID: 9663463

PubMed ID: 11735228

Title: Characterization of a mouse gene (Fbxw6) that encodes a homologue of Caenorhabditis elegans SEL-10.

PubMed ID: 11735228

DOI: 10.1006/geno.2001.6658

PubMed ID: 11967155

Title: The COP9 signalosome inhibits p27(kip1) degradation and impedes G1-S phase progression via deneddylation of SCF Cul1.

PubMed ID: 11967155

DOI: 10.1016/s0960-9822(02)00791-1

PubMed ID: 12140560

Title: E3 ubiquitin ligase that recognizes sugar chains.

PubMed ID: 12140560

DOI: 10.1038/nature00890

PubMed ID: 16880526

Title: Fbxw8 is essential for Cul1-Cul7 complex formation and for placental development.

PubMed ID: 16880526

DOI: 10.1128/mcb.00595-06

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20190741

Title: A deneddylase encoded by Epstein-Barr virus promotes viral DNA replication by regulating the activity of cullin-RING ligases.

PubMed ID: 20190741

DOI: 10.1038/ncb2035

PubMed ID: 23452855

Title: Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm.

PubMed ID: 23452855

DOI: 10.1016/j.cell.2013.01.055

PubMed ID: 23452856

Title: FBXL21 regulates oscillation of the circadian clock through ubiquitination and stabilization of cryptochromes.

PubMed ID: 23452856

DOI: 10.1016/j.cell.2013.01.054

PubMed ID: 23319590

Title: SCF(Fbxw15) mediates histone acetyltransferase binding to origin recognition complex (HBO1) ubiquitin-proteasomal degradation to regulate cell proliferation.

PubMed ID: 23319590

DOI: 10.1074/jbc.m112.426882

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

Sequence Information:

Length: 776
Mass: 89692
Checksum: 3E1F8B63C6E498F4
Sequence:

MSSNRSQNPH GLKQIGLDQI WDDLRAGIQQ VYTRQSMAKS RYMELYTHVY NYCTSVHQSN 
QARGAGVPPS KSKKGQTPGG AQFVGLELYK RLKEFLKNYL TNLLKDGEDL MDESVLKFYT 
QQWEDYRFSS KVLNGICAYL NRHWVRRECD EGRKGIYEIY SLALVTWRDC LFRPLNKQVT 
NAVLKLIEKE RNGETINTRL ISGVVQSYVE LGLNEDDAFA KGPTLTVYKE SFESQFLADT 
ERFYTRESTE FLQQNPVTEY MKKAEARLLE EQRRVQVYLH ESTQDELARK CEQVLIEKHL 
EIFHTEFQNL LDADKNEDLG RMYNLVSRIQ DGLGELKKLL ETHIHNQGLA AIEKCGEAAL 
NDPKMYVQTV LDVHKKYNAL VMSAFNNDAG FVAALDKACG RFINNNAVTK MAQSSSKSPE 
LLARYCDSLL KKSSKNPEEA ELEDTLNQVM VVFKYIEDKD VFQKFYAKML AKRLVHQNSA 
SDDAEASMIS KLKQACGFEY TSKLQRMFQD IGVSKDLNEQ FKKHLTNSEP LDLDFSIQVL 
SSGSWPFQQS CTFALPSELE RSYQRFTAFY ASRHSGRKLT WLYQLSKGEL VTNCFKNRYT 
LQASTFQMAI LLQYNTEDAY TVQQLTDSTQ IKMDILAQVL QILLKSKLLV LEDENANVDE 
VELKPDTLIK LYLGYKNKKL RVNINVPMKT EQKQEQETTH KNIEEDRKLL IQAAIVRIMK 
MRKVLKHQQL LGEVLTQLSS RFKPRVPVIK KCIDILIEKE YLERVDGEKD TYSYLA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Cul1

Associated with

Other Information

Ubiquitin-dependent degradation of IkappaBalpha is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1. PubMed ID: 10097128

Loss of Cul1 results in early embryonic lethality and dysregulation of cyclin E. PubMed ID: 10508527

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Human CUL-1, but not other cullin family members, selectively interacts with SKP1 to form a complex with SKP2 and cyclin A. PubMed ID: 9663463

Characterization of a mouse gene (Fbxw6) that encodes a homologue of Caenorhabditis elegans SEL-10. PubMed ID: 11735228

The COP9 signalosome inhibits p27(kip1) degradation and impedes G1-S phase progression via deneddylation of SCF Cul1. PubMed ID: 11967155

E3 ubiquitin ligase that recognizes sugar chains. PubMed ID: 12140560

Fbxw8 is essential for Cul1-Cul7 complex formation and for placental development. PubMed ID: 16880526

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

A deneddylase encoded by Epstein-Barr virus promotes viral DNA replication by regulating the activity of cullin-RING ligases. PubMed ID: 20190741

Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm. PubMed ID: 23452855

FBXL21 regulates oscillation of the circadian clock through ubiquitination and stabilization of cryptochromes. PubMed ID: 23452856

SCF(Fbxw15) mediates histone acetyltransferase binding to origin recognition complex (HBO1) ubiquitin-proteasomal degradation to regulate cell proliferation. PubMed ID: 23319590

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. PubMed ID: 24129315