Details for: Klrk1

Gene ID: 27007

Symbol: Klrk1

Ensembl ID: ENSMUSG00000030149

Description: killer cell lectin-like receptor subfamily K, member 1

Associated with

Other Information

Genular Protein ID: 1013971364

Symbol: NKG2D_MOUSE

Name: NKG2-D type II integral membrane protein

UniProtKB Accession Codes:

O54709

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 24 Gene3D 1 GeneTree 1 GlyCosmos 1 GlyGen 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PROSITE 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 9600963

Title: Murine Nkg2d and Cd94 are clustered within the natural killer complex and are expressed independently in natural killer cells.

PubMed ID: 9600963

DOI: 10.1073/pnas.95.11.6320

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9464811

Title: Cloning of a mouse homolog of CD94 extends the family of C-type lectins on murine natural killer cells.

PubMed ID: 9464811

DOI: 10.1002/eji.1830271222

PubMed ID: 10894171

Title: Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice.

PubMed ID: 10894171

DOI: 10.1016/s1074-7613(00)80222-8

PubMed ID: 11248803

Title: Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages.

PubMed ID: 11248803

DOI: 10.1038/77793

PubMed ID: 11557981

Title: Rae1 and H60 ligands of the NKG2D receptor stimulate tumour immunity.

PubMed ID: 11557981

DOI: 10.1038/35093109

PubMed ID: 11567106

Title: Regulation of cutaneous malignancy by gammadelta T cells.

PubMed ID: 11567106

DOI: 10.1126/science.1063916

PubMed ID: 12150888

Title: The role of the NKG2D immunoreceptor in immune cell activation and natural killing.

PubMed ID: 12150888

DOI: 10.1016/s1074-7613(02)00333-3

PubMed ID: 12370332

Title: Murine UL16-binding protein-like transcript 1: a newly described transcript encoding a high-affinity ligand for murine NKG2D.

PubMed ID: 12370332

DOI: 10.4049/jimmunol.169.8.4079

PubMed ID: 11973127

Title: Lymphocyte activation via NKG2D: towards a new paradigm in immune recognition?

PubMed ID: 11973127

DOI: 10.1016/s0952-7915(02)00337-0

PubMed ID: 12426565

Title: Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D.

PubMed ID: 12426565

DOI: 10.1038/ni858

PubMed ID: 12426564

Title: NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation.

PubMed ID: 12426564

DOI: 10.1038/ni857

PubMed ID: 15048723

Title: Involvement of NKR-P2/NKG2D in DC-mediated killing of tumor targets: indicative of a common, innate, target-recognition paradigm?

PubMed ID: 15048723

DOI: 10.1002/eji.200324793

PubMed ID: 15189740

Title: NKG2D blockade prevents autoimmune diabetes in NOD mice.

PubMed ID: 15189740

DOI: 10.1016/j.immuni.2004.05.008

PubMed ID: 15294961

Title: A Structural basis for the association of DAP12 with mouse, but not human, NKG2D.

PubMed ID: 15294961

DOI: 10.4049/jimmunol.173.4.2470

PubMed ID: 16086018

Title: Function of NKG2D in natural killer cell-mediated rejection of mouse bone marrow grafts.

PubMed ID: 16086018

DOI: 10.1038/ni1236

PubMed ID: 18394936

Title: NKG2D-deficient mice are defective in tumor surveillance in models of spontaneous malignancy.

PubMed ID: 18394936

DOI: 10.1016/j.immuni.2008.02.016

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 19631564

Title: Altered NK cell development and enhanced NK cell-mediated resistance to mouse cytomegalovirus in NKG2D-deficient mice.

PubMed ID: 19631564

DOI: 10.1016/j.immuni.2009.06.017

PubMed ID: 21898152

Title: Regulation of immune cell function and differentiation by the NKG2D receptor.

PubMed ID: 21898152

DOI: 10.1007/s00018-011-0797-0

PubMed ID: 23298206

Title: Regulation of ligands for the NKG2D activating receptor.

PubMed ID: 23298206

DOI: 10.1146/annurev-immunol-032712-095951

PubMed ID: 11224525

Title: Crystal structure of the murine NK cell-activating receptor NKG2D at 1.95 A.

PubMed ID: 11224525

DOI: 10.1038/85311

PubMed ID: 11825567

Title: Crystal structures of RAE-1beta and its complex with the activating immunoreceptor NKG2D.

PubMed ID: 11825567

DOI: 10.1016/s1074-7613(02)00258-3

Sequence Information:

  • Length: 232
  • Mass: 26710
  • Checksum: 050536EF8C23088A
  • Sequence:
    • MALIRDRKSH HSEMSKCHNY DLKPAKWDTS QEQQKQRLAL TTSQPGENGI IRGRYPIEKL 
KISPMFVVRV LAIALAIRFT LNTLMWLAIF KETFQPVLCN KEVPVSSREG YCGPCPNNWI 
CHRNNCYQFF NEEKTWNQSQ ASCLSQNSSL LKIYSKEEQD FLKLVKSYHW MGLVQIPANG 
SWQWEDGSSL SYNQLTLVEI PKGSCAVYGS SFKAYTEDCA NLNTYICMKR AV

Genular Protein ID: 229468517

Symbol: Q3TCW7_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3TCW7

Database IDs:

AGR 1 ARBA 12 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 Ensembl 2 GO 4 Gene3D 1 GeneTree 1 InterPro 5 MGI 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21750661

Title: Modernizing reference genome assemblies.

PubMed ID: 21750661

Sequence Information:

  • Length: 225
  • Mass: 25801
  • Checksum: 947712C8F0C9908C
  • Sequence:
    • MSKCHNYDLK PAKWDTSQEQ QKQRLALTTS QPGENGIIRG RYPIEKLKIS PMFVVRVLAI 
ALAIRFTLNT LMWLAIFKET FQPVIIILTV LCNKEVPVSS REGYCGPCPN NWICHRNNCY 
QFFNEEKTWN QSQASCLSQN SSLLKIYSKE EQDFLKLVKS YHWMGLVQIP ANGSWQWEDG 
SSLSYNQLTL VEIPKGSCAV YGSSFKAYTE DCANLNTYIC MKRAV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.