Details for: Eif2ak4

Gene ID: 27103

Symbol: Eif2ak4

Ensembl ID: ENSMUSG00000005102

Description: eukaryotic translation initiation factor 2 alpha kinase 4

Associated with

  • Adaptive immune response
    (GO:0002250)
  • Atp binding
    (GO:0005524)
  • Cellular response to amino acid starvation
    (GO:0034198)
  • Cellular response to cold
    (GO:0070417)
  • Cellular response to starvation
    (GO:0009267)
  • Cellular response to uv
    (GO:0034644)
  • Chromatin remodeling
    (GO:0006338)
  • Cytoplasm
    (GO:0005737)
  • Cytosol
    (GO:0005829)
  • Cytosolic ribosome
    (GO:0022626)
  • Defense response to virus
    (GO:0051607)
  • Dna damage checkpoint signaling
    (GO:0000077)
  • Eif2alpha phosphorylation in response to endoplasmic reticulum stress
    (GO:0036492)
  • Endoplasmic reticulum unfolded protein response
    (GO:0030968)
  • Eukaryotic initiation factor eif2 binding
    (GO:0071074)
  • Eukaryotic translation initiation factor 2alpha kinase activity
    (GO:0004694)
  • Gcn2-mediated signaling
    (GO:0140469)
  • Histone h2as1 kinase activity
    (GO:0044024)
  • Learning
    (GO:0007612)
  • Long-term memory
    (GO:0007616)
  • Negative regulation by host of viral genome replication
    (GO:0044828)
  • Negative regulation of creb transcription factor activity
    (GO:0032792)
  • Negative regulation of neuron differentiation
    (GO:0045665)
  • Negative regulation of translation
    (GO:0017148)
  • Negative regulation of translational initiation
    (GO:0045947)
  • Negative regulation of translational initiation in response to stress
    (GO:0032057)
  • Neuron projection extension
    (GO:1990138)
  • Nucleus
    (GO:0005634)
  • Positive regulation of adaptive immune response
    (GO:0002821)
  • Positive regulation of defense response to virus by host
    (GO:0002230)
  • Positive regulation of gene expression
    (GO:0010628)
  • Positive regulation of long-term synaptic potentiation
    (GO:1900273)
  • Positive regulation of protein phosphorylation
    (GO:0001934)
  • Positive regulation of translational initiation in response to starvation
    (GO:0071264)
  • Protein autophosphorylation
    (GO:0046777)
  • Protein binding
    (GO:0005515)
  • Protein phosphorylation
    (GO:0006468)
  • Protein serine/threonine kinase activity
    (GO:0004674)
  • Protein serine kinase activity
    (GO:0106310)
  • Regulation of cytoplasmic translational initiation in response to stress
    (GO:1990611)
  • Regulation of feeding behavior
    (GO:0060259)
  • Regulation of translational initiation
    (GO:0006446)
  • Regulation of translational initiation by eif2 alpha phosphorylation
    (GO:0010998)
  • Regulation of translational initiation in response to stress
    (GO:0043558)
  • Response to endoplasmic reticulum stress
    (GO:0034976)
  • T cell activation involved in immune response
    (GO:0002286)
  • Trna binding
    (GO:0000049)
  • Viral translation
    (GO:0019081)

Other Information

Genular Protein ID: 3629503853

Symbol: E2AK4_MOUSE

Name: GCN2-like protein

UniProtKB Accession Codes:

Q9QZ05 A2AUM3 A2AUM4 Q6GQT4 Q6ZPT5 Q8C5S0 Q8CIF5 Q9CT30 Q9CUV9 Q9ESB6 Q9ESB7 Q9ESB8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 2 CDD 2 CTD 1 ChEBI 12 ChiTaRS 1 DNASU 1 EC 2 EMBL 11 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 46 Gene3D 3 GeneTree 1 HOGENOM 1 InParanoid 1 InterPro 12 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 1 PDB 2 PDBsum 2 PIRSF 1 PRO 1 PROSITE 4 PaxDb 1 PeptideAtlas 1 Pfam 4 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 Pumba 1 RNAct 1 RefSeq 3 Rhea 6 SMART 2 SMR 1 STRING 1 SUPFAM 3 TCDB 1 UCSC 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 10504407

Title: Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2alpha kinase.

PubMed ID: 10504407

DOI: 10.1046/j.1432-1327.1999.00780.x

PubMed ID: 10655230

Title: A mammalian homologue of GCN2 protein kinase important for translational control by phosphorylation of eukaryotic initiation factor-2alpha.

PubMed ID: 10655230

DOI: 10.1093/genetics/154.2.787

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14621295

Title: Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

PubMed ID: 14621295

DOI: 10.1093/dnares/10.4.167

PubMed ID: 11106749

Title: Regulated translation initiation controls stress-induced gene expression in mammalian cells.

PubMed ID: 11106749

DOI: 10.1016/s1097-2765(00)00108-8

PubMed ID: 12176355

Title: Activation of GCN2 in UV-irradiated cells inhibits translation.

PubMed ID: 12176355

DOI: 10.1016/s0960-9822(02)01037-0

PubMed ID: 12215525

Title: The GCN2 eIF2alpha kinase is required for adaptation to amino acid deprivation in mice.

PubMed ID: 12215525

DOI: 10.1128/mcb.22.19.6681-6688.2002

PubMed ID: 15213227

Title: Preservation of liver protein synthesis during dietary leucine deprivation occurs at the expense of skeletal muscle mass in mice deleted for eIF2 kinase GCN2.

PubMed ID: 15213227

DOI: 10.1074/jbc.m404559200

PubMed ID: 16054071

Title: The GCN2 kinase biases feeding behavior to maintain amino acid homeostasis in omnivores.

PubMed ID: 16054071

DOI: 10.1016/j.cmet.2005.03.004

PubMed ID: 16176978

Title: PERK and GCN2 contribute to eIF2alpha phosphorylation and cell cycle arrest after activation of the unfolded protein response pathway.

PubMed ID: 16176978

DOI: 10.1091/mbc.e05-03-0268

PubMed ID: 16121183

Title: Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2.

PubMed ID: 16121183

DOI: 10.1038/nature03897

PubMed ID: 15774759

Title: Uncharged tRNA and sensing of amino acid deficiency in mammalian piriform cortex.

PubMed ID: 15774759

DOI: 10.1126/science.1104882

PubMed ID: 16601681

Title: Antiviral effect of the mammalian translation initiation factor 2alpha kinase GCN2 against RNA viruses.

PubMed ID: 16601681

DOI: 10.1038/sj.emboj.7601073

PubMed ID: 19797084

Title: Translational control of protein kinase Ceta by two upstream open reading frames.

PubMed ID: 19797084

DOI: 10.1128/mcb.01044-09

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20660158

Title: Phosphorylation of eIF2alpha at serine 51 is an important determinant of cell survival and adaptation to glucose deficiency.

PubMed ID: 20660158

DOI: 10.1091/mbc.e10-01-0023

PubMed ID: 23447528

Title: IMPACT is a developmentally regulated protein in neurons that opposes the eukaryotic initiation factor 2alpha kinase GCN2 in the modulation of neurite outgrowth.

PubMed ID: 23447528

DOI: 10.1074/jbc.m113.461970

PubMed ID: 24333428

Title: Evolutionarily conserved IMPACT impairs various stress responses that require GCN1 for activating the eIF2 kinase GCN2.

PubMed ID: 24333428

DOI: 10.1016/j.bbrc.2013.12.021

PubMed ID: 24310610

Title: Vaccine activation of the nutrient sensor GCN2 in dendritic cells enhances antigen presentation.

PubMed ID: 24310610

DOI: 10.1126/science.1246829

PubMed ID: 25329545

Title: p58IPK is an inhibitor of the eIF2alpha kinase GCN2 and its localization and expression underpin protein synthesis and ER processing capacity.

PubMed ID: 25329545

DOI: 10.1042/bj20140852

PubMed ID: 26102367

Title: Translational Upregulation of an Individual p21Cip1 Transcript Variant by GCN2 Regulates Cell Proliferation and Survival under Nutrient Stress.

PubMed ID: 26102367

DOI: 10.1371/journal.pgen.1005212

PubMed ID: 15273307

Title: Solution structure of the RWD domain of the mouse GCN2 protein.

PubMed ID: 15273307

DOI: 10.1110/ps.04751804

Sequence Information:

  • Length: 1648
  • Mass: 186487
  • Checksum: F27841DDB317EFCB
  • Sequence:
    • MAGGRGASGR GRAEPQESYS QRQDHELQAL EAIYGSDFQD LRPDARGRVR EPPEINLVLY 
PQGLAGEEVY VQVELQVKCP PTYPDVVPEI ELKNAKGLSN ESVNLLKSHL EELAKKQCGE 
VMIFELAHHV QSFLSEHNKP PPKSFHEEML ERQAQEKQQR LLEARRKEEQ EQREILHEIQ 
RRKEEIKEEK KRKEMAKQER LEITSLTNQD YASKRDPAGH RAAAILHGGS PDFVGNGKAR 
TYSSGRSRRE RQYSVCSGEP SPGSCDILHF SVGSPDQLMV HKGRCVGSDE QLGKVVYNAL 
ETATGSFVLL HEWVLQWQKM GPCLTSQEKE KIDKCKRQIQ GAETEFSSLV KLSHPNIVRY 
FAMNSREEED SIVIDILAEH VSGISLATHL SHSGPVPAHQ LRKYTAQLLA GLDYLHSNSV 
VHKVLSASSV LVDAEGTVKI TDYSISKRLA DICKEDVFEQ ARVRFSDSAL PYKTGKKGDV 
WRLGLLLLSL SQGQECGEYP VTIPSDLPAD FQDFLKKCVC LDDKERWSPQ QLLKHSFINP 
QPKLPLVEQS PEDSGGQDYI ETVIPSNQLP SAAFFSETQK QFSRYFIEFE ELQLLGKGAF 
GAVIKVQNKL DGCCYAVKRI PINPASRHFR RIKGEVTLLS RLHHENIVRY YNAWIERHER 
PAVPGTPPPD CTPQAQDSPA TCGKTSGDTE ELGSVEAAAP PPILSSSVEW STSAERSTST 
RFPVTGQDSS SDEEDEDERD GVFSQSFLPA SDSDSDIIFD NEDENSKSQN QDEDCNQKDG 
SHEIEPSVTA EAVHYLYIQM EYCEKSTLRD TIDQGLFRDT SRLWRLFREI LDGLAYIHEK 
GMIHRDLKPV NIFLDSDDHV KIGDFGLATD HLAFTAEGKQ DDQAGDGVIK SDPSGHLTGM 
VGTALYVSPE VQGSTKSAYN QKVDLFSLGI IFFEMSYHPM VTASERIFVL NQLRDPTSPK 
FPDDFDDGEH TKQKSVISWL LNHDPAKRPT AMELLKSELL PPPQMEESEL HEVLHHTLAN 
IDGKAYRTMM SQIFCQHISP AIDYTYDSDI LKGNFLIRTA KIQQLVCETI VRVFKRHGAV 
QLCTPLLLPR NRQIYEHNEA ALFMDHSGML VMLPFDLRVP FARYVARNNI LNLKRYCIER 
VFRPRKLDRF HPKELLECAF DIVTSTTNSS LPTAETIYTI YEIIQEFPAL QERNYSIYLN 
HTMLLKAILL HCGIPEDKLS QVYVILYDAV TEKLTRREVE AKFCNLSLSS NSLCRLYKFI 
EQKGDLQDLT PTINSLIKQK TGVAQLVKYS LKDLEDVVGL LKKLGVKLQV SINLGLVYKV 
QQHTGIIFQF LAFSKRRQRV VPEILAAGGR YDLLIPKFRG PQTVGPVPTA VGVSIAIDKI 
FAAVLNMEEP VTVSSCDLLV VSVGQMSMSR AINLTQKLWT AGITAEIMYD WSQSQEELQE 
YCRHHEITYV ALVSDKEGSH VKVKSFEKER QTEKRVLESD LVDHVMQKLR TKVGDERNFR 
DASDNLAVQT LKGSFSNASG LFEIHGTTVV PNVIVLAPEK LSASTRRRHE IQVQTRLQTT 
LANLHQKSSE IEILAVDLPK ETILQFLSLE WDADEQAFNT TVKQLLSRLP KQRYLKLVCD 
EIYNIKVEKK VSVLFLYSYR DDYYRILF

Genular Protein ID: 1020821684

Symbol: A2AUM0_MOUSE

Name: N/A

UniProtKB Accession Codes:

A2AUM0

Database IDs:

AGR 1 ARBA 8 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChEBI 12 ChiTaRS 1 DNASU 1 EC 2 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 3 GeneTree 1 InterPro 12 KEGG 1 MGI 2 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 1 PIRSF 1 PIRSR 2 PROSITE 6 PROSITE-ProRule 1 PeptideAtlas 2 Pfam 4 PhylomeDB 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 Rhea 6 SAM 2 SMART 2 SMR 1 SUPFAM 3 TreeFam 1 UCSC 1 VEuPathDB 1 jPOST 1

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21750661

Title: Modernizing reference genome assemblies.

PubMed ID: 21750661

Sequence Information:

  • Length: 1648
  • Mass: 186501
  • Checksum: E141BFAAB8778FA1
  • Sequence:
    • MAGGRGASGR GRAEPQESYS QRQDHELQAL EAIYGSDFQD LRPDARGRVR EPPEINLVLY 
PQGLAGEEVY VQVELRVKCP PTYPDVVPEI DLKNAKGLSN ESVNLLKSHL EELAKKQCGE 
VMIFELAHHV QSFLSEHNKP PPKSFHEEML ERQAQEKQQR LLEARRKEEQ EQREILHEIQ 
RRKEEIKEEK KRKEMAKQER LEITSLTNQD YASKRDPAGH RAAAILHGGS PDFVGNGKAR 
TYSSGRSRRE RQYSVCSGEP SPGSCDILHF SVGSPDQLMV HKGRCVGSDE QLGKVVYNAL 
ETATGSFVLL HEWVLQWQKM GPCLTSQEKE KIDKCKRQIQ GAETEFSSLV KLSHPNIVRY 
FAMNSREEED SIVIDILAEH VSGISLATHL SHSGPVPAHQ LRKYTAQLLA GLDYLHSNSV 
VHKVLSASSV LVDAEGTVKI TDYSISKRLA DICKEDVFEQ ARVRFSDSAL PYKTGKKGDV 
WRLGLLLLSL SQGQECGEYP VTIPSDLPAD FQDFLKKCVC LDDKERWSPQ QLLKHSFINP 
QPKLPLVEQS PEDSGGQDYI ETVIPSNQLP SAAFFSETQK QFSRYFIEFE ELQLLGKGAF 
GAVIKVQNKL DGCCYAVKRI PINPASRHFR RIKGEVTLLS RLHHENIVRY YNAWIERHER 
PAVPGTPPPD CTPQAQDSPA TCGKTSGDTE ELGSVEAAAP PPILSSSVEW STSAERSTST 
RFPVTGQDSS SDEEDEDERD GVFSQSFLPA SDSDSDIIFD NEDENSKSQN QDEDCNQKDG 
SHEIEPSVTA EAVHYLYIQM EYCEKSTLRD TIDQGLFRDT SRLWRLFREI LDGLAYIHEK 
GMIHRDLKPV NIFLDSDDHV KIGDFGLATD HLAFTAEGKQ DDQAGDGVIK SDPSGHLTGM 
VGTALYVSPE VQGSTKSAYN QKVDLFSLGI IFFEMSYHPM VTASERIFVL NQLRDPTSPK 
FPDDFDDGEH TKQKSVISWL LNHDPAKRPT AMELLKSELL PPPQMEESEL HEVLHHTLAN 
IDGKAYRTMM SQIFCQHISP AIDYTYDSDI LKGNFLIRTA KIQQLVCETI VRVFKRHGAV 
QLCTPLLLPR NRQIYEHNEA ALFMDHSGML VMLPFDLRVP FARYVARNNI LNLKRYCIER 
VFRPRKLDRF HPKELLECAF DIVTSTTNSS LPTAETIYTI YEIIQEFPAL QERNYSIYLN 
HTMLLKAILL HCGIPEDKLS QVYVILYDAV TEKLTRREVE AKFCNLSLSS NSLCRLYKFI 
EQKGDLQDLT PTINSLIKQK TGVAQLVKYS LKDLEDVVGL LKKLGVKLQV SINLGLVYKV 
QQHTGIIFQF LAFSKRRQRV VPEILAAGGR YDLLIPKFRG PQTVGPVPTA VGVSIAIDKI 
FAAVLNMEEP VTVSSCDLLV VSVGQMSMSR AINLTQKLWT AGITAEIMYD WSQSQEELQE 
YCRHHEITYV ALVSDKEGSH VKVKSFEKER QTEKRVLESD LVDHVMQKLR TKVGDERNFR 
DASDNLAVQT LKGSFSNASG LFEIHGTTVV PNVIVLAPEK LSASTRRRHE IQVQTRLQTT 
LANLHQKSSE IEILAVDLPK ETILQFLSLE WDADEQAFNT TVKQLLSRLP KQRYLKLVCD 
EIYNIKVEKK VSVLFLYSYR DDYYRILF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.