Details for: Eif2ak1

Gene ID: 27137

Symbol: Eif2ak1

Ensembl ID: ENSRNOG00000001050

Description: eukaryotic translation initiation factor 2 alpha kinase 1

Associated with

Other Information

Genular Protein ID: 2999402578

Symbol: E2AK1_RAT

Name: Heme-controlled repressor

UniProtKB Accession Codes:

Q63185 Q642C7

Database IDs:

AGR 1 AlphaFoldDB 1 Bgee 1 CDD 1 CTD 1 ChEBI 12 EC 2 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 26 Gene3D 1 GeneTree 1 InParanoid 1 InterPro 5 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 3 PaxDb 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 2 RGD 1 Reactome 1 RefSeq 1 Rhea 8 SMART 1 STRING 1 SUPFAM 1 TreeFam 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 7908290

Title: Cloning and characterization of cDNA encoding rat hemin-sensitive initiation factor-2 alpha (eIF-2 alpha) kinase. Evidence for multitissue expression.

PubMed ID: 7908290

DOI: 10.1016/s0021-9258(17)34044-9

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 20071449

Title: Hepatic heme-regulated inhibitor (HRI) eukaryotic initiation factor 2alpha kinase: a protagonist of heme-mediated translational control of CYP2B enzymes and a modulator of basal endoplasmic reticulum stress tone.

PubMed ID: 20071449

DOI: 10.1124/mol.109.061259

PubMed ID: 34404736

Title: Notice of Retraction: Acharya P, Chen J-J, Correia MA (2010) Hepatic heme-regulated inhibitor (HRI) eukaryotic initiation factor 2alpha kinase: a protagonist of heme-mediated translational control of CYP2B enzymes and a modulator of basal endoplasmic reticulum stress tone. Mol Pharmacol 77(4):575-592; doi:10.1124/mol.109.061259.

PubMed ID: 34404736

DOI: 10.1124/mol.109.061259retraction

PubMed ID: 22673903

Title: Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.

PubMed ID: 22673903

DOI: 10.1038/ncomms1871

Sequence Information:

  • Length: 620
  • Mass: 69586
  • Checksum: A4E56A2FBFCCEDDC
  • Sequence:
    • MLGGGSVDGE RDTDDDAAGA VAAPPAIDFP AEVSDPKYDE SDVPAELQVF KEPLQQPTFP 
FLVANQLLLV SLLEHLSHVH EPNPLHSKQV FKLLCQTFIK MGLLSSFTCS DEFSSLRLHH 
NRAITHLMRS AKERVRQDPC QDNSYMQKIR SREIALEAQT SRYLNEFEEL AILGKGGYGR 
VYKVRNKLDG QHYAIKKILI KSATKTDCMK VLREVKVLAG LQHPNIVGYH TAWIEHVHVL 
QPQDRVPIQL PSLEVLSEHE GDRNQGGVKD NESSSSIIFA ELTPEKENPL AESDVKNENN 
NLVSYRANLV IRSSSESESS IELQEDGLNE SPLRPVVKHQ LPLGHSSDVE GNFTSTDESS 
EDNLNLLGQT EARYHLMLHI QMQLCELSLW DWIAERNNRS RECVDEAACP YVMASVATKI 
FQELVEGVFY IHNMGIVHRD LKPRNIFLHG PDQQVKIGDF GLACADIIQK SADWTNRNGK 
GTPTHTSRVG TCLYASPEQL EGSEYDAKSD MYSLGVILLE LFQPFGTEME RATVLTGVRT 
GRIPESLSKR CPVQAKYIQL LTGRNAAQRP SALQLLQSEL FQTTGNVNLT LQMKIMEQEK 
EIEELKKQLS LLSQDKGLKR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.