Details for: Mixl1

Gene ID: 27217

Symbol: Mixl1

Ensembl ID: ENSMUSG00000026497

Description: Mix paired-like homeobox

Associated with

  • Cell migration involved in gastrulation
    (GO:0042074)
  • Chromatin
    (GO:0000785)
  • Cis-regulatory region sequence-specific dna binding
    (GO:0000987)
  • Digestive tract development
    (GO:0048565)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Endodermal cell differentiation
    (GO:0035987)
  • Endoderm development
    (GO:0007492)
  • Endoderm formation
    (GO:0001706)
  • Gastrulation
    (GO:0007369)
  • Heart development
    (GO:0007507)
  • Hematopoietic progenitor cell differentiation
    (GO:0002244)
  • Hemopoiesis
    (GO:0030097)
  • Identical protein binding
    (GO:0042802)
  • Negative regulation of hematopoietic progenitor cell differentiation
    (GO:1901533)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of mesoderm development
    (GO:2000382)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Protein homodimerization activity
    (GO:0042803)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii-specific dna-binding transcription factor binding
    (GO:0061629)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Other Information

Genular Protein ID: 32217779

Symbol: MIXL1_MOUSE

Name: Homeobox protein MIXL1

UniProtKB Accession Codes:

Q9WUI0 Q9QZ61

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 6 Ensembl 1 GO 23 Gene3D 1 GeneTree 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PaxDb 1 PeptideAtlas 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1

Citations:

PubMed ID: 10495285

Title: Mml, a mouse Mix-like gene expressed in the primitive streak.

PubMed ID: 10495285

DOI: 10.1016/s0925-4773(99)00135-5

PubMed ID: 11084649

Title: Cloning, expression analysis, and chromosomal localization of murine and human homologues of a Xenopus mix gene.

PubMed ID: 11084649

DOI: 10.1002/1097-0177(2000)9999:9999<::aid-dvdy1070>3.0.co;2-o

PubMed ID: 12095687

Title: Structure, upstream promoter region, and functional domains of a mouse and human Mix paired-like homeobox gene.

PubMed ID: 12095687

DOI: 10.1016/s0378-1119(02)00590-5

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12117810

Title: Mixl1 is required for axial mesendoderm morphogenesis and patterning in the murine embryo.

PubMed ID: 12117810

DOI: 10.1242/dev.129.15.3597

PubMed ID: 12619131

Title: Mouse Mix gene is activated early during differentiation of ES and F9 stem cells and induces endoderm in frog embryos.

PubMed ID: 12619131

DOI: 10.1002/dvdy.10263

PubMed ID: 15982639

Title: Transcriptional regulation of the homeobox gene Mixl1 by TGF-beta and FoxH1.

PubMed ID: 15982639

DOI: 10.1016/j.bbrc.2005.06.044

PubMed ID: 15673572

Title: The primitive streak gene Mixl1 is required for efficient haematopoiesis and BMP4-induced ventral mesoderm patterning in differentiating ES cells.

PubMed ID: 15673572

DOI: 10.1242/dev.01657

PubMed ID: 16433620

Title: Mixl1 and oct4 proteins are transiently co-expressed in differentiating mouse and human embryonic stem cells.

PubMed ID: 16433620

DOI: 10.1089/scd.2005.14.656

PubMed ID: 16403910

Title: Acceleration of mesoderm development and expansion of hematopoietic progenitors in differentiating ES cells by the mouse Mix-like homeodomain transcription factor.

PubMed ID: 16403910

DOI: 10.1182/blood-2005-10-4120

PubMed ID: 17060613

Title: Enforced expression of the homeobox gene Mixl1 impairs hematopoietic differentiation and results in acute myeloid leukemia.

PubMed ID: 17060613

DOI: 10.1073/pnas.0607776103

PubMed ID: 17151016

Title: Sequential allocation and global pattern of movement of the definitive endoderm in the mouse embryo during gastrulation.

PubMed ID: 17151016

DOI: 10.1242/dev.02724

PubMed ID: 17568773

Title: Foxh1 recruits Gsc to negatively regulate Mixl1 expression during early mouse development.

PubMed ID: 17568773

DOI: 10.1038/sj.emboj.7601753

PubMed ID: 17446562

Title: Dissecting the molecular hierarchy for mesendoderm differentiation through a combination of embryonic stem cell culture and RNA interference.

PubMed ID: 17446562

DOI: 10.1634/stemcells.2006-0681

Sequence Information:

  • Length: 231
  • Mass: 24844
  • Checksum: 59DA80A5E7E6EE33
  • Sequence:
    • MAAAGSQQLQ FAEGAAFPIF PAAHPGGQLL PAMRPASGLP AAPHDSRAPA ATQCFPNRDS 
SPTAQTPAGL DPPGPSKGSA APSAPQRRKR TSFSSEQLQL LELVFRQTMY PDIHLRERLA 
ALTLLPESRI QVWFQNRRAK SRRQSGKSFQ PLSSRRGVFL HCPAPGTEAR CLKPQLPLEA 
DVNHVPDPSM TGGGVCTSGS QSFETYSSLS EDIGSKLDSW EEHIFSALGN F

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.