Details for: Pdk4

Gene ID: 27273

Symbol: Pdk4

Ensembl ID: ENSMUSG00000019577

Description: pyruvate dehydrogenase kinase, isoenzyme 4

Associated with

Other Information

Genular Protein ID: 9457553

Symbol: PDK4_MOUSE

Name: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial

UniProtKB Accession Codes:

O70571

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChEBI 9 ChiTaRS 1 DNASU 1 EC 2 EMBL 3 Ensembl 1 ExpressionAtlas 1 GO 20 Gene3D 2 GeneTree 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PaxDb 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 Rhea 3 SMART 1 SMR 1 STRING 1 SUPFAM 2 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16606348

Title: Role of pyruvate dehydrogenase kinase isoenzyme 4 (PDHK4) in glucose homoeostasis during starvation.

PubMed ID: 16606348

DOI: 10.1042/bj20060125

PubMed ID: 17669420

Title: Three members of the human pyruvate dehydrogenase kinase gene family are direct targets of the peroxisome proliferator-activated receptor beta/delta.

PubMed ID: 17669420

DOI: 10.1016/j.jmb.2007.06.091

PubMed ID: 18430968

Title: Pyruvate dehydrogenase kinase-4 deficiency lowers blood glucose and improves glucose tolerance in diet-induced obese mice.

PubMed ID: 18430968

DOI: 10.1152/ajpendo.00536.2007

PubMed ID: 18083902

Title: Overexpression of pyruvate dehydrogenase kinase 4 in heart perturbs metabolism and exacerbates calcineurin-induced cardiomyopathy.

PubMed ID: 18083902

DOI: 10.1152/ajpheart.00870.2007

PubMed ID: 19627255

Title: Pyruvate dehydrogenase kinase isoenzyme 4 (PDHK4) deficiency attenuates the long-term negative effects of a high-saturated fat diet.

PubMed ID: 19627255

DOI: 10.1042/bj20090390

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21321124

Title: Chronic inhibition of pyruvate dehydrogenase in heart triggers an adaptive metabolic response.

PubMed ID: 21321124

DOI: 10.1074/jbc.m110.217349

PubMed ID: 22360721

Title: Fasting induces ketoacidosis and hypothermia in PDHK2/PDHK4-double-knockout mice.

PubMed ID: 22360721

DOI: 10.1042/bj20112197

PubMed ID: 21803180

Title: Pyruvate dehydrogenase kinase 4 induces bone loss at unloading by promoting osteoclastogenesis.

PubMed ID: 21803180

DOI: 10.1016/j.bone.2011.07.012

PubMed ID: 22436846

Title: Stimulation of glucose oxidation protects against acute myocardial infarction and reperfusion injury.

PubMed ID: 22436846

DOI: 10.1093/cvr/cvs129

Sequence Information:

  • Length: 412
  • Mass: 46596
  • Checksum: 74815502E711054C
  • Sequence:
    • MKAARFVMRS ASSLSSASLV PREVELFSRY SPSPLSMKQL LDFGSENACE RTSFAFLRQE 
LPVRLANILK EIDILPDRLV NTPSVQLVKS WYIQSLMDLV EFHEKSPEDQ KALSEFVDTL 
VKVRNRHHNV VPTMAQGILE YKDTCTVDPV TNQNLQYFLD RFYMNRISTR MLMNQHILIF 
SDSKTGNPSH IGSIDPNCDV VAVVQDAFEC AKMLCDQYYL TSPELNLTQV NGKFPGQPIH 
IVYVPSHLHH MLFELFKNAM RATVEHQENR PSLTPVEATV VLGKEDLTIK ISDRGGGVPL 
RITDRLFSYT YSTAPTPVMD NSRNAPLAGF GYGLPISRLY AKYFQGDLNL YSMSGYGTDA 
IIYLKALSSE SVEKLPVFNK SAFKHYQMSS EADDWCIPSR EPKNLAKEKL AV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.