Details for: Clnk

Gene ID: 27278

Symbol: Clnk

Ensembl ID: ENSMUSG00000039315

Description: cytokine-dependent hematopoietic cell linker

Associated with

Other Information

Genular Protein ID: 3568865957

Symbol: CLNK_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q9QZE2 Q8C479 Q9JMJ3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CTD 1 ChiTaRS 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneTree 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MGI 1 MINT 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 1 TopDownProteomics 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 10562326

Title: Clnk, a novel SLP-76-related adaptor molecule expressed in cytokine-stimulated hemopoietic cells.

PubMed ID: 10562326

DOI: 10.1084/jem.190.10.1527

PubMed ID: 10744659

Title: A BASH/SLP-76-related adaptor protein MIST/Clnk involved in IgE receptor-mediated mast cell degranulation.

PubMed ID: 10744659

DOI: 10.1093/intimm/12.4.573

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 11463797

Title: MIST functions through distinct domains in immunoreceptor signaling in the presence and absence of LAT.

PubMed ID: 11463797

DOI: 10.1074/jbc.m106390200

PubMed ID: 11509653

Title: Synergistic regulation of immunoreceptor signaling by SLP-76-related adaptor Clnk and serine/threonine protein kinase HPK-1.

PubMed ID: 11509653

DOI: 10.1128/mcb.21.18.6102-6112.2001

PubMed ID: 12681493

Title: Targeting of MIST to Src-family kinases via SKAP55-SLAP-130 adaptor complex in mast cells(1).

PubMed ID: 12681493

DOI: 10.1016/s0014-5793(03)00234-5

PubMed ID: 15199160

Title: Immune functions in mice lacking Clnk, an SLP-76-related adaptor expressed in a subset of immune cells.

PubMed ID: 15199160

DOI: 10.1128/mcb.24.13.6067-6075.2004

PubMed ID: 16439675

Title: Dual function for the adaptor MIST in IFN-gamma production by NK and CD4+NKT cells regulated by the Src kinase Fgr.

PubMed ID: 16439675

DOI: 10.1182/blood-2005-10-4102

PubMed ID: 17947660

Title: Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.

PubMed ID: 17947660

DOI: 10.4049/jimmunol.179.9.5864

PubMed ID: 26009488

Title: Clnk plays a role in TNF-alpha-induced cell death in murine fibrosarcoma cell line L929.

PubMed ID: 26009488

DOI: 10.1016/j.bbrc.2015.05.046

Sequence Information:

  • Length: 435
  • Mass: 49492
  • Checksum: 5CD27EC971FC0EA5
  • Sequence:
    • MTSQGNKRTT KEGFGDLRFQ NVSLLKNRSW PSLSSAKGRC RAVLEPLPDH RRNLAGVPGG 
EKCNSNNDYE DPEFQLLKAW PSMKILPARP IQESEYADTR YFQDTMEAPL LLPPKASVST 
ERQTRDVRMT HLEEVDKPTF KDVRSQRFKG FKYTKINKTP LPPPRPAITL PKKYQPLPPA 
PPEESSAYFA PKPTFPEVQR GPRQRSAKDF SRVLGAEEES HHQTKPESSC PSSNQNTQKS 
PPAIASSSYM PGKHSIQARD HTGSMQHCPA QRCQAAASHS PRMLPYENTN SEKPDPTKPD 
EKDVWQNEWY IGEYSRQAVE DVLMKENKDG TFLVRDCSTK SKAEPYVLVV FYGNKVYNVK 
IRFLESNQQF ALGTGLRGNE MFDSVEDIIE HYTYFPILLI DGKDKAARRK QCYLTQPLPL 
ARLLLTQYSS QALHE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.