Nbn | ENSMUSG00000028224 | NCBI 27354

Details for: Nbn

Gene ID: 27354

Symbol: Nbn

Ensembl ID: ENSMUSG00000028224

Description: nibrin

Associated with

Cell cycle
(R-MMU-1640170)
Cell cycle checkpoints
(R-MMU-69620)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular senescence
(R-MMU-2559583)
Dna damage/telomere stress induced senescence
(R-MMU-2559586)
Dna double-strand break repair
(R-MMU-5693532)
Dna double strand break response
(R-MMU-5693606)
Dna repair
(R-MMU-73894)
G2/m checkpoints
(R-MMU-69481)
G2/m dna damage checkpoint
(R-MMU-69473)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Hdr through homologous recombination (hrr)
(R-MMU-5685942)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-MMU-5693567)
Hdr through mmej (alt-nhej)
(R-MMU-5685939)
Hdr through single strand annealing (ssa)
(R-MMU-5685938)
Homologous dna pairing and strand exchange
(R-MMU-5693579)
Homology directed repair
(R-MMU-5693538)
Nonhomologous end-joining (nhej)
(R-MMU-5693571)
Presynaptic phase of homologous dna pairing and strand exchange
(R-MMU-5693616)
Processing of dna double-strand break ends
(R-MMU-5693607)
Recruitment and atm-mediated phosphorylation of repair and signaling proteins at dna double strand breaks
(R-MMU-5693565)
Regulation of tp53 activity
(R-MMU-5633007)
Regulation of tp53 activity through phosphorylation
(R-MMU-6804756)
Resolution of d-loop structures
(R-MMU-5693537)
Resolution of d-loop structures through holliday junction intermediates
(R-MMU-5693568)
Rna polymerase ii transcription
(R-MMU-73857)
Sensing of dna double strand breaks
(R-MMU-5693548)
Transcriptional regulation by tp53
(R-MMU-3700989)
Blastocyst growth
(GO:0001832)
Brca1-c complex
(GO:0070533)
Chromatin-protein adaptor activity
(GO:0140463)
Chromosomal region
(GO:0098687)
Chromosome, telomeric region
(GO:0000781)
Damaged dna binding
(GO:0003684)
Dna-binding transcription factor binding
(GO:0140297)
Dna damage checkpoint signaling
(GO:0000077)
Dna double-strand break processing
(GO:0000729)
Dna duplex unwinding
(GO:0032508)
Dna strand resection involved in replication fork processing
(GO:0110025)
Double-strand break repair
(GO:0006302)
Double-strand break repair via alternative nonhomologous end joining
(GO:0097681)
Double-strand break repair via homologous recombination
(GO:0000724)
Golgi apparatus
(GO:0005794)
Histone binding
(GO:0042393)
Homologous recombination
(GO:0035825)
Intrinsic apoptotic signaling pathway
(GO:0097193)
In utero embryonic development
(GO:0001701)
Isotype switching
(GO:0045190)
Meiotic cell cycle
(GO:0051321)
Mitotic g2 dna damage checkpoint signaling
(GO:0007095)
Mitotic g2/m transition checkpoint
(GO:0044818)
Mre11 complex
(GO:0030870)
Negative regulation of neuron differentiation
(GO:0045665)
Negative regulation of telomere capping
(GO:1904354)
Negative regulation of viral entry into host cell
(GO:0046597)
Neuroblast proliferation
(GO:0007405)
Neuromuscular process controlling balance
(GO:0050885)
Nuclear inclusion body
(GO:0042405)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Phosphorylation-dependent protein binding
(GO:0140031)
Pml body
(GO:0016605)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of kinase activity
(GO:0033674)
Positive regulation of protein autophosphorylation
(GO:0031954)
Positive regulation of telomere maintenance
(GO:0032206)
Protection from non-homologous end joining at telomere
(GO:0031848)
Protein binding
(GO:0005515)
Protein localization to site of double-strand break
(GO:1990166)
Protein serine/threonine kinase activator activity
(GO:0043539)
R-loop processing
(GO:0062176)
Regulation of fibroblast proliferation
(GO:0048145)
Replication fork
(GO:0005657)
Site of double-strand break
(GO:0035861)
T-circle formation
(GO:0090656)
Telomere maintenance
(GO:0000723)
Telomere maintenance in response to dna damage
(GO:0043247)
Telomere maintenance via telomere trimming
(GO:0090737)
Telomeric 3' overhang formation
(GO:0031860)

Other Information

Proteins

Cell cycle regulatory protein p95

Genular Protein ID: 152780811

Symbol: NBN_MOUSE

Name: Cell cycle regulatory protein p95

UniProtKB Accession Codes:

Q9R207 O88981 Q3UY57 Q811I6 Q8CCY0 Q9R1X1

Database IDs:

Citations:

PubMed ID: 10640816

Title: Identification, characterization, and mapping of a mouse homolog of the gene mutated in Nijmegen breakage syndrome.

PubMed ID: 10640816

DOI: 10.1159/000015396

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 10915761

Title: Expression pattern of the Nijmegen breakage syndrome gene, Nbs1, during murine development.

PubMed ID: 10915761

DOI: 10.1093/hmg/9.12.1739

PubMed ID: 11231126

Title: Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice.

PubMed ID: 11231126

DOI: 10.1016/s0960-9822(01)00019-7

PubMed ID: 12470659

Title: Recruitment of NBS1 into PML oncogenic domains via interaction with SP100 protein.

PubMed ID: 12470659

DOI: 10.1016/s0006-291x(02)02755-9

PubMed ID: 17291760

Title: The Mre11 complex influences DNA repair, synapsis, and crossing over in murine meiosis.

PubMed ID: 17291760

DOI: 10.1016/j.cub.2006.12.048

PubMed ID: 17376776

Title: Mice lacking protein phosphatase 5 are defective in ataxia telangiectasia mutated (ATM)-mediated cell cycle arrest.

PubMed ID: 17376776

DOI: 10.1074/jbc.c700019200

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22464731

Title: Skp2 E3 ligase integrates ATM activation and homologous recombination repair by ubiquitinating NBS1.

PubMed ID: 22464731

DOI: 10.1016/j.molcel.2012.02.018

PubMed ID: 28216226

Title: NBS1 phosphorylation status dictates repair choice of dysfunctional telomeres.

PubMed ID: 28216226

DOI: 10.1016/j.molcel.2017.01.016

PubMed ID: 30017584

Title: MRI is a DNA damage response adaptor during classical non-homologous end joining.

PubMed ID: 30017584

DOI: 10.1016/j.molcel.2018.06.018

Sequence Information:

Length: 751
Mass: 83795
Checksum: C9F597CC08227B2C
Sequence:

MWKLLPAAGA APGEPYRLLA GVEYVVGRKN CGILIENDQS ISRNHAVLTV NFPVTSLSQT 
DEIPTLTIKD NSKYGTFVNE EKMQTGLSCT LKTGDRVTFG VFESKFRVEY EPLVVCSSCL 
DVSGKTVLNQ AILQLGGLTA NNWTEECTHL VMSAVKVTIK TICALICGRP IIKPEYFSEF 
LKAVESKKQP PDIESFYPPI DEPAIGSKSV DLSGRHERKQ IFKGKTFVFL NAKQHKKLSS 
AVAFGGGEAR LMAEDDEEEQ SFFSAPGTCV VDVGITNTQL IISHSQKKWI HLIMDTLQRN 
GLRPIPEAEI GLAVIFMTTE NYCNPQGQPC TELKTTTPGP SLSQVLSANG KIIPSAPVNM 
TTYVADTESE PADTCMPLSE RPEEVKIPGL EQSSRKLSQE TFNIKEAPKP SSKANNVASD 
TLVRGKTPSY QLSPMKFPVA NKNKDWTSQQ QQNSIKNYFQ PCTRKRERDE DNPELSSCKS 
SRMELSCSLL EQTQPAGPSL WKSKEHQSQN ATLDREADTS SVGGMDIELN RKSPDRKPLP 
TETLRPRKRK DVDLATEEEV LEELLRSTKP ELAVQVKVEK QEADDTIRKK PRMDAERNRP 
LNGGSEPESN SALQEDEREK KDELQTESWS TKHEIANSDG LQDSSEELPR KLLLTEFRSL 
VVSNHNSTSR NLCVNECGPL KNFKKFKKAT FPGAGKLPHI IGGSDLVGHH ARKNTELEEW 
LKQEMEVQKQ QAKEESLADD LFRYNPNVKR R

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Nbn

Associated with

Other Information

Identification, characterization, and mapping of a mouse homolog of the gene mutated in Nijmegen breakage syndrome. PubMed ID: 10640816

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Expression pattern of the Nijmegen breakage syndrome gene, Nbs1, during murine development. PubMed ID: 10915761

Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice. PubMed ID: 11231126

Recruitment of NBS1 into PML oncogenic domains via interaction with SP100 protein. PubMed ID: 12470659

The Mre11 complex influences DNA repair, synapsis, and crossing over in murine meiosis. PubMed ID: 17291760

Mice lacking protein phosphatase 5 are defective in ataxia telangiectasia mutated (ATM)-mediated cell cycle arrest. PubMed ID: 17376776

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. PubMed ID: 17525332

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Skp2 E3 ligase integrates ATM activation and homologous recombination repair by ubiquitinating NBS1. PubMed ID: 22464731

NBS1 phosphorylation status dictates repair choice of dysfunctional telomeres. PubMed ID: 28216226

MRI is a DNA damage response adaptor during classical non-homologous end joining. PubMed ID: 30017584