Yme1l1 | ENSMUSG00000026775 | NCBI 27377

Details for: Yme1l1

Gene ID: 27377

Symbol: Yme1l1

Ensembl ID: ENSMUSG00000026775

Description: YME1-like 1 (S. cerevisiae)

Associated with

Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular response to mitochondrial stress
(R-MMU-9840373)
Mitochondrial calcium ion transport
(R-MMU-8949215)
Processing of smdt1
(R-MMU-8949664)
Transport of small molecules
(R-MMU-382551)
Atp-dependent peptidase activity
(GO:0004176)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Cell population proliferation
(GO:0008283)
Cellular response to starvation
(GO:0009267)
Metal ion binding
(GO:0046872)
Metalloendopeptidase activity
(GO:0004222)
Mitochondrial inner membrane
(GO:0005743)
Mitochondrial protein catabolic process
(GO:0035694)
Mitochondrial protein processing
(GO:0034982)
Mitochondrion
(GO:0005739)
Mitochondrion organization
(GO:0007005)
Negative regulation of apoptotic process
(GO:0043066)
Neuronal stem cell population maintenance
(GO:0097150)
Nuclear body
(GO:0016604)
Positive regulation of mitochondrial fusion
(GO:0010636)
Protein hexamerization
(GO:0034214)
Protein quality control for misfolded or incompletely synthesized proteins
(GO:0006515)
Regulation of stem cell division
(GO:2000035)

Other Information

Proteins

ATP-dependent zinc metalloprotease YME1L1

Genular Protein ID: 1324552867

Symbol: YMEL1_MOUSE

Name: ATP-dependent zinc metalloprotease YME1L1

UniProtKB Accession Codes:

O88967 Q7TNN5

Database IDs:

Citations:

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17709429

Title: OPA1 processing controls mitochondrial fusion and is regulated by mRNA splicing, membrane potential, and Yme1L.

PubMed ID: 17709429

DOI: 10.1083/jcb.200704110

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 24703695

Title: Proteolytic cleavage of Opa1 stimulates mitochondrial inner membrane fusion and couples fusion to oxidative phosphorylation.

PubMed ID: 24703695

DOI: 10.1016/j.cmet.2014.03.011

PubMed ID: 24616225

Title: The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission.

PubMed ID: 24616225

DOI: 10.1083/jcb.201308006

PubMed ID: 26785494

Title: Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice.

PubMed ID: 26785494

DOI: 10.1126/science.aad0116

PubMed ID: 27495975

Title: Homozygous YME1L1 mutation causes mitochondriopathy with optic atrophy and mitochondrial network fragmentation.

PubMed ID: 27495975

DOI: 10.7554/elife.16078

PubMed ID: 30389680

Title: Loss of the mitochondrial i-AAA protease YME1L leads to ocular dysfunction and spinal axonopathy.

PubMed ID: 30389680

DOI: 10.15252/emmm.201809288

PubMed ID: 33237841

Title: Identification of new OPA1 cleavage site reveals that short isoforms regulate mitochondrial fusion.

PubMed ID: 33237841

DOI: 10.1091/mbc.e20-09-0605

PubMed ID: 35172139

Title: Metabolic control of adult neural stem cell self-renewal by the mitochondrial protease YME1L.

PubMed ID: 35172139

DOI: 10.1016/j.celrep.2022.110370

Sequence Information:

Length: 715
Mass: 80028
Checksum: 28A861C55B305106
Sequence:

MFSLSSTVQP QVTIPLSHLI NAFHSPKNIS VSVNTPVSQK QHRDTVPEHE APSSEPVLNL 
RDLGLSELKI GQIDKMVENL LPGFYKDKRV SSCWHTSHIS AQSFFENKYG HLDMFSTLRS 
SSLYRQHPKT LRSICSDLQY FPVFIQSRGF KTLKSRTRRL QSTSERLVEA QNIAPSFVKG 
FLLRDRGTDL ESLDKLMKTK NIPEAHQDAF KTGFAEGFLK AQALTQKTND SLRRTRLILF 
VLLLFGIYGL LKNPFLSVRF RTTTGLDSAV DPVQMKNVTF EHVKGVEEAK QELQEVVEFL 
KNPQKFTVLG GKLPKGILLV GPPGTGKTLL ARAVAGEADV PFYYASGSEF DEMFVGVGAS 
RIRNLFREAK ANAPCVIFID ELDSVGGKRI ESPMHPYSRQ TINQLLAEMD GFKPNEGVII 
IGATNFPEAL DNALIRPGRF DMQVTVPRPD VKGRTEILKW YLNKIKFDKS VDPEIIARGT 
VGFSGAELEN LVNQAALKAA VDGKEMVTMK ELEFSKDKIL MGPERRSVEI DNKNKTITAY 
HESGHAIIAY YTKDAMPINK ATIMPRGPTL GHVSLLPEND RWNETRAQLL AQMDVSMGGR 
VAEELIFGTD HITTGASSDF DNATKIAKRM VTKFGMSEKL GVMTYSDTGK LSPETQSAIE 
QEIRILLRES YERAKHILKT HAKEHKNLAE ALLTYETLDA KEIQIVLEGK KLEVR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Yme1l1

Associated with

Other Information

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

OPA1 processing controls mitochondrial fusion and is regulated by mRNA splicing, membrane potential, and Yme1L. PubMed ID: 17709429

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Proteolytic cleavage of Opa1 stimulates mitochondrial inner membrane fusion and couples fusion to oxidative phosphorylation. PubMed ID: 24703695

The i-AAA protease YME1L and OMA1 cleave OPA1 to balance mitochondrial fusion and fission. PubMed ID: 24616225

Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice. PubMed ID: 26785494

Homozygous YME1L1 mutation causes mitochondriopathy with optic atrophy and mitochondrial network fragmentation. PubMed ID: 27495975

Loss of the mitochondrial i-AAA protease YME1L leads to ocular dysfunction and spinal axonopathy. PubMed ID: 30389680

Identification of new OPA1 cleavage site reveals that short isoforms regulate mitochondrial fusion. PubMed ID: 33237841

Metabolic control of adult neural stem cell self-renewal by the mitochondrial protease YME1L. PubMed ID: 35172139