Skp2 | ENSMUSG00000054115 | NCBI 27401

Details for: Skp2

Gene ID: 27401

Symbol: Skp2

Ensembl ID: ENSMUSG00000054115

Description: S-phase kinase-associated protein 2

Associated with

Adaptive immune system
(R-MMU-1280218)
Antigen processing: ubiquitination & proteasome degradation
(R-MMU-983168)
Apc/c-mediated degradation of cell cycle proteins
(R-MMU-174143)
Apc/c:cdh1 mediated degradation of cdc20 and other apc/c:cdh1 targeted proteins in late mitosis/early g1
(R-MMU-174178)
Cell cycle
(R-MMU-1640170)
Cell cycle, mitotic
(R-MMU-69278)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cellular response to chemical stress
(R-MMU-9711123)
Class i mhc mediated antigen processing & presentation
(R-MMU-983169)
Cyclin a:cdk2-associated events at s phase entry
(R-MMU-69656)
Cyclin d associated events in g1
(R-MMU-69231)
Cyclin e associated events during g1/s transition
(R-MMU-69202)
Deubiquitination
(R-MMU-5688426)
Dna replication
(R-MMU-69306)
G1 phase
(R-MMU-69236)
G1/s transition
(R-MMU-69206)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Immune system
(R-MMU-168256)
Keap1-nfe2l2 pathway
(R-MMU-9755511)
Metabolism of proteins
(R-MMU-392499)
Mitotic g1 phase and g1/s transition
(R-MMU-453279)
Neddylation
(R-MMU-8951664)
Orc1 removal from chromatin
(R-MMU-68949)
Post-translational protein modification
(R-MMU-597592)
Regulation of bach1 activity
(R-MMU-9708530)
Regulation of mitotic cell cycle
(R-MMU-453276)
Regulation of runx2 expression and activity
(R-MMU-8939902)
Rna polymerase ii transcription
(R-MMU-73857)
Scf(skp2)-mediated degradation of p27/p21
(R-MMU-187577)
S phase
(R-MMU-69242)
Switching of origins to a post-replicative state
(R-MMU-69052)
Synthesis of dna
(R-MMU-69239)
Transcriptional regulation by runx2
(R-MMU-8878166)
Ub-specific processing proteases
(R-MMU-5689880)
Cytosol
(GO:0005829)
Defense response to virus
(GO:0051607)
G1/s transition of mitotic cell cycle
(GO:0000082)
G2/m transition of mitotic cell cycle
(GO:0000086)
Identical protein binding
(GO:0042802)
Innate immune response
(GO:0045087)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of double-strand break repair via homologous recombination
(GO:1905168)
Positive regulation of intracellular estrogen receptor signaling pathway
(GO:0033148)
Positive regulation of protein polyubiquitination
(GO:1902916)
Positive regulation of smooth muscle cell proliferation
(GO:0048661)
Proteasome-mediated ubiquitin-dependent protein catabolic process
(GO:0043161)
Protein binding
(GO:0005515)
Protein k48-linked ubiquitination
(GO:0070936)
Protein k63-linked ubiquitination
(GO:0070534)
Protein polyubiquitination
(GO:0000209)
Regulation of apoptotic process
(GO:0042981)
Regulation of cell cycle
(GO:0051726)
Scf-dependent proteasomal ubiquitin-dependent protein catabolic process
(GO:0031146)
Scf ubiquitin ligase complex
(GO:0019005)
Ubiquitin-dependent protein catabolic process
(GO:0006511)
Ubiquitin-like ligase-substrate adaptor activity
(GO:1990756)

Other Information

Proteins

S-phase kinase-associated protein 2
A0A087WQ11_MOUSE

Genular Protein ID: 516498416

Symbol: SKP2_MOUSE

Name: S-phase kinase-associated protein 2

UniProtKB Accession Codes:

Q9Z0Z3 Q8BSG7 Q8C8Y9 Q8CB22 Q99J53

Database IDs:

Citations:

PubMed ID: 10790373

Title: Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication.

PubMed ID: 10790373

DOI: 10.1093/emboj/19.9.2069

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22464731

Title: Skp2 E3 ligase integrates ATM activation and homologous recombination repair by ubiquitinating NBS1.

PubMed ID: 22464731

DOI: 10.1016/j.molcel.2012.02.018

PubMed ID: 30366907

Title: A C9orf72-CARM1 axis regulates lipid metabolism under glucose starvation-induced nutrient stress.

PubMed ID: 30366907

DOI: 10.1101/gad.315564.118

Sequence Information:

Length: 424
Mass: 47766
Checksum: 5B7945C979D26AF9
Sequence:

MHRKHLQEIP DQSGNVTTSF TWGWDSSKTS ELLSGMGVSA LEKEEVDSEN IPHGLLSNLG 
HPQSPPRKRV KGKGSDKDFV IIRRPKLSRE NFPGVSWDSL PDELLLGIFS CLCLPELLRV 
SGVCKRWYRL SLDESLWQSL DLAGKNLHPD VTVRLLSRGV VAFRCPRSFM EQPLGESFSS 
FRVQHMDLSN SVINVSNLHK ILSECSKLQN LSLEGLQLSD PIVKTLAQNE NLVRLNLCGC 
SGFSESAVAT LLSSCSRLDE LNLSWCFDFT EKHVQAAVAH LPNTITQLNL SGYRKNLQKT 
DLCTIIKRCP NLIRLDLSDS IMLKNDCFPE FFQLNYLQHL SLSRCYDIIP DTLLELGEIP 
TLKTLQVFGI VPEGTLQLLR EALPRLQINC AYFTTIARPT MDSKKNLEIW GIKCRLTLQK 
PSCL

Genular Protein ID: 2147323883

Symbol: A0A087WQ11_MOUSE

Name: N/A

UniProtKB Accession Codes:

A0A087WQ11

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21750661

Title: Modernizing reference genome assemblies.

PubMed ID: 21750661

Sequence Information:

Length: 389
Mass: 43823
Checksum: 419276D9DB30212A
Sequence:

MGVSALEKEE VDSENIPHGL LSNLGHPQSP PRKRVKGKGS DKDFVIIRRP KLSRENFPGV 
SWDSLPDELL LGIFSCLCLP ELLRVSGVCK RWYRLSLDES LWQSLDLAGK NLHPDVTVRL 
LSRGVVAFRC PRSFMEQPLG ESFSSFRVQH MDLSNSVINV SNLHKILSEC SKLQNLSLEG 
LQLSDPIVKT LAQNENLVRL NLCGCSGFSE SAVATLLSSC SRLDELNLSW CFDFTEKHVQ 
AAVAHLPNTI TQLNLSGYRK NLQKTDLCTI IKRCPNLIRL DLSDSIMLKN DCFPEFFQLN 
YLQHLSLSRC YDIIPDTLLE LGEIPTLKTL QVFGIVPEGT LQLLREALPR LQINCAYFTT 
IARPTMDSKK NLEIWGIKCR LTLQKPSCL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Skp2

Associated with

Other Information

Targeted disruption of Skp2 results in accumulation of cyclin E and p27(Kip1), polyploidy and centrosome overduplication. PubMed ID: 10790373

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Skp2 E3 ligase integrates ATM activation and homologous recombination repair by ubiquitinating NBS1. PubMed ID: 22464731

A C9orf72-CARM1 axis regulates lipid metabolism under glucose starvation-induced nutrient stress. PubMed ID: 30366907

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

Modernizing reference genome assemblies. PubMed ID: 21750661