Details for: ABO

Gene ID: 28

Symbol: ABO

Ensembl ID: ENSG00000175164

Description: ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 2.53
    Marker Score: 7145
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 1.53
    Marker Score: 1695
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.38
    Marker Score: 520
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.37
    Marker Score: 394
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.37
    Marker Score: 2104
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.34
    Marker Score: 12703
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.27
    Marker Score: 1063
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.16
    Marker Score: 1703
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.15
    Marker Score: 889
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.13
    Marker Score: 3558
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 1.07
    Marker Score: 215
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.05
    Marker Score: 6990
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 787
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71798
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48022
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 502
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 456
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2411
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.95
    Marker Score: 909
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5318
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.9
    Marker Score: 948
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.89
    Marker Score: 2253
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.89
    Marker Score: 282
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.89
    Marker Score: 1020
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.88
    Marker Score: 590
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5286
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.86
    Marker Score: 7466
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.85
    Marker Score: 1377
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.84
    Marker Score: 242
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.84
    Marker Score: 833
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.8
    Marker Score: 862
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.79
    Marker Score: 1869
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.78
    Marker Score: 839
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 702
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 392
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.76
    Marker Score: 3970
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.75
    Marker Score: 300.5
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.74
    Marker Score: 4463.5
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 467
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.73
    Marker Score: 234
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.73
    Marker Score: 737
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.72
    Marker Score: 3472
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.72
    Marker Score: 755
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.72
    Marker Score: 9612
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 0.71
    Marker Score: 1352.5
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.7
    Marker Score: 489
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.7
    Marker Score: 6617
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.7
    Marker Score: 292
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.69
    Marker Score: 4427
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.68
    Marker Score: 5881
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.67
    Marker Score: 2812
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.67
    Marker Score: 1579
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.66
    Marker Score: 5650
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.65
    Marker Score: 785
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.65
    Marker Score: 2301
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.63
    Marker Score: 1017
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.63
    Marker Score: 430
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.63
    Marker Score: 575
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.62
    Marker Score: 301
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.62
    Marker Score: 871
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 0.61
    Marker Score: 3593
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.6
    Marker Score: 4436
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.59
    Marker Score: 311
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.56
    Marker Score: 408
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.55
    Marker Score: 5554
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.55
    Marker Score: 413.5
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.55
    Marker Score: 33869
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.55
    Marker Score: 149
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.53
    Marker Score: 839
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.52
    Marker Score: 1189
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.52
    Marker Score: 132
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.51
    Marker Score: 3343
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.51
    Marker Score: 100
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.51
    Marker Score: 134
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.5
    Marker Score: 300
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.5
    Marker Score: 144
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.49
    Marker Score: 148
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.48
    Marker Score: 151
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.48
    Marker Score: 249
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.48
    Marker Score: 235
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.47
    Marker Score: 171
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.45
    Marker Score: 204
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.45
    Marker Score: 168
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.45
    Marker Score: 742
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.45
    Marker Score: 187
  • Cell Name: tracheobronchial goblet cell (CL0019003)
    Fold Change: 0.43
    Marker Score: 118
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.43
    Marker Score: 3354
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 0.43
    Marker Score: 147
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.42
    Marker Score: 199
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.42
    Marker Score: 191
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.41
    Marker Score: 260
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.41
    Marker Score: 432
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.4
    Marker Score: 213
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.39
    Marker Score: 307
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.39
    Marker Score: 212

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Other Information

**Key characteristics:** - The ABO system is a complex network of antigens and antibodies that helps the body to recognize and respond to foreign pathogens. - The ABO genes are located on chromosome 1. - There are four different alleles of the ABO genes: A, B, AB, and O. - People with blood group A have antigen A on their red blood cells, people with blood group B have antigen B on their red blood cells, people with blood group AB have both antigens A and B on their red blood cells, and people with blood group O have neither antigen A nor B on their red blood cells. **Pathways and functions:** - The ABO system is involved in the processing and presentation of antigens on the surface of red blood cells. - This process is essential for the immune system to recognize and respond to foreign pathogens. - The ABO system is also involved in the regulation of inflammation. **Clinical significance:** - The ABO system is a major factor in blood transfusions. - People with incompatible blood types can develop a condition called ABO incompatibility, which can lead to hemolytic disease of the newborn (HDN). - HDN is a condition in which the immune system mistakenly attacks red blood cells, causing them to clump together and form blood clots. - ABO incompatibility can be prevented by matching blood types during a blood transfusion.

Genular Protein ID: 1625791966

Symbol: BGAT_HUMAN

Name: Histo-blood group ABO system transferase

UniProtKB Accession Codes:

P16442 B0JDB9 O14758 Q14490 Q53I57 Q6ISD4 Q6KFZ2 Q70V27 Q99484 Q99485 Q9NY01 Q9UQ68 Q9UQ69

Database IDs:

AGR 1 AlphaFoldDB 1 BRENDA 3 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CDD 1 CTD 1 ChEBI 20 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 13 EC 2 EMBL 29 EvolutionaryTrace 1 GO 13 GeneCards 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 InParanoid 1 InterPro 2 KEGG 1 MIM 2 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PDB 100 PDBsum 100 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 2 SMR 1 STRING 1 SUPFAM 1 UniPathway 1 UniProtKB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2104828

Title: Cloning and characterization of DNA complementary to human UDP-GalNAc: Fuc alpha 1-->2Gal alpha 1-->3GalNAc transferase (histo-blood group A transferase) mRNA.

PubMed ID: 2104828

DOI: 10.1016/s0021-9258(19)40170-1

PubMed ID: 2333095

Title: Molecular genetic basis of the histo-blood group ABO system.

PubMed ID: 2333095

DOI: 10.1038/345229a0

PubMed ID: 7598760

Title: Genomic cloning of the human histo-blood group ABO locus.

PubMed ID: 7598760

DOI: 10.1006/bbrc.1995.1044

PubMed ID: 7779106

Title:

PubMed ID: 7779106

DOI: 10.1006/bbrc.1995.1817

PubMed ID: 16533287

Title: A weak blood group A phenotype caused by a translation-initiator mutation in the ABO gene.

PubMed ID: 16533287

DOI: 10.1111/j.1537-2995.2006.00740.x

PubMed ID: 17764507

Title: Weak blood group B phenotypes may be caused by variations in the CCAAT-binding factor/NF-Y enhancer region of the ABO gene.

PubMed ID: 17764507

DOI: 10.1111/j.1537-2995.2007.01475.x

PubMed ID: 18513251

Title: Aberrant intracellular trafficking of a variant B glycosyltransferase.

PubMed ID: 18513251

DOI: 10.1111/j.1537-2995.2008.01782.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12829588

Title: The nature of diversity and diversification at the ABO locus.

PubMed ID: 12829588

DOI: 10.1182/blood-2003-03-0955

PubMed ID: 8839869

Title: Molecular genetic analysis of variant phenotypes of the ABO blood group system.

PubMed ID: 8839869

PubMed ID: 9800297

Title: Heterogeneity of the blood group Ax allele: genetic recombination of common alleles can result in the Ax phenotype.

PubMed ID: 9800297

DOI: 10.1046/j.1365-3148.1998.00161.x

PubMed ID: 15104652

Title: Evolution of the O alleles of the human ABO blood group gene.

PubMed ID: 15104652

DOI: 10.1111/j.1537-2995.2004.03346.x

PubMed ID: 1449469

Title: Animal histo-blood group ABO genes.

PubMed ID: 1449469

DOI: 10.1016/0006-291x(92)91538-2

PubMed ID: 2121736

Title: Sugar-nucleotide donor specificity of histo-blood group A and B transferases is based on amino acid substitutions.

PubMed ID: 2121736

DOI: 10.1016/s0021-9258(17)30652-x

PubMed ID: 10462501

Title: The molecular basis for the B(A) allele: an amino acid alteration in the human histoblood group B alpha-(1,3)-galactosyltransferase increases its intrinsic alpha-(1,3)-N-acetylgalactosaminyltransferase activity.

PubMed ID: 10462501

DOI: 10.1006/bbrc.1999.1246

PubMed ID: 12198488

Title: The structural basis for specificity in human ABO(H) blood group biosynthesis.

PubMed ID: 12198488

DOI: 10.1038/nsb832

PubMed ID: 12529355

Title: A single point mutation reverses the donor specificity of human blood group B-synthesizing galactosyltransferase.

PubMed ID: 12529355

DOI: 10.1074/jbc.m212002200

PubMed ID: 12972418

Title: The influence of an intramolecular hydrogen bond in differential recognition of inhibitory acceptor analogs by human ABO(H) blood group A and B glycosyltransferases.

PubMed ID: 12972418

DOI: 10.1074/jbc.m308770200

PubMed ID: 15475562

Title: Structural basis for the inactivity of human blood group O2 glycosyltransferase.

PubMed ID: 15475562

DOI: 10.1074/jbc.m410245200

PubMed ID: 16326711

Title: Differential recognition of the type I and II H antigen acceptors by the human ABO(H) blood group A and B glycosyltransferases.

PubMed ID: 16326711

DOI: 10.1074/jbc.m507620200

PubMed ID: 17259183

Title: Structural effects of naturally occurring human blood group B galactosyltransferase mutations adjacent to the DXD motif.

PubMed ID: 17259183

DOI: 10.1074/jbc.m610998200

Sequence Information:

  • Length: 354
  • Mass: 40934
  • Checksum: A03DA16E630C1608
  • Sequence:
    • MAEVLRTLAG KPKCHALRPM ILFLIMLVLV LFGYGVLSPR SLMPGSLERG FCMAVREPDH 
LQRVSLPRMV YPQPKVLTPC RKDVLVVTPW LAPIVWEGTF NIDILNEQFR LQNTTIGLTV 
FAIKKYVAFL KLFLETAEKH FMVGHRVHYY VFTDQPAAVP RVTLGTGRQL SVLEVRAYKR 
WQDVSMRRME MISDFCERRF LSEVDYLVCV DVDMEFRDHV GVEILTPLFG TLHPGFYGSS 
REAFTYERRP QSQAYIPKDE GDFYYLGGFF GGSVQEVQRL TRACHQAMMV DQANGIEAVW 
HDESHLNKYL LRHKPTKVLS PEYLWDQQLL GWPAVLRKLR FTAVPKNHQA VRNP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.