Larp7 | ENSMUSG00000027968 | NCBI 28036

Details for: Larp7

Gene ID: 28036

Symbol: Larp7

Ensembl ID: ENSMUSG00000027968

Description: La ribonucleoprotein 7, transcriptional regulator

Associated with

7sk snrna binding
(GO:0097322)
7sk snrnp
(GO:0120259)
Box c/d rna 3'-end processing
(GO:0000494)
Cell differentiation
(GO:0030154)
Cytosol
(GO:0005829)
Germ cell proliferation
(GO:0036093)
Mrna binding
(GO:0003729)
Mrna processing
(GO:0006397)
Negative regulation of chromatin binding
(GO:0035562)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of viral transcription
(GO:0032897)
Nucleic acid binding
(GO:0003676)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Positive regulation of g1/s transition of mitotic cell cycle
(GO:1900087)
Positive regulation of protein localization to cajal body
(GO:1904871)
Positive regulation of snrna transcription by rna polymerase ii
(GO:1905382)
Regulation of mrna splicing, via spliceosome
(GO:0048024)
Ribonucleoprotein complex
(GO:1990904)
Rna binding
(GO:0003723)
Rna processing
(GO:0006396)
Rna splicing
(GO:0008380)
Spermatogenesis
(GO:0007283)
U6 2'-o-snrna methylation
(GO:1990438)
U6 snrna binding
(GO:0017070)

Other Information

Proteins

LARP7_MOUSE

Genular Protein ID: 437622458

Symbol: LARP7_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q05CL8 Q3TSC2 Q8K2Y6 Q8VDW3 Q9CSI2 Q9CSI9 Q9CUQ5

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 17242355

Title: Large-scale phosphorylation analysis of mouse liver.

PubMed ID: 17242355

DOI: 10.1073/pnas.0609836104

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 19131326

Title: Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry.

PubMed ID: 19131326

DOI: 10.1074/mcp.m800451-mcp200

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23154982

Title: Cell cycle gene-specific control of transcription has a critical role in proliferation of primordial germ cells.

PubMed ID: 23154982

DOI: 10.1101/gad.202242.112

PubMed ID: 22865833

Title: Loss of function mutation in LARP7, chaperone of 7SK ncRNA, causes a syndrome of facial dysmorphism, intellectual disability, and primordial dwarfism.

PubMed ID: 22865833

DOI: 10.1002/humu.22175

PubMed ID: 32017896

Title: LARP7-mediated U6 snRNA modification ensures splicing fidelity and spermatogenesis in mice.

PubMed ID: 32017896

DOI: 10.1016/j.molcel.2020.01.002

Sequence Information:

Length: 570
Mass: 64802
Checksum: 025EB8EC3CA58F22
Sequence:

METENQKTME ESTKRKEEKK KRSRVKQVLA DIAKQVDFWF GDANLHKDKF LREQIEKSRD 
GYVDISLLVS FNKMKKLTTD GKLIARALKS SSVVELDLEG TRIRRKKPLG ERPKDEEERT 
VYVELLPKNV THSWIERVFG KCGNVVYISI PHYKSTGDPK GFAFVEFETK EQAAKAIEFL 
NNPPEEAPRK PGIFPKTVKN KPIPSLRVAE EKKKKKKKKG RIKKEESVQA KESAVDSSSS 
GVCKATKRPR TASEGSEAET PEAPKQPAKK KKKRDKVEAS SLPEARAGKR ERCSAEDEDC 
LPPRPKAKKR AQKDGVGQAA SEVSKESRDL EFCSTEEEKE TDRKGDSLSK VKRKHKKKHK 
ERHKMGEEVI PLRVLSKTEW MDLKKEYLAL QKASMASLKK TISQIKLESE METDCKAPTA 
GSGQECSTQE KVSAQGPQFV TGVIVKIVSG EPLPGRKQVK DILATISEVV YIDLLEGDTE 
CHARFKTPED AQAVMNAQTE IRKKHSWNLE VLSGDHEQRY WQKILVDRQA KLNQPREKKR 
GTEKLITKAE KIRLAKTQQA SQHIRFSEYD

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Larp7

Associated with

Other Information

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Large-scale phosphorylation analysis of mouse liver. PubMed ID: 17242355

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. PubMed ID: 17525332

Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry. PubMed ID: 19131326

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Cell cycle gene-specific control of transcription has a critical role in proliferation of primordial germ cells. PubMed ID: 23154982

Loss of function mutation in LARP7, chaperone of 7SK ncRNA, causes a syndrome of facial dysmorphism, intellectual disability, and primordial dwarfism. PubMed ID: 22865833

LARP7-mediated U6 snRNA modification ensures splicing fidelity and spermatogenesis in mice. PubMed ID: 32017896