Trpm2 | ENSMUSG00000009292 | NCBI 28240

Details for: Trpm2

Gene ID: 28240

Symbol: Trpm2

Ensembl ID: ENSMUSG00000009292

Description: transient receptor potential cation channel, subfamily M, member 2

Associated with

Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Ion channel transport
(R-MMU-983712)
Neutrophil degranulation
(R-MMU-6798695)
Stimuli-sensing channels
(R-MMU-2672351)
Transport of small molecules
(R-MMU-382551)
Trp channels
(R-MMU-3295583)
Calcium-mediated signaling using intracellular calcium source
(GO:0035584)
Calcium-release channel activity
(GO:0015278)
Calcium channel activity
(GO:0005262)
Calcium ion binding
(GO:0005509)
Calcium ion import across plasma membrane
(GO:0098703)
Calcium ion transmembrane import into cytosol
(GO:0097553)
Calcium ion transmembrane transport
(GO:0070588)
Calcium ion transport
(GO:0006816)
Cell projection
(GO:0042995)
Cellular response to calcium ion
(GO:0071277)
Cellular response to hydrogen peroxide
(GO:0070301)
Cellular response to purine-containing compound
(GO:0071415)
Cellular response to temperature stimulus
(GO:0071502)
Cytoplasmic vesicle
(GO:0031410)
Cytoplasmic vesicle membrane
(GO:0030659)
Dendritic cell chemotaxis
(GO:0002407)
Dendritic cell differentiation
(GO:0097028)
Ligand-gated calcium channel activity
(GO:0099604)
Lysosomal membrane
(GO:0005765)
Lysosome
(GO:0005764)
Manganese ion transmembrane transporter activity
(GO:0005384)
Manganese ion transport
(GO:0006828)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Mono-adp-d-ribose binding
(GO:0072571)
Monoatomic cation channel activity
(GO:0005261)
Monoatomic ion channel activity
(GO:0005216)
Monoatomic ion transmembrane transport
(GO:0034220)
Monoatomic ion transport
(GO:0006811)
Neuronal cell body
(GO:0043025)
Plasma membrane
(GO:0005886)
Positive regulation of cellular response to oxidative stress
(GO:1900409)
Positive regulation of insulin secretion
(GO:0032024)
Protein homotetramerization
(GO:0051289)
Regulation of actin cytoskeleton organization
(GO:0032956)
Regulation of filopodium assembly
(GO:0051489)
Release of sequestered calcium ion into cytosol
(GO:0051209)
Response to heat
(GO:0009408)
Response to hydroperoxide
(GO:0033194)
Response to purine-containing compound
(GO:0014074)
Sodium channel activity
(GO:0005272)
Sodium ion transport
(GO:0006814)
Temperature homeostasis
(GO:0001659)
Transmembrane transport
(GO:0055085)
Zinc ion transmembrane transport
(GO:0071577)

Other Information

Proteins

Transient receptor potential cation channel subfamily M member 2
Q3UYE9_MOUSE

Genular Protein ID: 2969751340

Symbol: TRPM2_MOUSE

Name: Transient receptor potential cation channel subfamily M member 2

UniProtKB Accession Codes:

Q91YD4 Q5KTC0

Database IDs:

Citations:

PubMed ID: 15708008

Title: Characterization of human and mouse TRPM2 genes: identification of a novel N-terminal truncated protein specifically expressed in human striatum.

PubMed ID: 15708008

DOI: 10.1016/j.bbrc.2005.01.086

PubMed ID: 16260005

Title: Characterisation of recombinant rat TRPM2 and a TRPM2-like conductance in cultured rat striatal neurones.

PubMed ID: 16260005

DOI: 10.1016/j.neuropharm.2005.08.021

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11804595

Title: LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death.

PubMed ID: 11804595

DOI: 10.1016/s1097-2765(01)00438-5

PubMed ID: 16601673

Title: TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion.

PubMed ID: 16601673

DOI: 10.1038/sj.emboj.7601083

PubMed ID: 19454650

Title: TRPM2 functions as a lysosomal Ca2+-release channel in beta cells.

PubMed ID: 19454650

DOI: 10.1126/scisignal.2000278

PubMed ID: 20921208

Title: Lack of TRPM2 impaired insulin secretion and glucose metabolisms in mice.

PubMed ID: 20921208

DOI: 10.2337/db10-0276

PubMed ID: 21753080

Title: Dendritic cell maturation and chemotaxis is regulated by TRPM2-mediated lysosomal Ca2+ release.

PubMed ID: 21753080

DOI: 10.1096/fj.10-178483

PubMed ID: 21709234

Title: Transient receptor potential melastatin 2 (TRPM2) ion channel is required for innate immunity against Listeria monocytogenes.

PubMed ID: 21709234

DOI: 10.1073/pnas.1010678108

PubMed ID: 22493272

Title: Redox signal-mediated sensitization of transient receptor potential melastatin 2 (TRPM2) to temperature affects macrophage functions.

PubMed ID: 22493272

DOI: 10.1073/pnas.1114193109

PubMed ID: 25562606

Title: TRPM2-mediated intracellular Zn2+ release triggers pancreatic beta-cell death.

PubMed ID: 25562606

DOI: 10.1042/bj20140747

PubMed ID: 25817999

Title: Redox signal-mediated enhancement of the temperature sensitivity of transient receptor potential melastatin 2 (TRPM2) elevates glucose-induced insulin secretion from pancreatic islets.

PubMed ID: 25817999

DOI: 10.1074/jbc.m115.649913

PubMed ID: 27533035

Title: The TRPM2 ion channel is required for sensitivity to warmth.

PubMed ID: 27533035

DOI: 10.1038/nature19074

PubMed ID: 27562954

Title: The TRPM2 channel is a hypothalamic heat sensor that limits fever and can drive hypothermia.

PubMed ID: 27562954

DOI: 10.1126/science.aaf7537

Sequence Information:

Length: 1506
Mass: 172202
Checksum: E340C2F4DED121F4
Sequence:

MESLDRRRTG SEQEEGFGVQ SRRATDLGMV PNLRRSNSSL CKSRRFLCSF SSEKQENLSS 
WIPENIKKKE CVYFVESSKL SDAGKVVCAC GYTHEQHLEV AIKPHTFQGK EWDPKKHVQE 
MPTDAFGDIV FTDLSQKVGK YVRVSQDTPS SVIYQLMTQH WGLDVPNLLI SVTGGAKNFN 
MKLRLKSIFR RGLVKVAQTT GAWIITGGSH TGVMKQVGEA VRDFSLSSSC KEGEVITIGV 
ATWGTIHNRE GLIHPMGGFP AEYMLDEEGQ GNLTCLDSNH SHFILVDDGT HGQYGVEIPL 
RTKLEKFISE QTKERGGVAI KIPIVCVVLE GGPGTLHTIY NAINNGTPCV IVEGSGRVAD 
VIAQVATLPV SEITISLIQQ KLSIFFQEMF ETFTENQIVE WTKKIQDIVR RRQLLTIFRE 
GKDGQQDVDV AILQALLKAS RSQDHFGHEN WDHQLKLAVA WNRVDIARSE IFTDEWQWKP 
ADLHPMMTAA LISNKPEFVR LFLENGVRLK EFVTWDTLLC LYENLEPSCL FHSKLQKVLA 
EEQRLAYASA TPRLHMHHVA QVLRELLGDS TQLLYPRPRY TDRPRLSMTV PHIKLNVQGV 
SLRSLYKRST GHVTFTIDPV RDLLIWAVIQ NHRELAGIIW AQSQDCTAAA LACSKILKEL 
SKEEEDTDSS EEMLALADEF EHRAIGVFTE CYRKDEERAQ KLLVRVSEAW GKTTCLQLAL 
EAKDMKFVSH GGIQAFLTKV WWGQLCVDNG LWRIILCMLA FPLLFTGFIS FREKRLQALC 
RPARVRAFFN APVVIFHMNI LSYFAFLCLF AYVLMVDFQP SPSWCEYLIY LWLFSLVCEE 
TRQLFYDPDG CGLMKMASLY FSDFWNKLDV GAILLFIVGL TCRLIPATLY PGRIILSLDF 
IMFCLRLMHI FTISKTLGPK IIIVKRMMKD VFFFLFLLAV WVVSFGVAKQ AILIHNESRV 
DWIFRGVVYH SYLTIFGQIP TYIDGVNFSM DQCSPNGTDP YKPKCPESDW TGQAPAFPEW 
LTVTLLCLYL LFANILLLNL LIAMFNYTFQ EVQEHTDQIW KFQRHDLIEE YHGRPPAPPP 
LILLSHLQLL IKRIVLKIPA KRHKQLKNKL EKNEETALLS WELYLKENYL QNQQYQQKQR 
PEQKIQDISE KVDTMVDLLD MDQVKRSGST EQRLASLEEQ VTQVTRALHW IVTTLKDSGF 
GSGAGALTLA PQRAFDEPDA ELSIRRKVEE PGDGYHVSAR HLLYPNARIM RFPVPNEKVP 
WAAEFLIYDP PFYTAEKDVA LTDPVGDTAE PLSKISYNVV DGPTDRRSFH GVYVVEYGFP 
LNPMGRTGLR GRGSLSWFGP NHTLQPVVTR WKRNQGGAIC RKSVRKMLEV LVMKLPRSEH 
WALPGGSREP GEMLPRKLKR VLRQEFWVAF ETLLMQGTEV YKGYVDDPRN TDNAWIETVA 
VSIHFQDQND MELKRLEENL HTHDPKELTR DLKLSTEWQV VDRRIPLYAN HKTILQKVAS 
LFGAHF

Genular Protein ID: 1792814329

Symbol: Q3UYE9_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3UYE9

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 807
Mass: 93080
Checksum: BA99CCCBBA42B22E
Sequence:

WDTLLCLYEN LEPSCLFHSK LQKVLAEEQR LAYASATPRL HMHHVAQVLR ELLGDSTQLL 
YPRPRYTDRP RLSMTVPHIK LNVQGVSLRS LYKRSTGHVT FTIDPVRDLL IWAVIQNHRE 
LAGIIWAQSQ DCTAAALACS KILKELSKEE EDTDSSEEML ALADEFEHRA IGVFTECYRK 
DEERAQKLLV RVSEAWGKTT CLQLALEAKD MKFVSHGGIQ AFLTKVWWGQ LCVDNGLWRI 
ILCMLAFPLL FTGFISFREK RLQALCRPAR VRAFFNAPVV IFHMNILSYF AFLCLFAYVL 
MVDFQPSPSW CEYLIYLWLF SLVCEETRQL FYDPDGCGLM KMASLYFSDF WNKLDVGAIL 
LFIVGLTCRL IPATLYPGRI ILSLDFIMFC LRLMHIFTIS KTLGPKIIIV KRMMKDVFFF 
LFLLAVWVVS FGVAKQAILI HNESRVDWIF RGVVYHSYLT IFGQIPTYID GVNFSMDQCS 
PNGTDPYKPK CPESDWTGQA PAFPEWLTVT LLCLYLLFAN ILLLNLLIAM FNYTFQEVQE 
HTDQIWKFQR HDLIEEYHGR PPAPPPLILL SHLQLLIKRI VLKIPAKRHK QLKNKLEKNE 
ETALLSWELY LKENYLQNQQ YQQKQRPEQK IQDISEKVDT MVDLLDMDQV KRSGSTEQRL 
ASLEEQVTQV TRALHWIVTT LKDSGFGSGA GALTLAHQRA FDEPDAELSI RRKVEEPGDG 
YHVSARHLLY PNARIMRFPV PNEKVPWAAE FLIYDPPFYT AEKDVALTDP VGDTAEPLSK 
ISYNVVDGPT DRRSFHGVYV VEYGFPL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Trpm2

Associated with

Other Information

Characterization of human and mouse TRPM2 genes: identification of a novel N-terminal truncated protein specifically expressed in human striatum. PubMed ID: 15708008

Characterisation of recombinant rat TRPM2 and a TRPM2-like conductance in cultured rat striatal neurones. PubMed ID: 16260005

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death. PubMed ID: 11804595

TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion. PubMed ID: 16601673

TRPM2 functions as a lysosomal Ca2+-release channel in beta cells. PubMed ID: 19454650

Lack of TRPM2 impaired insulin secretion and glucose metabolisms in mice. PubMed ID: 20921208

Dendritic cell maturation and chemotaxis is regulated by TRPM2-mediated lysosomal Ca2+ release. PubMed ID: 21753080

Transient receptor potential melastatin 2 (TRPM2) ion channel is required for innate immunity against Listeria monocytogenes. PubMed ID: 21709234

Redox signal-mediated sensitization of transient receptor potential melastatin 2 (TRPM2) to temperature affects macrophage functions. PubMed ID: 22493272

TRPM2-mediated intracellular Zn2+ release triggers pancreatic beta-cell death. PubMed ID: 25562606

Redox signal-mediated enhancement of the temperature sensitivity of transient receptor potential melastatin 2 (TRPM2) elevates glucose-induced insulin secretion from pancreatic islets. PubMed ID: 25817999

The TRPM2 ion channel is required for sensitivity to warmth. PubMed ID: 27533035

The TRPM2 channel is a hypothalamic heat sensor that limits fever and can drive hypothermia. PubMed ID: 27562954

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073