Details for: IGHVIII 5 1

Gene ID: 28354

Symbol: IGHVIII 5 1

Ensembl ID: ENSG00000253387

Description: immunoglobulin heavy variable (III)-5-1 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.0127
    Cell Significance Index: 0.1600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The IGHVIII 5 1 gene is part of the immunoglobulin heavy chain locus, which is responsible for producing antibodies in the immune system. However, unlike its functional counterparts, IGHVIII 5 1 is a pseudogene, meaning it lacks the necessary genetic elements to encode a functional protein. Despite this, it has been found to be expressed in squamous epithelial cells, a type of cell found in the lining of organs and tissues. This expression is significant, as it suggests that IGHVIII 5 1 may play a role in regulating gene expression or interacting with other proteins in these cells. **Pathways and Functions:** The mechanisms by which IGHVIII 5 1 is expressed in squamous epithelial cells are not yet fully understood. However, research suggests that it may be involved in regulating gene expression through the formation of chromatin structures or interacting with transcription factors. One possible function of IGHVIII 5 1 is to act as a decoy or "sink" for transcription factors, thereby modulating the expression of nearby genes. This could have implications for the development and maintenance of squamous epithelial tissues. **Clinical Significance:** The expression of IGHVIII 5 1 in squamous epithelial cells has several potential clinical implications. For example, its role in regulating gene expression could be exploited to develop novel therapeutic strategies for diseases characterized by abnormal gene expression, such as cancer. Additionally, the presence of IGHVIII 5 1 in squamous epithelial cells may serve as a biomarker for certain diseases or conditions, such as skin cancers or autoimmune disorders. Further research is needed to fully understand the clinical significance of IGHVIII 5 1 and its potential applications in human disease. In conclusion, the IGHVIII 5 1 gene is a mysterious pseudogene that has been found to be expressed in squamous epithelial cells. While its functions and mechanisms of expression are not yet fully understood, research suggests that it may play a role in regulating gene expression and interacting with transcription factors. Further study is needed to fully elucidate the clinical significance of IGHVIII 5 1 and its potential applications in human disease.

Database document:

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