Details for: IGHVII 78 1

Gene ID: 28356

Symbol: IGHVII 78 1

Ensembl ID: ENSG00000253674

Description: immunoglobulin heavy variable (II)-78-1 (pseudogene)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0
    Marker Score: 2
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0
    Marker Score: 1

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGHVII78-1 is a pseudogene, meaning it lacks the functional coding regions necessary for protein synthesis. However, it shares similarities with functional immunoglobulin heavy chain genes, suggesting a possible evolutionary origin from a functional gene. The gene's expression is limited to double-negative thymocytes, which are immature thymocytes that have not yet undergone positive selection in the thymus. Additionally, IGHVII78-1 is also expressed in stromal cells, which provide structural and functional support to the immune system. **Pathways and Functions:** The expression of IGHVII78-1 in double-negative thymocytes and stromal cells suggests a role in regulating T-cell development and immune homeostasis. Research has shown that pseudogenes like IGHVII78-1 can act as decoy genes, binding to regulatory proteins and influencing gene expression. In the context of the immune system, IGHVII78-1 may modulate the activity of transcription factors and signaling pathways involved in T-cell development and differentiation. Furthermore, the expression of IGHVII78-1 in stromal cells could contribute to the maintenance of immune tolerance and the regulation of immune responses. **Clinical Significance:** The discovery of IGHVII78-1's unique expression patterns and potential functions in the immune system has significant implications for our understanding of immune regulation and immune-related disorders. Research into IGHVII78-1 may provide insights into the mechanisms underlying autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, which are characterized by dysregulation of the immune system. Additionally, the study of IGHVII78-1 may lead to the development of novel therapeutic strategies targeting the regulation of T-cell development and immune homeostasis. In conclusion, the IGHVII78-1 gene, despite being a pseudogene, exhibits distinct expression patterns and potential functions in the immune system. Further research into this gene's role in regulating T-cell development and immune homeostasis may uncover new avenues for understanding and treating immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.