Details for: IGHVII 53 1

Gene ID: 28362

Symbol: IGHVII 53 1

Ensembl ID: ENSG00000253714

Description: immunoglobulin heavy variable (II)-53-1 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0020
    Cell Significance Index: -0.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Pseudogene status**: IGHVII 53 1 is a non-functional pseudogene, meaning it lacks the necessary exons and splice sites to produce a mature antibody. 2. **Erythrocyte specificity**: IGHVII 53 1 is predominantly expressed in erythrocytes, suggesting a unique role in red blood cell development or function. 3. **Limited sequence similarity**: Compared to functional IGHV genes, IGHVII 53 1 exhibits limited sequence similarity, indicating a distinct evolutionary history. 4. **No known functional antibodies**: IGHVII 53 1 does not encode a functional antibody, which is a significant departure from its functional counterparts. **Pathways and Functions** While IGHVII 53 1 is not directly involved in the humoral immune response, its expression in erythrocytes suggests a potential role in red blood cell development or function. Several hypotheses have been proposed: 1. **Regulation of erythropoiesis**: IGHVII 53 1 may play a role in regulating erythropoiesis, the process of red blood cell production, by influencing the expression of other genes involved in this process. 2. **Modulation of erythrocyte function**: IGHVII 53 1 may contribute to the modulation of erythrocyte function, such as the regulation of membrane protein expression or the maintenance of erythrocyte integrity. 3. **Evolutionary conservation**: The expression of IGHVII 53 1 in erythrocytes may be an evolutionary conserved mechanism, suggesting a shared genetic basis between vertebrates. **Clinical Significance** The study of IGHVII 53 1 has significant implications for our understanding of erythrocyte biology and the evolution of the immune system. While the clinical significance of IGHVII 53 1 is still unclear, several potential applications have been proposed: 1. **Erythrocyte disorders**: Further research on IGHVII 53 1 may shed light on the molecular mechanisms underlying erythrocyte disorders, such as anemia or erythrocyte dysfunction. 2. **Immunological surveillance**: The expression of IGHVII 53 1 in erythrocytes may serve as a unique marker for immunological surveillance, allowing for the detection of immune responses in erythrocytes. 3. **Evolutionary conservation**: The study of IGHVII 53 1 may provide insights into the evolutionary conservation of genetic mechanisms between vertebrates, with potential applications in the field of evolutionary biology. In conclusion, the IGHVII 53 1 gene is a fascinating example of a pseudogene with unique expression patterns and functional implications. Further research is necessary to fully elucidate the role of IGHVII 53 1 in erythrocyte biology and the evolution of the immune system.

Database document:

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