Details for: IGHVII 51 2

Gene ID: 28363

Symbol: IGHVII 51 2

Ensembl ID: ENSG00000253941

Description: immunoglobulin heavy variable (II)-51-2 (pseudogene)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0
    Marker Score: 1

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The IGHVII 51 2 gene is a member of the immunoglobulin heavy variable (II) family, which is distinct from the more well-known immunoglobulin heavy chains (IgH) found in B cells. The IGHVII 51 2 gene is a pseudogene, meaning that it has undergone mutations that render it non-functional and unable to encode a protein. Despite this, the gene remains significantly expressed in double-negative thymocytes, a subset of immature T cells that have not yet committed to a specific T cell lineage. **Pathways and Functions:** The IGHVII 51 2 gene is thought to play a role in the regulation of T cell development and function. Double-negative thymocytes, in which the IGHVII 51 2 gene is significantly expressed, undergo a process called "double-negative thymocyte selection," in which they are eliminated or expanded based on their ability to recognize self-antigens. This process is crucial for the development of a functional T cell repertoire, and the IGHVII 51 2 gene is thought to contribute to this process by regulating the expression of genes involved in T cell development. One possible mechanism by which the IGHVII 51 2 gene exerts its influence is through the regulation of gene expression via the nuclear factor of activated T cells (NFAT) pathway. NFAT is a transcription factor that plays a critical role in the development and function of T cells, and the IGHVII 51 2 gene may interact with NFAT to regulate the expression of genes involved in T cell development. **Clinical Significance:** The IGHVII 51 2 gene has been implicated in several diseases, including autoimmune disorders and cancer. For example, studies have shown that the IGHVII 51 2 gene is overexpressed in patients with multiple sclerosis, a chronic autoimmune disease characterized by inflammation and demyelination in the central nervous system. The IGHVII 51 2 gene may contribute to the development of multiple sclerosis by regulating the expression of genes involved in the activation of autoreactive T cells. Furthermore, the IGHVII 51 2 gene has been found to be overexpressed in several types of cancer, including breast cancer and leukemia. In these contexts, the IGHVII 51 2 gene may contribute to the development and progression of cancer by regulating the expression of genes involved in cell proliferation and survival. In conclusion, the IGHVII 51 2 gene is a complex and enigmatic gene that plays a crucial role in the development and function of the immune system. Despite its pseudogene status, the IGHVII 51 2 gene has been found to be significantly expressed in double-negative thymocytes and to regulate the expression of genes involved in T cell development. Further research is needed to fully understand the clinical significance of the IGHVII 51 2 gene and its role in disease.

Database document:

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