Details for: IGHD6 13

Gene ID: 28487

Symbol: IGHD6 13

Ensembl ID: ENSG00000211920

Description: immunoglobulin heavy diversity 6-13

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.01
    Marker Score: 19
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0
    Marker Score: 1
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0
    Marker Score: 1

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IGHD6-13 is a member of the immunoglobulin heavy chain gene family, which is responsible for the production of antibodies. The gene is characterized by its unique structure, which includes a variable region, a diversity region, and a constant region. The variable region is responsible for recognizing specific antigens, while the diversity region generates a vast array of possible antibody sequences. The constant region determines the effector functions of the antibody. IGHD6-13 is specifically expressed in cells that are not involved in the recognition of antigens, such as double negative thymocytes and memory B cells, suggesting its role in regulating immune responses rather than directly participating in antigen recognition. **Pathways and Functions:** IGHD6-13 is involved in the regulation of immune responses through several mechanisms. Firstly, the gene contributes to the generation of antibody diversity, which is essential for the recognition and neutralization of pathogens. The diversity region of IGHD6-13 contains repetitive sequences that undergo somatic hypermutation, resulting in the creation of novel antibody sequences. These sequences can recognize a wide range of antigens, providing immunity against infections. Secondly, IGHD6-13 is involved in the regulation of B cell development and function. The gene is expressed in double negative thymocytes, which are precursor cells to B cells, suggesting its role in the development of B cells. Additionally, IGHD6-13 is expressed in unswitched memory B cells and class switched memory B cells, which are mature B cells that have undergone class switching and somatic hypermutation. These cells play a crucial role in long-term immunity and are essential for the production of antibodies against specific pathogens. **Clinical Significance:** IGHD6-13 has significant implications for the diagnosis and treatment of autoimmune and inflammatory disorders. Dysregulation of antibody diversity and B cell function has been implicated in several diseases, including rheumatoid arthritis, lupus, and multiple sclerosis. Mutations in IGHD6-13 have been associated with autoimmune diseases, highlighting its potential as a therapeutic target. Furthermore, the gene's role in regulating B cell function and antibody production makes it an important target for the development of immunotherapies, such as antibody replacement therapies and adoptive T cell therapies. In conclusion, IGHD6-13 is a gene that plays a crucial role in the regulation of immune responses, particularly in the generation of antibody diversity and the development and function of B cells. Its clinical significance highlights its potential as a therapeutic target for autoimmune and inflammatory disorders. Further research is needed to fully elucidate the mechanisms by which IGHD6-13 regulates immune responses and to explore its potential as a therapeutic agent.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.