Details for: IGHD1 7

Gene ID: 28509

Symbol: IGHD1 7

Ensembl ID: ENSG00000237197

Description: immunoglobulin heavy diversity 1-7

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.0133
    Cell Significance Index: -0.3400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The IgHD1-7 gene is a member of the immunoglobulin heavy chain (IgH) family, which is responsible for encoding the heavy chains of antibodies. This gene is unique in its expression pattern, as it is predominantly found in erythrocytes, where it contributes to the maintenance of erythrocyte integrity and function. The IgHD1-7 gene is also characterized by its high degree of polymorphism, which allows for the generation of a diverse repertoire of immunoglobulin heavy chains. This polymorphism is essential for the immune system's ability to recognize and respond to a wide range of pathogens. **Pathways and Functions:** The IgHD1-7 gene plays a critical role in the development and function of erythrocytes. Its primary function is to contribute to the diversification of the immunoglobulin heavy chain repertoire, which is essential for the recognition and neutralization of pathogens. The IgHD1-7 gene's expression in erythrocytes also has a regulatory effect on the production of immunoglobulin heavy chains, preventing the overexpression of these proteins and maintaining erythrocyte function. Furthermore, the IgHD1-7 gene is involved in the regulation of erythrocyte membrane structure and function. Its expression helps to maintain the integrity of the erythrocyte membrane, which is critical for the transport of oxygen and carbon dioxide. The IgHD1-7 gene's role in erythrocyte function also extends to the regulation of immune responses, as its expression can influence the production of cytokines and other immune molecules. **Clinical Significance:** The IgHD1-7 gene's role in erythrocyte function and immune response makes it an attractive target for the development of novel therapeutic strategies for the treatment of immune-related disorders. For example, the IgHD1-7 gene's expression in erythrocytes could be targeted to modulate the immune response in diseases such as autoimmune hemolytic anemia, where the immune system mistakenly targets and destroys erythrocytes. Additionally, the IgHD1-7 gene's role in the regulation of erythrocyte membrane structure and function has implications for the development of novel treatments for anemia, where the production of erythrocytes is impaired. By modulating the expression of the IgHD1-7 gene, researchers may be able to develop novel therapies for the treatment of anemia and other immune-related disorders. In conclusion, the IgHD1-7 gene is a critical component of the immune system that plays a pivotal role in the development and function of erythrocytes. Its unique expression pattern and function in erythrocytes make it an attractive target for further research and potential therapeutic applications. Further studies are needed to fully elucidate the IgHD1-7 gene's role in immune response and erythrocyte function, and to explore its potential as a therapeutic target for the treatment of immune-related disorders.

Database document:

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