Details for: ANK1

Gene ID: 286

Symbol: ANK1

Ensembl ID: ENSG00000029534

Description: ankyrin 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 47.7048
    Cell Significance Index: -12.1000
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 23.7534
    Cell Significance Index: -9.6500
  • Cell Name: basophilic erythroblast (CL0000549)
    Fold Change: 11.6819
    Cell Significance Index: 5.3200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 10.1074
    Cell Significance Index: -9.6500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.2986
    Cell Significance Index: -5.3000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 4.0343
    Cell Significance Index: 98.4400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 3.8426
    Cell Significance Index: 84.1400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 3.5979
    Cell Significance Index: 44.6300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.0740
    Cell Significance Index: -12.1300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.0490
    Cell Significance Index: -9.3700
  • Cell Name: chandelier cell (CL4023083)
    Fold Change: 2.8089
    Cell Significance Index: 22.6800
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: 2.5051
    Cell Significance Index: 40.4200
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: 2.3894
    Cell Significance Index: 24.8900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 2.1750
    Cell Significance Index: 133.3500
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 2.1691
    Cell Significance Index: 28.1300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.7783
    Cell Significance Index: 56.9600
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.5130
    Cell Significance Index: 3.5300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 1.3590
    Cell Significance Index: 23.2900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.0900
    Cell Significance Index: 753.8500
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.0443
    Cell Significance Index: 8.6200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8273
    Cell Significance Index: 37.5000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.8122
    Cell Significance Index: 291.3300
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.7802
    Cell Significance Index: 8.1500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: 0.5702
    Cell Significance Index: 7.1100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.4947
    Cell Significance Index: 12.7200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.4682
    Cell Significance Index: 35.9300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4283
    Cell Significance Index: 42.3700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3583
    Cell Significance Index: 22.0200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3488
    Cell Significance Index: 314.9400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3163
    Cell Significance Index: 62.7700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.2622
    Cell Significance Index: 5.5900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2270
    Cell Significance Index: 36.9300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2182
    Cell Significance Index: 43.7800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2178
    Cell Significance Index: 41.4400
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.2146
    Cell Significance Index: 3.2700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2125
    Cell Significance Index: 23.1200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2051
    Cell Significance Index: 24.1900
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: 0.2020
    Cell Significance Index: 2.5500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.1878
    Cell Significance Index: 3.9200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1666
    Cell Significance Index: 4.0000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.1581
    Cell Significance Index: 3.2800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.1524
    Cell Significance Index: 9.1500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0947
    Cell Significance Index: 42.9900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0898
    Cell Significance Index: 6.2100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0879
    Cell Significance Index: 1.9100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0762
    Cell Significance Index: 4.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0660
    Cell Significance Index: 124.1900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0632
    Cell Significance Index: 1.5800
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.0552
    Cell Significance Index: 0.6300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0546
    Cell Significance Index: 29.8000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0206
    Cell Significance Index: 3.7100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0113
    Cell Significance Index: 7.1500
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.0111
    Cell Significance Index: 0.2400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.0068
    Cell Significance Index: 0.1000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.0035
    Cell Significance Index: 0.0700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0034
    Cell Significance Index: 0.1200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0009
    Cell Significance Index: -1.6100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0026
    Cell Significance Index: -3.9800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0048
    Cell Significance Index: -0.6000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0058
    Cell Significance Index: -7.8700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0069
    Cell Significance Index: -0.2000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0098
    Cell Significance Index: -0.1400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0100
    Cell Significance Index: -0.2000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0120
    Cell Significance Index: -1.7500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0122
    Cell Significance Index: -5.3800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0129
    Cell Significance Index: -0.6700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0145
    Cell Significance Index: -10.7500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0167
    Cell Significance Index: -12.6300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0187
    Cell Significance Index: -10.5400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0210
    Cell Significance Index: -13.0900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0273
    Cell Significance Index: -1.5300
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.0301
    Cell Significance Index: -0.3600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0313
    Cell Significance Index: -9.0100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0390
    Cell Significance Index: -4.5500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0529
    Cell Significance Index: -11.1500
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.0539
    Cell Significance Index: -0.6800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0556
    Cell Significance Index: -9.4900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0657
    Cell Significance Index: -0.9900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0733
    Cell Significance Index: -10.0600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0745
    Cell Significance Index: -1.6100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0764
    Cell Significance Index: -5.1400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0835
    Cell Significance Index: -8.6900
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.0876
    Cell Significance Index: -1.3100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0939
    Cell Significance Index: -12.1300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0962
    Cell Significance Index: -9.8300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0976
    Cell Significance Index: -11.1900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0980
    Cell Significance Index: -2.7400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1161
    Cell Significance Index: -3.1100
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: -0.1310
    Cell Significance Index: -1.3200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1355
    Cell Significance Index: -8.5400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1492
    Cell Significance Index: -7.7700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1551
    Cell Significance Index: -11.5600
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.1703
    Cell Significance Index: -2.2300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1852
    Cell Significance Index: -11.9500
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.1918
    Cell Significance Index: -2.4600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1968
    Cell Significance Index: -2.8200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.2001
    Cell Significance Index: -4.9900
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2110
    Cell Significance Index: -2.0000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2153
    Cell Significance Index: -9.3600
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.2160
    Cell Significance Index: -2.5200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ANK1 is a 375-amino acid protein, belonging to the ankyrin family, which is characterized by its high degree of homology with other ankyrin proteins. The protein exhibits a unique structure, featuring a cytoplasmic domain with multiple ankyrin repeats, a transmembrane domain, and a cytoskeletal binding domain. ANK1 is predominantly expressed in the nervous system, epithelial cells, and muscle cells, with highest levels observed in Purkinje cells, chandelier neurons, and skeletal muscle cells. **Pathways and Functions:** ANK1's primary function is to maintain epithelial cell polarity by regulating the interaction between the cytoskeleton and the plasma membrane. It achieves this by binding to spectrin, a cytoskeletal protein, and the transmembrane protein L1cam, thereby stabilizing the cytoskeletal structure and preventing its disassembly. ANK1 also plays a crucial role in regulating axon guidance, neuronal development, and migration by interacting with axonal proteins, such as L1cam and neurofascin. Additionally, ANK1 has been implicated in the regulation of protein trafficking, including endoplasmic reticulum to Golgi vesicle-mediated transport and exocytosis. **Clinical Significance:** Dysregulation of ANK1 has been linked to various neurological and muscular disorders, including: 1. **Epilepsy:** Mutations in ANK1 have been associated with epilepsy, particularly in individuals with a history of seizures. 2. **Muscular dystrophy:** ANK1 has been implicated in the pathogenesis of muscular dystrophy, particularly in the context of muscle cell adhesion and cytoskeletal organization. 3. **Neurodevelopmental disorders:** ANK1 has been linked to neurodevelopmental disorders, such as autism spectrum disorder, schizophrenia, and attention-deficit/hyperactivity disorder (ADHD). In conclusion, ANK1 plays a critical role in maintaining epithelial cell polarity, cytoskeletal organization, and axon guidance. Its dysregulation has significant implications for various neurological and muscular disorders, highlighting the need for further research into the molecular mechanisms underlying ANK1's functions and its potential as a therapeutic target for the treatment of these diseases.

Genular Protein ID: 3886806893

Symbol: ANK1_HUMAN

Name: Ankyrin-R

UniProtKB Accession Codes:

P16157 A0PJN8 A6NJ23 E5RFL7 O43400 Q13768 Q53ER1 Q59FP2 Q8N604 Q99407

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 6 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 55 EMDB 13 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 29 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 21 PDBsum 21 PIR 2 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 24 Pumba 1 RNAct 1 Reactome 5 RefSeq 8 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2137557

Title: Analysis of cDNA for human erythrocyte ankyrin indicates a repeated structure with homology to tissue-differentiation and cell-cycle control proteins.

PubMed ID: 2137557

DOI: 10.1038/344036a0

PubMed ID: 1689849

Title: cDNA sequence for human erythrocyte ankyrin.

PubMed ID: 1689849

DOI: 10.1073/pnas.87.5.1730

PubMed ID: 9235914

Title: Structure and organization of the human ankyrin-1 gene. Basis for complexity of pre-mRNA processing.

PubMed ID: 9235914

DOI: 10.1074/jbc.272.31.19220

PubMed ID: 9430667

Title: An alternate promoter directs expression of a truncated, muscle-specific isoform of the human ankyrin 1 gene.

PubMed ID: 9430667

DOI: 10.1074/jbc.273.3.1339

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2141335

Title: Mapping the binding sites of human erythrocyte ankyrin for the anion exchanger and spectrin.

PubMed ID: 2141335

DOI: 10.1016/s0021-9258(18)86987-3

PubMed ID: 21177872

Title: Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor.

PubMed ID: 21177872

DOI: 10.1074/jbc.m110.193540

PubMed ID: 7665627

Title: The ANK repeats of erythrocyte ankyrin form two distinct but cooperative binding sites for the erythrocyte anion exchanger.

PubMed ID: 7665627

DOI: 10.1074/jbc.270.37.22050

PubMed ID: 12444090

Title: The hydrophilic domain of small ankyrin-1 interacts with the two N-terminal immunoglobulin domains of titin.

PubMed ID: 12444090

DOI: 10.1074/jbc.m209012200

PubMed ID: 12527750

Title: Binding of an ankyrin-1 isoform to obscurin suggests a molecular link between the sarcoplasmic reticulum and myofibrils in striated muscles.

PubMed ID: 12527750

DOI: 10.1083/jcb.200208109

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 29459732

Title: A protease cascade regulates release of the human malaria parasite Plasmodium falciparum from host red blood cells.

PubMed ID: 29459732

DOI: 10.1038/s41564-018-0111-0

PubMed ID: 12456646

Title: Crystal structure of a 12 ANK repeat stack from human ankyrinR.

PubMed ID: 12456646

DOI: 10.1093/emboj/cdf651

PubMed ID: 22310050

Title: Structurally similar but functionally diverse ZU5 domains in human erythrocyte ankyrin.

PubMed ID: 22310050

DOI: 10.1016/j.jmb.2012.01.041

PubMed ID: 35835865

Title: Architecture of the human erythrocyte ankyrin-1 complex.

PubMed ID: 35835865

DOI: 10.1038/s41594-022-00792-w

PubMed ID: 8640229

Title: Ankyrin-1 mutations are a major cause of dominant and recessive hereditary spherocytosis.

PubMed ID: 8640229

DOI: 10.1038/ng0696-214

PubMed ID: 11102985

Title: Low frequency of ankyrin mutations in hereditary spherocytosis: identification of three novel mutations.

PubMed ID: 11102985

DOI: 10.1002/1098-1004(200012)16:6<529::aid-humu13>3.0.co;2-n

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 1881
  • Mass: 206265
  • Checksum: 49466F6F915019EC
  • Sequence:
    • MPYSVGFREA DAATSFLRAA RSGNLDKALD HLRNGVDINT CNQNGLNGLH LASKEGHVKM 
VVELLHKEII LETTTKKGNT ALHIAALAGQ DEVVRELVNY GANVNAQSQK GFTPLYMAAQ 
ENHLEVVKFL LENGANQNVA TEDGFTPLAV ALQQGHENVV AHLINYGTKG KVRLPALHIA 
ARNDDTRTAA VLLQNDPNPD VLSKTGFTPL HIAAHYENLN VAQLLLNRGA SVNFTPQNGI 
TPLHIASRRG NVIMVRLLLD RGAQIETKTK DELTPLHCAA RNGHVRISEI LLDHGAPIQA 
KTKNGLSPIH MAAQGDHLDC VRLLLQYDAE IDDITLDHLT PLHVAAHCGH HRVAKVLLDK 
GAKPNSRALN GFTPLHIACK KNHVRVMELL LKTGASIDAV TESGLTPLHV ASFMGHLPIV 
KNLLQRGASP NVSNVKVETP LHMAARAGHT EVAKYLLQNK AKVNAKAKDD QTPLHCAARI 
GHTNMVKLLL ENNANPNLAT TAGHTPLHIA AREGHVETVL ALLEKEASQA CMTKKGFTPL 
HVAAKYGKVR VAELLLERDA HPNAAGKNGL TPLHVAVHHN NLDIVKLLLP RGGSPHSPAW 
NGYTPLHIAA KQNQVEVARS LLQYGGSANA ESVQGVTPLH LAAQEGHAEM VALLLSKQAN 
GNLGNKSGLT PLHLVAQEGH VPVADVLIKH GVMVDATTRM GYTPLHVASH YGNIKLVKFL 
LQHQADVNAK TKLGYSPLHQ AAQQGHTDIV TLLLKNGASP NEVSSDGTTP LAIAKRLGYI 
SVTDVLKVVT DETSFVLVSD KHRMSFPETV DEILDVSEDE GEELISFKAE RRDSRDVDEE 
KELLDFVPKL DQVVESPAIP RIPCAMPETV VIRSEEQEQA SKEYDEDSLI PSSPATETSD 
NISPVASPVH TGFLVSFMVD ARGGSMRGSR HNGLRVVIPP RTCAAPTRIT CRLVKPQKLS 
TPPPLAEEEG LASRIIALGP TGAQFLSPVI VEIPHFASHG RGDRELVVLR SENGSVWKEH 
RSRYGESYLD QILNGMDEEL GSLEELEKKR VCRIITTDFP LYFVIMSRLC QDYDTIGPEG 
GSLKSKLVPL VQATFPENAV TKRVKLALQA QPVPDELVTK LLGNQATFSP IVTVEPRRRK 
FHRPIGLRIP LPPSWTDNPR DSGEGDTTSL RLLCSVIGGT DQAQWEDITG TTKLVYANEC 
ANFTTNVSAR FWLSDCPRTA EAVNFATLLY KELTAVPYMA KFVIFAKMND PREGRLRCYC 
MTDDKVDKTL EQHENFVEVA RSRDIEVLEG MSLFAELSGN LVPVKKAAQQ RSFHFQSFRE 
NRLAMPVKVR DSSREPGGSL SFLRKAMKYE DTQHILCHLN ITMPPCAKGS GAEDRRRTPT 
PLALRYSILS ESTPGSLSGT EQAEMKMAVI SEHLGLSWAE LARELQFSVE DINRIRVENP 
NSLLEQSVAL LNLWVIREGQ NANMENLYTA LQSIDRGEIV NMLEGSGRQS RNLKPDRRHT 
DRDYSLSPSQ MNGYSSLQDE LLSPASLGCA LSSPLRADQY WNEVAVLDAI PLAATEHDTM 
LEMSDMQVWS AGLTPSLVTA EDSSLECSKA EDSDATGHEW KLEGALSEEP RGPELGSLEL 
VEDDTVDSDA TNGLIDLLEQ EEGQRSEEKL PGSKRQDDAT GAGQDSENEV SLVSGHQRGQ 
ARITHSPTVS QVTERSQDRL QDWDADGSIV SYLQDAAQGS WQEEVTQGPH SFQGTSTMTE 
GLEPGGSQEY EKVLVSVSEH TWTEQPEAES SQADRDRRQQ GQEEQVQEAK NTFTQVVQGN 
EFQNIPGEQV TEEQFTDEQG NIVTKKIIRK VVRQIDLSSA DAAQEHEEVT VEGPLEDPSE 
LEVDIDYFMK HSKDHTSTPN P

Genular Protein ID: 809939584

Symbol: B3KX39_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KX39

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 4 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 6 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 RefSeq 1 SAM 1 SMART 3 SUPFAM 2

Sequence Information:

  • Length: 1034
  • Mass: 115228
  • Checksum: 696555E3E876AD8D
  • Sequence:
    • MVDATTRMGY TPLHVASHYG NIKLVKFLLQ HQADVNAKTK LGYSPLHQAA QQGHTDIVTL 
LLKNGASPNE VSSDGTTPLA IAKRLGYISV TDVLKVVTDE TSFVLVSDKH RMSFPETVDE 
ILDVSEDEGT AHITIMGEEL ISFKAERRDS RDVDEEKELL DFVPKLDQVV ESPAIPRIPC 
AMPETVVIRS EEQEQASKEY DEDSLIPSSP ATETSDNISP VASPVHTGFL VSFMVDARGG 
SMRGSRHNGL RVVIPPRTCA APTRITCRLV KPQKLSTPPP LAEEEGLASR IIALGPTGAQ 
FLSPVIVEIP HFASHGRGDR ELVVLRSENG SVWKEHRSRY GESYLDQILN GMDEELGSLE 
ELEKKRVCRI ITTDFPLYFV IMSRLCQDYD TIGPEGGSLK SKLVPLVQAT FPENAVTKRV 
KLALQAQPVP DELVTKLLGN QATFSPIVTV EPRRRKFHRP IGLRIPLPPS WTDNPRDSGE 
GDTTSLRLLC SVIGGTDQAQ WEDITGTTKL VYANECANFT TNVSARFWLS DCPRTAEAVN 
FATLLYKELT AVPYMAKFVI FAKMNDPREG RLRCYCMTDD KVDKTLEQHE NFVEVARSRD 
IEVLEGMSLF AELSGNLVPV KKAAQQRSFH FQSFRENRLA MPVKVRDSSR EPGGSLSFLR 
KAMKYEDTQH ILCHLNITMP PCAKGSGAED RRRTPTPLAL RYSILSESTP GSLSGTEQAE 
MKMAVISEHL GLSWAELARE LQFSVEDINR IRVENPNSLL EQSVALLNLW VIREGQNANM 
ENLYTALQSI DRGEIVNMLE GSGRQSRNLK PDRRHTDRDY SLSPSQMNGH QRGQARITHS 
PTVSQVTERS QDRLQDWDAD GSIVSYLQDA AQGSWQEEVT QGPHSFQGTS TMTEGLEPGG 
SQEYEKVLVS VSEHTWTEQP EAESSQADRD RRQQGQEEQV QEAKNTFTQV VQGNEFQNIP 
GEQVTEEQFT DEQGNIVTKK IIRKVVRQID LSSADAAQEH EEVELRGSGL QPDLIEGRKG 
AQIVKRASLK RGKQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.