Details for: ANK1

Gene ID: 286

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: ANK1

Ensembl ID: ENSG00000029534

Description: ankyrin 1

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • pvalb GABAergic cortical interneuron CL4023018
    CSI 32.51
    rCSI 40.45%
    PRS 94.37
  • sst GABAergic cortical interneuron CL4023017
    CSI 21.1
    rCSI 27.21%
    PRS 95.68
  • VIP GABAergic cortical interneuron CL4023016
    CSI 20.11
    rCSI 24.03%
    PRS 95.13
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 17.13
    rCSI 28.76%
    PRS 95.4
  • retinal ganglion cell CL0000740
    CSI 13.86
    rCSI 30.62%
    PRS 94.99
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 13.13
    rCSI 41.07%
    PRS 95.73
  • sncg GABAergic cortical interneuron CL4023015
    CSI 12.74
    rCSI 20.49%
    PRS 95.07
  • cerebellar granule cell CL0001031
    CSI 10.24
    rCSI 15.05%
    PRS 96.31
  • erythrocyte CL0000232
    CSI 7.99
    rCSI 18.13%
    PRS 97.2
  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 6.83
    rCSI 16.33%
    PRS 94.12
  • serotonergic neuron CL0000850
    CSI 6.74
    rCSI 30.1%
    PRS 91.27
  • inhibitory interneuron CL0000498
    CSI 6.57
    rCSI 15.17%
    PRS 95.4
  • pancreatic D cell CL0000173
    CSI 6.46
    rCSI 6.36%
    PRS 98.39
  • interneuron CL0000099
    CSI 6.36
    rCSI 12.77%
    PRS 96.94
  • muscle cell CL0000187
    CSI 6.14
    rCSI 12.6%
    PRS 97.65
  • regular atrial cardiac myocyte CL0002129
    CSI 5.7
    rCSI 18.34%
    PRS 96.67
  • GABAergic amacrine cell CL4030027
    CSI 4.93
    rCSI 16.9%
    PRS 92.83
  • platelet CL0000233
    CSI 4.93
    rCSI 20.44%
    PRS 95.66
  • retinal cone cell CL0000573
    CSI 4.85
    rCSI 7.81%
    PRS 95.52
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 4.83
    rCSI 8.52%
    PRS 95.14
  • glycinergic amacrine cell CL4030028
    CSI 4.64
    rCSI 12.08%
    PRS 95.23
  • primitive red blood cell CL0002355
    CSI 4.46
    rCSI 24.06%
    PRS 98.49
  • cardiac muscle cell CL0000746
    CSI 4.42
    rCSI 6.34%
    PRS 95.35
  • lung neuroendocrine cell CL1000223
    CSI 4.33
    rCSI 6.4%
    PRS 97.96
  • erythroid lineage cell CL0000764
    CSI 4.27
    rCSI 27.44%
    PRS 97.85
  • central nervous system neuron CL2000029
    CSI 4
    rCSI 29.41%
    PRS 95.78
  • megakaryocyte CL0000556
    CSI 3.82
    rCSI 16.57%
    PRS 97.35
  • amacrine cell CL0000561
    CSI 3.78
    rCSI 10.95%
    PRS 95.43
  • dopaminergic neuron CL0000700
    CSI 3.56
    rCSI 20.13%
    PRS 94.07
  • GABAergic neuron CL0000617
    CSI 3.15
    rCSI 10.55%
    PRS 92.62
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 3
    rCSI 7.29%
    PRS 93.92
  • regular ventricular cardiac myocyte CL0002131
    CSI 2.75
    rCSI 17.2%
    PRS 95.86
  • ON parasol ganglion cell CL4033052
    CSI 2.73
    rCSI 38.72%
    PRS 94.67
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 2.64
    rCSI 2.38%
    PRS 98.33
  • erythroid progenitor cell CL0000038
    CSI 2.57
    rCSI 14.71%
    PRS 98.76
  • fast muscle cell CL0000190
    CSI 2.42
    rCSI 9.45%
    PRS 93.22
  • cerebellar neuron CL1001611
    CSI 2.31
    rCSI 20.35%
    PRS 92.78
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 2.04
    rCSI 7.71%
    PRS 94.71
  • ON midget ganglion cell CL4033046
    CSI 1.98
    rCSI 40.34%
    PRS 94.56
  • OFF midget ganglion cell CL4033047
    CSI 1.96
    rCSI 39.89%
    PRS 94.64
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 1.31
    rCSI 4.72%
    PRS 94.22
  • erythroblast CL0000765
    CSI 1.2
    rCSI 3.19%
    PRS 98.07

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.
Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

Loading network (please wait)...

Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [ANK1](/details-gene/286), or ankyrin 1, is a protein-coding gene located on chromosome 8p11.21. It encodes a crucial cytoskeletal anchor protein that links the plasma membrane to the underlying spectrin-actin cytoskeleton. Historically known for its essential role in maintaining the structural integrity and biconcave shape of [erythrocytes](/details-cell/CL0000232) [Link](https://doi.org/10.1038/344036a0), expression data reveals its most significant role may be within the central nervous system. **Overall**, [ANK1](/details-gene/286) shows exceptionally high significance in various subtypes of GABAergic cortical interneurons, including [pvalb GABAergic cortical interneuron](/details-cell/CL4023018) and [sst GABAergic cortical interneuron](/details-cell/CL4023017), suggesting a fundamental role in neuronal architecture and function. Mutations in [ANK1](/details-gene/286) are clinically associated with hereditary spherocytosis, a genetic disorder of red blood cells ([182900](https://omim.org/entry/182900)). ## Cellular Roles and Expression Landscape The expression profile of [ANK1](/details-gene/286) highlights its primary function as a structural and organizing protein in electrically excitable cells. The highest significance scores are observed across a wide array of neuronal subtypes, indicating a foundational role in the nervous system. Specifically, it is a top marker in multiple classes of inhibitory interneurons, such as [pvalb GABAergic cortical interneuron](/details-cell/CL4023018) (CSI: 32.51), [sst GABAergic cortical interneuron](/details-cell/CL4023017) (CSI: 21.10), [VIP GABAergic cortical interneuron](/details-cell/CL4023016) (CSI: 20.11), and [lamp5 GABAergic cortical interneuron](/details-cell/CL4023011) (CSI: 17.13). Its significance extends to other key neuronal populations including [retinal ganglion cells](/details-cell/CL0000740) and [cerebellar granule cells](/details-cell/CL0001031). Beyond its prominent role in the CNS, [ANK1](/details-gene/286) expression is also significant, albeit at lower levels, in cell types consistent with its classically defined functions. This includes a notable CSI in [erythrocytes](/details-cell/CL0000232) (CSI: 7.99), where it anchors the anion exchanger to the spectrin cytoskeleton, and in [muscle cells](/details-cell/CL0000187) (CSI: 6.14), where specific isoforms are known to be expressed [Link](https://doi.org/10.1074/jbc.273.3.1339). This expression pattern suggests that while [ANK1](/details-gene/286) is often defined by its function in red blood cells, its biological impact is substantially broader, with a particularly critical role in establishing and maintaining the complex architecture of neurons. ## Pathways and Molecular Function The molecular functions of [ANK1](/details-gene/286) are centered on its role as a structural scaffold. Gene Ontology annotations confirm its involvement in '[Cytoskeleton organization](/details-gene/GO:0007010)' and '[Protein localization to plasma membrane](/details-gene/GO:0072659)', driven by its molecular function as a '[Structural constituent of cytoskeleton](/details-gene/GO:0005200)' with '[Cytoskeletal anchor activity](/details-gene/GO:0008093)'. It achieves this by binding to key partners, including spectrin ([GO:0030507](https://www.ebi.ac.uk/QuickGO/term/GO:0030507)) and transmembrane transporters ([GO:0044325](https://www.ebi.ac.uk/QuickGO/term/GO:0044325)). This scaffolding function is directly relevant to its observed high expression in neurons. Reactome pathways such as '[Axon guidance](/details-gene/R-HSA-422475)' and '[Nervous system development](/details-gene/R-HSA-9675108)' highlight its participation in neural circuit formation. Specifically, its documented interaction with cell adhesion molecules like L1CAM ([R-HSA-373760](https://reactome.org/content/detail/R-HSA-373760)) and Neurofascin ([R-HSA-447043](https://reactome.org/content/detail/R-HSA-447043)) suggests that [ANK1](/details-gene/286) is responsible for tethering these molecules to the cytoskeleton at critical locations like the '[Axolemma](/details-gene/GO:0030673)' and '[Postsynaptic membrane](/details-gene/GO:0045211)'. Furthermore, its role in vesicle-mediated transport pathways, such as '[ER to Golgi anterograde transport](/details-gene/R-HSA-199977)', suggests it may also help organize membrane trafficking machinery. ## Research Directions The data underscore a potentially underappreciated role for [ANK1](/details-gene/286) in neuronal function, moving beyond its canonical identity as an erythroid protein. This opens several avenues for future research. **Proposed Hypotheses:** 1. Given its high significance in fast-spiking [pvalb GABAergic cortical interneurons](/details-cell/CL4023018), [ANK1](/details-gene/286) may be essential for organizing the dense clusters of voltage-gated ion channels at the axon initial segment and nodes of Ranvier, thereby enabling the high-frequency firing patterns characteristic of these cells. 2. Based on its involvement in the '[Axon guidance](/details-gene/R-HSA-422475)' pathway, [ANK1](/details-gene/286) may play a critical role during neurodevelopment by anchoring specific cell adhesion molecules at the growth cone, thus mediating contact-dependent guidance cues that establish precise synaptic connections. 3. The diverse isoforms of [ANK1](/details-gene/286) may be differentially expressed across neuronal subtypes, with specific variants tailored to anchor distinct sets of membrane proteins (e.g., channels, receptors, transporters) required for the unique physiological properties of cell types like [retinal ganglion cells](/details-cell/CL0000740) versus [cerebellar granule cells](/details-cell/CL0001031). **Experimental Approach:** To test the first hypothesis regarding the role of [ANK1](/details-gene/286) in interneuron excitability, one could employ a conditional knockout strategy. By crossing a floxed-[ANK1](/details-gene/286) mouse line with a Pvalb-Cre driver line, the gene can be specifically deleted in parvalbumin-expressing interneurons. Subsequent analysis using patch-clamp electrophysiology on cortical slices would allow for direct measurement of changes in firing frequency, action potential threshold, and back-propagation. Furthermore, super-resolution microscopy (e.g., STED or STORM) could be used to visualize the localization and density of key proteins like Nav1.6 channels and βIV-spectrin at the axon initial segment to determine if their organization is disrupted by the loss of [ANK1](/details-gene/286). **Therapeutic Potential:** [ANK1](/details-gene/286) is a challenging therapeutic target due to its fundamental structural role in a variety of essential cell types, particularly neurons. Systemic inhibition or activation would likely lead to severe off-target effects. However, for monogenic diseases like hereditary spherocytosis ([182900](https://omim.org/entry/182900)) caused by [ANK1](/details-gene/286) deficiency, therapeutic strategies would focus on restoration of function. This could involve gene therapy approaches aimed at hematopoietic stem cells to correct the defect in the erythroid lineage. Targeting [ANK1](/details-gene/286) for neurological disorders would be far more complex and would likely require highly specific strategies, such as isoform-specific modulation, which are not currently feasible.

Genular Protein ID: 3886806893

Symbol: ANK1_HUMAN

Name: Ankyrin-R

UniProtKB Accession Codes:

P16157 A0PJN8 A6NJ23 E5RFL7 O43400 Q13768 Q53ER1 Q59FP2 Q8N604 Q99407

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 6 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 55 EMDB 13 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 29 Gene3D 4 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 21 PDBsum 21 PIR 2 PRINTS 1 PRO 1 PROSITE 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 6 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 24 Pumba 1 RNAct 1 Reactome 5 RefSeq 8 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2137557

Title: Analysis of cDNA for human erythrocyte ankyrin indicates a repeated structure with homology to tissue-differentiation and cell-cycle control proteins.

PubMed ID: 2137557

DOI: 10.1038/344036a0

PubMed ID: 1689849

Title: cDNA sequence for human erythrocyte ankyrin.

PubMed ID: 1689849

DOI: 10.1073/pnas.87.5.1730

PubMed ID: 9235914

Title: Structure and organization of the human ankyrin-1 gene. Basis for complexity of pre-mRNA processing.

PubMed ID: 9235914

DOI: 10.1074/jbc.272.31.19220

PubMed ID: 9430667

Title: An alternate promoter directs expression of a truncated, muscle-specific isoform of the human ankyrin 1 gene.

PubMed ID: 9430667

DOI: 10.1074/jbc.273.3.1339

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2141335

Title: Mapping the binding sites of human erythrocyte ankyrin for the anion exchanger and spectrin.

PubMed ID: 2141335

DOI: 10.1016/s0021-9258(18)86987-3

PubMed ID: 21177872

Title: Asparagine and aspartate hydroxylation of the cytoskeletal ankyrin family is catalyzed by factor-inhibiting hypoxia-inducible factor.

PubMed ID: 21177872

DOI: 10.1074/jbc.m110.193540

PubMed ID: 7665627

Title: The ANK repeats of erythrocyte ankyrin form two distinct but cooperative binding sites for the erythrocyte anion exchanger.

PubMed ID: 7665627

DOI: 10.1074/jbc.270.37.22050

PubMed ID: 12444090

Title: The hydrophilic domain of small ankyrin-1 interacts with the two N-terminal immunoglobulin domains of titin.

PubMed ID: 12444090

DOI: 10.1074/jbc.m209012200

PubMed ID: 12527750

Title: Binding of an ankyrin-1 isoform to obscurin suggests a molecular link between the sarcoplasmic reticulum and myofibrils in striated muscles.

PubMed ID: 12527750

DOI: 10.1083/jcb.200208109

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 29459732

Title: A protease cascade regulates release of the human malaria parasite Plasmodium falciparum from host red blood cells.

PubMed ID: 29459732

DOI: 10.1038/s41564-018-0111-0

PubMed ID: 12456646

Title: Crystal structure of a 12 ANK repeat stack from human ankyrinR.

PubMed ID: 12456646

DOI: 10.1093/emboj/cdf651

PubMed ID: 22310050

Title: Structurally similar but functionally diverse ZU5 domains in human erythrocyte ankyrin.

PubMed ID: 22310050

DOI: 10.1016/j.jmb.2012.01.041

PubMed ID: 35835865

Title: Architecture of the human erythrocyte ankyrin-1 complex.

PubMed ID: 35835865

DOI: 10.1038/s41594-022-00792-w

PubMed ID: 8640229

Title: Ankyrin-1 mutations are a major cause of dominant and recessive hereditary spherocytosis.

PubMed ID: 8640229

DOI: 10.1038/ng0696-214

PubMed ID: 11102985

Title: Low frequency of ankyrin mutations in hereditary spherocytosis: identification of three novel mutations.

PubMed ID: 11102985

DOI: 10.1002/1098-1004(200012)16:6<529::aid-humu13>3.0.co;2-n

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 1881
  • Mass: 206265
  • Checksum: 49466F6F915019EC
  • Sequence:
    • MPYSVGFREA DAATSFLRAA RSGNLDKALD HLRNGVDINT CNQNGLNGLH LASKEGHVKM 
VVELLHKEII LETTTKKGNT ALHIAALAGQ DEVVRELVNY GANVNAQSQK GFTPLYMAAQ 
ENHLEVVKFL LENGANQNVA TEDGFTPLAV ALQQGHENVV AHLINYGTKG KVRLPALHIA 
ARNDDTRTAA VLLQNDPNPD VLSKTGFTPL HIAAHYENLN VAQLLLNRGA SVNFTPQNGI 
TPLHIASRRG NVIMVRLLLD RGAQIETKTK DELTPLHCAA RNGHVRISEI LLDHGAPIQA 
KTKNGLSPIH MAAQGDHLDC VRLLLQYDAE IDDITLDHLT PLHVAAHCGH HRVAKVLLDK 
GAKPNSRALN GFTPLHIACK KNHVRVMELL LKTGASIDAV TESGLTPLHV ASFMGHLPIV 
KNLLQRGASP NVSNVKVETP LHMAARAGHT EVAKYLLQNK AKVNAKAKDD QTPLHCAARI 
GHTNMVKLLL ENNANPNLAT TAGHTPLHIA AREGHVETVL ALLEKEASQA CMTKKGFTPL 
HVAAKYGKVR VAELLLERDA HPNAAGKNGL TPLHVAVHHN NLDIVKLLLP RGGSPHSPAW 
NGYTPLHIAA KQNQVEVARS LLQYGGSANA ESVQGVTPLH LAAQEGHAEM VALLLSKQAN 
GNLGNKSGLT PLHLVAQEGH VPVADVLIKH GVMVDATTRM GYTPLHVASH YGNIKLVKFL 
LQHQADVNAK TKLGYSPLHQ AAQQGHTDIV TLLLKNGASP NEVSSDGTTP LAIAKRLGYI 
SVTDVLKVVT DETSFVLVSD KHRMSFPETV DEILDVSEDE GEELISFKAE RRDSRDVDEE 
KELLDFVPKL DQVVESPAIP RIPCAMPETV VIRSEEQEQA SKEYDEDSLI PSSPATETSD 
NISPVASPVH TGFLVSFMVD ARGGSMRGSR HNGLRVVIPP RTCAAPTRIT CRLVKPQKLS 
TPPPLAEEEG LASRIIALGP TGAQFLSPVI VEIPHFASHG RGDRELVVLR SENGSVWKEH 
RSRYGESYLD QILNGMDEEL GSLEELEKKR VCRIITTDFP LYFVIMSRLC QDYDTIGPEG 
GSLKSKLVPL VQATFPENAV TKRVKLALQA QPVPDELVTK LLGNQATFSP IVTVEPRRRK 
FHRPIGLRIP LPPSWTDNPR DSGEGDTTSL RLLCSVIGGT DQAQWEDITG TTKLVYANEC 
ANFTTNVSAR FWLSDCPRTA EAVNFATLLY KELTAVPYMA KFVIFAKMND PREGRLRCYC 
MTDDKVDKTL EQHENFVEVA RSRDIEVLEG MSLFAELSGN LVPVKKAAQQ RSFHFQSFRE 
NRLAMPVKVR DSSREPGGSL SFLRKAMKYE DTQHILCHLN ITMPPCAKGS GAEDRRRTPT 
PLALRYSILS ESTPGSLSGT EQAEMKMAVI SEHLGLSWAE LARELQFSVE DINRIRVENP 
NSLLEQSVAL LNLWVIREGQ NANMENLYTA LQSIDRGEIV NMLEGSGRQS RNLKPDRRHT 
DRDYSLSPSQ MNGYSSLQDE LLSPASLGCA LSSPLRADQY WNEVAVLDAI PLAATEHDTM 
LEMSDMQVWS AGLTPSLVTA EDSSLECSKA EDSDATGHEW KLEGALSEEP RGPELGSLEL 
VEDDTVDSDA TNGLIDLLEQ EEGQRSEEKL PGSKRQDDAT GAGQDSENEV SLVSGHQRGQ 
ARITHSPTVS QVTERSQDRL QDWDADGSIV SYLQDAAQGS WQEEVTQGPH SFQGTSTMTE 
GLEPGGSQEY EKVLVSVSEH TWTEQPEAES SQADRDRRQQ GQEEQVQEAK NTFTQVVQGN 
EFQNIPGEQV TEEQFTDEQG NIVTKKIIRK VVRQIDLSSA DAAQEHEEVT VEGPLEDPSE 
LEVDIDYFMK HSKDHTSTPN P

Genular Protein ID: 809939584

Symbol: B3KX39_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KX39

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 4 InterPro 6 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 6 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 RefSeq 1 SAM 1 SMART 3 SUPFAM 2

Sequence Information:

  • Length: 1034
  • Mass: 115228
  • Checksum: 696555E3E876AD8D
  • Sequence:
    • MVDATTRMGY TPLHVASHYG NIKLVKFLLQ HQADVNAKTK LGYSPLHQAA QQGHTDIVTL 
LLKNGASPNE VSSDGTTPLA IAKRLGYISV TDVLKVVTDE TSFVLVSDKH RMSFPETVDE 
ILDVSEDEGT AHITIMGEEL ISFKAERRDS RDVDEEKELL DFVPKLDQVV ESPAIPRIPC 
AMPETVVIRS EEQEQASKEY DEDSLIPSSP ATETSDNISP VASPVHTGFL VSFMVDARGG 
SMRGSRHNGL RVVIPPRTCA APTRITCRLV KPQKLSTPPP LAEEEGLASR IIALGPTGAQ 
FLSPVIVEIP HFASHGRGDR ELVVLRSENG SVWKEHRSRY GESYLDQILN GMDEELGSLE 
ELEKKRVCRI ITTDFPLYFV IMSRLCQDYD TIGPEGGSLK SKLVPLVQAT FPENAVTKRV 
KLALQAQPVP DELVTKLLGN QATFSPIVTV EPRRRKFHRP IGLRIPLPPS WTDNPRDSGE 
GDTTSLRLLC SVIGGTDQAQ WEDITGTTKL VYANECANFT TNVSARFWLS DCPRTAEAVN 
FATLLYKELT AVPYMAKFVI FAKMNDPREG RLRCYCMTDD KVDKTLEQHE NFVEVARSRD 
IEVLEGMSLF AELSGNLVPV KKAAQQRSFH FQSFRENRLA MPVKVRDSSR EPGGSLSFLR 
KAMKYEDTQH ILCHLNITMP PCAKGSGAED RRRTPTPLAL RYSILSESTP GSLSGTEQAE 
MKMAVISEHL GLSWAELARE LQFSVEDINR IRVENPNSLL EQSVALLNLW VIREGQNANM 
ENLYTALQSI DRGEIVNMLE GSGRQSRNLK PDRRHTDRDY SLSPSQMNGH QRGQARITHS 
PTVSQVTERS QDRLQDWDAD GSIVSYLQDA AQGSWQEEVT QGPHSFQGTS TMTEGLEPGG 
SQEYEKVLVS VSEHTWTEQP EAESSQADRD RRQQGQEEQV QEAKNTFTQV VQGNEFQNIP 
GEQVTEEQFT DEQGNIVTKK IIRKVVRQID LSSADAAQEH EEVELRGSGL QPDLIEGRKG 
AQIVKRASLK RGKQ