Details for: IGKV3 34

Gene ID: 28909

Symbol: IGKV3 34

Ensembl ID: ENSG00000253860

Description: immunoglobulin kappa variable 3-34 (pseudogene)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.0008
    Cell Significance Index: 0.0100
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.0001
    Cell Significance Index: 0.0000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Non-coding nature:** The IGKV3-34 gene lacks a coding sequence, rendering it a pseudogene. This characteristic makes it challenging to predict its functional role, as pseudogenes often do not undergo significant selective pressure. 2. **Limited expression:** The gene is primarily expressed in precursor B cells and erythrocytes, suggesting a potential role in the development and maturation of these cell types. 3. **High degree of similarity:** IGKV3-34 shares significant sequence homology with functional kappa light chain genes, hinting at a possible evolutionary relationship. **Pathways and Functions:** While the exact function of IGKV3-34 remains unclear, several theories have emerged: 1. **Regulation of B cell development:** As expressed in precursor B cells, IGKV3-34 may play a role in the regulation of B cell development, potentially influencing the differentiation of these cells into antibody-secreting plasma cells. 2. **Erythropoiesis:** The expression of IGKV3-34 in erythrocytes suggests a possible connection to the erythropoietic process. It is conceivable that this gene contributes to the regulation of erythropoiesis, although the mechanisms remain speculative. 3. **Gene regulation and imprinting:** Some research suggests that pseudogenes like IGKV3-34 may function as "decoy" genes, binding to regulatory elements and influencing the expression of nearby functional genes. This theory could provide insight into the role of IGKV3-34 in gene regulation. **Clinical Significance:** The clinical significance of IGKV3-34 remains largely unknown. However, as a pseudogene, it is possible that alterations in its expression or function could contribute to various diseases, such as: 1. **Autoimmune disorders:** Dysregulation of B cell development and function could lead to autoimmune diseases, such as rheumatoid arthritis or lupus. 2. **Erythrocyte disorders:** Abnormalities in erythropoiesis could result in anemia or other erythrocyte-related disorders. 3. **Cancer:** The role of IGKV3-34 in gene regulation and its potential connection to cancer development warrant further investigation. In conclusion, the IGKV3-34 gene, although seemingly innocuous, holds secrets to the intricacies of immune regulation and erythropoiesis. Further research is necessary to unravel the mysteries of this enigmatic pseudogene and its potential clinical implications.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.