Details for: ABR

Gene ID: 29

Symbol: ABR

Ensembl ID: ENSG00000159842

Description: ABR activator of RhoGEF and GTPase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 362.9491
    Cell Significance Index: -56.4600
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 221.7681
    Cell Significance Index: -56.2500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 122.3623
    Cell Significance Index: -57.7700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 107.6043
    Cell Significance Index: -43.7200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 101.5581
    Cell Significance Index: -52.2400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 45.9862
    Cell Significance Index: -43.9100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 45.8411
    Cell Significance Index: -56.5200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 19.7043
    Cell Significance Index: -52.7900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 19.0333
    Cell Significance Index: -58.4600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 17.0064
    Cell Significance Index: -37.2200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.4017
    Cell Significance Index: -56.8300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.4968
    Cell Significance Index: 500.8500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.3230
    Cell Significance Index: 833.2100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.8192
    Cell Significance Index: 1642.6000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.7485
    Cell Significance Index: 134.1800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.7289
    Cell Significance Index: 119.5600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.6743
    Cell Significance Index: 48.2400
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.5875
    Cell Significance Index: 1097.9700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.5845
    Cell Significance Index: 71.8200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.5461
    Cell Significance Index: 2911.0900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.4938
    Cell Significance Index: 66.0800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.4522
    Cell Significance Index: 54.9900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.3261
    Cell Significance Index: 37.0600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.2489
    Cell Significance Index: 31.2200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.9691
    Cell Significance Index: 105.4100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.6822
    Cell Significance Index: 14.7800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6512
    Cell Significance Index: 105.9100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.4182
    Cell Significance Index: 21.1400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4146
    Cell Significance Index: 74.7400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3885
    Cell Significance Index: 77.1000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3452
    Cell Significance Index: 42.4500
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.3118
    Cell Significance Index: 4.4900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3105
    Cell Significance Index: 16.1300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2563
    Cell Significance Index: 162.7900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2437
    Cell Significance Index: 3.3300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1630
    Cell Significance Index: 73.9700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1450
    Cell Significance Index: 223.2800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1046
    Cell Significance Index: 192.9600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0820
    Cell Significance Index: 2.8800
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.0388
    Cell Significance Index: 0.8500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0326
    Cell Significance Index: 6.2000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0233
    Cell Significance Index: 1.3100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0206
    Cell Significance Index: 28.0500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0191
    Cell Significance Index: 10.4500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0076
    Cell Significance Index: 3.3800
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: 0.0075
    Cell Significance Index: 0.1000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0009
    Cell Significance Index: 0.0400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0202
    Cell Significance Index: -2.9300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0292
    Cell Significance Index: -21.6200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0464
    Cell Significance Index: -28.9900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0616
    Cell Significance Index: -46.6600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0619
    Cell Significance Index: -45.4200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0662
    Cell Significance Index: -37.3100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.0823
    Cell Significance Index: -1.2200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1127
    Cell Significance Index: -2.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1458
    Cell Significance Index: -20.0200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1464
    Cell Significance Index: -30.8300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1662
    Cell Significance Index: -47.8300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.1679
    Cell Significance Index: -16.6100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1856
    Cell Significance Index: -11.9800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1903
    Cell Significance Index: -22.4400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1947
    Cell Significance Index: -33.2400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2101
    Cell Significance Index: -3.6000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2310
    Cell Significance Index: -4.9200
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.2380
    Cell Significance Index: -4.1200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2388
    Cell Significance Index: -24.8600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2535
    Cell Significance Index: -25.8900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2652
    Cell Significance Index: -12.3700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3118
    Cell Significance Index: -36.3400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3133
    Cell Significance Index: -40.4700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.3164
    Cell Significance Index: -40.5700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3343
    Cell Significance Index: -38.3100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4211
    Cell Significance Index: -22.1100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.4336
    Cell Significance Index: -6.2100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5075
    Cell Significance Index: -37.8300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5215
    Cell Significance Index: -59.5300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.5328
    Cell Significance Index: -25.0400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5731
    Cell Significance Index: -36.1200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5953
    Cell Significance Index: -47.1500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.6242
    Cell Significance Index: -5.0900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.6351
    Cell Significance Index: -13.4800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6650
    Cell Significance Index: -21.1800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.6868
    Cell Significance Index: -13.5800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6869
    Cell Significance Index: -22.4900
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.6875
    Cell Significance Index: -7.4900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.6907
    Cell Significance Index: -48.8500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7001
    Cell Significance Index: -42.9200
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.7299
    Cell Significance Index: -9.3600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.8349
    Cell Significance Index: -26.7400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.8716
    Cell Significance Index: -13.0600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.8932
    Cell Significance Index: -31.0400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.9211
    Cell Significance Index: -11.4300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.9357
    Cell Significance Index: -32.7800
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.9487
    Cell Significance Index: -11.8300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -1.0733
    Cell Significance Index: -22.4000
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -1.0776
    Cell Significance Index: -26.8800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -1.1011
    Cell Significance Index: -29.9700
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -1.1164
    Cell Significance Index: -14.0900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -1.1451
    Cell Significance Index: -24.7400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -1.1481
    Cell Significance Index: -23.0500

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ABR is a highly conserved protein that belongs to the Rho GEF family. It is primarily expressed in mature microglial cells, pigmented epithelial cells, central nervous system macrophages, astrocytes, and specific subsets of GABAergic cortical interneurons. ABR's ability to activate Rho GTPases is essential for its role in regulating small GTPase-mediated signal transduction. The gene's expression is tightly regulated, and its dysregulation has been implicated in various neurological disorders, including neurodegenerative diseases and synaptic dysfunction. **Pathways and Functions:** ABR's activation of Rho GTPases leads to the regulation of various signaling pathways, including: 1. **Axon guidance**: ABR's activation of RhoA and Rac1 promotes the formation of axonal projections and guidance, which is essential for neural development and regeneration. 2. **Cell death signaling**: ABR's activation of RhoA and Rac2 regulates cell death signaling via the NrgE/NrF/NrE3 pathway, which is involved in the regulation of apoptosis and necroptosis. 3. **Synaptic transmission**: ABR's activation of Rac1 and Rac3 regulates glutamatergic synaptic transmission, which is essential for neural communication and learning. 4. **G protein-coupled receptor signaling**: ABR's activation of RhoA and Rac1 regulates signaling events initiated by G protein-coupled receptors (GPCRs), which are involved in various cellular processes, including cell growth, differentiation, and survival. **Clinical Significance:** Dysregulation of ABR's function has been implicated in various neurological disorders, including: 1. **Neurodegenerative diseases**: ABR's dysregulation has been linked to neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and Huntington's disease, which are characterized by synaptic dysfunction and neuronal death. 2. **Synaptic dysfunction**: ABR's dysregulation has been implicated in synaptic dysfunction, which is a hallmark of various neurological disorders, including autism spectrum disorder, schizophrenia, and attention deficit hyperactivity disorder. 3. **Cancer**: ABR's dysregulation has been linked to cancer, particularly in the context of glioblastoma, where ABR's activation of RhoA and Rac1 promotes tumor growth and invasion. In conclusion, ABR is a critical regulator of Rho GTPase signaling in the central nervous system, and its dysregulation has been implicated in various neurological disorders. Further research is necessary to fully elucidate the role of ABR in normal and pathological processes, and to explore its potential as a therapeutic target for the treatment of neurological diseases.

Genular Protein ID: 2460095897

Symbol: ABR_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q12979 B3KW89 B7Z6H7 D3DTH3 D3DTH4 F5H3S2 F5H8B3 Q13693 Q13694

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 4 CDD 4 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 Ensembl 11 ExpressionAtlas 1 GO 12 Gene3D 4 GeneCards 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 2 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 Reactome 9 RefSeq 6 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 4 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8262969

Title: The human active breakpoint cluster region-related gene encodes a brain protein with homology to guanine nucleotide exchange proteins and GTPase-activating proteins.

PubMed ID: 8262969

DOI: 10.1016/s0021-9258(19)74248-3

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 8349582

Title: Human ABR encodes a protein with GAPrac activity and homology to the DBL nucleotide exchange factor domain.

PubMed ID: 8349582

DOI: 10.1016/s0021-9258(19)85281-x

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 2587217

Title: ABR, an active BCR-related gene.

PubMed ID: 2587217

DOI: 10.1093/nar/17.21.8821

PubMed ID: 7479768

Title: Abr and Bcr are multifunctional regulators of the Rho GTP-binding protein family.

PubMed ID: 7479768

DOI: 10.1073/pnas.92.22.10282

PubMed ID: 17116687

Title: Abr and Bcr, two homologous Rac GTPase-activating proteins, control multiple cellular functions of murine macrophages.

PubMed ID: 17116687

DOI: 10.1128/mcb.00756-06

PubMed ID: 20962234

Title: Regulation of synaptic Rac1 activity, long-term potentiation maintenance, and learning and memory by BCR and ABR Rac GTPase-activating proteins.

PubMed ID: 20962234

DOI: 10.1523/jneurosci.1711-10.2010

Sequence Information:

  • Length: 859
  • Mass: 97598
  • Checksum: 3A5BE3AD2455A194
  • Sequence:
    • MEPLSHRGLP RLSWIDTLYS NFSYGTDEYD GEGNEEQKGP PEGSETMPYI DESPTMSPQL 
SARSQGGGDG VSPTPPEGLA PGVEAGKGLE MRKLVLSGFL ASEEIYINQL EALLLPMKPL 
KATATTSQPV LTIQQIETIF YKIQDIYEIH KEFYDNLCPK VQQWDSQVTM GHLFQKLASQ 
LGVYKAFVDN YKVALETAEK CSQSNNQFQK ISEELKVKGP KDSKDSHTSV TMEALLYKPI 
DRVTRSTLVL HDLLKHTPVD HPDYPLLQDA LRISQNFLSS INEDIDPRRT AVTTPKGETR 
QLVKDGFLVE VSESSRKLRH VFLFTDVLLC AKLKKTSAGK HQQYDCKWYI PLADLVFPSP 
EESEASPQVH PFPDHELEDM KMKISALKSE IQKEKANKGQ SRAIERLKKK MFENEFLLLL 
NSPTIPFRIH NRNGKSYLFL LSSDYERSEW REAIQKLQKK DLQAFVLSSV ELQVLTGSCF 
KLRTVHNIPV TSNKDDDESP GLYGFLHVIV HSAKGFKQSA NLYCTLEVDS FGYFVSKAKT 
RVFRDTAEPK WDEEFEIELE GSQSLRILCY EKCYDKTKVN KDNNEIVDKI MGKGQIQLDP 
QTVETKNWHT DVIEMNGIKV EFSMKFTSRD MSLKRTPSKK QTGVFGVKIS VVTKRERSKV 
PYIVRQCVEE VEKRGIEEVG IYRISGVATD IQALKAVFDA NNKDILLMLS DMDINAIAGT 
LKLYFRELPE PLLTDRLYPA FMEGIALSDP AAKENCMMHL LRSLPDPNLI TFLFLLEHLK 
RVAEKEPINK MSLHNLATVF GPTLLRPSEV ESKAHLTSAA DIWSHDVMAQ VQVLLYYLQH 
PPISFAELKR NTLYFSTDV

Genular Protein ID: 1660933203

Symbol: B7Z7Z1_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z7Z1

Database IDs:

ARBA 8 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 4 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 4 InterPro 11 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 9 PeptideAtlas 1 Pfam 4 RefSeq 4 SAM 1 SMART 4 SUPFAM 4

Sequence Information:

  • Length: 813
  • Mass: 92397
  • Checksum: FE5F70FFF4B4F5C5
  • Sequence:
    • MPYIDESPTM SPQLSARSQG GGDGVSPTPP EGLAPGVEAG KGLEMRKLVL SGFLASEEIY 
INQLEALLLP MKPLKATATT SQPVLTIQQI ETIFYKIQDI YEIHKEFYDN LCPKVQQWDS 
QVTMGHLFQK LASQLGVYKA FVDNYKVALE TAEKCSQSNN QFQKISEELK VKGPKDSKDS 
HTSVTMEALL YKPIDRVTRS TLVLHDLLKH TPVDHPDYPL LQDALRISQN FLSSINEDID 
PRRTAVTTPK GETRQLVKDG FLVEVSESSR KLRHVFLFTD VLLCAKLKKT SAGKHQQYDC 
KWYIPLADLV FPSPEESEAS PQVHPFPDHE LEDMKMKISA LKSEIQKEKA NKGQSRAIER 
LKKKMFENEF LLLLNSPTIP FRIHNRNGKS YLFLLSSDYE RSEWREAIQK LQKKDLQAFV 
LSSVELQVLT GSCFKLRTVH NIPVTSNKDD DESPGLYGFL HVIVHSAKGF KQSANLYCTL 
EVDSFGYFVS KAKTRVFRDT AEPKWDEEFE IELEGSQSLR ILCYEKCYDK TKVNKDNNEI 
VDKIMGKGQI QLDPQTVETK NWHTDVIEMN GIKVEFSMKF TSRDMSLKRT PSKKQTGVFG 
VKISVVTKRE RSKVPYIVRQ CVEEVEKRGI EEVGIYRISG VATDIQALKA VFDANNKDIL 
LMLSDMDINA IAGTLKLYFR ELPEPLLTDR LYPAFMEGIA LSDPAAKENC MMHLLRSLPD 
PNLITFLFLL EHLKRVAEKE PINKMSLHNL ATAFGPTLLR PSEVESKAHL TSAADIWSHD 
VMAQVQVLLY YLQHPPISFA ELKRNTLYFS TDV

Genular Protein ID: 4175720552

Symbol: B7Z2X0_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z2X0

Database IDs:

ARBA 8 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 4 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 6 Gene3D 4 InterPro 11 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 9 PeptideAtlas 1 Pfam 4 RefSeq 1 SMART 4 SUPFAM 4

Sequence Information:

  • Length: 769
  • Mass: 88075
  • Checksum: 967A05498C2E23F7
  • Sequence:
    • MRKLVLSGFL ASEEIYINQL EALLLPMKPL KATATTSQPV LTIQQIETIF YKIQDIYEIH 
KEFYDNLCPK VQQWDSQVTM GHLFQKLASQ LGVYKAFVDN YKVALETAEK CSQSNNQFQK 
ISEELKVKGP KDSKDSHTSV TMEALLYKPI DRVTRSTLVL HDLLKHTPVD HPDYPLLQDA 
LRISQNFLSS INEDIDPRRT AVTTPKGETR QLVKDGFLVE VSESSRKLRH VFLFTDVLLC 
AKLKKTSAGK HQQYDCKWYI PLADLVFPSP EESEASPQVH PFPDHELEDM KMKISALKSE 
IQKEKANKGQ SRAIERLKKK MFENEFLLLL NSPTIPFRIH NRNGKSYLFL LSSDYERSEW 
REAIQKLQKK DLQAFVLSSV ELQVLTGSCF KLRTVHNIPV TSNKDDDESP GLYGFLHVIV 
HSAKGFKQSA NLYCTLEVDS FGYFVSKAKT RVFRDTAEPK WDEEFEIELE GSQSLRILCY 
EKCYDKTKVN KDNNEIVDKI MGKGQIQLDP QTVETKNWHT DVIEMNGIKV EFSMKFTSRD 
MSLKRTPSKK QTGVFGVKIS VVTKRERSKV PYIVRQCVEE VEKRGIEEVG IYRISGVATD 
IQALKAVFDA NNKDILLMLS DMDINAIAGT LKLYFRELPE PLLTDRLYPA FMEGIALSDP 
AAKENCMMHL LRSLPDPNLI TFLFLLEHLK RVAEKEPINK MSLHNLATVF GPTLLRPSEV 
ESKAHLTSAA DIWSHDVMAQ VQVLLYYLQH PPISFAELKR NTLYFSTDV

Genular Protein ID: 4222051928

Symbol: B7Z683_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z683

Database IDs:

ARBA 6 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 3 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 4 GO 5 Gene3D 4 GeneTree 1 HGNC 1 InterPro 10 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 8 PeptideAtlas 1 Pfam 4 Proteomes 2 ProteomicsDB 2 RefSeq 2 SMART 3 SUPFAM 4 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 641
  • Mass: 73517
  • Checksum: FE84A80387020D68
  • Sequence:
    • MEILLIIRFC CNCTYALLYK PIDRVTRSTL VLHDLLKHTP VDHPDYPLLQ DALRISQNFL 
SSINEDIDPR RTAVTTPKGE TRQLVKDGFL VEVSESSRKL RHVFLFTDVL LCAKLKKTSA 
GKHQQYDCKW YIPLADLVFP SPEESEASPQ VHPFPDHELE DMKMKISALK SEIQKEKANK 
GQSRAIERLK KKMFENEFLL LLNSPTIPFR IHNRNGKSYL FLLSSDYERS EWREAIQKLQ 
KKDLQAFVLS SVELQVLTGS CFKLRTVHNI PVTSNKDDDE SPGLYGFLHV IVHSAKGFKQ 
SANLYCTLEV DSFGYFVSKA KTRVFRDTAE PKWDEEFEIE LEGSQSLRIL CYEKCYDKTK 
VNKDNNEIVD KIMGKGQIQL DPQTVETKNW HTDVIEMNGI KVEFSMKFTS RDMSLKRTPS 
KKQTGVFGVK ISVVTKRERS KVPYIVRQCV EEVEKRGIEE VGIYRISGVA TDIQALKAVF 
DANNKDILLM LSDMDINAIA GTLKLYFREL PEPLLTDRLY PAFMEGIALS DPAAKENCMM 
HLLRSLPDPN LITFLFLLEH LKRVAEKEPI NKMSLHNLAT VFGPTLLRPS EVESKAHLTS 
AADIWSHDVM AQVQVLLYYL QHPPISFAEL KRNTLYFSTD V

Genular Protein ID: 3557649304

Symbol: I3L4Y1_HUMAN

Name: N/A

UniProtKB Accession Codes:

I3L4Y1

Database IDs:

ARBA 8 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 CDD 4 CTD 1 ChiTaRS 1 DisGeNET 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 6 Gene3D 5 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 13 MassIVE 1 NCBI Taxonomy 1 PANTHER 2 PROSITE 9 PeptideAtlas 1 Pfam 5 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 2 SMART 4 SMR 1 SUPFAM 5 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 1118
  • Mass: 126296
  • Checksum: 28E6E6C1624CA43A
  • Sequence:
    • MWDPRAFERR WRAEFPGAEA PVPRLESVRD AERELERRRL NLERLQQVLA EEQLKASLPQ 
AALARGGGGD SGEPGRPDPE AESPRGDPGR PDPEAESPRG DLPAGPGAAG EAGGGRSWAD 
AVHRQLLQPQ LRFRAREDDA PLGDPQAAPG TDEGGDGGDH DFEMVDFNEK FILSHWLVAP 
CRFGTRERAR SPRRWMHLIP GGRRPQRGTR DLEQREAEAK GRPGSPLAAE ETPGREHLPP 
WRRRRFLRVP ERDSPGHSSP ERDSDGSRHS SDREDDFSAD FSYGTDEYDG EGNEEQKGPP 
EGSETMPYID ESPTMSPQLS ARSQGGGDGV SPTPPEGLAP GVEAGKGLEM RKLVLSGFLA 
SEEIYINQLE ALLLPMKPLK ATATTSQPVL TIQQIETIFY KIQDIYEIHK EFYDNLCPKV 
QQWDSQVTMG HLFQKLASQL GVYKAFVDNY KVALETAEKC SQSNNQFQKI SEELKVKGPK 
DSKDSHTSVT MEALLYKPID RVTRSTLVLH DLLKHTPVDH PDYPLLQDAL RISQNFLSSI 
NEDIDPRRTA VTTPKGETRQ LVKDGFLVEV SESSRKLRHV FLFTDVLLCA KLKKTSAGKH 
QQYDCKWYIP LADLVFPSPE ESEASPQVHP FPDHELEDMK MKISALKSEI QKEKANKGQS 
RAIERLKKKM FENEFLLLLN SPTIPFRIHN RNGKSYLFLL SSDYERSEWR EAIQKLQKKD 
LQAFVLSSVE LQVLTGSCFK LRTVHNIPVT SNKDDDESPG LYGFLHVIVH SAKGFKQSAN 
LYCTLEVDSF GYFVSKAKTR VFRDTAEPKW DEEFEIELEG SQSLRILCYE KCYDKTKVNK 
DNNEIVDKIM GKGQIQLDPQ TVETKNWHTD VIEMNGIKVE FSMKFTSRDM SLKRTPSKKQ 
TGVFGVKISV VTKRERSKVP YIVRQCVEEV EKRGIEEVGI YRISGVATDI QALKAVFDAN 
NKDILLMLSD MDINAIAGTL KLYFRELPEP LLTDRLYPAF MEGIALSDPA AKENCMMHLL 
RSLPDPNLIT FLFLLEHLKR VAEKEPINKM SLHNLATVFG PTLLRPSEVE SKAHLTSAAD 
IWSHDVMAQV QVLLYYLQHP PISFAELKRN TLYFSTDV

Genular Protein ID: 1460877146

Symbol: Q6ZT60_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6ZT60

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 3 InterPro 7 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 5 PeptideAtlas 1 Pfam 3 PharmGKB 1 RefSeq 6 SMART 1 SUPFAM 3

Sequence Information:

  • Length: 362
  • Mass: 41155
  • Checksum: 6DD596C803BFD4E7
  • Sequence:
    • MKPLKATATT SQPVLTIQQI ETIFYKIQDI YEIHKEFYDN LCPKVQQWDS QVTMGHLFQK 
LASQLGVYKA FVDNYKVALE TAEKCSQSNN QFQKISEELK VKGPKDSKDS HTSVTMEALL 
YKPIDRVTRS TLVLHDLLKH TPVDHPDYPL LQDALRISQN FLSSINEDID PRRTAVTTPK 
GETRQLVKDG FLVEVSESSR KLRHVFLFTD VLLCAKLKKT SAGKHQQYDC KWYIPLADLV 
FPSPEESEAS PQVHPFPDHE LEDMKMKISA LKSEIQKEVE KRGIEEVGIY RISGVATDIQ 
ALKAVFDANN KDILLMLSDM DINAIAGTLK LYFRELPEPL LTDRLRPCPT PTSSPSSSCW 
NT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.